Elongation of fatty acids protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid elongase, putative

Species:

Leishmania major

UniProt:

Q4QFR4_LEIMA

TriTrypDb:

LmjF.14.0700 , LMJLV39_140012900 , LMJSD75_140012800

Length:

325

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 67
NetGPI	no	yes: 0, no: 68

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	62
GO:0110165	cellular anatomical entity	1	65
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

Q4QFR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFR4

Function

Biological processes
Term	Name	Level	Count
GO:0000038	very long-chain fatty acid metabolic process	5	7
GO:0006082	organic acid metabolic process	3	69
GO:0006629	lipid metabolic process	3	69
GO:0006631	fatty acid metabolic process	4	69
GO:0006633	fatty acid biosynthetic process	5	69
GO:0006643	membrane lipid metabolic process	4	7
GO:0006665	sphingolipid metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	69
GO:0008610	lipid biosynthetic process	4	69
GO:0009058	biosynthetic process	2	69
GO:0009987	cellular process	1	69
GO:0016053	organic acid biosynthetic process	4	69
GO:0019367	fatty acid elongation, saturated fatty acid	7	7
GO:0019368	fatty acid elongation, unsaturated fatty acid	7	7
GO:0019752	carboxylic acid metabolic process	5	69
GO:0030148	sphingolipid biosynthetic process	5	7
GO:0030497	fatty acid elongation	6	7
GO:0032787	monocarboxylic acid metabolic process	6	69
GO:0034625	fatty acid elongation, monounsaturated fatty acid	8	7
GO:0034626	fatty acid elongation, polyunsaturated fatty acid	8	7
GO:0042761	very long-chain fatty acid biosynthetic process	6	7
GO:0043436	oxoacid metabolic process	4	69
GO:0044237	cellular metabolic process	2	69
GO:0044238	primary metabolic process	2	69
GO:0044249	cellular biosynthetic process	3	69
GO:0044255	cellular lipid metabolic process	3	69
GO:0044281	small molecule metabolic process	2	69
GO:0044283	small molecule biosynthetic process	3	69
GO:0046394	carboxylic acid biosynthetic process	5	69
GO:0046467	membrane lipid biosynthetic process	4	7
GO:0071704	organic substance metabolic process	2	69
GO:0072330	monocarboxylic acid biosynthetic process	6	69
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	69
GO:0001676	long-chain fatty acid metabolic process	5	1
GO:0042759	long-chain fatty acid biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	69
GO:0004312	fatty acid synthase activity	5	69
GO:0009922	fatty acid elongase activity	6	69
GO:0016740	transferase activity	2	69
GO:0016746	acyltransferase activity	3	69
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	69
GO:0102756	very-long-chain 3-ketoacyl-CoA synthase activity	5	69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	318	320	PF00675	0.396
CLV_PCSK_FUR_1	316	320	PF00082	0.399
CLV_PCSK_KEX2_1	312	314	PF00082	0.280
CLV_PCSK_KEX2_1	318	320	PF00082	0.378
CLV_PCSK_PC1ET2_1	312	314	PF00082	0.279
CLV_PCSK_SKI1_1	152	156	PF00082	0.452
DEG_Nend_UBRbox_2	1	3	PF02207	0.470
DOC_MAPK_RevD_3	299	313	PF00069	0.298
DOC_PP2B_LxvP_1	3	6	PF13499	0.311
DOC_PP2B_PxIxI_1	5	11	PF00149	0.309
DOC_USP7_MATH_1	206	210	PF00917	0.436
DOC_USP7_MATH_1	245	249	PF00917	0.540
DOC_USP7_MATH_1	4	8	PF00917	0.322
DOC_WW_Pin1_4	16	21	PF00397	0.498
DOC_WW_Pin1_4	45	50	PF00397	0.285
DOC_WW_Pin1_4	80	85	PF00397	0.396
LIG_14-3-3_CanoR_1	244	250	PF00244	0.540
LIG_14-3-3_CanoR_1	270	276	PF00244	0.299
LIG_APCC_ABBA_1	301	306	PF00400	0.353
LIG_BRCT_BRCA1_1	284	288	PF00533	0.359
LIG_EH_1	23	27	PF12763	0.259
LIG_EH1_1	216	224	PF00400	0.308
LIG_eIF4E_1	103	109	PF01652	0.329
LIG_FHA_1	176	182	PF00498	0.295
LIG_FHA_1	266	272	PF00498	0.321
LIG_FHA_1	81	87	PF00498	0.522
LIG_FHA_2	113	119	PF00498	0.327
LIG_FHA_2	127	133	PF00498	0.341
LIG_LIR_Gen_1	160	169	PF02991	0.303
LIG_LIR_Gen_1	177	188	PF02991	0.306
LIG_LIR_Gen_1	295	304	PF02991	0.308
LIG_LIR_Nem_3	160	166	PF02991	0.269
LIG_LIR_Nem_3	177	183	PF02991	0.310
LIG_LIR_Nem_3	226	232	PF02991	0.324
LIG_LIR_Nem_3	285	291	PF02991	0.311
LIG_LIR_Nem_3	295	299	PF02991	0.289
LIG_MYND_1	120	124	PF01753	0.299
LIG_MYND_1	80	84	PF01753	0.361
LIG_Pex14_1	163	167	PF04695	0.228
LIG_Pex14_1	28	32	PF04695	0.400
LIG_Pex14_1	89	93	PF04695	0.362
LIG_Pex14_2	300	304	PF04695	0.311
LIG_PTB_Apo_2	87	94	PF02174	0.362
LIG_SH2_CRK	103	107	PF00017	0.306
LIG_SH2_GRB2like	149	152	PF00017	0.212
LIG_SH2_PTP2	296	299	PF00017	0.342
LIG_SH2_STAP1	267	271	PF00017	0.337
LIG_SH2_STAT3	308	311	PF00017	0.441
LIG_SH2_STAT5	103	106	PF00017	0.296
LIG_SH2_STAT5	229	232	PF00017	0.328
LIG_SH2_STAT5	267	270	PF00017	0.331
LIG_SH2_STAT5	272	275	PF00017	0.276
LIG_SH2_STAT5	293	296	PF00017	0.307
LIG_SH2_STAT5	308	311	PF00017	0.462
LIG_SH2_STAT5	32	35	PF00017	0.306
LIG_SH2_STAT5	59	62	PF00017	0.309
LIG_SH3_3	17	23	PF00018	0.284
LIG_SH3_3	270	276	PF00018	0.341
LIG_SH3_3	46	52	PF00018	0.341
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.562
LIG_SUMO_SIM_par_1	170	178	PF11976	0.348
LIG_TYR_ITIM	294	299	PF00017	0.303
LIG_UBA3_1	165	171	PF00899	0.346
LIG_WRC_WIRS_1	33	38	PF05994	0.422
MOD_CK1_1	18	24	PF00069	0.280
MOD_CK1_1	209	215	PF00069	0.226
MOD_CK1_1	248	254	PF00069	0.519
MOD_CK1_1	282	288	PF00069	0.301
MOD_CK1_1	94	100	PF00069	0.345
MOD_CK2_1	112	118	PF00069	0.216
MOD_CK2_1	126	132	PF00069	0.183
MOD_GlcNHglycan	208	211	PF01048	0.464
MOD_GlcNHglycan	280	284	PF01048	0.491
MOD_GSK3_1	278	285	PF00069	0.264
MOD_GSK3_1	4	11	PF00069	0.465
MOD_GSK3_1	91	98	PF00069	0.349
MOD_N-GLC_1	167	172	PF02516	0.394
MOD_NEK2_1	112	117	PF00069	0.299
MOD_NEK2_1	143	148	PF00069	0.256
MOD_NEK2_1	15	20	PF00069	0.408
MOD_NEK2_1	167	172	PF00069	0.314
MOD_NEK2_1	175	180	PF00069	0.345
MOD_NEK2_1	223	228	PF00069	0.312
MOD_NEK2_1	266	271	PF00069	0.323
MOD_NEK2_1	292	297	PF00069	0.311
MOD_NEK2_1	91	96	PF00069	0.316
MOD_NEK2_2	32	37	PF00069	0.381
MOD_PKA_2	127	133	PF00069	0.350
MOD_Plk_4	175	181	PF00069	0.281
MOD_Plk_4	195	201	PF00069	0.311
MOD_Plk_4	223	229	PF00069	0.279
MOD_Plk_4	245	251	PF00069	0.463
MOD_Plk_4	287	293	PF00069	0.281
MOD_ProDKin_1	16	22	PF00069	0.493
MOD_ProDKin_1	45	51	PF00069	0.285
MOD_ProDKin_1	80	86	PF00069	0.396
MOD_SUMO_rev_2	317	324	PF00179	0.667
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.366
TRG_DiLeu_BaLyEn_6	69	74	PF01217	0.456
TRG_ENDOCYTIC_2	231	234	PF00928	0.324
TRG_ENDOCYTIC_2	296	299	PF00928	0.295
TRG_ENDOCYTIC_2	59	62	PF00928	0.301
TRG_ER_diArg_1	318	320	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.203

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5E5	Leptomonas seymouri	37%	100%
A0A0N0P7D1	Leptomonas seymouri	40%	97%
A0A0N0P7D6	Leptomonas seymouri	27%	100%
A0A0N0P7R2	Leptomonas seymouri	42%	100%
A0A0N1HZJ8	Leptomonas seymouri	61%	100%
A0A0N1I9H5	Leptomonas seymouri	31%	100%
A0A0N1IM10	Leptomonas seymouri	25%	100%
A0A0N1PDR8	Leptomonas seymouri	34%	100%
A0A0S4IS29	Bodo saltans	38%	100%
A0A0S4IVJ6	Bodo saltans	30%	100%
A0A0S4IVS6	Bodo saltans	37%	100%
A0A0S4IW98	Bodo saltans	38%	100%
A0A1X0NNK7	Trypanosomatidae	37%	100%
A0A1X0NNL0	Trypanosomatidae	31%	100%
A0A1X0NNM4	Trypanosomatidae	32%	100%
A0A1X0NNM5	Trypanosomatidae	44%	100%
A0A1X0NP89	Trypanosomatidae	40%	100%
A0A3Q8I8T7	Leishmania donovani	32%	83%
A0A3Q8I9T2	Leishmania donovani	30%	87%
A0A3Q8I9U9	Leishmania donovani	95%	100%
A0A3Q8I9X8	Leishmania donovani	39%	97%
A0A3Q8IC05	Leishmania donovani	34%	100%
A0A3Q8ID51	Leishmania donovani	30%	82%
A0A3Q8IIA9	Leishmania donovani	29%	100%
A0A3R7MJR2	Trypanosoma rangeli	34%	100%
A0A3R7NSQ3	Trypanosoma rangeli	34%	100%
A0A3S5H6R7	Leishmania donovani	27%	100%
A0A3S5H6R8	Leishmania donovani	30%	100%
A0A3S7WSY8	Leishmania donovani	30%	100%
A0A3S7WSZ1	Leishmania donovani	40%	100%
A0A3S7WT03	Leishmania donovani	44%	100%
A0A3S7WT05	Leishmania donovani	20%	100%
A0A3S7WT16	Leishmania donovani	37%	100%
A0A422NNP1	Trypanosoma rangeli	40%	100%
A4H7M1	Leishmania braziliensis	21%	100%
A4H7M2	Leishmania braziliensis	32%	100%
A4H7M3	Leishmania braziliensis	28%	100%
A4H7M4	Leishmania braziliensis	30%	100%
A4H7M5	Leishmania braziliensis	32%	100%
A4H7M6	Leishmania braziliensis	41%	100%
A4H7M7	Leishmania braziliensis	39%	100%
A4H7M8	Leishmania braziliensis	31%	85%
A4H7M9	Leishmania braziliensis	31%	80%
A4H7N0	Leishmania braziliensis	37%	100%
A4HSN8	Leishmania infantum	29%	100%
A4HW06	Leishmania infantum	21%	100%
A4HW07	Leishmania infantum	30%	100%
A4HW08	Leishmania infantum	27%	100%
A4HW09	Leishmania infantum	29%	100%
A4HW10	Leishmania infantum	30%	100%
A4HW12	Leishmania infantum	38%	97%
A4HW13	Leishmania infantum	95%	100%
A4HW14	Leishmania infantum	39%	100%
A4HW15	Leishmania infantum	30%	87%
A4HW16	Leishmania infantum	30%	87%
A4HW17	Leishmania infantum	32%	83%
A4HW18	Leishmania infantum	34%	100%
C9ZT13	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZT15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZT16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E8NHR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	87%
E8NHR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	85%
E9AGL0	Leishmania infantum	44%	100%
E9AGL2	Leishmania infantum	40%	100%
E9APQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	87%
E9APR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9APR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9APR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9APR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9APR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	97%
E9APR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9APR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9APR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	84%
E9APR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
P49191	Caenorhabditis elegans	30%	100%
Q20300	Caenorhabditis elegans	27%	100%
Q4QFQ9	Leishmania major	35%	100%
Q4QFR0	Leishmania major	29%	100%
Q4QFR1	Leishmania major	29%	100%
Q4QFR2	Leishmania major	30%	100%
Q4QFR3	Leishmania major	39%	100%
Q4QFR5	Leishmania major	39%	90%
Q4QFR6	Leishmania major	40%	100%
Q4QFR7	Leishmania major	30%	100%
Q4QFR8	Leishmania major	29%	99%
Q4QFR9	Leishmania major	28%	96%
Q4QFS0	Leishmania major	31%	96%
Q4QFS1	Leishmania major	21%	100%
Q4R516	Macaca fascicularis	24%	100%
Q5M8U1	Xenopus tropicalis	23%	100%
Q5RFL5	Pongo abelii	24%	100%
Q5ZJR8	Gallus gallus	29%	100%
Q7LKX0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	89%
Q920L5	Mus musculus	28%	100%
Q920L6	Rattus norvegicus	28%	100%
Q9H5J4	Homo sapiens	27%	100%
Q9NYP7	Homo sapiens	24%	100%
Q9VV87	Drosophila melanogaster	30%	100%
Q9XVQ9	Caenorhabditis elegans	28%	100%
V5BIX9	Trypanosoma cruzi	33%	100%
V5BND3	Trypanosoma cruzi	42%	100%
V5DF68	Trypanosoma cruzi	30%	100%