Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania major

UniProt:

Q4QFR8_LEIMA

TriTrypDb:

LmjF.14.0660 , LMJLV39_140012600 , LMJSD75_140012200

Length:

284

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 45

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 37
NetGPI	no	yes: 0, no: 38

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	33
GO:0110165	cellular anatomical entity	1	34
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4QFR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFR8

Function

Biological processes
Term	Name	Level	Count
GO:0000038	very long-chain fatty acid metabolic process	5	6
GO:0001676	long-chain fatty acid metabolic process	5	4
GO:0006082	organic acid metabolic process	3	39
GO:0006629	lipid metabolic process	3	39
GO:0006631	fatty acid metabolic process	4	39
GO:0006633	fatty acid biosynthetic process	5	39
GO:0006643	membrane lipid metabolic process	4	6
GO:0006665	sphingolipid metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	39
GO:0008610	lipid biosynthetic process	4	39
GO:0009058	biosynthetic process	2	39
GO:0009987	cellular process	1	39
GO:0016053	organic acid biosynthetic process	4	39
GO:0019367	fatty acid elongation, saturated fatty acid	7	6
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	6
GO:0019752	carboxylic acid metabolic process	5	39
GO:0030148	sphingolipid biosynthetic process	5	6
GO:0030497	fatty acid elongation	6	6
GO:0032787	monocarboxylic acid metabolic process	6	39
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	6
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	6
GO:0042759	long-chain fatty acid biosynthetic process	6	4
GO:0042761	very long-chain fatty acid biosynthetic process	6	6
GO:0043436	oxoacid metabolic process	4	39
GO:0044237	cellular metabolic process	2	39
GO:0044238	primary metabolic process	2	39
GO:0044249	cellular biosynthetic process	3	39
GO:0044255	cellular lipid metabolic process	3	39
GO:0044281	small molecule metabolic process	2	39
GO:0044283	small molecule biosynthetic process	3	39
GO:0046394	carboxylic acid biosynthetic process	5	39
GO:0046467	membrane lipid biosynthetic process	4	6
GO:0071704	organic substance metabolic process	2	39
GO:0072330	monocarboxylic acid biosynthetic process	6	39
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	39

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	39
GO:0004312	fatty acid synthase activity	5	39
GO:0009922	fatty acid elongase activity	6	39
GO:0016740	transferase activity	2	39
GO:0016746	acyltransferase activity	3	39
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	39
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.251
CLV_NRD_NRD_1	137	139	PF00675	0.322
CLV_NRD_NRD_1	264	266	PF00675	0.274
CLV_NRD_NRD_1	89	91	PF00675	0.379
CLV_PCSK_KEX2_1	137	139	PF00082	0.300
CLV_PCSK_KEX2_1	282	284	PF00082	0.504
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.334
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.530
CLV_PCSK_SKI1_1	193	197	PF00082	0.340
CLV_PCSK_SKI1_1	57	61	PF00082	0.292
DEG_Nend_UBRbox_2	1	3	PF02207	0.346
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.521
DOC_MAPK_gen_1	192	202	PF00069	0.409
DOC_MAPK_MEF2A_6	196	204	PF00069	0.467
DOC_PP4_FxxP_1	40	43	PF00568	0.310
DOC_USP7_MATH_1	269	273	PF00917	0.703
DOC_USP7_UBL2_3	192	196	PF12436	0.472
DOC_USP7_UBL2_3	225	229	PF12436	0.172
DOC_USP7_UBL2_3	91	95	PF12436	0.172
LIG_AP2alpha_1	126	130	PF02296	0.399
LIG_APCC_ABBA_1	250	255	PF00400	0.382
LIG_BRCT_BRCA1_1	253	257	PF00533	0.299
LIG_BRCT_BRCA1_2	253	259	PF00533	0.367
LIG_EH1_1	173	181	PF00400	0.351
LIG_eIF4E_1	79	85	PF01652	0.204
LIG_FHA_1	127	133	PF00498	0.311
LIG_FHA_1	148	154	PF00498	0.275
LIG_FHA_1	206	212	PF00498	0.398
LIG_FHA_1	233	239	PF00498	0.345
LIG_FHA_1	54	60	PF00498	0.516
LIG_FHA_1	79	85	PF00498	0.217
LIG_LIR_Apic_2	37	43	PF02991	0.346
LIG_LIR_Gen_1	144	154	PF02991	0.361
LIG_LIR_Gen_1	163	174	PF02991	0.217
LIG_LIR_Gen_1	178	189	PF02991	0.356
LIG_LIR_Gen_1	217	226	PF02991	0.418
LIG_LIR_Nem_3	128	133	PF02991	0.458
LIG_LIR_Nem_3	144	149	PF02991	0.327
LIG_LIR_Nem_3	163	169	PF02991	0.215
LIG_LIR_Nem_3	178	184	PF02991	0.318
LIG_LIR_Nem_3	188	194	PF02991	0.459
LIG_LIR_Nem_3	217	223	PF02991	0.324
LIG_LIR_Nem_3	74	79	PF02991	0.304
LIG_PCNA_PIPBox_1	1	10	PF02747	0.388
LIG_Pex14_2	126	130	PF04695	0.391
LIG_Pex14_2	142	146	PF04695	0.334
LIG_Pex14_2	152	156	PF04695	0.332
LIG_Pex14_2	216	220	PF04695	0.204
LIG_Pex14_2	253	257	PF04695	0.286
LIG_SH2_CRK	79	83	PF00017	0.268
LIG_SH2_PTP2	201	204	PF00017	0.350
LIG_SH2_PTP2	261	264	PF00017	0.522
LIG_SH2_STAP1	154	158	PF00017	0.349
LIG_SH2_STAP1	181	185	PF00017	0.404
LIG_SH2_STAT5	107	110	PF00017	0.272
LIG_SH2_STAT5	174	177	PF00017	0.349
LIG_SH2_STAT5	181	184	PF00017	0.308
LIG_SH2_STAT5	201	204	PF00017	0.425
LIG_SH2_STAT5	215	218	PF00017	0.330
LIG_SH2_STAT5	246	249	PF00017	0.319
LIG_SH2_STAT5	251	254	PF00017	0.308
LIG_SH2_STAT5	261	264	PF00017	0.442
LIG_SH2_STAT5	30	33	PF00017	0.299
LIG_SH2_STAT5	35	38	PF00017	0.305
LIG_SH2_STAT5	7	10	PF00017	0.339
LIG_UBA3_1	117	122	PF00899	0.322
LIG_UBA3_1	252	259	PF00899	0.295
LIG_WRC_WIRS_1	215	220	PF05994	0.306
LIG_WRC_WIRS_1	35	40	PF05994	0.363
MOD_CK1_1	219	225	PF00069	0.274
MOD_CMANNOS	63	66	PF00535	0.378
MOD_Cter_Amidation	135	138	PF01082	0.284
MOD_GlcNHglycan	271	274	PF01048	0.481
MOD_GSK3_1	175	182	PF00069	0.385
MOD_GSK3_1	269	276	PF00069	0.632
MOD_N-GLC_1	231	236	PF02516	0.544
MOD_NEK2_1	118	123	PF00069	0.313
MOD_NEK2_1	126	131	PF00069	0.320
MOD_NEK2_1	175	180	PF00069	0.295
MOD_NEK2_1	200	205	PF00069	0.481
MOD_NEK2_1	214	219	PF00069	0.269
MOD_NEK2_1	61	66	PF00069	0.471
MOD_NEK2_2	71	76	PF00069	0.375
MOD_PIKK_1	205	211	PF00454	0.370
MOD_Plk_4	126	132	PF00069	0.295
MOD_Plk_4	141	147	PF00069	0.308
MOD_Plk_4	161	167	PF00069	0.214
MOD_Plk_4	175	181	PF00069	0.271
MOD_Plk_4	34	40	PF00069	0.309
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.508
TRG_ENDOCYTIC_2	154	157	PF00928	0.328
TRG_ENDOCYTIC_2	181	184	PF00928	0.326
TRG_ENDOCYTIC_2	201	204	PF00928	0.217
TRG_ENDOCYTIC_2	215	218	PF00928	0.337
TRG_ENDOCYTIC_2	35	38	PF00928	0.298
TRG_ENDOCYTIC_2	79	82	PF00928	0.344
TRG_ER_diLys_1	281	284	PF00400	0.642
TRG_NES_CRM1_1	242	255	PF08389	0.435
TRG_NLS_MonoExtC_3	136	141	PF00514	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	25%	97%
A0A0N0P5E5	Leptomonas seymouri	32%	95%
A0A0N0P7D1	Leptomonas seymouri	34%	85%
A0A0N0P7D6	Leptomonas seymouri	40%	98%
A0A0N0P7R2	Leptomonas seymouri	37%	93%
A0A0N1HZJ8	Leptomonas seymouri	28%	88%
A0A0N1I9H5	Leptomonas seymouri	57%	100%
A0A0N1ILQ4	Leptomonas seymouri	36%	97%
A0A0N1IM10	Leptomonas seymouri	47%	99%
A0A0N1PDR8	Leptomonas seymouri	32%	100%
A0A0N1PFE8	Leptomonas seymouri	81%	100%
A0A0S4IS29	Bodo saltans	38%	100%
A0A0S4IVJ6	Bodo saltans	33%	89%
A0A0S4IVS6	Bodo saltans	33%	100%
A0A0S4IW98	Bodo saltans	38%	90%
A0A0S4JH58	Bodo saltans	25%	95%
A0A1X0NNK7	Trypanosomatidae	34%	100%
A0A1X0NNL0	Trypanosomatidae	41%	94%
A0A1X0NNM4	Trypanosomatidae	38%	99%
A0A1X0NNM5	Trypanosomatidae	31%	92%
A0A1X0NP89	Trypanosomatidae	27%	89%
A0A3Q8I8T7	Leishmania donovani	29%	72%
A0A3Q8I9T2	Leishmania donovani	31%	76%
A0A3Q8I9U9	Leishmania donovani	29%	87%
A0A3Q8I9X8	Leishmania donovani	36%	85%
A0A3Q8IC05	Leishmania donovani	33%	93%
A0A3Q8IIA9	Leishmania donovani	95%	100%
A0A3R7KG78	Trypanosoma rangeli	31%	100%
A0A3R7MJR2	Trypanosoma rangeli	36%	100%
A0A3R7NSQ3	Trypanosoma rangeli	43%	99%
A0A3S5H6R7	Leishmania donovani	49%	100%
A0A3S5H6R8	Leishmania donovani	36%	97%
A0A3S7WSY8	Leishmania donovani	57%	100%
A0A3S7WSZ1	Leishmania donovani	32%	95%
A0A3S7WT03	Leishmania donovani	34%	95%
A0A3S7WT05	Leishmania donovani	25%	93%
A0A3S7WT16	Leishmania donovani	30%	88%
A0A422NNP1	Trypanosoma rangeli	30%	95%
A4H7M1	Leishmania braziliensis	24%	93%
A4H7M2	Leishmania braziliensis	59%	99%
A4H7M3	Leishmania braziliensis	49%	100%
A4H7M4	Leishmania braziliensis	90%	100%
A4H7M5	Leishmania braziliensis	34%	97%
A4H7M6	Leishmania braziliensis	33%	95%
A4H7M7	Leishmania braziliensis	31%	88%
A4H7M8	Leishmania braziliensis	28%	75%
A4H7M9	Leishmania braziliensis	28%	70%
A4H7N0	Leishmania braziliensis	34%	96%
A4HW06	Leishmania infantum	25%	93%
A4HW07	Leishmania infantum	57%	100%
A4HW08	Leishmania infantum	49%	100%
A4HW09	Leishmania infantum	95%	100%
A4HW10	Leishmania infantum	36%	97%
A4HW12	Leishmania infantum	36%	85%
A4HW13	Leishmania infantum	29%	87%
A4HW14	Leishmania infantum	31%	88%
A4HW15	Leishmania infantum	31%	76%
A4HW17	Leishmania infantum	29%	72%
A4HW18	Leishmania infantum	33%	94%
C9ZT13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	94%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	93%
D4A612	Rattus norvegicus	28%	100%
E9AGL0	Leishmania infantum	34%	95%
E9AGL2	Leishmania infantum	33%	95%
E9APQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	93%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	76%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	97%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	95%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	95%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	85%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	87%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	88%
E9APR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	74%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	94%
G5EEE5	Caenorhabditis elegans	31%	99%
O35949	Mus musculus	35%	100%
P49191	Caenorhabditis elegans	31%	89%
Q20300	Caenorhabditis elegans	31%	100%
Q32NI8	Xenopus laevis	27%	96%
Q3S8M4	Macaca mulatta	26%	90%
Q4QFQ9	Leishmania major	32%	100%
Q4QFR1	Leishmania major	29%	100%
Q4QFR2	Leishmania major	30%	76%
Q4QFR3	Leishmania major	31%	100%
Q4QFR4	Leishmania major	29%	87%
Q4QFR5	Leishmania major	37%	79%
Q4QFR6	Leishmania major	33%	100%
Q4QFR7	Leishmania major	36%	97%
Q4QFR9	Leishmania major	48%	100%
Q4QFS0	Leishmania major	59%	100%
Q4QFS1	Leishmania major	25%	93%
Q5M8U1	Xenopus tropicalis	26%	96%
Q5ZJR8	Gallus gallus	34%	100%
Q6PC64	Danio rerio	32%	100%
Q920L5	Mus musculus	33%	100%
Q920L6	Rattus norvegicus	36%	100%
Q95K73	Macaca fascicularis	26%	90%
Q9EQC4	Mus musculus	24%	91%
Q9GZR5	Homo sapiens	26%	90%
Q9H5J4	Homo sapiens	34%	100%
Q9HB03	Homo sapiens	34%	100%
Q9VV87	Drosophila melanogaster	33%	90%
Q9XVQ9	Caenorhabditis elegans	33%	100%
V5BE99	Trypanosoma cruzi	34%	99%
V5BIX9	Trypanosoma cruzi	38%	100%
V5BND3	Trypanosoma cruzi	30%	95%
V5DF68	Trypanosoma cruzi	41%	98%