Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania major

UniProt:

Q4QFS0_LEIMA

TriTrypDb:

LmjF.14.0640 , LMJLV39_140012400 , LMJSD75_140012000

Length:

280

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 25
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	25
GO:0016020	membrane	2	23

Expansion

Sequence features

Q4QFS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFS0

Function

Biological processes
Term	Name	Level	Count
GO:0000038	very long-chain fatty acid metabolic process	5	4
GO:0001676	long-chain fatty acid metabolic process	5	4
GO:0006082	organic acid metabolic process	3	27
GO:0006629	lipid metabolic process	3	27
GO:0006631	fatty acid metabolic process	4	27
GO:0006633	fatty acid biosynthetic process	5	27
GO:0006643	membrane lipid metabolic process	4	4
GO:0006665	sphingolipid metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	27
GO:0008610	lipid biosynthetic process	4	27
GO:0009058	biosynthetic process	2	27
GO:0009987	cellular process	1	27
GO:0016053	organic acid biosynthetic process	4	27
GO:0019367	fatty acid elongation, saturated fatty acid	7	4
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	4
GO:0019752	carboxylic acid metabolic process	5	27
GO:0030148	sphingolipid biosynthetic process	5	4
GO:0030497	fatty acid elongation	6	4
GO:0032787	monocarboxylic acid metabolic process	6	27
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	4
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	4
GO:0042759	long-chain fatty acid biosynthetic process	6	4
GO:0042761	very long-chain fatty acid biosynthetic process	6	4
GO:0043436	oxoacid metabolic process	4	27
GO:0044237	cellular metabolic process	2	27
GO:0044238	primary metabolic process	2	27
GO:0044249	cellular biosynthetic process	3	27
GO:0044255	cellular lipid metabolic process	3	27
GO:0044281	small molecule metabolic process	2	27
GO:0044283	small molecule biosynthetic process	3	27
GO:0046394	carboxylic acid biosynthetic process	5	27
GO:0046467	membrane lipid biosynthetic process	4	4
GO:0071704	organic substance metabolic process	2	27
GO:0072330	monocarboxylic acid biosynthetic process	6	27
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901566	organonitrogen compound biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	27

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004312	fatty acid synthase activity	5	27
GO:0009922	fatty acid elongase activity	6	27
GO:0016740	transferase activity	2	27
GO:0016746	acyltransferase activity	3	27
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	27
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	264	266	PF00675	0.328
CLV_NRD_NRD_1	272	274	PF00675	0.520
CLV_NRD_NRD_1	86	88	PF00675	0.419
CLV_PCSK_KEX2_1	272	274	PF00082	0.489
CLV_PCSK_KEX2_1	278	280	PF00082	0.531
CLV_PCSK_KEX2_1	86	88	PF00082	0.376
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.543
CLV_PCSK_SKI1_1	137	141	PF00082	0.160
CLV_PCSK_SKI1_1	191	195	PF00082	0.357
DEG_Nend_UBRbox_3	1	3	PF02207	0.373
DOC_AGCK_PIF_1	152	157	PF00069	0.405
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.545
DOC_MAPK_gen_1	190	200	PF00069	0.451
DOC_MAPK_MEF2A_6	194	202	PF00069	0.469
DOC_MAPK_MEF2A_6	240	247	PF00069	0.333
DOC_PP1_RVXF_1	107	113	PF00149	0.405
DOC_PP1_RVXF_1	135	141	PF00149	0.550
DOC_PP4_FxxP_1	40	43	PF00568	0.333
DOC_USP7_MATH_1	274	278	PF00917	0.695
DOC_USP7_UBL2_3	190	194	PF12436	0.481
DOC_WW_Pin1_4	272	277	PF00397	0.672
LIG_Actin_WH2_2	64	81	PF00022	0.466
LIG_APCC_ABBA_1	250	255	PF00400	0.388
LIG_BRCT_BRCA1_1	253	257	PF00533	0.307
LIG_BRCT_BRCA1_2	253	259	PF00533	0.378
LIG_EH1_1	171	179	PF00400	0.371
LIG_FHA_1	105	111	PF00498	0.225
LIG_FHA_1	126	132	PF00498	0.463
LIG_FHA_1	146	152	PF00498	0.277
LIG_FHA_1	204	210	PF00498	0.416
LIG_FHA_1	239	245	PF00498	0.433
LIG_FHA_2	97	103	PF00498	0.238
LIG_HCF-1_HBM_1	9	12	PF13415	0.275
LIG_LIR_Gen_1	127	138	PF02991	0.497
LIG_LIR_Gen_1	142	152	PF02991	0.384
LIG_LIR_Gen_1	176	187	PF02991	0.346
LIG_LIR_Gen_1	215	223	PF02991	0.430
LIG_LIR_Nem_3	142	147	PF02991	0.338
LIG_LIR_Nem_3	149	155	PF02991	0.308
LIG_LIR_Nem_3	176	182	PF02991	0.321
LIG_LIR_Nem_3	186	192	PF02991	0.460
LIG_LIR_Nem_3	215	220	PF02991	0.304
LIG_LIR_Nem_3	70	75	PF02991	0.314
LIG_Pex14_1	3	7	PF04695	0.365
LIG_Pex14_2	140	144	PF04695	0.386
LIG_Pex14_2	253	257	PF04695	0.309
LIG_SH2_PTP2	199	202	PF00017	0.345
LIG_SH2_PTP2	217	220	PF00017	0.253
LIG_SH2_PTP2	261	264	PF00017	0.553
LIG_SH2_STAP1	106	110	PF00017	0.260
LIG_SH2_STAT3	155	158	PF00017	0.328
LIG_SH2_STAT5	106	109	PF00017	0.273
LIG_SH2_STAT5	150	153	PF00017	0.330
LIG_SH2_STAT5	172	175	PF00017	0.352
LIG_SH2_STAT5	181	184	PF00017	0.308
LIG_SH2_STAT5	199	202	PF00017	0.373
LIG_SH2_STAT5	217	220	PF00017	0.227
LIG_SH2_STAT5	246	249	PF00017	0.328
LIG_SH2_STAT5	251	254	PF00017	0.308
LIG_SH2_STAT5	261	264	PF00017	0.434
LIG_SH2_STAT5	30	33	PF00017	0.313
LIG_SH2_STAT5	35	38	PF00017	0.311
LIG_SH3_3	77	83	PF00018	0.361
LIG_UBA3_1	116	121	PF00899	0.319
LIG_UBA3_1	252	259	PF00899	0.337
LIG_UBA3_1	45	53	PF00899	0.515
LIG_WRC_WIRS_1	97	102	PF05994	0.326
MOD_CDC14_SPxK_1	275	278	PF00782	0.710
MOD_CDK_SPxK_1	272	278	PF00069	0.688
MOD_CDK_SPxxK_3	272	279	PF00069	0.739
MOD_CK1_1	232	238	PF00069	0.316
MOD_CK1_1	70	76	PF00069	0.230
MOD_CK2_1	96	102	PF00069	0.268
MOD_CMANNOS	62	65	PF00535	0.388
MOD_GlcNHglycan	133	136	PF01048	0.315
MOD_GlcNHglycan	214	217	PF01048	0.417
MOD_GlcNHglycan	231	234	PF01048	0.534
MOD_GlcNHglycan	236	239	PF01048	0.537
MOD_GSK3_1	234	241	PF00069	0.341
MOD_LATS_1	51	57	PF00433	0.360
MOD_NEK2_1	105	110	PF00069	0.226
MOD_NEK2_1	117	122	PF00069	0.321
MOD_NEK2_1	125	130	PF00069	0.470
MOD_NEK2_1	131	136	PF00069	0.457
MOD_NEK2_1	173	178	PF00069	0.315
MOD_NEK2_1	198	203	PF00069	0.508
MOD_NEK2_1	212	217	PF00069	0.305
MOD_NEK2_1	38	43	PF00069	0.317
MOD_NEK2_1	67	72	PF00069	0.311
MOD_NEK2_1	93	98	PF00069	0.249
MOD_PIKK_1	203	209	PF00454	0.380
MOD_PIKK_1	238	244	PF00454	0.385
MOD_Plk_4	125	131	PF00069	0.469
MOD_Plk_4	139	145	PF00069	0.292
MOD_Plk_4	146	152	PF00069	0.279
MOD_Plk_4	159	165	PF00069	0.159
MOD_Plk_4	173	179	PF00069	0.251
MOD_Plk_4	67	73	PF00069	0.230
MOD_ProDKin_1	272	278	PF00069	0.673
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.441
TRG_ENDOCYTIC_2	179	182	PF00928	0.333
TRG_ENDOCYTIC_2	199	202	PF00928	0.136
TRG_ENDOCYTIC_2	217	220	PF00928	0.344
TRG_ENDOCYTIC_2	35	38	PF00928	0.308
TRG_ENDOCYTIC_2	75	78	PF00928	0.383
TRG_ER_diArg_1	271	273	PF00400	0.747
TRG_ER_diArg_1	85	87	PF00400	0.176
TRG_NES_CRM1_1	242	255	PF08389	0.440
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	26%	95%
A0A0N0P5E5	Leptomonas seymouri	34%	94%
A0A0N0P7D1	Leptomonas seymouri	34%	84%
A0A0N0P7D6	Leptomonas seymouri	43%	97%
A0A0N0P7R2	Leptomonas seymouri	36%	92%
A0A0N1HZJ8	Leptomonas seymouri	29%	86%
A0A0N1I9H5	Leptomonas seymouri	73%	100%
A0A0N1IIZ8	Leptomonas seymouri	24%	91%
A0A0N1ILQ4	Leptomonas seymouri	38%	96%
A0A0N1IM10	Leptomonas seymouri	52%	98%
A0A0N1PDR8	Leptomonas seymouri	32%	100%
A0A0N1PFE8	Leptomonas seymouri	60%	100%
A0A0S4IS29	Bodo saltans	35%	100%
A0A0S4IVJ6	Bodo saltans	33%	88%
A0A0S4IVS6	Bodo saltans	31%	99%
A0A0S4IW98	Bodo saltans	34%	88%
A0A0S4JH58	Bodo saltans	27%	93%
A0A1X0NNK7	Trypanosomatidae	34%	98%
A0A1X0NNL0	Trypanosomatidae	44%	93%
A0A1X0NNM4	Trypanosomatidae	40%	98%
A0A1X0NNM5	Trypanosomatidae	31%	91%
A0A1X0NP89	Trypanosomatidae	30%	88%
A0A3Q8I8T7	Leishmania donovani	27%	71%
A0A3Q8I9T2	Leishmania donovani	31%	75%
A0A3Q8I9U9	Leishmania donovani	31%	86%
A0A3Q8I9X8	Leishmania donovani	33%	84%
A0A3Q8IC05	Leishmania donovani	32%	92%
A0A3Q8ID51	Leishmania donovani	30%	71%
A0A3Q8IIA9	Leishmania donovani	61%	99%
A0A3R7KG78	Trypanosoma rangeli	30%	99%
A0A3R7MJR2	Trypanosoma rangeli	43%	100%
A0A3R7NSQ3	Trypanosoma rangeli	48%	97%
A0A3S5H6R7	Leishmania donovani	54%	98%
A0A3S5H6R8	Leishmania donovani	37%	95%
A0A3S7WSY8	Leishmania donovani	95%	100%
A0A3S7WSZ1	Leishmania donovani	34%	94%
A0A3S7WT03	Leishmania donovani	34%	94%
A0A3S7WT05	Leishmania donovani	25%	92%
A0A3S7WT16	Leishmania donovani	29%	87%
A0A422NNP1	Trypanosoma rangeli	31%	93%
A4H7M1	Leishmania braziliensis	23%	92%
A4H7M2	Leishmania braziliensis	84%	98%
A4H7M3	Leishmania braziliensis	56%	98%
A4H7M4	Leishmania braziliensis	58%	99%
A4H7M5	Leishmania braziliensis	36%	95%
A4H7M6	Leishmania braziliensis	32%	94%
A4H7M7	Leishmania braziliensis	30%	87%
A4H7M8	Leishmania braziliensis	32%	73%
A4H7M9	Leishmania braziliensis	28%	69%
A4H7N0	Leishmania braziliensis	36%	94%
A4HW06	Leishmania infantum	25%	92%
A4HW07	Leishmania infantum	95%	100%
A4HW08	Leishmania infantum	54%	98%
A4HW09	Leishmania infantum	61%	99%
A4HW10	Leishmania infantum	37%	95%
A4HW12	Leishmania infantum	33%	84%
A4HW13	Leishmania infantum	31%	86%
A4HW14	Leishmania infantum	29%	87%
A4HW15	Leishmania infantum	31%	75%
A4HW16	Leishmania infantum	30%	75%
A4HW17	Leishmania infantum	28%	71%
A4HW18	Leishmania infantum	32%	92%
C9ZT13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	93%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	92%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	75%
E8NHR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	73%
E9AGL0	Leishmania infantum	33%	94%
E9AGL2	Leishmania infantum	34%	94%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	75%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	98%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	99%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	95%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	94%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	94%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	84%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	86%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	87%
E9APR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	73%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	93%
G5EEE5	Caenorhabditis elegans	25%	97%
O35949	Mus musculus	30%	100%
P39540	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	90%
P40319	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	81%
P49191	Caenorhabditis elegans	30%	88%
Q03574	Caenorhabditis elegans	31%	96%
Q2KJD9	Bos taurus	24%	94%
Q32NI8	Xenopus laevis	26%	95%
Q3S8M4	Macaca mulatta	25%	89%
Q4QFQ9	Leishmania major	31%	100%
Q4QFR0	Leishmania major	27%	100%
Q4QFR2	Leishmania major	32%	75%
Q4QFR3	Leishmania major	29%	100%
Q4QFR4	Leishmania major	31%	86%
Q4QFR5	Leishmania major	33%	78%
Q4QFR6	Leishmania major	34%	100%
Q4QFR7	Leishmania major	38%	95%
Q4QFR8	Leishmania major	59%	99%
Q4QFR9	Leishmania major	54%	100%
Q4QFS1	Leishmania major	23%	92%
Q4R516	Macaca fascicularis	26%	94%
Q5RFL5	Pongo abelii	25%	94%
Q5ZJR8	Gallus gallus	35%	100%
Q6PC64	Danio rerio	34%	100%
Q7LKX0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	77%
Q86JM5	Dictyostelium discoideum	27%	95%
Q8BHI7	Mus musculus	27%	94%
Q920L5	Mus musculus	35%	100%
Q920L6	Rattus norvegicus	39%	100%
Q920L7	Rattus norvegicus	26%	94%
Q95K73	Macaca fascicularis	25%	89%
Q9EQC4	Mus musculus	25%	90%
Q9GZR5	Homo sapiens	22%	89%
Q9H5J4	Homo sapiens	35%	100%
Q9HB03	Homo sapiens	29%	100%
Q9NYP7	Homo sapiens	26%	94%
Q9VV87	Drosophila melanogaster	30%	89%
Q9XVQ9	Caenorhabditis elegans	30%	100%
V5BE99	Trypanosoma cruzi	30%	98%
V5BIX9	Trypanosoma cruzi	42%	100%
V5BND3	Trypanosoma cruzi	31%	93%
V5DF68	Trypanosoma cruzi	47%	97%