LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania major
UniProt:
Q4QFR1_LEIMA
TriTrypDb:
LmjF.14.0720 , LMJLV39_140013400 , LMJSD75_140012600 *
Length:
397

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 61
NetGPI no yes: 0, no: 61
Cellular components
Term Name Level Count
GO:0016020 membrane 2 52
GO:0110165 cellular anatomical entity 1 54
GO:0005737 cytoplasm 2 2

Expansion

Sequence features

Q4QFR1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFR1

Function

Biological processes
Term Name Level Count
GO:0000038 very long-chain fatty acid metabolic process 5 10
GO:0006082 organic acid metabolic process 3 62
GO:0006629 lipid metabolic process 3 62
GO:0006631 fatty acid metabolic process 4 62
GO:0006633 fatty acid biosynthetic process 5 62
GO:0006643 membrane lipid metabolic process 4 10
GO:0006665 sphingolipid metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 62
GO:0008610 lipid biosynthetic process 4 62
GO:0009058 biosynthetic process 2 62
GO:0009987 cellular process 1 62
GO:0016053 organic acid biosynthetic process 4 62
GO:0019367 fatty acid elongation, saturated fatty acid 7 10
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 10
GO:0019752 carboxylic acid metabolic process 5 62
GO:0030148 sphingolipid biosynthetic process 5 10
GO:0030497 fatty acid elongation 6 10
GO:0032787 monocarboxylic acid metabolic process 6 62
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 10
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 10
GO:0042761 very long-chain fatty acid biosynthetic process 6 10
GO:0043436 oxoacid metabolic process 4 62
GO:0044237 cellular metabolic process 2 62
GO:0044238 primary metabolic process 2 62
GO:0044249 cellular biosynthetic process 3 62
GO:0044255 cellular lipid metabolic process 3 62
GO:0044281 small molecule metabolic process 2 62
GO:0044283 small molecule biosynthetic process 3 62
GO:0046394 carboxylic acid biosynthetic process 5 62
GO:0046467 membrane lipid biosynthetic process 4 10
GO:0071704 organic substance metabolic process 2 62
GO:0072330 monocarboxylic acid biosynthetic process 6 62
GO:1901564 organonitrogen compound metabolic process 3 10
GO:1901566 organonitrogen compound biosynthetic process 4 10
GO:1901576 organic substance biosynthetic process 3 62
GO:0001676 long-chain fatty acid metabolic process 5 1
GO:0042759 long-chain fatty acid biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 62
GO:0004312 fatty acid synthase activity 5 62
GO:0009922 fatty acid elongase activity 6 62
GO:0016740 transferase activity 2 62
GO:0016746 acyltransferase activity 3 62
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 62
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 62

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 16 18 PF00675 0.467
CLV_NRD_NRD_1 180 182 PF00675 0.333
CLV_NRD_NRD_1 235 237 PF00675 0.296
CLV_NRD_NRD_1 364 366 PF00675 0.462
CLV_NRD_NRD_1 54 56 PF00675 0.366
CLV_PCSK_FUR_1 14 18 PF00082 0.463
CLV_PCSK_KEX2_1 16 18 PF00082 0.467
CLV_PCSK_KEX2_1 354 356 PF00082 0.361
CLV_PCSK_KEX2_1 54 56 PF00082 0.361
CLV_PCSK_PC1ET2_1 354 356 PF00082 0.357
CLV_PCSK_SKI1_1 146 150 PF00082 0.474
CLV_PCSK_SKI1_1 24 28 PF00082 0.599
DEG_Nend_UBRbox_2 1 3 PF02207 0.430
DOC_CKS1_1 166 171 PF01111 0.499
DOC_CKS1_1 384 389 PF01111 0.590
DOC_CYCLIN_RxL_1 345 353 PF00134 0.445
DOC_MAPK_gen_1 54 61 PF00069 0.435
DOC_MAPK_MEF2A_6 240 248 PF00069 0.509
DOC_MAPK_MEF2A_6 54 61 PF00069 0.474
DOC_MAPK_NFAT4_5 54 62 PF00069 0.416
DOC_MAPK_RevD_3 40 55 PF00069 0.219
DOC_PP1_RVXF_1 180 187 PF00149 0.498
DOC_PP2B_LxvP_1 46 49 PF13499 0.310
DOC_USP7_MATH_1 206 210 PF00917 0.346
DOC_USP7_MATH_1 305 309 PF00917 0.238
DOC_USP7_UBL2_3 374 378 PF12436 0.512
DOC_WW_Pin1_4 138 143 PF00397 0.359
DOC_WW_Pin1_4 165 170 PF00397 0.499
DOC_WW_Pin1_4 383 388 PF00397 0.586
LIG_14-3-3_CanoR_1 181 187 PF00244 0.554
LIG_Actin_WH2_2 223 238 PF00022 0.455
LIG_BRCT_BRCA1_1 315 319 PF00533 0.244
LIG_eIF4E_1 225 231 PF01652 0.473
LIG_FHA_1 139 145 PF00498 0.369
LIG_FHA_1 166 172 PF00498 0.353
LIG_FHA_1 301 307 PF00498 0.228
LIG_FHA_1 75 81 PF00498 0.454
LIG_FHA_2 124 130 PF00498 0.286
LIG_GBD_Chelix_1 193 201 PF00786 0.235
LIG_Integrin_isoDGR_2 22 24 PF01839 0.453
LIG_KLC1_Yacidic_2 349 353 PF13176 0.435
LIG_LIR_Gen_1 173 184 PF02991 0.338
LIG_LIR_Gen_1 195 206 PF02991 0.486
LIG_LIR_Gen_1 222 231 PF02991 0.422
LIG_LIR_Gen_1 261 270 PF02991 0.411
LIG_LIR_Gen_1 277 287 PF02991 0.289
LIG_LIR_Gen_1 338 347 PF02991 0.358
LIG_LIR_Nem_3 173 179 PF02991 0.392
LIG_LIR_Nem_3 195 201 PF02991 0.427
LIG_LIR_Nem_3 222 228 PF02991 0.343
LIG_LIR_Nem_3 261 266 PF02991 0.343
LIG_LIR_Nem_3 277 283 PF02991 0.256
LIG_LIR_Nem_3 28 33 PF02991 0.336
LIG_LIR_Nem_3 288 294 PF02991 0.393
LIG_LIR_Nem_3 338 342 PF02991 0.339
LIG_LIR_Nem_3 76 81 PF02991 0.423
LIG_LIR_Nem_3 9 13 PF02991 0.342
LIG_PDZ_Class_1 392 397 PF00595 0.599
LIG_Pex14_1 200 204 PF04695 0.301
LIG_Pex14_2 219 223 PF04695 0.250
LIG_Pex14_2 279 283 PF04695 0.230
LIG_Pex14_2 343 347 PF04695 0.362
LIG_PTB_Apo_2 273 280 PF02174 0.234
LIG_PTB_Apo_2 286 293 PF02174 0.205
LIG_PTB_Phospho_1 286 292 PF10480 0.214
LIG_Rb_pABgroove_1 146 154 PF01858 0.190
LIG_SH2_CRK 339 343 PF00017 0.261
LIG_SH2_CRK 36 40 PF00017 0.356
LIG_SH2_GRB2like 274 277 PF00017 0.231
LIG_SH2_PTP2 198 201 PF00017 0.286
LIG_SH2_PTP2 259 262 PF00017 0.502
LIG_SH2_STAP1 274 278 PF00017 0.379
LIG_SH2_STAP1 36 40 PF00017 0.393
LIG_SH2_STAT5 165 168 PF00017 0.363
LIG_SH2_STAT5 198 201 PF00017 0.399
LIG_SH2_STAT5 218 221 PF00017 0.263
LIG_SH2_STAT5 225 228 PF00017 0.366
LIG_SH2_STAT5 259 262 PF00017 0.358
LIG_SH2_STAT5 263 266 PF00017 0.343
LIG_SH2_STAT5 294 297 PF00017 0.232
LIG_SH2_STAT5 339 342 PF00017 0.348
LIG_SH2_STAT5 351 354 PF00017 0.489
LIG_SH2_STAT5 41 44 PF00017 0.350
LIG_SH2_STAT5 47 50 PF00017 0.354
LIG_SH2_STAT5 63 66 PF00017 0.572
LIG_SH3_3 238 244 PF00018 0.485
LIG_SH3_3 28 34 PF00018 0.390
LIG_SH3_3 381 387 PF00018 0.796
LIG_TRFH_1 268 272 PF08558 0.240
LIG_UBA3_1 162 167 PF00899 0.413
LIG_UBA3_1 175 182 PF00899 0.383
LIG_UBA3_1 232 237 PF00899 0.429
LIG_UBA3_1 342 348 PF00899 0.341
LIG_WRC_WIRS_1 220 225 PF05994 0.248
LIG_WRC_WIRS_1 93 98 PF05994 0.374
MOD_CK1_1 299 305 PF00069 0.237
MOD_CK1_1 324 330 PF00069 0.360
MOD_CK1_1 73 79 PF00069 0.387
MOD_CK1_1 92 98 PF00069 0.177
MOD_CK2_1 123 129 PF00069 0.269
MOD_CK2_1 137 143 PF00069 0.254
MOD_CK2_1 96 102 PF00069 0.260
MOD_GlcNHglycan 106 109 PF01048 0.505
MOD_GlcNHglycan 18 21 PF01048 0.545
MOD_GlcNHglycan 208 211 PF01048 0.508
MOD_GSK3_1 296 303 PF00069 0.237
MOD_GSK3_1 70 77 PF00069 0.410
MOD_GSK3_1 92 99 PF00069 0.321
MOD_NEK2_1 103 108 PF00069 0.356
MOD_NEK2_1 171 176 PF00069 0.372
MOD_NEK2_1 219 224 PF00069 0.390
MOD_NEK2_1 235 240 PF00069 0.562
MOD_NEK2_1 258 263 PF00069 0.390
MOD_NEK2_1 335 340 PF00069 0.328
MOD_NEK2_1 70 75 PF00069 0.375
MOD_NEK2_1 96 101 PF00069 0.348
MOD_NEK2_2 274 279 PF00069 0.394
MOD_OFUCOSY 322 328 PF10250 0.426
MOD_PIKK_1 305 311 PF00454 0.217
MOD_PKA_1 16 22 PF00069 0.267
MOD_PKA_2 16 22 PF00069 0.267
MOD_PKA_2 235 241 PF00069 0.449
MOD_PKB_1 14 22 PF00069 0.264
MOD_Plk_1 146 152 PF00069 0.270
MOD_Plk_1 357 363 PF00069 0.678
MOD_Plk_2-3 147 153 PF00069 0.190
MOD_Plk_4 123 129 PF00069 0.297
MOD_Plk_4 147 153 PF00069 0.272
MOD_Plk_4 171 177 PF00069 0.319
MOD_Plk_4 182 188 PF00069 0.497
MOD_Plk_4 200 206 PF00069 0.332
MOD_Plk_4 219 225 PF00069 0.313
MOD_Plk_4 261 267 PF00069 0.355
MOD_Plk_4 274 280 PF00069 0.333
MOD_Plk_4 296 302 PF00069 0.237
MOD_Plk_4 35 41 PF00069 0.380
MOD_Plk_4 357 363 PF00069 0.699
MOD_Plk_4 70 76 PF00069 0.367
MOD_ProDKin_1 138 144 PF00069 0.359
MOD_ProDKin_1 165 171 PF00069 0.499
MOD_ProDKin_1 383 389 PF00069 0.587
MOD_SUMO_rev_2 367 375 PF00179 0.522
TRG_ENDOCYTIC_2 190 193 PF00928 0.383
TRG_ENDOCYTIC_2 198 201 PF00928 0.402
TRG_ENDOCYTIC_2 204 207 PF00928 0.345
TRG_ENDOCYTIC_2 227 230 PF00928 0.345
TRG_ENDOCYTIC_2 259 262 PF00928 0.408
TRG_ENDOCYTIC_2 263 266 PF00928 0.385
TRG_ENDOCYTIC_2 339 342 PF00928 0.345
TRG_ENDOCYTIC_2 36 39 PF00928 0.346
TRG_ENDOCYTIC_2 78 81 PF00928 0.374
TRG_ENDOCYTIC_2 84 87 PF00928 0.318
TRG_ER_diArg_1 13 16 PF00400 0.270

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5E5 Leptomonas seymouri 32% 100%
A0A0N0P7D1 Leptomonas seymouri 29% 100%
A0A0N0P7D6 Leptomonas seymouri 27% 100%
A0A0N1HZJ8 Leptomonas seymouri 29% 100%
A0A0N1I9H5 Leptomonas seymouri 30% 100%
A0A0N1PDR8 Leptomonas seymouri 30% 100%
A0A0S4IVS6 Bodo saltans 33% 100%
A0A1X0NNK7 Trypanosomatidae 33% 100%
A0A1X0NNM5 Trypanosomatidae 33% 100%
A0A3Q8I8T7 Leishmania donovani 69% 100%
A0A3Q8I9T2 Leishmania donovani 75% 100%
A0A3Q8I9U9 Leishmania donovani 31% 100%
A0A3Q8I9X8 Leishmania donovani 31% 100%
A0A3Q8IC05 Leishmania donovani 31% 100%
A0A3Q8ID51 Leishmania donovani 95% 100%
A0A3Q8IIA9 Leishmania donovani 30% 100%
A0A3R7KG78 Trypanosoma rangeli 32% 100%
A0A3R7MJR2 Trypanosoma rangeli 29% 100%
A0A3S7WSZ1 Leishmania donovani 30% 100%
A0A3S7WT03 Leishmania donovani 31% 100%
A0A3S7WT16 Leishmania donovani 28% 100%
A0A422NNP1 Trypanosoma rangeli 30% 100%
A4H7M3 Leishmania braziliensis 28% 100%
A4H7M4 Leishmania braziliensis 28% 100%
A4H7M6 Leishmania braziliensis 29% 100%
A4H7M7 Leishmania braziliensis 29% 100%
A4H7M8 Leishmania braziliensis 70% 100%
A4H7M9 Leishmania braziliensis 62% 98%
A4H7N0 Leishmania braziliensis 35% 100%
A4HW09 Leishmania infantum 30% 100%
A4HW12 Leishmania infantum 31% 100%
A4HW13 Leishmania infantum 30% 100%
A4HW14 Leishmania infantum 27% 100%
A4HW15 Leishmania infantum 75% 100%
A4HW16 Leishmania infantum 95% 100%
A4HW17 Leishmania infantum 70% 100%
A4HW18 Leishmania infantum 32% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
E9AGL0 Leishmania infantum 31% 100%
E9AGL2 Leishmania infantum 30% 100%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 100%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
Q4QFQ9 Leishmania major 33% 80%
Q4QFR0 Leishmania major 70% 100%
Q4QFR2 Leishmania major 76% 100%
Q4QFR3 Leishmania major 28% 100%
Q4QFR4 Leishmania major 29% 100%
Q4QFR5 Leishmania major 31% 100%
Q4QFR6 Leishmania major 30% 100%
Q4QFR8 Leishmania major 29% 100%
V5BE99 Trypanosoma cruzi 30% 100%
V5BND3 Trypanosoma cruzi 29% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS