LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania major
UniProt:
Q4QFR3_LEIMA
TriTrypDb:
LmjF.14.0705 , LMJLV39_140013000 , LMJSD75_140012900
Length:
323

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 50
NetGPI no yes: 0, no: 50
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 48
GO:0016020 membrane 2 45

Expansion

Sequence features

Q4QFR3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFR3

Function

Biological processes
Term Name Level Count
GO:0000038 very long-chain fatty acid metabolic process 5 6
GO:0006082 organic acid metabolic process 3 51
GO:0006629 lipid metabolic process 3 51
GO:0006631 fatty acid metabolic process 4 51
GO:0006633 fatty acid biosynthetic process 5 51
GO:0006643 membrane lipid metabolic process 4 6
GO:0006665 sphingolipid metabolic process 4 6
GO:0006807 nitrogen compound metabolic process 2 6
GO:0008152 metabolic process 1 51
GO:0008610 lipid biosynthetic process 4 51
GO:0009058 biosynthetic process 2 51
GO:0009987 cellular process 1 51
GO:0016053 organic acid biosynthetic process 4 51
GO:0019367 fatty acid elongation, saturated fatty acid 7 6
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 6
GO:0019752 carboxylic acid metabolic process 5 51
GO:0030148 sphingolipid biosynthetic process 5 6
GO:0030497 fatty acid elongation 6 6
GO:0032787 monocarboxylic acid metabolic process 6 51
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 6
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 6
GO:0042761 very long-chain fatty acid biosynthetic process 6 6
GO:0043436 oxoacid metabolic process 4 51
GO:0044237 cellular metabolic process 2 51
GO:0044238 primary metabolic process 2 51
GO:0044249 cellular biosynthetic process 3 51
GO:0044255 cellular lipid metabolic process 3 51
GO:0044281 small molecule metabolic process 2 51
GO:0044283 small molecule biosynthetic process 3 51
GO:0046394 carboxylic acid biosynthetic process 5 51
GO:0046467 membrane lipid biosynthetic process 4 6
GO:0071704 organic substance metabolic process 2 51
GO:0072330 monocarboxylic acid biosynthetic process 6 51
GO:1901564 organonitrogen compound metabolic process 3 6
GO:1901566 organonitrogen compound biosynthetic process 4 6
GO:1901576 organic substance biosynthetic process 3 51
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 51
GO:0004312 fatty acid synthase activity 5 51
GO:0009922 fatty acid elongase activity 6 51
GO:0016740 transferase activity 2 51
GO:0016746 acyltransferase activity 3 51
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 51
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 51

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 123 127 PF00656 0.369
CLV_NRD_NRD_1 112 114 PF00675 0.361
CLV_NRD_NRD_1 147 149 PF00675 0.361
CLV_PCSK_KEX2_1 112 114 PF00082 0.361
CLV_PCSK_KEX2_1 147 149 PF00082 0.361
CLV_PCSK_SKI1_1 277 281 PF00082 0.457
CLV_PCSK_SKI1_1 297 301 PF00082 0.164
DEG_Nend_UBRbox_2 1 3 PF02207 0.335
DEG_SPOP_SBC_1 303 307 PF00917 0.341
DOC_CYCLIN_yCln2_LP_2 233 239 PF00134 0.468
DOC_MAPK_gen_1 176 182 PF00069 0.446
DOC_MAPK_MEF2A_6 235 243 PF00069 0.443
DOC_PP1_RVXF_1 175 182 PF00149 0.456
DOC_USP7_MATH_1 201 205 PF00917 0.318
DOC_USP7_UBL2_3 300 304 PF12436 0.462
DOC_WW_Pin1_4 105 110 PF00397 0.366
DOC_WW_Pin1_4 197 202 PF00397 0.146
DOC_WW_Pin1_4 304 309 PF00397 0.616
LIG_Actin_WH2_2 89 104 PF00022 0.300
LIG_APCC_ABBA_1 138 143 PF00400 0.160
LIG_APCC_ABBA_1 313 318 PF00400 0.525
LIG_BRCT_BRCA1_1 290 294 PF00533 0.304
LIG_BRCT_BRCA1_1 45 49 PF00533 0.187
LIG_BRCT_BRCA1_2 45 51 PF00533 0.187
LIG_EH1_1 185 193 PF00400 0.305
LIG_EH1_1 212 220 PF00400 0.305
LIG_FHA_1 167 173 PF00498 0.286
LIG_FHA_1 187 193 PF00498 0.285
LIG_FHA_1 3 9 PF00498 0.375
LIG_FHA_1 308 314 PF00498 0.665
LIG_FHA_1 58 64 PF00498 0.515
LIG_GBD_Chelix_1 33 41 PF00786 0.301
LIG_GBD_Chelix_1 63 71 PF00786 0.389
LIG_HP1_1 31 35 PF01393 0.151
LIG_LIR_Gen_1 168 179 PF02991 0.299
LIG_LIR_Gen_1 242 251 PF02991 0.377
LIG_LIR_Gen_1 25 35 PF02991 0.274
LIG_LIR_Gen_1 285 294 PF02991 0.296
LIG_LIR_Gen_1 70 79 PF02991 0.292
LIG_LIR_Nem_3 168 174 PF02991 0.297
LIG_LIR_Nem_3 217 223 PF02991 0.316
LIG_LIR_Nem_3 242 246 PF02991 0.320
LIG_LIR_Nem_3 25 30 PF02991 0.251
LIG_LIR_Nem_3 285 290 PF02991 0.277
LIG_LIR_Nem_3 70 75 PF02991 0.328
LIG_MLH1_MIPbox_1 290 294 PF16413 0.335
LIG_PCNA_PIPBox_1 1 10 PF02747 0.400
LIG_Pex14_1 23 27 PF04695 0.331
LIG_Pex14_2 290 294 PF04695 0.308
LIG_Pex14_2 68 72 PF04695 0.267
LIG_REV1ctd_RIR_1 291 301 PF16727 0.354
LIG_SH2_CRK 230 234 PF00017 0.450
LIG_SH2_CRK 79 83 PF00017 0.319
LIG_SH2_NCK_1 85 89 PF00017 0.340
LIG_SH2_PTP2 27 30 PF00017 0.289
LIG_SH2_SRC 27 30 PF00017 0.345
LIG_SH2_STAP1 230 234 PF00017 0.523
LIG_SH2_STAT3 261 264 PF00017 0.333
LIG_SH2_STAT5 103 106 PF00017 0.377
LIG_SH2_STAT5 193 196 PF00017 0.314
LIG_SH2_STAT5 220 223 PF00017 0.325
LIG_SH2_STAT5 258 261 PF00017 0.324
LIG_SH2_STAT5 27 30 PF00017 0.241
LIG_SH2_STAT5 283 286 PF00017 0.297
LIG_SH2_STAT5 38 41 PF00017 0.292
LIG_SH2_STAT5 79 82 PF00017 0.323
LIG_SH3_3 113 119 PF00018 0.349
LIG_SH3_3 12 18 PF00018 0.384
LIG_SH3_3 233 239 PF00018 0.424
LIG_SH3_3 85 91 PF00018 0.303
LIG_TYR_ITIM 284 289 PF00017 0.320
LIG_Vh1_VBS_1 30 48 PF01044 0.173
LIG_WRC_WIRS_1 240 245 PF05994 0.386
LIG_WRC_WIRS_1 71 76 PF05994 0.386
MOD_CDK_SPxxK_3 105 112 PF00069 0.160
MOD_CDK_SPxxK_3 304 311 PF00069 0.588
MOD_CK1_1 133 139 PF00069 0.257
MOD_CK1_1 200 206 PF00069 0.235
MOD_CK1_1 214 220 PF00069 0.204
MOD_CK1_1 307 313 PF00069 0.627
MOD_CK1_1 70 76 PF00069 0.331
MOD_CK2_1 91 97 PF00069 0.345
MOD_CMANNOS 195 198 PF00535 0.187
MOD_GlcNHglycan 150 153 PF01048 0.459
MOD_GlcNHglycan 203 206 PF01048 0.451
MOD_GlcNHglycan 93 96 PF01048 0.455
MOD_GSK3_1 126 133 PF00069 0.249
MOD_GSK3_1 197 204 PF00069 0.316
MOD_GSK3_1 207 214 PF00069 0.300
MOD_GSK3_1 302 309 PF00069 0.644
MOD_N-GLC_1 105 110 PF02516 0.528
MOD_N-GLC_1 148 153 PF02516 0.507
MOD_N-GLC_1 211 216 PF02516 0.195
MOD_N-GLC_2 317 319 PF02516 0.329
MOD_NEK2_1 134 139 PF00069 0.237
MOD_NEK2_1 158 163 PF00069 0.319
MOD_NEK2_1 166 171 PF00069 0.324
MOD_NEK2_1 211 216 PF00069 0.341
MOD_NEK2_1 282 287 PF00069 0.298
MOD_NEK2_1 293 298 PF00069 0.279
MOD_NEK2_1 67 72 PF00069 0.314
MOD_PKA_2 130 136 PF00069 0.262
MOD_PKA_2 271 277 PF00069 0.242
MOD_Plk_1 134 140 PF00069 0.271
MOD_Plk_1 211 217 PF00069 0.157
MOD_Plk_4 186 192 PF00069 0.311
MOD_Plk_4 214 220 PF00069 0.282
MOD_Plk_4 250 256 PF00069 0.274
MOD_Plk_4 282 288 PF00069 0.289
MOD_Plk_4 45 51 PF00069 0.302
MOD_Plk_4 67 73 PF00069 0.305
MOD_ProDKin_1 105 111 PF00069 0.366
MOD_ProDKin_1 197 203 PF00069 0.146
MOD_ProDKin_1 304 310 PF00069 0.618
TRG_DiLeu_BaLyEn_6 236 241 PF01217 0.452
TRG_ENDOCYTIC_2 185 188 PF00928 0.299
TRG_ENDOCYTIC_2 222 225 PF00928 0.311
TRG_ENDOCYTIC_2 230 233 PF00928 0.450
TRG_ENDOCYTIC_2 27 30 PF00928 0.248
TRG_ENDOCYTIC_2 286 289 PF00928 0.284
TRG_ENDOCYTIC_2 38 41 PF00928 0.293
TRG_ENDOCYTIC_2 85 88 PF00928 0.269
TRG_ER_diArg_1 111 113 PF00400 0.160
TRG_ER_diArg_1 146 148 PF00400 0.160
TRG_ER_diArg_1 294 297 PF00400 0.420
TRG_ER_diLys_1 320 323 PF00400 0.628
TRG_NLS_MonoCore_2 300 305 PF00514 0.540
TRG_NLS_MonoExtC_3 299 304 PF00514 0.451
TRG_NLS_MonoExtN_4 297 304 PF00514 0.424
TRG_Pf-PMV_PEXEL_1 22 26 PF00026 0.360

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0C5PHQ7 Tachysurus fulvidraco 25% 100%
A0A0N0P5E5 Leptomonas seymouri 37% 100%
A0A0N0P7D1 Leptomonas seymouri 49% 97%
A0A0N0P7D6 Leptomonas seymouri 28% 100%
A0A0N0P7R2 Leptomonas seymouri 44% 100%
A0A0N1HZJ8 Leptomonas seymouri 37% 100%
A0A0N1I9H5 Leptomonas seymouri 29% 100%
A0A0N1ILQ4 Leptomonas seymouri 35% 100%
A0A0N1IM10 Leptomonas seymouri 27% 100%
A0A0N1PDR8 Leptomonas seymouri 37% 100%
A0A0S4IS29 Bodo saltans 40% 100%
A0A0S4IVJ6 Bodo saltans 31% 100%
A0A0S4IVS6 Bodo saltans 40% 100%
A0A0S4IW98 Bodo saltans 42% 100%
A0A1X0NNK7 Trypanosomatidae 40% 100%
A0A1X0NNL0 Trypanosomatidae 36% 100%
A0A1X0NNM4 Trypanosomatidae 34% 100%
A0A1X0NNM5 Trypanosomatidae 48% 100%
A0A1X0NP89 Trypanosomatidae 41% 100%
A0A3Q8I8T7 Leishmania donovani 31% 82%
A0A3Q8I9T2 Leishmania donovani 29% 86%
A0A3Q8I9U9 Leishmania donovani 40% 99%
A0A3Q8I9X8 Leishmania donovani 51% 96%
A0A3Q8IC05 Leishmania donovani 36% 100%
A0A3Q8ID51 Leishmania donovani 28% 81%
A0A3Q8IIA9 Leishmania donovani 30% 100%
A0A3R7KG78 Trypanosoma rangeli 41% 100%
A0A3R7MJR2 Trypanosoma rangeli 34% 100%
A0A3R7NSQ3 Trypanosoma rangeli 34% 100%
A0A3S5H6R7 Leishmania donovani 29% 100%
A0A3S5H6R8 Leishmania donovani 32% 100%
A0A3S7WSY8 Leishmania donovani 30% 100%
A0A3S7WSZ1 Leishmania donovani 42% 100%
A0A3S7WT03 Leishmania donovani 46% 100%
A0A3S7WT16 Leishmania donovani 94% 100%
A0A422NNP1 Trypanosoma rangeli 46% 100%
A0A422NYI1 Trypanosoma rangeli 25% 100%
A0JNC4 Bos taurus 26% 100%
A1L3X0 Homo sapiens 28% 100%
A4H7M2 Leishmania braziliensis 29% 100%
A4H7M3 Leishmania braziliensis 29% 100%
A4H7M4 Leishmania braziliensis 30% 100%
A4H7M5 Leishmania braziliensis 32% 100%
A4H7M6 Leishmania braziliensis 43% 100%
A4H7M7 Leishmania braziliensis 77% 100%
A4H7M8 Leishmania braziliensis 30% 85%
A4H7M9 Leishmania braziliensis 32% 79%
A4H7N0 Leishmania braziliensis 36% 100%
A4HW07 Leishmania infantum 30% 100%
A4HW08 Leishmania infantum 29% 100%
A4HW09 Leishmania infantum 30% 100%
A4HW10 Leishmania infantum 32% 100%
A4HW12 Leishmania infantum 51% 96%
A4HW13 Leishmania infantum 40% 99%
A4HW14 Leishmania infantum 94% 100%
A4HW15 Leishmania infantum 29% 86%
A4HW16 Leishmania infantum 28% 86%
A4HW17 Leishmania infantum 31% 82%
A4HW18 Leishmania infantum 36% 100%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
D4ADY9 Rattus norvegicus 26% 100%
E8NHR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 86%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 84%
E9AGL0 Leishmania infantum 46% 100%
E9AGL2 Leishmania infantum 43% 100%
E9APQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 86%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 50% 96%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 99%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 84%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
G5EEE5 Caenorhabditis elegans 29% 100%
O35949 Mus musculus 31% 100%
P49191 Caenorhabditis elegans 34% 100%
Q03574 Caenorhabditis elegans 27% 100%
Q20300 Caenorhabditis elegans 29% 100%
Q4QFQ9 Leishmania major 37% 96%
Q4QFR0 Leishmania major 30% 100%
Q4QFR1 Leishmania major 28% 100%
Q4QFR2 Leishmania major 29% 86%
Q4QFR4 Leishmania major 39% 99%
Q4QFR5 Leishmania major 50% 90%
Q4QFR6 Leishmania major 45% 100%
Q4QFR7 Leishmania major 32% 100%
Q4QFR8 Leishmania major 31% 100%
Q4QFR9 Leishmania major 28% 100%
Q4QFS0 Leishmania major 29% 100%
Q4QFS1 Leishmania major 23% 100%
Q5ZJR8 Gallus gallus 30% 100%
Q6PC64 Danio rerio 31% 100%
Q86JM5 Dictyostelium discoideum 28% 100%
Q920L5 Mus musculus 30% 100%
Q920L6 Rattus norvegicus 29% 100%
Q9D2Y9 Mus musculus 26% 100%
Q9H5J4 Homo sapiens 29% 100%
Q9HB03 Homo sapiens 32% 100%
Q9VV87 Drosophila melanogaster 34% 100%
Q9XVQ9 Caenorhabditis elegans 28% 100%
V5BE99 Trypanosoma cruzi 41% 100%
V5BIX9 Trypanosoma cruzi 37% 100%
V5BND3 Trypanosoma cruzi 45% 100%
V5DF68 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS