LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania major
UniProt:
Q4QFR0_LEIMA
TriTrypDb:
LmjF.14.0730 * , LMJLV39_140013400 * , LMJSD75_140013000 *
Length:
392

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 68
NetGPI no yes: 0, no: 69
Cellular components
Term Name Level Count
GO:0016020 membrane 2 60
GO:0110165 cellular anatomical entity 1 63
GO:0005737 cytoplasm 2 3

Expansion

Sequence features

Q4QFR0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFR0

Function

Biological processes
Term Name Level Count
GO:0000038 very long-chain fatty acid metabolic process 5 10
GO:0006082 organic acid metabolic process 3 70
GO:0006629 lipid metabolic process 3 70
GO:0006631 fatty acid metabolic process 4 70
GO:0006633 fatty acid biosynthetic process 5 70
GO:0006643 membrane lipid metabolic process 4 10
GO:0006665 sphingolipid metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 70
GO:0008610 lipid biosynthetic process 4 70
GO:0009058 biosynthetic process 2 70
GO:0009987 cellular process 1 70
GO:0016053 organic acid biosynthetic process 4 70
GO:0019367 fatty acid elongation, saturated fatty acid 7 10
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 10
GO:0019752 carboxylic acid metabolic process 5 70
GO:0030148 sphingolipid biosynthetic process 5 10
GO:0030497 fatty acid elongation 6 10
GO:0032787 monocarboxylic acid metabolic process 6 70
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 10
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 10
GO:0042761 very long-chain fatty acid biosynthetic process 6 10
GO:0043436 oxoacid metabolic process 4 70
GO:0044237 cellular metabolic process 2 70
GO:0044238 primary metabolic process 2 70
GO:0044249 cellular biosynthetic process 3 70
GO:0044255 cellular lipid metabolic process 3 70
GO:0044281 small molecule metabolic process 2 70
GO:0044283 small molecule biosynthetic process 3 70
GO:0046394 carboxylic acid biosynthetic process 5 70
GO:0046467 membrane lipid biosynthetic process 4 10
GO:0071704 organic substance metabolic process 2 70
GO:0072330 monocarboxylic acid biosynthetic process 6 70
GO:1901564 organonitrogen compound metabolic process 3 10
GO:1901566 organonitrogen compound biosynthetic process 4 10
GO:1901576 organic substance biosynthetic process 3 70
GO:0001676 long-chain fatty acid metabolic process 5 1
GO:0042759 long-chain fatty acid biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 70
GO:0004312 fatty acid synthase activity 5 70
GO:0009922 fatty acid elongase activity 6 70
GO:0016740 transferase activity 2 70
GO:0016746 acyltransferase activity 3 70
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 70
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 70

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 175 177 PF00675 0.317
CLV_NRD_NRD_1 230 232 PF00675 0.278
CLV_NRD_NRD_1 359 361 PF00675 0.424
CLV_PCSK_KEX2_1 349 351 PF00082 0.311
CLV_PCSK_PC1ET2_1 349 351 PF00082 0.313
CLV_PCSK_SKI1_1 16 20 PF00082 0.618
DEG_Nend_UBRbox_2 1 3 PF02207 0.436
DOC_CKS1_1 161 166 PF01111 0.474
DOC_CKS1_1 379 384 PF01111 0.553
DOC_CKS1_1 4 9 PF01111 0.268
DOC_CYCLIN_RxL_1 340 348 PF00134 0.422
DOC_CYCLIN_yClb5_NLxxxL_5 57 66 PF00134 0.367
DOC_MAPK_MEF2A_6 235 243 PF00069 0.479
DOC_PP1_RVXF_1 175 182 PF00149 0.481
DOC_PP4_FxxP_1 38 41 PF00568 0.330
DOC_USP7_MATH_1 300 304 PF00917 0.202
DOC_USP7_UBL2_3 369 373 PF12436 0.661
DOC_WW_Pin1_4 115 120 PF00397 0.355
DOC_WW_Pin1_4 160 165 PF00397 0.456
DOC_WW_Pin1_4 3 8 PF00397 0.431
DOC_WW_Pin1_4 378 383 PF00397 0.547
LIG_14-3-3_CanoR_1 134 139 PF00244 0.310
LIG_14-3-3_CanoR_1 151 161 PF00244 0.291
LIG_14-3-3_CanoR_1 176 182 PF00244 0.521
LIG_Actin_WH2_2 218 233 PF00022 0.440
LIG_BIR_III_2 20 24 PF00653 0.167
LIG_BRCT_BRCA1_1 101 105 PF00533 0.163
LIG_BRCT_BRCA1_1 310 314 PF00533 0.207
LIG_deltaCOP1_diTrp_1 2 10 PF00928 0.463
LIG_eIF4E_1 220 226 PF01652 0.408
LIG_eIF4E_1 74 80 PF01652 0.350
LIG_FHA_1 137 143 PF00498 0.310
LIG_FHA_1 161 167 PF00498 0.324
LIG_FHA_1 296 302 PF00498 0.192
LIG_FHA_1 52 58 PF00498 0.538
LIG_FHA_1 80 86 PF00498 0.281
LIG_GBD_Chelix_1 62 70 PF00786 0.179
LIG_KLC1_Yacidic_2 344 348 PF13176 0.399
LIG_LIR_Apic_2 113 117 PF02991 0.164
LIG_LIR_Apic_2 144 150 PF02991 0.273
LIG_LIR_Gen_1 155 166 PF02991 0.345
LIG_LIR_Gen_1 168 179 PF02991 0.319
LIG_LIR_Gen_1 198 207 PF02991 0.362
LIG_LIR_Gen_1 217 226 PF02991 0.363
LIG_LIR_Gen_1 256 265 PF02991 0.377
LIG_LIR_Gen_1 272 282 PF02991 0.309
LIG_LIR_Gen_1 333 342 PF02991 0.318
LIG_LIR_Nem_3 155 161 PF02991 0.314
LIG_LIR_Nem_3 168 174 PF02991 0.321
LIG_LIR_Nem_3 198 202 PF02991 0.342
LIG_LIR_Nem_3 217 223 PF02991 0.325
LIG_LIR_Nem_3 24 28 PF02991 0.291
LIG_LIR_Nem_3 256 261 PF02991 0.321
LIG_LIR_Nem_3 272 278 PF02991 0.250
LIG_LIR_Nem_3 283 289 PF02991 0.171
LIG_LIR_Nem_3 333 337 PF02991 0.300
LIG_LIR_Nem_3 72 76 PF02991 0.370
LIG_PDZ_Class_1 387 392 PF00595 0.564
LIG_Pex14_1 195 199 PF04695 0.260
LIG_Pex14_2 214 218 PF04695 0.213
LIG_Pex14_2 274 278 PF04695 0.194
LIG_Pex14_2 338 342 PF04695 0.324
LIG_Pex14_2 80 84 PF04695 0.330
LIG_PTB_Apo_2 109 116 PF02174 0.167
LIG_PTB_Apo_2 268 275 PF02174 0.198
LIG_PTB_Apo_2 281 288 PF02174 0.170
LIG_PTB_Phospho_1 109 115 PF10480 0.167
LIG_PTB_Phospho_1 281 287 PF10480 0.179
LIG_SH2_CRK 147 151 PF00017 0.294
LIG_SH2_CRK 154 158 PF00017 0.370
LIG_SH2_CRK 28 32 PF00017 0.352
LIG_SH2_CRK 334 338 PF00017 0.223
LIG_SH2_GRB2like 269 272 PF00017 0.195
LIG_SH2_PTP2 199 202 PF00017 0.305
LIG_SH2_PTP2 254 257 PF00017 0.407
LIG_SH2_SRC 115 118 PF00017 0.346
LIG_SH2_SRC 33 36 PF00017 0.459
LIG_SH2_STAP1 138 142 PF00017 0.255
LIG_SH2_STAP1 154 158 PF00017 0.270
LIG_SH2_STAP1 269 273 PF00017 0.326
LIG_SH2_STAP1 28 32 PF00017 0.387
LIG_SH2_STAT3 138 141 PF00017 0.172
LIG_SH2_STAT3 74 77 PF00017 0.172
LIG_SH2_STAT5 138 141 PF00017 0.270
LIG_SH2_STAT5 154 157 PF00017 0.305
LIG_SH2_STAT5 160 163 PF00017 0.339
LIG_SH2_STAT5 193 196 PF00017 0.356
LIG_SH2_STAT5 199 202 PF00017 0.271
LIG_SH2_STAT5 213 216 PF00017 0.267
LIG_SH2_STAT5 220 223 PF00017 0.334
LIG_SH2_STAT5 254 257 PF00017 0.334
LIG_SH2_STAT5 258 261 PF00017 0.323
LIG_SH2_STAT5 289 292 PF00017 0.196
LIG_SH2_STAT5 33 36 PF00017 0.316
LIG_SH2_STAT5 334 337 PF00017 0.313
LIG_SH2_STAT5 346 349 PF00017 0.458
LIG_SH2_STAT5 55 58 PF00017 0.552
LIG_SH2_STAT5 74 77 PF00017 0.310
LIG_SH3_3 197 203 PF00018 0.172
LIG_SH3_3 20 26 PF00018 0.367
LIG_SH3_3 233 239 PF00018 0.450
LIG_SH3_3 376 382 PF00018 0.541
LIG_SUMO_SIM_anti_2 65 72 PF11976 0.184
LIG_TRFH_1 199 203 PF08558 0.164
LIG_TRFH_1 263 267 PF08558 0.203
LIG_TYR_ITIM 31 36 PF00017 0.267
LIG_UBA3_1 157 162 PF00899 0.357
LIG_UBA3_1 170 177 PF00899 0.324
LIG_UBA3_1 227 232 PF00899 0.393
LIG_UBA3_1 337 343 PF00899 0.330
LIG_UBA3_1 79 87 PF00899 0.305
LIG_WRC_WIRS_1 215 220 PF05994 0.211
MOD_CK1_1 294 300 PF00069 0.200
MOD_CK1_1 319 325 PF00069 0.324
MOD_CK1_1 65 71 PF00069 0.350
MOD_GlcNHglycan 13 16 PF01048 0.533
MOD_GlcNHglycan 203 206 PF01048 0.469
MOD_GSK3_1 291 298 PF00069 0.200
MOD_GSK3_1 6 13 PF00069 0.394
MOD_GSK3_1 65 72 PF00069 0.340
MOD_GSK3_1 95 102 PF00069 0.346
MOD_NEK2_1 10 15 PF00069 0.405
MOD_NEK2_1 123 128 PF00069 0.271
MOD_NEK2_1 166 171 PF00069 0.341
MOD_NEK2_1 214 219 PF00069 0.344
MOD_NEK2_1 230 235 PF00069 0.522
MOD_NEK2_1 253 258 PF00069 0.352
MOD_NEK2_1 330 335 PF00069 0.302
MOD_NEK2_1 51 56 PF00069 0.485
MOD_NEK2_1 62 67 PF00069 0.337
MOD_NEK2_1 79 84 PF00069 0.257
MOD_NEK2_1 89 94 PF00069 0.314
MOD_NEK2_2 269 274 PF00069 0.345
MOD_NEK2_2 95 100 PF00069 0.358
MOD_OFUCOSY 317 323 PF10250 0.391
MOD_PIKK_1 300 306 PF00454 0.182
MOD_PKA_2 133 139 PF00069 0.294
MOD_PKA_2 230 236 PF00069 0.412
MOD_Plk_1 352 358 PF00069 0.668
MOD_Plk_1 51 57 PF00069 0.472
MOD_Plk_4 166 172 PF00069 0.289
MOD_Plk_4 177 183 PF00069 0.465
MOD_Plk_4 195 201 PF00069 0.291
MOD_Plk_4 214 220 PF00069 0.270
MOD_Plk_4 256 262 PF00069 0.305
MOD_Plk_4 269 275 PF00069 0.282
MOD_Plk_4 291 297 PF00069 0.200
MOD_Plk_4 352 358 PF00069 0.646
MOD_Plk_4 62 68 PF00069 0.327
MOD_Plk_4 69 75 PF00069 0.329
MOD_Plk_4 79 85 PF00069 0.235
MOD_ProDKin_1 115 121 PF00069 0.355
MOD_ProDKin_1 160 166 PF00069 0.456
MOD_ProDKin_1 3 9 PF00069 0.431
MOD_ProDKin_1 378 384 PF00069 0.549
MOD_SUMO_rev_2 362 370 PF00179 0.678
TRG_ENDOCYTIC_2 154 157 PF00928 0.283
TRG_ENDOCYTIC_2 185 188 PF00928 0.329
TRG_ENDOCYTIC_2 199 202 PF00928 0.290
TRG_ENDOCYTIC_2 222 225 PF00928 0.324
TRG_ENDOCYTIC_2 254 257 PF00928 0.362
TRG_ENDOCYTIC_2 258 261 PF00928 0.350
TRG_ENDOCYTIC_2 28 31 PF00928 0.312
TRG_ENDOCYTIC_2 33 36 PF00928 0.309
TRG_ENDOCYTIC_2 334 337 PF00928 0.302
TRG_ENDOCYTIC_2 73 76 PF00928 0.357

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5E5 Leptomonas seymouri 34% 100%
A0A0N0P7D1 Leptomonas seymouri 27% 100%
A0A0N0P7D6 Leptomonas seymouri 30% 100%
A0A0N0P7R2 Leptomonas seymouri 35% 100%
A0A0N1HZJ8 Leptomonas seymouri 30% 100%
A0A0N1I9H5 Leptomonas seymouri 27% 100%
A0A0N1ILQ4 Leptomonas seymouri 30% 100%
A0A0N1IM10 Leptomonas seymouri 28% 100%
A0A0N1PDR8 Leptomonas seymouri 30% 100%
A0A0S4IVS6 Bodo saltans 30% 100%
A0A1X0NNK7 Trypanosomatidae 34% 100%
A0A1X0NNM5 Trypanosomatidae 34% 100%
A0A1X0NP89 Trypanosomatidae 35% 100%
A0A3Q8I8T7 Leishmania donovani 96% 100%
A0A3Q8I9T2 Leishmania donovani 66% 100%
A0A3Q8I9U9 Leishmania donovani 31% 100%
A0A3Q8I9X8 Leishmania donovani 32% 100%
A0A3Q8IC05 Leishmania donovani 36% 100%
A0A3Q8ID51 Leishmania donovani 69% 99%
A0A3Q8IIA9 Leishmania donovani 28% 100%
A0A3R7KG78 Trypanosoma rangeli 34% 100%
A0A3R7MJR2 Trypanosoma rangeli 28% 100%
A0A3R7NSQ3 Trypanosoma rangeli 29% 100%
A0A3S7WSY8 Leishmania donovani 28% 100%
A0A3S7WSZ1 Leishmania donovani 33% 100%
A0A3S7WT03 Leishmania donovani 34% 100%
A0A3S7WT16 Leishmania donovani 31% 100%
A0A422NNP1 Trypanosoma rangeli 30% 100%
A4H7M2 Leishmania braziliensis 28% 100%
A4H7M6 Leishmania braziliensis 31% 100%
A4H7M7 Leishmania braziliensis 31% 100%
A4H7M8 Leishmania braziliensis 61% 100%
A4H7M9 Leishmania braziliensis 82% 96%
A4H7N0 Leishmania braziliensis 37% 100%
A4HW07 Leishmania infantum 28% 100%
A4HW09 Leishmania infantum 28% 100%
A4HW12 Leishmania infantum 31% 100%
A4HW13 Leishmania infantum 30% 100%
A4HW14 Leishmania infantum 30% 100%
A4HW15 Leishmania infantum 67% 100%
A4HW16 Leishmania infantum 68% 100%
A4HW17 Leishmania infantum 95% 100%
A4HW18 Leishmania infantum 34% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 100%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 65% 100%
E9AGL0 Leishmania infantum 34% 100%
E9AGL2 Leishmania infantum 33% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9APR6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
Q4QFQ9 Leishmania major 35% 80%
Q4QFR1 Leishmania major 70% 99%
Q4QFR2 Leishmania major 69% 100%
Q4QFR3 Leishmania major 30% 100%
Q4QFR4 Leishmania major 29% 100%
Q4QFR5 Leishmania major 32% 100%
Q4QFR6 Leishmania major 33% 100%
Q4QFS0 Leishmania major 27% 100%
Q9VV87 Drosophila melanogaster 24% 100%
Q9XVQ9 Caenorhabditis elegans 26% 100%
V5BE99 Trypanosoma cruzi 35% 100%
V5BND3 Trypanosoma cruzi 31% 100%
V5DF68 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS