LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania major
UniProt:
Q4QFR5_LEIMA
TriTrypDb:
LmjF.14.0690 , LMJLV39_140012800 * , LMJSD75_140012700
Length:
360

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 56
NetGPI no yes: 0, no: 56
Cellular components
Term Name Level Count
GO:0016020 membrane 2 49
GO:0110165 cellular anatomical entity 1 51
GO:0005737 cytoplasm 2 2

Expansion

Sequence features

Q4QFR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFR5

Function

Biological processes
Term Name Level Count
GO:0000038 very long-chain fatty acid metabolic process 5 8
GO:0006082 organic acid metabolic process 3 57
GO:0006629 lipid metabolic process 3 57
GO:0006631 fatty acid metabolic process 4 57
GO:0006633 fatty acid biosynthetic process 5 57
GO:0006643 membrane lipid metabolic process 4 8
GO:0006665 sphingolipid metabolic process 4 8
GO:0006807 nitrogen compound metabolic process 2 8
GO:0008152 metabolic process 1 57
GO:0008610 lipid biosynthetic process 4 57
GO:0009058 biosynthetic process 2 57
GO:0009987 cellular process 1 57
GO:0016053 organic acid biosynthetic process 4 57
GO:0019367 fatty acid elongation, saturated fatty acid 7 8
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 8
GO:0019752 carboxylic acid metabolic process 5 57
GO:0030148 sphingolipid biosynthetic process 5 8
GO:0030497 fatty acid elongation 6 8
GO:0032787 monocarboxylic acid metabolic process 6 57
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 8
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 8
GO:0042761 very long-chain fatty acid biosynthetic process 6 8
GO:0043436 oxoacid metabolic process 4 57
GO:0044237 cellular metabolic process 2 57
GO:0044238 primary metabolic process 2 57
GO:0044249 cellular biosynthetic process 3 57
GO:0044255 cellular lipid metabolic process 3 57
GO:0044281 small molecule metabolic process 2 57
GO:0044283 small molecule biosynthetic process 3 57
GO:0046394 carboxylic acid biosynthetic process 5 57
GO:0046467 membrane lipid biosynthetic process 4 8
GO:0071704 organic substance metabolic process 2 57
GO:0072330 monocarboxylic acid biosynthetic process 6 57
GO:1901564 organonitrogen compound metabolic process 3 8
GO:1901566 organonitrogen compound biosynthetic process 4 8
GO:1901576 organic substance biosynthetic process 3 57
GO:0001676 long-chain fatty acid metabolic process 5 1
GO:0042759 long-chain fatty acid biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 57
GO:0004312 fatty acid synthase activity 5 57
GO:0009922 fatty acid elongase activity 6 57
GO:0016740 transferase activity 2 57
GO:0016746 acyltransferase activity 3 57
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 57
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 57

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 202 204 PF00675 0.260
CLV_NRD_NRD_1 273 275 PF00675 0.272
CLV_NRD_NRD_1 333 335 PF00675 0.471
CLV_PCSK_KEX2_1 149 151 PF00082 0.350
CLV_PCSK_KEX2_1 273 275 PF00082 0.248
CLV_PCSK_KEX2_1 292 294 PF00082 0.383
CLV_PCSK_KEX2_1 332 334 PF00082 0.500
CLV_PCSK_PC1ET2_1 149 151 PF00082 0.350
CLV_PCSK_PC1ET2_1 292 294 PF00082 0.400
CLV_PCSK_PC1ET2_1 332 334 PF00082 0.500
CLV_PCSK_SKI1_1 150 154 PF00082 0.253
CLV_PCSK_SKI1_1 292 296 PF00082 0.461
CLV_PCSK_SKI1_1 349 353 PF00082 0.355
CLV_PCSK_SKI1_1 82 86 PF00082 0.506
DEG_Nend_Nbox_1 1 3 PF02207 0.382
DOC_CYCLIN_RxL_1 289 297 PF00134 0.658
DOC_CYCLIN_RxL_1 79 88 PF00134 0.276
DOC_CYCLIN_yClb5_NLxxxL_5 54 63 PF00134 0.497
DOC_MAPK_gen_1 148 154 PF00069 0.444
DOC_MAPK_gen_1 332 340 PF00069 0.548
DOC_MAPK_RevD_3 326 342 PF00069 0.545
DOC_PP1_RVXF_1 147 154 PF00149 0.454
DOC_PP2B_LxvP_1 24 27 PF13499 0.320
DOC_PP2B_LxvP_1 39 42 PF13499 0.259
DOC_USP7_MATH_1 208 212 PF00917 0.546
DOC_USP7_MATH_1 316 320 PF00917 0.551
DOC_USP7_UBL2_3 332 336 PF12436 0.548
DOC_WW_Pin1_4 351 356 PF00397 0.544
LIG_14-3-3_CanoR_1 207 213 PF00244 0.546
LIG_Actin_WH2_2 259 275 PF00022 0.429
LIG_APCC_ABBA_1 223 228 PF00400 0.206
LIG_BIR_III_2 315 319 PF00653 0.555
LIG_BRCT_BRCA1_1 263 267 PF00533 0.303
LIG_EH_1 2 6 PF12763 0.290
LIG_EH1_1 157 165 PF00400 0.320
LIG_EH1_1 184 192 PF00400 0.309
LIG_FHA_1 139 145 PF00498 0.293
LIG_FHA_1 159 165 PF00498 0.282
LIG_FHA_1 97 103 PF00498 0.297
LIG_GBD_Chelix_1 29 37 PF00786 0.295
LIG_Integrin_RGD_1 12 14 PF01839 0.583
LIG_IRF3_LxIS_1 80 87 PF10401 0.258
LIG_LIR_Apic_2 116 122 PF02991 0.262
LIG_LIR_Gen_1 140 151 PF02991 0.293
LIG_LIR_Gen_1 214 223 PF02991 0.375
LIG_LIR_Gen_1 258 268 PF02991 0.297
LIG_LIR_Gen_1 31 42 PF02991 0.294
LIG_LIR_Nem_3 105 110 PF02991 0.251
LIG_LIR_Nem_3 140 146 PF02991 0.311
LIG_LIR_Nem_3 189 195 PF02991 0.320
LIG_LIR_Nem_3 199 205 PF02991 0.465
LIG_LIR_Nem_3 214 218 PF02991 0.318
LIG_LIR_Nem_3 227 233 PF02991 0.310
LIG_LIR_Nem_3 258 263 PF02991 0.282
LIG_LIR_Nem_3 79 84 PF02991 0.282
LIG_PDZ_Class_3 355 360 PF00595 0.538
LIG_Pex14_2 126 130 PF04695 0.398
LIG_Pex14_2 263 267 PF04695 0.301
LIG_Pex14_2 81 85 PF04695 0.318
LIG_SH2_CRK 107 111 PF00017 0.251
LIG_SH2_CRK 119 123 PF00017 0.267
LIG_SH2_PTP2 205 208 PF00017 0.526
LIG_SH2_PTP2 337 340 PF00017 0.548
LIG_SH2_SRC 337 340 PF00017 0.548
LIG_SH2_STAP1 268 272 PF00017 0.484
LIG_SH2_STAT5 165 168 PF00017 0.308
LIG_SH2_STAT5 192 195 PF00017 0.323
LIG_SH2_STAT5 205 208 PF00017 0.464
LIG_SH2_STAT5 230 233 PF00017 0.320
LIG_SH2_STAT5 236 239 PF00017 0.242
LIG_SH2_STAT5 259 262 PF00017 0.299
LIG_SH2_STAT5 271 274 PF00017 0.450
LIG_SH2_STAT5 337 340 PF00017 0.548
LIG_SH2_STAT5 34 37 PF00017 0.292
LIG_SH2_STAT5 40 43 PF00017 0.302
LIG_SH2_STAT5 7 10 PF00017 0.320
LIG_SH2_STAT5 75 78 PF00017 0.317
LIG_SUMO_SIM_anti_2 28 34 PF11976 0.256
LIG_UBA3_1 129 134 PF00899 0.332
LIG_WRC_WIRS_1 212 217 PF05994 0.384
MOD_CDC14_SPxK_1 354 357 PF00782 0.536
MOD_CDK_SPxK_1 351 357 PF00069 0.543
MOD_CK1_1 211 217 PF00069 0.522
MOD_CK1_1 244 250 PF00069 0.290
MOD_CK1_1 28 34 PF00069 0.390
MOD_CK1_1 284 290 PF00069 0.624
MOD_CK1_1 308 314 PF00069 0.726
MOD_CK1_1 66 72 PF00069 0.331
MOD_CK1_1 87 93 PF00069 0.245
MOD_CK2_1 92 98 PF00069 0.369
MOD_Cter_Amidation 274 277 PF01082 0.215
MOD_GlcNHglycan 174 177 PF01048 0.453
MOD_GlcNHglycan 237 240 PF01048 0.397
MOD_GSK3_1 224 231 PF00069 0.291
MOD_GSK3_1 277 284 PF00069 0.657
MOD_GSK3_1 80 87 PF00069 0.251
MOD_GSK3_1 92 99 PF00069 0.238
MOD_N-GLC_1 244 249 PF02516 0.457
MOD_N-GLC_1 343 348 PF02516 0.350
MOD_N-GLC_1 92 97 PF02516 0.539
MOD_NEK2_1 102 107 PF00069 0.253
MOD_NEK2_1 130 135 PF00069 0.319
MOD_NEK2_1 138 143 PF00069 0.322
MOD_NEK2_1 196 201 PF00069 0.366
MOD_NEK2_1 235 240 PF00069 0.290
MOD_NEK2_1 255 260 PF00069 0.299
MOD_NEK2_1 267 272 PF00069 0.281
MOD_NEK2_1 281 286 PF00069 0.628
MOD_NEK2_1 294 299 PF00069 0.628
MOD_NEK2_1 63 68 PF00069 0.313
MOD_NEK2_2 300 305 PF00069 0.705
MOD_Plk_1 308 314 PF00069 0.549
MOD_Plk_1 87 93 PF00069 0.315
MOD_Plk_4 102 108 PF00069 0.232
MOD_Plk_4 158 164 PF00069 0.315
MOD_Plk_4 166 172 PF00069 0.311
MOD_Plk_4 186 192 PF00069 0.294
MOD_Plk_4 208 214 PF00069 0.469
MOD_Plk_4 228 234 PF00069 0.281
MOD_Plk_4 25 31 PF00069 0.319
MOD_Plk_4 255 261 PF00069 0.293
MOD_Plk_4 267 273 PF00069 0.288
MOD_Plk_4 277 283 PF00069 0.697
MOD_Plk_4 316 322 PF00069 0.703
MOD_Plk_4 63 69 PF00069 0.310
MOD_Plk_4 80 86 PF00069 0.217
MOD_ProDKin_1 351 357 PF00069 0.543
TRG_AP2beta_CARGO_1 140 150 PF09066 0.168
TRG_DiLeu_BaLyEn_6 290 295 PF01217 0.495
TRG_ENDOCYTIC_2 107 110 PF00928 0.274
TRG_ENDOCYTIC_2 157 160 PF00928 0.311
TRG_ENDOCYTIC_2 194 197 PF00928 0.311
TRG_ENDOCYTIC_2 259 262 PF00928 0.288
TRG_ENDOCYTIC_2 337 340 PF00928 0.548
TRG_ENDOCYTIC_2 34 37 PF00928 0.294
TRG_ENDOCYTIC_2 74 77 PF00928 0.323
TRG_ER_diArg_1 272 274 PF00400 0.523
TRG_NLS_MonoExtC_3 331 336 PF00514 0.546
TRG_Pf-PMV_PEXEL_1 6 10 PF00026 0.603

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0C5PHQ7 Tachysurus fulvidraco 23% 100%
A0A0N0P5E5 Leptomonas seymouri 42% 100%
A0A0N0P7D1 Leptomonas seymouri 66% 100%
A0A0N0P7D6 Leptomonas seymouri 31% 100%
A0A0N0P7R2 Leptomonas seymouri 61% 100%
A0A0N1HZJ8 Leptomonas seymouri 40% 100%
A0A0N1I9H5 Leptomonas seymouri 34% 100%
A0A0N1ILQ4 Leptomonas seymouri 41% 100%
A0A0N1IM10 Leptomonas seymouri 32% 100%
A0A0N1PDR8 Leptomonas seymouri 39% 100%
A0A0S4IS29 Bodo saltans 47% 100%
A0A0S4IVJ6 Bodo saltans 35% 100%
A0A0S4IVS6 Bodo saltans 40% 100%
A0A0S4IW98 Bodo saltans 46% 100%
A0A1X0NNK7 Trypanosomatidae 48% 100%
A0A1X0NNL0 Trypanosomatidae 33% 100%
A0A1X0NNM4 Trypanosomatidae 36% 100%
A0A1X0NNM5 Trypanosomatidae 52% 100%
A0A1X0NP89 Trypanosomatidae 42% 100%
A0A3Q8I8T7 Leishmania donovani 32% 92%
A0A3Q8I9T2 Leishmania donovani 32% 96%
A0A3Q8I9U9 Leishmania donovani 41% 100%
A0A3Q8I9X8 Leishmania donovani 90% 100%
A0A3Q8IC05 Leishmania donovani 39% 100%
A0A3Q8ID51 Leishmania donovani 31% 91%
A0A3Q8IIA9 Leishmania donovani 37% 100%
A0A3Q8IT78 Leishmania donovani 24% 94%
A0A3R7KG78 Trypanosoma rangeli 48% 100%
A0A3R7MJR2 Trypanosoma rangeli 40% 100%
A0A3R7NSQ3 Trypanosoma rangeli 37% 100%
A0A3S5H6R7 Leishmania donovani 33% 100%
A0A3S5H6R8 Leishmania donovani 35% 100%
A0A3S7WSY8 Leishmania donovani 33% 100%
A0A3S7WSZ1 Leishmania donovani 59% 100%
A0A3S7WT03 Leishmania donovani 64% 100%
A0A3S7WT16 Leishmania donovani 52% 100%
A0A422NNP1 Trypanosoma rangeli 52% 100%
A4H7M1 Leishmania braziliensis 23% 100%
A4H7M2 Leishmania braziliensis 33% 100%
A4H7M3 Leishmania braziliensis 33% 100%
A4H7M4 Leishmania braziliensis 36% 100%
A4H7M5 Leishmania braziliensis 34% 100%
A4H7M6 Leishmania braziliensis 58% 100%
A4H7M7 Leishmania braziliensis 47% 100%
A4H7M8 Leishmania braziliensis 29% 94%
A4H7M9 Leishmania braziliensis 30% 88%
A4H7N0 Leishmania braziliensis 41% 100%
A4HKA3 Leishmania braziliensis 25% 100%
A4HW07 Leishmania infantum 33% 100%
A4HW08 Leishmania infantum 33% 100%
A4HW09 Leishmania infantum 37% 100%
A4HW10 Leishmania infantum 35% 100%
A4HW12 Leishmania infantum 90% 100%
A4HW13 Leishmania infantum 41% 100%
A4HW14 Leishmania infantum 52% 100%
A4HW15 Leishmania infantum 32% 96%
A4HW16 Leishmania infantum 31% 96%
A4HW17 Leishmania infantum 32% 92%
A4HW18 Leishmania infantum 40% 100%
A4I7T3 Leishmania infantum 24% 94%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 100%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
D4ADY9 Rattus norvegicus 27% 100%
E8NHR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 96%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 94%
E9AGL0 Leishmania infantum 64% 100%
E9AGL2 Leishmania infantum 59% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 96%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 100%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 100%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 94%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
G5EEE5 Caenorhabditis elegans 31% 100%
P49191 Caenorhabditis elegans 33% 100%
Q03574 Caenorhabditis elegans 29% 100%
Q20303 Caenorhabditis elegans 34% 100%
Q2KJD9 Bos taurus 25% 100%
Q3S8M4 Macaca mulatta 27% 100%
Q4Q5G6 Leishmania major 27% 94%
Q4QFQ9 Leishmania major 40% 100%
Q4QFR0 Leishmania major 32% 100%
Q4QFR1 Leishmania major 31% 100%
Q4QFR2 Leishmania major 33% 100%
Q4QFR3 Leishmania major 50% 100%
Q4QFR4 Leishmania major 39% 100%
Q4QFR6 Leishmania major 65% 99%
Q4QFR7 Leishmania major 39% 100%
Q4QFR8 Leishmania major 37% 97%
Q4QFR9 Leishmania major 33% 100%
Q4QFS0 Leishmania major 33% 98%
Q4R516 Macaca fascicularis 24% 100%
Q5RFL5 Pongo abelii 24% 100%
Q5ZJR8 Gallus gallus 35% 100%
Q6PC64 Danio rerio 35% 100%
Q7LKX0 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 26% 99%
Q8BHI7 Mus musculus 24% 100%
Q920L5 Mus musculus 34% 100%
Q920L6 Rattus norvegicus 34% 100%
Q95K73 Macaca fascicularis 27% 100%
Q9H5J4 Homo sapiens 34% 100%
Q9HB03 Homo sapiens 34% 100%
Q9JLJ5 Mus musculus 26% 100%
Q9NYP7 Homo sapiens 24% 100%
Q9VV87 Drosophila melanogaster 32% 100%
Q9XVQ9 Caenorhabditis elegans 31% 100%
V5BE99 Trypanosoma cruzi 47% 100%
V5BIX9 Trypanosoma cruzi 37% 100%
V5BND3 Trypanosoma cruzi 54% 100%
V5DF68 Trypanosoma cruzi 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS