Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania major

UniProt:

Q4QFR6_LEIMA

TriTrypDb:

LmjF.14.0680 , LMJLV39_000018000 , LMJSD75_140012700

Length:

299

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 49
NetGPI	no	yes: 0, no: 49

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	42
GO:0110165	cellular anatomical entity	1	44
GO:0005737	cytoplasm	2	2

Expansion

Sequence features

Q4QFR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFR6

Function

Biological processes
Term	Name	Level	Count
GO:0000038	very long-chain fatty acid metabolic process	5	8
GO:0006082	organic acid metabolic process	3	50
GO:0006629	lipid metabolic process	3	50
GO:0006631	fatty acid metabolic process	4	50
GO:0006633	fatty acid biosynthetic process	5	50
GO:0006643	membrane lipid metabolic process	4	8
GO:0006665	sphingolipid metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	50
GO:0008610	lipid biosynthetic process	4	50
GO:0009058	biosynthetic process	2	50
GO:0009987	cellular process	1	50
GO:0016053	organic acid biosynthetic process	4	50
GO:0019367	fatty acid elongation, saturated fatty acid	7	8
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	8
GO:0019752	carboxylic acid metabolic process	5	50
GO:0030148	sphingolipid biosynthetic process	5	8
GO:0030497	fatty acid elongation	6	8
GO:0032787	monocarboxylic acid metabolic process	6	50
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	8
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	8
GO:0042761	very long-chain fatty acid biosynthetic process	6	8
GO:0043436	oxoacid metabolic process	4	50
GO:0044237	cellular metabolic process	2	50
GO:0044238	primary metabolic process	2	50
GO:0044249	cellular biosynthetic process	3	50
GO:0044255	cellular lipid metabolic process	3	50
GO:0044281	small molecule metabolic process	2	50
GO:0044283	small molecule biosynthetic process	3	50
GO:0046394	carboxylic acid biosynthetic process	5	50
GO:0046467	membrane lipid biosynthetic process	4	8
GO:0071704	organic substance metabolic process	2	50
GO:0072330	monocarboxylic acid biosynthetic process	6	50
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	50

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	50
GO:0004312	fatty acid synthase activity	5	50
GO:0009922	fatty acid elongase activity	6	50
GO:0016740	transferase activity	2	50
GO:0016746	acyltransferase activity	3	50
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	50
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.263
CLV_NRD_NRD_1	237	239	PF00675	0.540
CLV_PCSK_KEX2_1	146	148	PF00082	0.317
CLV_PCSK_KEX2_1	237	239	PF00082	0.552
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.317
CLV_PCSK_SKI1_1	147	151	PF00082	0.246
CLV_PCSK_SKI1_1	79	83	PF00082	0.503
DOC_CDC14_PxL_1	71	79	PF14671	0.286
DOC_MAPK_gen_1	145	151	PF00069	0.437
DOC_PP1_RVXF_1	144	151	PF00149	0.452
DOC_PP1_RVXF_1	245	251	PF00149	0.365
DOC_PP2B_LxvP_1	36	39	PF13499	0.260
DOC_USP7_MATH_1	205	209	PF00917	0.545
LIG_14-3-3_CanoR_1	204	210	PF00244	0.545
LIG_Actin_WH2_2	256	272	PF00022	0.425
LIG_APCC_ABBA_1	220	225	PF00400	0.215
LIG_BRCT_BRCA1_1	260	264	PF00533	0.299
LIG_EH1_1	154	162	PF00400	0.349
LIG_EH1_1	181	189	PF00400	0.285
LIG_FHA_1	136	142	PF00498	0.295
LIG_FHA_1	156	162	PF00498	0.273
LIG_FHA_1	226	232	PF00498	0.314
LIG_FHA_1	78	84	PF00498	0.266
LIG_FHA_2	85	91	PF00498	0.325
LIG_LIR_Apic_2	266	271	PF02991	0.434
LIG_LIR_Gen_1	137	148	PF02991	0.295
LIG_LIR_Gen_1	211	220	PF02991	0.363
LIG_LIR_Gen_1	255	265	PF02991	0.318
LIG_LIR_Nem_3	137	143	PF02991	0.316
LIG_LIR_Nem_3	186	192	PF02991	0.325
LIG_LIR_Nem_3	196	202	PF02991	0.467
LIG_LIR_Nem_3	211	215	PF02991	0.316
LIG_LIR_Nem_3	255	260	PF02991	0.302
LIG_Pex14_2	123	127	PF04695	0.379
LIG_Pex14_2	260	264	PF04695	0.305
LIG_Pex14_2	4	8	PF04695	0.264
LIG_Pex14_2	82	86	PF04695	0.319
LIG_SH2_CRK	116	120	PF00017	0.305
LIG_SH2_CRK	72	76	PF00017	0.286
LIG_SH2_CRK	78	82	PF00017	0.245
LIG_SH2_GRB2like	91	94	PF00017	0.177
LIG_SH2_PTP2	202	205	PF00017	0.538
LIG_SH2_STAP1	227	231	PF00017	0.374
LIG_SH2_STAP1	265	269	PF00017	0.490
LIG_SH2_STAT5	162	165	PF00017	0.321
LIG_SH2_STAT5	189	192	PF00017	0.327
LIG_SH2_STAT5	202	205	PF00017	0.480
LIG_SH2_STAT5	227	230	PF00017	0.318
LIG_SH2_STAT5	233	236	PF00017	0.262
LIG_SH2_STAT5	256	259	PF00017	0.303
LIG_SH2_STAT5	268	271	PF00017	0.456
LIG_SH2_STAT5	37	40	PF00017	0.305
LIG_SH2_STAT5	72	75	PF00017	0.306
LIG_SH2_STAT5	91	94	PF00017	0.334
LIG_SH3_1	268	274	PF00018	0.463
LIG_SH3_3	268	274	PF00018	0.462
LIG_SUMO_SIM_par_1	60	66	PF11976	0.281
LIG_UBA3_1	126	131	PF00899	0.348
LIG_WRC_WIRS_1	209	214	PF05994	0.375
LIG_WRC_WIRS_1	5	10	PF05994	0.408
LIG_WW_3	272	276	PF00397	0.503
MOD_CK1_1	208	214	PF00069	0.535
MOD_CK1_1	241	247	PF00069	0.304
MOD_GlcNHglycan	171	174	PF01048	0.459
MOD_GlcNHglycan	205	208	PF01048	0.298
MOD_GlcNHglycan	275	278	PF01048	0.501
MOD_GSK3_1	221	228	PF00069	0.275
MOD_N-GLC_1	241	246	PF02516	0.428
MOD_N-GLC_2	12	14	PF02516	0.568
MOD_NEK2_1	127	132	PF00069	0.311
MOD_NEK2_1	135	140	PF00069	0.323
MOD_NEK2_1	193	198	PF00069	0.369
MOD_NEK2_1	232	237	PF00069	0.268
MOD_NEK2_1	252	257	PF00069	0.314
MOD_NEK2_1	264	269	PF00069	0.295
MOD_NEK2_1	4	9	PF00069	0.340
MOD_NEK2_1	60	65	PF00069	0.319
MOD_NEK2_1	77	82	PF00069	0.254
MOD_NEK2_2	84	89	PF00069	0.334
MOD_PKA_2	203	209	PF00069	0.369
MOD_Plk_1	282	288	PF00069	0.735
MOD_Plk_1	84	90	PF00069	0.310
MOD_Plk_4	155	161	PF00069	0.325
MOD_Plk_4	163	169	PF00069	0.320
MOD_Plk_4	183	189	PF00069	0.298
MOD_Plk_4	205	211	PF00069	0.471
MOD_Plk_4	252	258	PF00069	0.306
MOD_Plk_4	264	270	PF00069	0.307
MOD_Plk_4	60	66	PF00069	0.331
TRG_AP2beta_CARGO_1	137	147	PF09066	0.174
TRG_DiLeu_BaEn_1	22	27	PF01217	0.410
TRG_ENDOCYTIC_2	104	107	PF00928	0.271
TRG_ENDOCYTIC_2	154	157	PF00928	0.323
TRG_ENDOCYTIC_2	191	194	PF00928	0.308
TRG_ENDOCYTIC_2	256	259	PF00928	0.303
TRG_ENDOCYTIC_2	31	34	PF00928	0.292
TRG_ENDOCYTIC_2	71	74	PF00928	0.298
TRG_ENDOCYTIC_2	78	81	PF00928	0.253
TRG_ER_diLys_1	296	299	PF00400	0.757

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PHQ7	Tachysurus fulvidraco	23%	100%
A0A0N0P5E5	Leptomonas seymouri	43%	100%
A0A0N0P7D1	Leptomonas seymouri	62%	90%
A0A0N0P7D6	Leptomonas seymouri	32%	100%
A0A0N0P7R2	Leptomonas seymouri	77%	98%
A0A0N0P994	Leptomonas seymouri	24%	83%
A0A0N1HZJ8	Leptomonas seymouri	39%	92%
A0A0N1I9H5	Leptomonas seymouri	32%	100%
A0A0N1IIZ8	Leptomonas seymouri	23%	97%
A0A0N1ILQ4	Leptomonas seymouri	36%	100%
A0A0N1IM10	Leptomonas seymouri	33%	100%
A0A0N1PBS4	Leptomonas seymouri	26%	100%
A0A0N1PDR8	Leptomonas seymouri	37%	100%
A0A0S4IS29	Bodo saltans	48%	100%
A0A0S4IVJ6	Bodo saltans	33%	94%
A0A0S4IVS6	Bodo saltans	44%	100%
A0A0S4IW98	Bodo saltans	45%	94%
A0A0S4JH58	Bodo saltans	26%	100%
A0A0S4KMP5	Bodo saltans	28%	91%
A0A1X0NNK7	Trypanosomatidae	43%	100%
A0A1X0NNL0	Trypanosomatidae	33%	99%
A0A1X0NNM4	Trypanosomatidae	35%	100%
A0A1X0NNM5	Trypanosomatidae	50%	97%
A0A1X0NP89	Trypanosomatidae	40%	94%
A0A3Q8I8T7	Leishmania donovani	33%	76%
A0A3Q8I9T2	Leishmania donovani	31%	80%
A0A3Q8I9U9	Leishmania donovani	41%	92%
A0A3Q8I9X8	Leishmania donovani	62%	89%
A0A3Q8IC05	Leishmania donovani	39%	98%
A0A3Q8ID51	Leishmania donovani	30%	75%
A0A3Q8IIA9	Leishmania donovani	35%	100%
A0A3R7KG78	Trypanosoma rangeli	45%	100%
A0A3R7MJR2	Trypanosoma rangeli	38%	100%
A0A3R7NSQ3	Trypanosoma rangeli	36%	100%
A0A3S5H6R7	Leishmania donovani	29%	100%
A0A3S5H6R8	Leishmania donovani	39%	100%
A0A3S7WSY8	Leishmania donovani	35%	100%
A0A3S7WSZ1	Leishmania donovani	88%	100%
A0A3S7WT03	Leishmania donovani	94%	100%
A0A3S7WT16	Leishmania donovani	48%	93%
A0A422NNP1	Trypanosoma rangeli	53%	100%
A0JNC4	Bos taurus	27%	100%
A1L3X0	Homo sapiens	29%	100%
A4H7M2	Leishmania braziliensis	34%	100%
A4H7M3	Leishmania braziliensis	30%	100%
A4H7M4	Leishmania braziliensis	33%	100%
A4H7M5	Leishmania braziliensis	35%	100%
A4H7M6	Leishmania braziliensis	76%	100%
A4H7M7	Leishmania braziliensis	44%	93%
A4H7M8	Leishmania braziliensis	28%	78%
A4H7M9	Leishmania braziliensis	30%	73%
A4H7N0	Leishmania braziliensis	44%	100%
A4HW07	Leishmania infantum	35%	100%
A4HW08	Leishmania infantum	29%	100%
A4HW09	Leishmania infantum	35%	100%
A4HW10	Leishmania infantum	36%	100%
A4HW12	Leishmania infantum	62%	89%
A4HW13	Leishmania infantum	41%	92%
A4HW14	Leishmania infantum	47%	93%
A4HW15	Leishmania infantum	31%	80%
A4HW16	Leishmania infantum	30%	80%
A4HW17	Leishmania infantum	32%	76%
A4HW18	Leishmania infantum	39%	99%
C9ZT13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	99%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
D4A612	Rattus norvegicus	27%	100%
D4ADY9	Rattus norvegicus	30%	100%
E8NHR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	80%
E8NHR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	78%
E9AGL0	Leishmania infantum	94%	100%
E9AGL2	Leishmania infantum	89%	100%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	80%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	89%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	92%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	93%
E9APR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	78%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	99%
G5EEE5	Caenorhabditis elegans	33%	100%
O35949	Mus musculus	33%	100%
P39540	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	96%
P49191	Caenorhabditis elegans	34%	93%
Q03574	Caenorhabditis elegans	30%	100%
Q20300	Caenorhabditis elegans	29%	100%
Q20303	Caenorhabditis elegans	34%	100%
Q2KJD9	Bos taurus	25%	100%
Q32NI8	Xenopus laevis	27%	100%
Q3S8M4	Macaca mulatta	25%	95%
Q4QFQ9	Leishmania major	41%	100%
Q4QFR0	Leishmania major	33%	100%
Q4QFR1	Leishmania major	30%	100%
Q4QFR2	Leishmania major	31%	80%
Q4QFR3	Leishmania major	45%	100%
Q4QFR4	Leishmania major	40%	92%
Q4QFR5	Leishmania major	65%	83%
Q4QFR7	Leishmania major	39%	100%
Q4QFR8	Leishmania major	33%	100%
Q4QFR9	Leishmania major	29%	100%
Q4QFS0	Leishmania major	34%	100%
Q4R516	Macaca fascicularis	25%	100%
Q5M8U1	Xenopus tropicalis	26%	100%
Q5RFL5	Pongo abelii	25%	100%
Q5ZJR8	Gallus gallus	35%	100%
Q6PC64	Danio rerio	37%	100%
Q7LKX0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	82%
Q8BHI7	Mus musculus	25%	100%
Q920L5	Mus musculus	34%	100%
Q920L6	Rattus norvegicus	34%	100%
Q920L7	Rattus norvegicus	24%	100%
Q95K73	Macaca fascicularis	25%	95%
Q9BW60	Homo sapiens	27%	100%
Q9D2Y9	Mus musculus	30%	100%
Q9EQC4	Mus musculus	24%	96%
Q9GZR5	Homo sapiens	25%	95%
Q9H5J4	Homo sapiens	35%	100%
Q9HB03	Homo sapiens	33%	100%
Q9JLJ4	Mus musculus	27%	100%
Q9JLJ5	Mus musculus	26%	100%
Q9NYP7	Homo sapiens	25%	100%
Q9UTF7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	90%
Q9VV87	Drosophila melanogaster	35%	95%
Q9XVQ9	Caenorhabditis elegans	28%	100%
V5BE99	Trypanosoma cruzi	46%	100%
V5BIX9	Trypanosoma cruzi	41%	100%
V5BND3	Trypanosoma cruzi	53%	100%
V5DF68	Trypanosoma cruzi	37%	100%