Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 50 |
NetGPI | no | yes: 0, no: 50 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005737 | cytoplasm | 2 | 3 |
GO:0110165 | cellular anatomical entity | 1 | 48 |
GO:0016020 | membrane | 2 | 45 |
Related structures:
AlphaFold database: Q4QFR3
Term | Name | Level | Count |
---|---|---|---|
GO:0000038 | very long-chain fatty acid metabolic process | 5 | 6 |
GO:0006082 | organic acid metabolic process | 3 | 51 |
GO:0006629 | lipid metabolic process | 3 | 51 |
GO:0006631 | fatty acid metabolic process | 4 | 51 |
GO:0006633 | fatty acid biosynthetic process | 5 | 51 |
GO:0006643 | membrane lipid metabolic process | 4 | 6 |
GO:0006665 | sphingolipid metabolic process | 4 | 6 |
GO:0006807 | nitrogen compound metabolic process | 2 | 6 |
GO:0008152 | metabolic process | 1 | 51 |
GO:0008610 | lipid biosynthetic process | 4 | 51 |
GO:0009058 | biosynthetic process | 2 | 51 |
GO:0009987 | cellular process | 1 | 51 |
GO:0016053 | organic acid biosynthetic process | 4 | 51 |
GO:0019367 | fatty acid elongation, saturated fatty acid | 7 | 6 |
GO:0019368 | fatty acid elongation, unsaturated fatty acid | 7 | 6 |
GO:0019752 | carboxylic acid metabolic process | 5 | 51 |
GO:0030148 | sphingolipid biosynthetic process | 5 | 6 |
GO:0030497 | fatty acid elongation | 6 | 6 |
GO:0032787 | monocarboxylic acid metabolic process | 6 | 51 |
GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 8 | 6 |
GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 8 | 6 |
GO:0042761 | very long-chain fatty acid biosynthetic process | 6 | 6 |
GO:0043436 | oxoacid metabolic process | 4 | 51 |
GO:0044237 | cellular metabolic process | 2 | 51 |
GO:0044238 | primary metabolic process | 2 | 51 |
GO:0044249 | cellular biosynthetic process | 3 | 51 |
GO:0044255 | cellular lipid metabolic process | 3 | 51 |
GO:0044281 | small molecule metabolic process | 2 | 51 |
GO:0044283 | small molecule biosynthetic process | 3 | 51 |
GO:0046394 | carboxylic acid biosynthetic process | 5 | 51 |
GO:0046467 | membrane lipid biosynthetic process | 4 | 6 |
GO:0071704 | organic substance metabolic process | 2 | 51 |
GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 51 |
GO:1901564 | organonitrogen compound metabolic process | 3 | 6 |
GO:1901566 | organonitrogen compound biosynthetic process | 4 | 6 |
GO:1901576 | organic substance biosynthetic process | 3 | 51 |
Term | Name | Level | Count |
---|---|---|---|
GO:0003824 | catalytic activity | 1 | 51 |
GO:0004312 | fatty acid synthase activity | 5 | 51 |
GO:0009922 | fatty acid elongase activity | 6 | 51 |
GO:0016740 | transferase activity | 2 | 51 |
GO:0016746 | acyltransferase activity | 3 | 51 |
GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 51 |
GO:0102756 | very-long-chain 3-ketoacyl-CoA synthase activity | 5 | 51 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 123 | 127 | PF00656 | 0.369 |
CLV_NRD_NRD_1 | 112 | 114 | PF00675 | 0.361 |
CLV_NRD_NRD_1 | 147 | 149 | PF00675 | 0.361 |
CLV_PCSK_KEX2_1 | 112 | 114 | PF00082 | 0.361 |
CLV_PCSK_KEX2_1 | 147 | 149 | PF00082 | 0.361 |
CLV_PCSK_SKI1_1 | 277 | 281 | PF00082 | 0.457 |
CLV_PCSK_SKI1_1 | 297 | 301 | PF00082 | 0.164 |
DEG_Nend_UBRbox_2 | 1 | 3 | PF02207 | 0.335 |
DEG_SPOP_SBC_1 | 303 | 307 | PF00917 | 0.341 |
DOC_CYCLIN_yCln2_LP_2 | 233 | 239 | PF00134 | 0.468 |
DOC_MAPK_gen_1 | 176 | 182 | PF00069 | 0.446 |
DOC_MAPK_MEF2A_6 | 235 | 243 | PF00069 | 0.443 |
DOC_PP1_RVXF_1 | 175 | 182 | PF00149 | 0.456 |
DOC_USP7_MATH_1 | 201 | 205 | PF00917 | 0.318 |
DOC_USP7_UBL2_3 | 300 | 304 | PF12436 | 0.462 |
DOC_WW_Pin1_4 | 105 | 110 | PF00397 | 0.366 |
DOC_WW_Pin1_4 | 197 | 202 | PF00397 | 0.146 |
DOC_WW_Pin1_4 | 304 | 309 | PF00397 | 0.616 |
LIG_Actin_WH2_2 | 89 | 104 | PF00022 | 0.300 |
LIG_APCC_ABBA_1 | 138 | 143 | PF00400 | 0.160 |
LIG_APCC_ABBA_1 | 313 | 318 | PF00400 | 0.525 |
LIG_BRCT_BRCA1_1 | 290 | 294 | PF00533 | 0.304 |
LIG_BRCT_BRCA1_1 | 45 | 49 | PF00533 | 0.187 |
LIG_BRCT_BRCA1_2 | 45 | 51 | PF00533 | 0.187 |
LIG_EH1_1 | 185 | 193 | PF00400 | 0.305 |
LIG_EH1_1 | 212 | 220 | PF00400 | 0.305 |
LIG_FHA_1 | 167 | 173 | PF00498 | 0.286 |
LIG_FHA_1 | 187 | 193 | PF00498 | 0.285 |
LIG_FHA_1 | 3 | 9 | PF00498 | 0.375 |
LIG_FHA_1 | 308 | 314 | PF00498 | 0.665 |
LIG_FHA_1 | 58 | 64 | PF00498 | 0.515 |
LIG_GBD_Chelix_1 | 33 | 41 | PF00786 | 0.301 |
LIG_GBD_Chelix_1 | 63 | 71 | PF00786 | 0.389 |
LIG_HP1_1 | 31 | 35 | PF01393 | 0.151 |
LIG_LIR_Gen_1 | 168 | 179 | PF02991 | 0.299 |
LIG_LIR_Gen_1 | 242 | 251 | PF02991 | 0.377 |
LIG_LIR_Gen_1 | 25 | 35 | PF02991 | 0.274 |
LIG_LIR_Gen_1 | 285 | 294 | PF02991 | 0.296 |
LIG_LIR_Gen_1 | 70 | 79 | PF02991 | 0.292 |
LIG_LIR_Nem_3 | 168 | 174 | PF02991 | 0.297 |
LIG_LIR_Nem_3 | 217 | 223 | PF02991 | 0.316 |
LIG_LIR_Nem_3 | 242 | 246 | PF02991 | 0.320 |
LIG_LIR_Nem_3 | 25 | 30 | PF02991 | 0.251 |
LIG_LIR_Nem_3 | 285 | 290 | PF02991 | 0.277 |
LIG_LIR_Nem_3 | 70 | 75 | PF02991 | 0.328 |
LIG_MLH1_MIPbox_1 | 290 | 294 | PF16413 | 0.335 |
LIG_PCNA_PIPBox_1 | 1 | 10 | PF02747 | 0.400 |
LIG_Pex14_1 | 23 | 27 | PF04695 | 0.331 |
LIG_Pex14_2 | 290 | 294 | PF04695 | 0.308 |
LIG_Pex14_2 | 68 | 72 | PF04695 | 0.267 |
LIG_REV1ctd_RIR_1 | 291 | 301 | PF16727 | 0.354 |
LIG_SH2_CRK | 230 | 234 | PF00017 | 0.450 |
LIG_SH2_CRK | 79 | 83 | PF00017 | 0.319 |
LIG_SH2_NCK_1 | 85 | 89 | PF00017 | 0.340 |
LIG_SH2_PTP2 | 27 | 30 | PF00017 | 0.289 |
LIG_SH2_SRC | 27 | 30 | PF00017 | 0.345 |
LIG_SH2_STAP1 | 230 | 234 | PF00017 | 0.523 |
LIG_SH2_STAT3 | 261 | 264 | PF00017 | 0.333 |
LIG_SH2_STAT5 | 103 | 106 | PF00017 | 0.377 |
LIG_SH2_STAT5 | 193 | 196 | PF00017 | 0.314 |
LIG_SH2_STAT5 | 220 | 223 | PF00017 | 0.325 |
LIG_SH2_STAT5 | 258 | 261 | PF00017 | 0.324 |
LIG_SH2_STAT5 | 27 | 30 | PF00017 | 0.241 |
LIG_SH2_STAT5 | 283 | 286 | PF00017 | 0.297 |
LIG_SH2_STAT5 | 38 | 41 | PF00017 | 0.292 |
LIG_SH2_STAT5 | 79 | 82 | PF00017 | 0.323 |
LIG_SH3_3 | 113 | 119 | PF00018 | 0.349 |
LIG_SH3_3 | 12 | 18 | PF00018 | 0.384 |
LIG_SH3_3 | 233 | 239 | PF00018 | 0.424 |
LIG_SH3_3 | 85 | 91 | PF00018 | 0.303 |
LIG_TYR_ITIM | 284 | 289 | PF00017 | 0.320 |
LIG_Vh1_VBS_1 | 30 | 48 | PF01044 | 0.173 |
LIG_WRC_WIRS_1 | 240 | 245 | PF05994 | 0.386 |
LIG_WRC_WIRS_1 | 71 | 76 | PF05994 | 0.386 |
MOD_CDK_SPxxK_3 | 105 | 112 | PF00069 | 0.160 |
MOD_CDK_SPxxK_3 | 304 | 311 | PF00069 | 0.588 |
MOD_CK1_1 | 133 | 139 | PF00069 | 0.257 |
MOD_CK1_1 | 200 | 206 | PF00069 | 0.235 |
MOD_CK1_1 | 214 | 220 | PF00069 | 0.204 |
MOD_CK1_1 | 307 | 313 | PF00069 | 0.627 |
MOD_CK1_1 | 70 | 76 | PF00069 | 0.331 |
MOD_CK2_1 | 91 | 97 | PF00069 | 0.345 |
MOD_CMANNOS | 195 | 198 | PF00535 | 0.187 |
MOD_GlcNHglycan | 150 | 153 | PF01048 | 0.459 |
MOD_GlcNHglycan | 203 | 206 | PF01048 | 0.451 |
MOD_GlcNHglycan | 93 | 96 | PF01048 | 0.455 |
MOD_GSK3_1 | 126 | 133 | PF00069 | 0.249 |
MOD_GSK3_1 | 197 | 204 | PF00069 | 0.316 |
MOD_GSK3_1 | 207 | 214 | PF00069 | 0.300 |
MOD_GSK3_1 | 302 | 309 | PF00069 | 0.644 |
MOD_N-GLC_1 | 105 | 110 | PF02516 | 0.528 |
MOD_N-GLC_1 | 148 | 153 | PF02516 | 0.507 |
MOD_N-GLC_1 | 211 | 216 | PF02516 | 0.195 |
MOD_N-GLC_2 | 317 | 319 | PF02516 | 0.329 |
MOD_NEK2_1 | 134 | 139 | PF00069 | 0.237 |
MOD_NEK2_1 | 158 | 163 | PF00069 | 0.319 |
MOD_NEK2_1 | 166 | 171 | PF00069 | 0.324 |
MOD_NEK2_1 | 211 | 216 | PF00069 | 0.341 |
MOD_NEK2_1 | 282 | 287 | PF00069 | 0.298 |
MOD_NEK2_1 | 293 | 298 | PF00069 | 0.279 |
MOD_NEK2_1 | 67 | 72 | PF00069 | 0.314 |
MOD_PKA_2 | 130 | 136 | PF00069 | 0.262 |
MOD_PKA_2 | 271 | 277 | PF00069 | 0.242 |
MOD_Plk_1 | 134 | 140 | PF00069 | 0.271 |
MOD_Plk_1 | 211 | 217 | PF00069 | 0.157 |
MOD_Plk_4 | 186 | 192 | PF00069 | 0.311 |
MOD_Plk_4 | 214 | 220 | PF00069 | 0.282 |
MOD_Plk_4 | 250 | 256 | PF00069 | 0.274 |
MOD_Plk_4 | 282 | 288 | PF00069 | 0.289 |
MOD_Plk_4 | 45 | 51 | PF00069 | 0.302 |
MOD_Plk_4 | 67 | 73 | PF00069 | 0.305 |
MOD_ProDKin_1 | 105 | 111 | PF00069 | 0.366 |
MOD_ProDKin_1 | 197 | 203 | PF00069 | 0.146 |
MOD_ProDKin_1 | 304 | 310 | PF00069 | 0.618 |
TRG_DiLeu_BaLyEn_6 | 236 | 241 | PF01217 | 0.452 |
TRG_ENDOCYTIC_2 | 185 | 188 | PF00928 | 0.299 |
TRG_ENDOCYTIC_2 | 222 | 225 | PF00928 | 0.311 |
TRG_ENDOCYTIC_2 | 230 | 233 | PF00928 | 0.450 |
TRG_ENDOCYTIC_2 | 27 | 30 | PF00928 | 0.248 |
TRG_ENDOCYTIC_2 | 286 | 289 | PF00928 | 0.284 |
TRG_ENDOCYTIC_2 | 38 | 41 | PF00928 | 0.293 |
TRG_ENDOCYTIC_2 | 85 | 88 | PF00928 | 0.269 |
TRG_ER_diArg_1 | 111 | 113 | PF00400 | 0.160 |
TRG_ER_diArg_1 | 146 | 148 | PF00400 | 0.160 |
TRG_ER_diArg_1 | 294 | 297 | PF00400 | 0.420 |
TRG_ER_diLys_1 | 320 | 323 | PF00400 | 0.628 |
TRG_NLS_MonoCore_2 | 300 | 305 | PF00514 | 0.540 |
TRG_NLS_MonoExtC_3 | 299 | 304 | PF00514 | 0.451 |
TRG_NLS_MonoExtN_4 | 297 | 304 | PF00514 | 0.424 |
TRG_Pf-PMV_PEXEL_1 | 22 | 26 | PF00026 | 0.360 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0C5PHQ7 | Tachysurus fulvidraco | 25% | 100% |
A0A0N0P5E5 | Leptomonas seymouri | 37% | 100% |
A0A0N0P7D1 | Leptomonas seymouri | 49% | 97% |
A0A0N0P7D6 | Leptomonas seymouri | 28% | 100% |
A0A0N0P7R2 | Leptomonas seymouri | 44% | 100% |
A0A0N1HZJ8 | Leptomonas seymouri | 37% | 100% |
A0A0N1I9H5 | Leptomonas seymouri | 29% | 100% |
A0A0N1ILQ4 | Leptomonas seymouri | 35% | 100% |
A0A0N1IM10 | Leptomonas seymouri | 27% | 100% |
A0A0N1PDR8 | Leptomonas seymouri | 37% | 100% |
A0A0S4IS29 | Bodo saltans | 40% | 100% |
A0A0S4IVJ6 | Bodo saltans | 31% | 100% |
A0A0S4IVS6 | Bodo saltans | 40% | 100% |
A0A0S4IW98 | Bodo saltans | 42% | 100% |
A0A1X0NNK7 | Trypanosomatidae | 40% | 100% |
A0A1X0NNL0 | Trypanosomatidae | 36% | 100% |
A0A1X0NNM4 | Trypanosomatidae | 34% | 100% |
A0A1X0NNM5 | Trypanosomatidae | 48% | 100% |
A0A1X0NP89 | Trypanosomatidae | 41% | 100% |
A0A3Q8I8T7 | Leishmania donovani | 31% | 82% |
A0A3Q8I9T2 | Leishmania donovani | 29% | 86% |
A0A3Q8I9U9 | Leishmania donovani | 40% | 99% |
A0A3Q8I9X8 | Leishmania donovani | 51% | 96% |
A0A3Q8IC05 | Leishmania donovani | 36% | 100% |
A0A3Q8ID51 | Leishmania donovani | 28% | 81% |
A0A3Q8IIA9 | Leishmania donovani | 30% | 100% |
A0A3R7KG78 | Trypanosoma rangeli | 41% | 100% |
A0A3R7MJR2 | Trypanosoma rangeli | 34% | 100% |
A0A3R7NSQ3 | Trypanosoma rangeli | 34% | 100% |
A0A3S5H6R7 | Leishmania donovani | 29% | 100% |
A0A3S5H6R8 | Leishmania donovani | 32% | 100% |
A0A3S7WSY8 | Leishmania donovani | 30% | 100% |
A0A3S7WSZ1 | Leishmania donovani | 42% | 100% |
A0A3S7WT03 | Leishmania donovani | 46% | 100% |
A0A3S7WT16 | Leishmania donovani | 94% | 100% |
A0A422NNP1 | Trypanosoma rangeli | 46% | 100% |
A0A422NYI1 | Trypanosoma rangeli | 25% | 100% |
A0JNC4 | Bos taurus | 26% | 100% |
A1L3X0 | Homo sapiens | 28% | 100% |
A4H7M2 | Leishmania braziliensis | 29% | 100% |
A4H7M3 | Leishmania braziliensis | 29% | 100% |
A4H7M4 | Leishmania braziliensis | 30% | 100% |
A4H7M5 | Leishmania braziliensis | 32% | 100% |
A4H7M6 | Leishmania braziliensis | 43% | 100% |
A4H7M7 | Leishmania braziliensis | 77% | 100% |
A4H7M8 | Leishmania braziliensis | 30% | 85% |
A4H7M9 | Leishmania braziliensis | 32% | 79% |
A4H7N0 | Leishmania braziliensis | 36% | 100% |
A4HW07 | Leishmania infantum | 30% | 100% |
A4HW08 | Leishmania infantum | 29% | 100% |
A4HW09 | Leishmania infantum | 30% | 100% |
A4HW10 | Leishmania infantum | 32% | 100% |
A4HW12 | Leishmania infantum | 51% | 96% |
A4HW13 | Leishmania infantum | 40% | 99% |
A4HW14 | Leishmania infantum | 94% | 100% |
A4HW15 | Leishmania infantum | 29% | 86% |
A4HW16 | Leishmania infantum | 28% | 86% |
A4HW17 | Leishmania infantum | 31% | 82% |
A4HW18 | Leishmania infantum | 36% | 100% |
C9ZT13 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 47% | 100% |
C9ZT15 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 32% | 100% |
C9ZT16 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 36% | 100% |
D4ADY9 | Rattus norvegicus | 26% | 100% |
E8NHR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
E8NHR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 86% |
E8NHR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 84% |
E9AGL0 | Leishmania infantum | 46% | 100% |
E9AGL2 | Leishmania infantum | 43% | 100% |
E9APQ8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 24% | 100% |
E9APQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 86% |
E9APR0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
E9APR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 29% | 100% |
E9APR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
E9APR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 43% | 100% |
E9APR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 44% | 100% |
E9APR5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 50% | 96% |
E9APR6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 40% | 99% |
E9APR7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 88% | 100% |
E9APR8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 84% |
E9APR9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 35% | 100% |
G5EEE5 | Caenorhabditis elegans | 29% | 100% |
O35949 | Mus musculus | 31% | 100% |
P49191 | Caenorhabditis elegans | 34% | 100% |
Q03574 | Caenorhabditis elegans | 27% | 100% |
Q20300 | Caenorhabditis elegans | 29% | 100% |
Q4QFQ9 | Leishmania major | 37% | 96% |
Q4QFR0 | Leishmania major | 30% | 100% |
Q4QFR1 | Leishmania major | 28% | 100% |
Q4QFR2 | Leishmania major | 29% | 86% |
Q4QFR4 | Leishmania major | 39% | 99% |
Q4QFR5 | Leishmania major | 50% | 90% |
Q4QFR6 | Leishmania major | 45% | 100% |
Q4QFR7 | Leishmania major | 32% | 100% |
Q4QFR8 | Leishmania major | 31% | 100% |
Q4QFR9 | Leishmania major | 28% | 100% |
Q4QFS0 | Leishmania major | 29% | 100% |
Q4QFS1 | Leishmania major | 23% | 100% |
Q5ZJR8 | Gallus gallus | 30% | 100% |
Q6PC64 | Danio rerio | 31% | 100% |
Q86JM5 | Dictyostelium discoideum | 28% | 100% |
Q920L5 | Mus musculus | 30% | 100% |
Q920L6 | Rattus norvegicus | 29% | 100% |
Q9D2Y9 | Mus musculus | 26% | 100% |
Q9H5J4 | Homo sapiens | 29% | 100% |
Q9HB03 | Homo sapiens | 32% | 100% |
Q9VV87 | Drosophila melanogaster | 34% | 100% |
Q9XVQ9 | Caenorhabditis elegans | 28% | 100% |
V5BE99 | Trypanosoma cruzi | 41% | 100% |
V5BIX9 | Trypanosoma cruzi | 37% | 100% |
V5BND3 | Trypanosoma cruzi | 45% | 100% |
V5DF68 | Trypanosoma cruzi | 39% | 100% |