Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 36 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 1, no: 77 |
| NetGPI | no | yes: 0, no: 78 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 67 |
| GO:0110165 | cellular anatomical entity | 1 | 70 |
| GO:0005737 | cytoplasm | 2 | 3 |
Related structures:
AlphaFold database: Q4QFR2
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000038 | very long-chain fatty acid metabolic process | 5 | 12 |
| GO:0006082 | organic acid metabolic process | 3 | 79 |
| GO:0006629 | lipid metabolic process | 3 | 79 |
| GO:0006631 | fatty acid metabolic process | 4 | 79 |
| GO:0006633 | fatty acid biosynthetic process | 5 | 79 |
| GO:0006643 | membrane lipid metabolic process | 4 | 12 |
| GO:0006665 | sphingolipid metabolic process | 4 | 12 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 12 |
| GO:0008152 | metabolic process | 1 | 79 |
| GO:0008610 | lipid biosynthetic process | 4 | 79 |
| GO:0009058 | biosynthetic process | 2 | 79 |
| GO:0009987 | cellular process | 1 | 79 |
| GO:0016053 | organic acid biosynthetic process | 4 | 79 |
| GO:0019367 | fatty acid elongation, saturated fatty acid | 7 | 12 |
| GO:0019368 | fatty acid elongation, unsaturated fatty acid | 7 | 12 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 79 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 12 |
| GO:0030497 | fatty acid elongation | 6 | 12 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 79 |
| GO:0034625 | fatty acid elongation, monounsaturated fatty acid | 8 | 12 |
| GO:0034626 | fatty acid elongation, polyunsaturated fatty acid | 8 | 12 |
| GO:0042761 | very long-chain fatty acid biosynthetic process | 6 | 12 |
| GO:0043436 | oxoacid metabolic process | 4 | 79 |
| GO:0044237 | cellular metabolic process | 2 | 79 |
| GO:0044238 | primary metabolic process | 2 | 79 |
| GO:0044249 | cellular biosynthetic process | 3 | 79 |
| GO:0044255 | cellular lipid metabolic process | 3 | 79 |
| GO:0044281 | small molecule metabolic process | 2 | 79 |
| GO:0044283 | small molecule biosynthetic process | 3 | 79 |
| GO:0046394 | carboxylic acid biosynthetic process | 5 | 79 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 12 |
| GO:0071704 | organic substance metabolic process | 2 | 79 |
| GO:0072330 | monocarboxylic acid biosynthetic process | 6 | 79 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 12 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 12 |
| GO:1901576 | organic substance biosynthetic process | 3 | 79 |
| GO:0001676 | long-chain fatty acid metabolic process | 5 | 3 |
| GO:0042759 | long-chain fatty acid biosynthetic process | 6 | 3 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 79 |
| GO:0004312 | fatty acid synthase activity | 5 | 79 |
| GO:0009922 | fatty acid elongase activity | 6 | 79 |
| GO:0016740 | transferase activity | 2 | 79 |
| GO:0016746 | acyltransferase activity | 3 | 79 |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 79 |
| GO:0102756 | very-long-chain 3-ketoacyl-CoA synthase activity | 5 | 79 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 116 | 118 | PF00675 | 0.367 |
| CLV_NRD_NRD_1 | 181 | 183 | PF00675 | 0.320 |
| CLV_NRD_NRD_1 | 236 | 238 | PF00675 | 0.271 |
| CLV_PCSK_KEX2_1 | 116 | 118 | PF00082 | 0.367 |
| CLV_PCSK_KEX2_1 | 130 | 132 | PF00082 | 0.367 |
| CLV_PCSK_KEX2_1 | 355 | 357 | PF00082 | 0.312 |
| CLV_PCSK_PC1ET2_1 | 130 | 132 | PF00082 | 0.367 |
| CLV_PCSK_PC1ET2_1 | 355 | 357 | PF00082 | 0.316 |
| CLV_PCSK_SKI1_1 | 16 | 20 | PF00082 | 0.584 |
| CLV_PCSK_SKI1_1 | 24 | 28 | PF00082 | 0.602 |
| DEG_Nend_UBRbox_2 | 1 | 3 | PF02207 | 0.442 |
| DOC_CKS1_1 | 138 | 143 | PF01111 | 0.325 |
| DOC_CKS1_1 | 167 | 172 | PF01111 | 0.458 |
| DOC_CYCLIN_RxL_1 | 346 | 354 | PF00134 | 0.357 |
| DOC_MAPK_MEF2A_6 | 241 | 249 | PF00069 | 0.483 |
| DOC_MAPK_MEF2A_6 | 54 | 61 | PF00069 | 0.428 |
| DOC_MAPK_NFAT4_5 | 54 | 62 | PF00069 | 0.378 |
| DOC_PP1_RVXF_1 | 129 | 136 | PF00149 | 0.167 |
| DOC_PP1_RVXF_1 | 181 | 188 | PF00149 | 0.467 |
| DOC_PP4_FxxP_1 | 46 | 49 | PF00568 | 0.344 |
| DOC_USP7_MATH_1 | 207 | 211 | PF00917 | 0.318 |
| DOC_USP7_MATH_1 | 306 | 310 | PF00917 | 0.199 |
| DOC_USP7_MATH_1 | 367 | 371 | PF00917 | 0.649 |
| DOC_WW_Pin1_4 | 137 | 142 | PF00397 | 0.350 |
| DOC_WW_Pin1_4 | 166 | 171 | PF00397 | 0.443 |
| LIG_14-3-3_CanoR_1 | 16 | 26 | PF00244 | 0.242 |
| LIG_14-3-3_CanoR_1 | 182 | 188 | PF00244 | 0.526 |
| LIG_14-3-3_CanoR_1 | 92 | 97 | PF00244 | 0.254 |
| LIG_Actin_WH2_2 | 224 | 239 | PF00022 | 0.403 |
| LIG_BRCT_BRCA1_1 | 316 | 320 | PF00533 | 0.198 |
| LIG_eIF4E_1 | 226 | 232 | PF01652 | 0.377 |
| LIG_FHA_1 | 156 | 162 | PF00498 | 0.299 |
| LIG_FHA_1 | 167 | 173 | PF00498 | 0.314 |
| LIG_FHA_1 | 302 | 308 | PF00498 | 0.188 |
| LIG_FHA_1 | 78 | 84 | PF00498 | 0.345 |
| LIG_FHA_1 | 91 | 97 | PF00498 | 0.278 |
| LIG_FHA_2 | 138 | 144 | PF00498 | 0.321 |
| LIG_FHA_2 | 97 | 103 | PF00498 | 0.264 |
| LIG_GBD_Chelix_1 | 194 | 202 | PF00786 | 0.198 |
| LIG_KLC1_Yacidic_2 | 350 | 354 | PF13176 | 0.397 |
| LIG_LIR_Gen_1 | 174 | 185 | PF02991 | 0.304 |
| LIG_LIR_Gen_1 | 196 | 207 | PF02991 | 0.421 |
| LIG_LIR_Gen_1 | 223 | 232 | PF02991 | 0.410 |
| LIG_LIR_Gen_1 | 262 | 271 | PF02991 | 0.361 |
| LIG_LIR_Gen_1 | 278 | 288 | PF02991 | 0.301 |
| LIG_LIR_Gen_1 | 339 | 348 | PF02991 | 0.305 |
| LIG_LIR_Gen_1 | 38 | 49 | PF02991 | 0.314 |
| LIG_LIR_Nem_3 | 174 | 180 | PF02991 | 0.315 |
| LIG_LIR_Nem_3 | 196 | 202 | PF02991 | 0.368 |
| LIG_LIR_Nem_3 | 223 | 229 | PF02991 | 0.314 |
| LIG_LIR_Nem_3 | 262 | 267 | PF02991 | 0.314 |
| LIG_LIR_Nem_3 | 278 | 284 | PF02991 | 0.249 |
| LIG_LIR_Nem_3 | 28 | 33 | PF02991 | 0.299 |
| LIG_LIR_Nem_3 | 289 | 295 | PF02991 | 0.170 |
| LIG_LIR_Nem_3 | 339 | 343 | PF02991 | 0.299 |
| LIG_LIR_Nem_3 | 38 | 44 | PF02991 | 0.332 |
| LIG_LIR_Nem_3 | 76 | 81 | PF02991 | 0.358 |
| LIG_PCNA_PIPBox_1 | 1 | 10 | PF02747 | 0.485 |
| LIG_Pex14_1 | 201 | 205 | PF04695 | 0.253 |
| LIG_Pex14_2 | 220 | 224 | PF04695 | 0.210 |
| LIG_Pex14_2 | 280 | 284 | PF04695 | 0.190 |
| LIG_Pex14_2 | 344 | 348 | PF04695 | 0.323 |
| LIG_PTB_Apo_2 | 274 | 281 | PF02174 | 0.194 |
| LIG_PTB_Apo_2 | 287 | 294 | PF02174 | 0.171 |
| LIG_PTB_Phospho_1 | 287 | 293 | PF10480 | 0.179 |
| LIG_SH2_CRK | 153 | 157 | PF00017 | 0.273 |
| LIG_SH2_CRK | 340 | 344 | PF00017 | 0.220 |
| LIG_SH2_CRK | 36 | 40 | PF00017 | 0.335 |
| LIG_SH2_CRK | 78 | 82 | PF00017 | 0.301 |
| LIG_SH2_GRB2like | 275 | 278 | PF00017 | 0.362 |
| LIG_SH2_NCK_1 | 36 | 40 | PF00017 | 0.436 |
| LIG_SH2_PTP2 | 199 | 202 | PF00017 | 0.434 |
| LIG_SH2_PTP2 | 260 | 263 | PF00017 | 0.439 |
| LIG_SH2_SRC | 47 | 50 | PF00017 | 0.425 |
| LIG_SH2_STAP1 | 275 | 279 | PF00017 | 0.314 |
| LIG_SH2_STAP1 | 36 | 40 | PF00017 | 0.387 |
| LIG_SH2_STAT3 | 122 | 125 | PF00017 | 0.179 |
| LIG_SH2_STAT5 | 166 | 169 | PF00017 | 0.352 |
| LIG_SH2_STAT5 | 199 | 202 | PF00017 | 0.345 |
| LIG_SH2_STAT5 | 219 | 222 | PF00017 | 0.268 |
| LIG_SH2_STAT5 | 226 | 229 | PF00017 | 0.319 |
| LIG_SH2_STAT5 | 260 | 263 | PF00017 | 0.324 |
| LIG_SH2_STAT5 | 264 | 267 | PF00017 | 0.326 |
| LIG_SH2_STAT5 | 295 | 298 | PF00017 | 0.366 |
| LIG_SH2_STAT5 | 340 | 343 | PF00017 | 0.318 |
| LIG_SH2_STAT5 | 352 | 355 | PF00017 | 0.457 |
| LIG_SH2_STAT5 | 47 | 50 | PF00017 | 0.312 |
| LIG_SH2_STAT5 | 51 | 54 | PF00017 | 0.475 |
| LIG_SH2_STAT5 | 63 | 66 | PF00017 | 0.546 |
| LIG_SH2_STAT5 | 89 | 92 | PF00017 | 0.268 |
| LIG_SH3_3 | 135 | 141 | PF00018 | 0.157 |
| LIG_SH3_3 | 239 | 245 | PF00018 | 0.451 |
| LIG_SH3_3 | 28 | 34 | PF00018 | 0.339 |
| LIG_TRFH_1 | 269 | 273 | PF08558 | 0.201 |
| LIG_UBA3_1 | 163 | 168 | PF00899 | 0.361 |
| LIG_UBA3_1 | 176 | 183 | PF00899 | 0.317 |
| LIG_UBA3_1 | 233 | 238 | PF00899 | 0.392 |
| LIG_UBA3_1 | 343 | 349 | PF00899 | 0.324 |
| LIG_WRC_WIRS_1 | 221 | 226 | PF05994 | 0.209 |
| MOD_CK1_1 | 300 | 306 | PF00069 | 0.198 |
| MOD_CK1_1 | 325 | 331 | PF00069 | 0.332 |
| MOD_CK1_1 | 73 | 79 | PF00069 | 0.363 |
| MOD_CK2_1 | 96 | 102 | PF00069 | 0.336 |
| MOD_GlcNHglycan | 209 | 212 | PF01048 | 0.462 |
| MOD_GSK3_1 | 297 | 304 | PF00069 | 0.373 |
| MOD_GSK3_1 | 70 | 77 | PF00069 | 0.362 |
| MOD_GSK3_1 | 92 | 99 | PF00069 | 0.288 |
| MOD_NEK2_1 | 172 | 177 | PF00069 | 0.328 |
| MOD_NEK2_1 | 220 | 225 | PF00069 | 0.338 |
| MOD_NEK2_1 | 236 | 241 | PF00069 | 0.515 |
| MOD_NEK2_1 | 259 | 264 | PF00069 | 0.345 |
| MOD_NEK2_1 | 336 | 341 | PF00069 | 0.289 |
| MOD_NEK2_1 | 70 | 75 | PF00069 | 0.323 |
| MOD_NEK2_1 | 90 | 95 | PF00069 | 0.299 |
| MOD_NEK2_1 | 96 | 101 | PF00069 | 0.269 |
| MOD_NEK2_2 | 275 | 280 | PF00069 | 0.343 |
| MOD_OFUCOSY | 323 | 329 | PF10250 | 0.389 |
| MOD_PIKK_1 | 306 | 312 | PF00454 | 0.179 |
| MOD_PKA_2 | 236 | 242 | PF00069 | 0.409 |
| MOD_PKA_2 | 53 | 59 | PF00069 | 0.538 |
| MOD_Plk_1 | 358 | 364 | PF00069 | 0.699 |
| MOD_Plk_4 | 172 | 178 | PF00069 | 0.289 |
| MOD_Plk_4 | 183 | 189 | PF00069 | 0.462 |
| MOD_Plk_4 | 201 | 207 | PF00069 | 0.284 |
| MOD_Plk_4 | 220 | 226 | PF00069 | 0.266 |
| MOD_Plk_4 | 262 | 268 | PF00069 | 0.306 |
| MOD_Plk_4 | 275 | 281 | PF00069 | 0.273 |
| MOD_Plk_4 | 297 | 303 | PF00069 | 0.198 |
| MOD_Plk_4 | 358 | 364 | PF00069 | 0.678 |
| MOD_Plk_4 | 70 | 76 | PF00069 | 0.324 |
| MOD_ProDKin_1 | 137 | 143 | PF00069 | 0.350 |
| MOD_ProDKin_1 | 166 | 172 | PF00069 | 0.443 |
| MOD_SUMO_for_1 | 18 | 21 | PF00179 | 0.341 |
| TRG_ENDOCYTIC_2 | 191 | 194 | PF00928 | 0.333 |
| TRG_ENDOCYTIC_2 | 199 | 202 | PF00928 | 0.348 |
| TRG_ENDOCYTIC_2 | 205 | 208 | PF00928 | 0.295 |
| TRG_ENDOCYTIC_2 | 228 | 231 | PF00928 | 0.312 |
| TRG_ENDOCYTIC_2 | 260 | 263 | PF00928 | 0.381 |
| TRG_ENDOCYTIC_2 | 264 | 267 | PF00928 | 0.359 |
| TRG_ENDOCYTIC_2 | 340 | 343 | PF00928 | 0.296 |
| TRG_ENDOCYTIC_2 | 36 | 39 | PF00928 | 0.318 |
| TRG_ENDOCYTIC_2 | 78 | 81 | PF00928 | 0.343 |
| TRG_ER_diArg_1 | 91 | 94 | PF00400 | 0.174 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N0P5E5 | Leptomonas seymouri | 33% | 100% |
| A0A0N0P7D1 | Leptomonas seymouri | 29% | 100% |
| A0A0N0P7D6 | Leptomonas seymouri | 27% | 100% |
| A0A0N0P7R2 | Leptomonas seymouri | 35% | 100% |
| A0A0N1HZJ8 | Leptomonas seymouri | 30% | 100% |
| A0A0N1I9H5 | Leptomonas seymouri | 31% | 100% |
| A0A0N1IM10 | Leptomonas seymouri | 29% | 100% |
| A0A0N1PDR8 | Leptomonas seymouri | 28% | 100% |
| A0A0S4IS29 | Bodo saltans | 33% | 100% |
| A0A0S4IVJ6 | Bodo saltans | 31% | 100% |
| A0A0S4IVS6 | Bodo saltans | 30% | 100% |
| A0A0S4IW98 | Bodo saltans | 36% | 100% |
| A0A1X0NNK7 | Trypanosomatidae | 33% | 100% |
| A0A1X0NNM5 | Trypanosomatidae | 32% | 100% |
| A0A1X0NP89 | Trypanosomatidae | 30% | 100% |
| A0A3Q8I8T7 | Leishmania donovani | 66% | 96% |
| A0A3Q8I9T2 | Leishmania donovani | 97% | 100% |
| A0A3Q8I9U9 | Leishmania donovani | 30% | 100% |
| A0A3Q8I9X8 | Leishmania donovani | 32% | 100% |
| A0A3Q8IC05 | Leishmania donovani | 35% | 100% |
| A0A3Q8ID51 | Leishmania donovani | 74% | 94% |
| A0A3Q8IIA9 | Leishmania donovani | 29% | 100% |
| A0A3R7KG78 | Trypanosoma rangeli | 30% | 100% |
| A0A3R7MJR2 | Trypanosoma rangeli | 29% | 100% |
| A0A3S5H6R7 | Leishmania donovani | 31% | 100% |
| A0A3S7WSY8 | Leishmania donovani | 32% | 100% |
| A0A3S7WSZ1 | Leishmania donovani | 30% | 100% |
| A0A3S7WT03 | Leishmania donovani | 31% | 100% |
| A0A3S7WT16 | Leishmania donovani | 28% | 100% |
| A0A422NNP1 | Trypanosoma rangeli | 31% | 100% |
| A4H7M2 | Leishmania braziliensis | 32% | 100% |
| A4H7M3 | Leishmania braziliensis | 32% | 100% |
| A4H7M4 | Leishmania braziliensis | 27% | 100% |
| A4H7M6 | Leishmania braziliensis | 29% | 100% |
| A4H7M7 | Leishmania braziliensis | 29% | 100% |
| A4H7M8 | Leishmania braziliensis | 84% | 98% |
| A4H7M9 | Leishmania braziliensis | 64% | 92% |
| A4H7N0 | Leishmania braziliensis | 36% | 100% |
| A4HW07 | Leishmania infantum | 32% | 100% |
| A4HW08 | Leishmania infantum | 31% | 100% |
| A4HW09 | Leishmania infantum | 29% | 100% |
| A4HW12 | Leishmania infantum | 33% | 100% |
| A4HW13 | Leishmania infantum | 30% | 100% |
| A4HW14 | Leishmania infantum | 28% | 100% |
| A4HW15 | Leishmania infantum | 97% | 100% |
| A4HW16 | Leishmania infantum | 74% | 100% |
| A4HW17 | Leishmania infantum | 66% | 96% |
| A4HW18 | Leishmania infantum | 35% | 100% |
| C9ZT13 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 31% | 100% |
| C9ZT15 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 33% | 100% |
| E8NHR1 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 87% | 100% |
| E8NHR2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 75% | 100% |
| E8NHR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 92% | 98% |
| E9AGL0 | Leishmania infantum | 31% | 100% |
| E9AGL2 | Leishmania infantum | 31% | 100% |
| E9APQ9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 100% |
| E9APR0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 100% |
| E9APR3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 100% |
| E9APR4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 31% | 100% |
| E9APR5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
| E9APR6 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 100% |
| E9APR7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 100% |
| E9APR8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 68% | 97% |
| E9APR9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 36% | 100% |
| Q4QFQ9 | Leishmania major | 35% | 83% |
| Q4QFR0 | Leishmania major | 69% | 100% |
| Q4QFR1 | Leishmania major | 76% | 100% |
| Q4QFR3 | Leishmania major | 29% | 94% |
| Q4QFR4 | Leishmania major | 30% | 100% |
| Q4QFR5 | Leishmania major | 33% | 100% |
| Q4QFR6 | Leishmania major | 31% | 88% |
| Q4QFR8 | Leishmania major | 30% | 100% |
| Q4QFR9 | Leishmania major | 31% | 100% |
| Q4QFS0 | Leishmania major | 32% | 100% |
| Q9VV87 | Drosophila melanogaster | 25% | 100% |
| V5BE99 | Trypanosoma cruzi | 31% | 100% |
| V5BND3 | Trypanosoma cruzi | 29% | 100% |
| V5DF68 | Trypanosoma cruzi | 26% | 100% |