Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania major

UniProt:

Q4QFR7_LEIMA

TriTrypDb:

LmjF.14.0670 , LMJLV39_140012700 , LMJSD75_140012300

Length:

294

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

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Expansion

Sequence features

Q4QFR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFR7

Function

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Biological processes
Term	Name	Level	Count
GO:0000038	very long-chain fatty acid metabolic process	5	4
GO:0006082	organic acid metabolic process	3	27
GO:0006629	lipid metabolic process	3	27
GO:0006631	fatty acid metabolic process	4	27
GO:0006633	fatty acid biosynthetic process	5	27
GO:0006643	membrane lipid metabolic process	4	4
GO:0006665	sphingolipid metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	27
GO:0008610	lipid biosynthetic process	4	27

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004312	fatty acid synthase activity	5	27
GO:0009922	fatty acid elongase activity	6	27
GO:0016740	transferase activity	2	27
GO:0016746	acyltransferase activity	3	27
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	27
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	27

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	59	61	PF00675	0.273
CLV_PCSK_KEX2_1	59	61	PF00082	0.258
CLV_PCSK_SKI1_1	203	207	PF00082	0.330
CLV_PCSK_SKI1_1	43	47	PF00082	0.289
CLV_PCSK_SKI1_1	59	63	PF00082	0.347
DEG_APCC_DBOX_1	112	120	PF00400	0.293
DOC_CDC14_PxL_1	131	139	PF14671	0.213
DOC_CDC14_PxL_1	90	98	PF14671	0.309
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.483
DOC_USP7_MATH_1	121	125	PF00917	0.165

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E5	Leptomonas seymouri	37%	98%
A0A0N0P7D1	Leptomonas seymouri	33%	88%
A0A0N0P7D6	Leptomonas seymouri	33%	100%
A0A0N0P7R2	Leptomonas seymouri	41%	96%
A0A0N1I9H5	Leptomonas seymouri	35%	100%
A0A0N1IIZ8	Leptomonas seymouri	28%	96%
A0A0N1ILQ4	Leptomonas seymouri	77%	100%
A0A0N1IM10	Leptomonas seymouri	34%	100%
A0A0N1PDR8	Leptomonas seymouri	38%	100%
A0A0N1PFE8	Leptomonas seymouri	36%	100%

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