LeishMANIAdb
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Elongation of fatty acids protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Elongation of fatty acids protein
Gene product:
fatty acid elongase, putative
Species:
Leishmania major
UniProt:
Q4QFQ9_LEIMA
TriTrypDb:
LmjF.14.0740 , LMJLV39_140013500 , LMJSD75_140013100
Length:
301

Annotations

LeishMANIAdb annotations

Elongation of fatty acids protein, responsible for very long carbon chain llipid biosynthesis (conserved in Eukaryota).. This group of enzymes has expanded heavily in kinetoplastids.. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 33
NetGPI no yes: 0, no: 33
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 32
GO:0016020 membrane 2 30

Expansion

Sequence features

Q4QFQ9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFQ9

Function

Biological processes
Term Name Level Count
GO:0000038 very long-chain fatty acid metabolic process 5 4
GO:0006082 organic acid metabolic process 3 34
GO:0006629 lipid metabolic process 3 34
GO:0006631 fatty acid metabolic process 4 34
GO:0006633 fatty acid biosynthetic process 5 34
GO:0006643 membrane lipid metabolic process 4 4
GO:0006665 sphingolipid metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 34
GO:0008610 lipid biosynthetic process 4 34
GO:0009058 biosynthetic process 2 34
GO:0009987 cellular process 1 34
GO:0016053 organic acid biosynthetic process 4 34
GO:0019367 fatty acid elongation, saturated fatty acid 7 4
GO:0019368 fatty acid elongation, unsaturated fatty acid 7 4
GO:0019752 carboxylic acid metabolic process 5 34
GO:0030148 sphingolipid biosynthetic process 5 4
GO:0030497 fatty acid elongation 6 4
GO:0032787 monocarboxylic acid metabolic process 6 34
GO:0034625 fatty acid elongation, monounsaturated fatty acid 8 4
GO:0034626 fatty acid elongation, polyunsaturated fatty acid 8 4
GO:0042761 very long-chain fatty acid biosynthetic process 6 4
GO:0043436 oxoacid metabolic process 4 34
GO:0044237 cellular metabolic process 2 34
GO:0044238 primary metabolic process 2 34
GO:0044249 cellular biosynthetic process 3 34
GO:0044255 cellular lipid metabolic process 3 34
GO:0044281 small molecule metabolic process 2 34
GO:0044283 small molecule biosynthetic process 3 34
GO:0046394 carboxylic acid biosynthetic process 5 34
GO:0046467 membrane lipid biosynthetic process 4 4
GO:0071704 organic substance metabolic process 2 34
GO:0072330 monocarboxylic acid biosynthetic process 6 34
GO:1901564 organonitrogen compound metabolic process 3 4
GO:1901566 organonitrogen compound biosynthetic process 4 4
GO:1901576 organic substance biosynthetic process 3 34
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 34
GO:0004312 fatty acid synthase activity 5 34
GO:0009922 fatty acid elongase activity 6 34
GO:0016740 transferase activity 2 34
GO:0016746 acyltransferase activity 3 34
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 34
GO:0102756 very-long-chain 3-ketoacyl-CoA synthase activity 5 34

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 191 193 PF00675 0.265
CLV_NRD_NRD_1 269 271 PF00675 0.413
CLV_PCSK_SKI1_1 3 7 PF00082 0.640
DEG_APCC_DBOX_1 2 10 PF00400 0.270
DEG_ODPH_VHL_1 198 210 PF01847 0.395
DOC_CYCLIN_yCln2_LP_2 194 200 PF00134 0.384
DOC_MAPK_gen_1 137 143 PF00069 0.443
DOC_MAPK_MEF2A_6 236 244 PF00069 0.232
DOC_PP1_RVXF_1 136 143 PF00149 0.443
DOC_PP4_FxxP_1 47 50 PF00568 0.272
DOC_USP7_MATH_1 52 56 PF00917 0.382
LIG_Actin_RPEL_3 189 208 PF02755 0.472
LIG_AP2alpha_1 28 32 PF02296 0.365
LIG_APCC_ABBA_1 34 39 PF00400 0.363
LIG_eIF4E_1 157 163 PF01652 0.393
LIG_eIF4E_1 59 65 PF01652 0.516
LIG_FHA_1 111 117 PF00498 0.202
LIG_FHA_1 128 134 PF00498 0.285
LIG_FHA_1 148 154 PF00498 0.281
LIG_FHA_1 212 218 PF00498 0.301
LIG_FHA_1 252 258 PF00498 0.425
LIG_FHA_1 78 84 PF00498 0.336
LIG_FHA_1 98 104 PF00498 0.330
LIG_FHA_2 24 30 PF00498 0.231
LIG_LIR_Gen_1 129 140 PF02991 0.284
LIG_LIR_Gen_1 247 257 PF02991 0.285
LIG_LIR_Gen_1 29 40 PF02991 0.290
LIG_LIR_Gen_1 73 81 PF02991 0.304
LIG_LIR_Nem_3 111 117 PF02991 0.256
LIG_LIR_Nem_3 129 135 PF02991 0.278
LIG_LIR_Nem_3 152 157 PF02991 0.339
LIG_LIR_Nem_3 178 184 PF02991 0.293
LIG_LIR_Nem_3 220 226 PF02991 0.288
LIG_LIR_Nem_3 247 252 PF02991 0.279
LIG_LIR_Nem_3 25 31 PF02991 0.310
LIG_LIR_Nem_3 254 259 PF02991 0.274
LIG_LIR_Nem_3 39 45 PF02991 0.212
LIG_LIR_Nem_3 73 77 PF02991 0.312
LIG_Pex14_1 115 119 PF04695 0.203
LIG_Pex14_1 156 160 PF04695 0.215
LIG_Pex14_2 252 256 PF04695 0.284
LIG_Pex14_2 28 32 PF04695 0.298
LIG_SH2_CRK 160 164 PF00017 0.329
LIG_SH2_CRK 223 227 PF00017 0.334
LIG_SH2_NCK_1 160 164 PF00017 0.173
LIG_SH2_PTP2 42 45 PF00017 0.332
LIG_SH2_SRC 63 66 PF00017 0.365
LIG_SH2_STAP1 160 164 PF00017 0.249
LIG_SH2_STAP1 219 223 PF00017 0.311
LIG_SH2_STAP1 37 41 PF00017 0.343
LIG_SH2_STAT5 102 105 PF00017 0.275
LIG_SH2_STAT5 160 163 PF00017 0.271
LIG_SH2_STAT5 181 184 PF00017 0.285
LIG_SH2_STAT5 219 222 PF00017 0.306
LIG_SH2_STAT5 225 228 PF00017 0.252
LIG_SH2_STAT5 248 251 PF00017 0.278
LIG_SH2_STAT5 31 34 PF00017 0.237
LIG_SH2_STAT5 42 45 PF00017 0.262
LIG_SH2_STAT5 63 66 PF00017 0.401
LIG_SH3_3 194 200 PF00018 0.428
LIG_SUMO_SIM_anti_2 214 220 PF11976 0.362
LIG_SUMO_SIM_anti_2 84 90 PF11976 0.172
LIG_SUMO_SIM_par_1 214 220 PF11976 0.265
LIG_TRAF2_1 90 93 PF00917 0.173
LIG_TYR_ITIM 35 40 PF00017 0.251
LIG_UBA3_1 116 123 PF00899 0.341
LIG_UBA3_1 255 263 PF00899 0.262
LIG_UBA3_1 44 51 PF00899 0.316
LIG_WRC_WIRS_1 218 223 PF05994 0.321
MOD_CK1_1 269 275 PF00069 0.602
MOD_CK1_1 73 79 PF00069 0.351
MOD_CK2_1 87 93 PF00069 0.316
MOD_GlcNHglycan 164 167 PF01048 0.439
MOD_GlcNHglycan 293 296 PF01048 0.454
MOD_GSK3_1 158 165 PF00069 0.280
MOD_GSK3_1 287 294 PF00069 0.718
MOD_GSK3_1 73 80 PF00069 0.314
MOD_N-GLC_2 291 293 PF02516 0.349
MOD_NEK2_1 103 108 PF00069 0.204
MOD_NEK2_1 119 124 PF00069 0.288
MOD_NEK2_1 127 132 PF00069 0.275
MOD_NEK2_1 133 138 PF00069 0.275
MOD_NEK2_1 149 154 PF00069 0.280
MOD_NEK2_1 162 167 PF00069 0.234
MOD_NEK2_1 185 190 PF00069 0.395
MOD_NEK2_1 244 249 PF00069 0.286
MOD_NEK2_1 251 256 PF00069 0.278
MOD_NEK2_1 70 75 PF00069 0.317
MOD_NEK2_1 77 82 PF00069 0.356
MOD_NEK2_1 96 101 PF00069 0.213
MOD_NEK2_2 97 102 PF00069 0.277
MOD_PKA_2 269 275 PF00069 0.660
MOD_Plk_1 110 116 PF00069 0.172
MOD_Plk_1 97 103 PF00069 0.241
MOD_Plk_4 103 109 PF00069 0.236
MOD_Plk_4 110 116 PF00069 0.253
MOD_Plk_4 127 133 PF00069 0.227
MOD_Plk_4 149 155 PF00069 0.298
MOD_Plk_4 158 164 PF00069 0.296
MOD_Plk_4 175 181 PF00069 0.297
MOD_Plk_4 211 217 PF00069 0.261
MOD_Plk_4 23 29 PF00069 0.306
MOD_Plk_4 244 250 PF00069 0.282
MOD_Plk_4 251 257 PF00069 0.284
MOD_Plk_4 70 76 PF00069 0.319
MOD_Plk_4 81 87 PF00069 0.343
TRG_ENDOCYTIC_2 146 149 PF00928 0.313
TRG_ENDOCYTIC_2 160 163 PF00928 0.258
TRG_ENDOCYTIC_2 183 186 PF00928 0.276
TRG_ENDOCYTIC_2 223 226 PF00928 0.277
TRG_ENDOCYTIC_2 248 251 PF00928 0.273
TRG_ENDOCYTIC_2 31 34 PF00928 0.240
TRG_ENDOCYTIC_2 37 40 PF00928 0.264
TRG_ENDOCYTIC_2 42 45 PF00928 0.265
TRG_ER_diArg_1 59 62 PF00400 0.439

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0C5PHQ7 Tachysurus fulvidraco 28% 100%
A0A0N0P5E5 Leptomonas seymouri 67% 100%
A0A0N0P7D1 Leptomonas seymouri 39% 90%
A0A0N0P7D6 Leptomonas seymouri 32% 100%
A0A0N0P7R2 Leptomonas seymouri 45% 99%
A0A0N1HZJ8 Leptomonas seymouri 34% 93%
A0A0N1I9H5 Leptomonas seymouri 32% 100%
A0A0N1IIZ8 Leptomonas seymouri 23% 98%
A0A0N1ILQ4 Leptomonas seymouri 40% 100%
A0A0N1IM10 Leptomonas seymouri 29% 100%
A0A0N1PDR8 Leptomonas seymouri 51% 100%
A0A0S4IS29 Bodo saltans 48% 100%
A0A0S4IVJ6 Bodo saltans 35% 95%
A0A0S4IVS6 Bodo saltans 42% 100%
A0A0S4IW98 Bodo saltans 41% 95%
A0A0S4J4C4 Bodo saltans 27% 100%
A0A0S4JH58 Bodo saltans 27% 100%
A0A0S4KMP5 Bodo saltans 28% 91%
A0A1X0NNK7 Trypanosomatidae 55% 100%
A0A1X0NNL0 Trypanosomatidae 39% 100%
A0A1X0NNM4 Trypanosomatidae 37% 100%
A0A1X0NNM5 Trypanosomatidae 41% 98%
A0A1X0NP89 Trypanosomatidae 35% 94%
A0A1X0NUJ4 Trypanosomatidae 31% 83%
A0A3Q8I8T7 Leishmania donovani 35% 77%
A0A3Q8I9T2 Leishmania donovani 36% 80%
A0A3Q8I9U9 Leishmania donovani 35% 92%
A0A3Q8I9X8 Leishmania donovani 40% 90%
A0A3Q8IC05 Leishmania donovani 93% 99%
A0A3Q8ID51 Leishmania donovani 32% 76%
A0A3Q8IIA9 Leishmania donovani 31% 100%
A0A3Q8IT78 Leishmania donovani 27% 79%
A0A3R7KG78 Trypanosoma rangeli 58% 100%
A0A3R7MJR2 Trypanosoma rangeli 39% 100%
A0A3R7NSQ3 Trypanosoma rangeli 38% 100%
A0A3S5H5M3 Leishmania donovani 33% 100%
A0A3S5H6R7 Leishmania donovani 33% 100%
A0A3S5H6R8 Leishmania donovani 38% 100%
A0A3S7WSY8 Leishmania donovani 31% 100%
A0A3S7WSZ1 Leishmania donovani 41% 100%
A0A3S7WT03 Leishmania donovani 43% 100%
A0A3S7WT16 Leishmania donovani 37% 93%
A0A422NNP1 Trypanosoma rangeli 48% 100%
A0A422NYI1 Trypanosoma rangeli 27% 100%
A0JNC4 Bos taurus 31% 100%
A4H4G1 Leishmania braziliensis 33% 100%
A4H7M2 Leishmania braziliensis 33% 100%
A4H7M3 Leishmania braziliensis 32% 100%
A4H7M4 Leishmania braziliensis 30% 100%
A4H7M5 Leishmania braziliensis 34% 100%
A4H7M6 Leishmania braziliensis 41% 100%
A4H7M7 Leishmania braziliensis 38% 93%
A4H7M8 Leishmania braziliensis 33% 79%
A4H7M9 Leishmania braziliensis 34% 74%
A4H7N0 Leishmania braziliensis 71% 100%
A4HSN8 Leishmania infantum 33% 100%
A4HW07 Leishmania infantum 31% 100%
A4HW08 Leishmania infantum 33% 100%
A4HW09 Leishmania infantum 31% 100%
A4HW10 Leishmania infantum 38% 100%
A4HW12 Leishmania infantum 40% 90%
A4HW13 Leishmania infantum 35% 92%
A4HW14 Leishmania infantum 36% 93%
A4HW15 Leishmania infantum 35% 80%
A4HW16 Leishmania infantum 32% 80%
A4HW17 Leishmania infantum 35% 77%
A4HW18 Leishmania infantum 93% 99%
A4I7T3 Leishmania infantum 27% 79%
B4QVX4 Drosophila simulans 30% 100%
C9ZT13 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
C9ZT15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
C9ZT16 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 98%
D4A612 Rattus norvegicus 28% 100%
D4ADY9 Rattus norvegicus 30% 100%
E8NHR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E8NHR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 80%
E8NHR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 79%
E9AGL0 Leishmania infantum 43% 100%
E9AGL2 Leishmania infantum 41% 100%
E9AKM3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9APQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 80%
E9APR0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9APR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9APR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9APR3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9APR4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9APR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 90%
E9APR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 93%
E9APR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 78%
E9APR9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B2P1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 79%
G5EEE5 Caenorhabditis elegans 29% 100%
O35949 Mus musculus 36% 100%
P25358 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 87%
P39540 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 97%
P40319 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 87%
P49191 Caenorhabditis elegans 37% 94%
Q03574 Caenorhabditis elegans 33% 100%
Q20300 Caenorhabditis elegans 30% 100%
Q20303 Caenorhabditis elegans 34% 100%
Q2KJD9 Bos taurus 31% 100%
Q32NI8 Xenopus laevis 28% 100%
Q3S8M4 Macaca mulatta 30% 96%
Q4QFR0 Leishmania major 35% 77%
Q4QFR1 Leishmania major 33% 76%
Q4QFR2 Leishmania major 35% 80%
Q4QFR3 Leishmania major 37% 93%
Q4QFR4 Leishmania major 35% 93%
Q4QFR5 Leishmania major 40% 84%
Q4QFR6 Leishmania major 41% 100%
Q4QFR7 Leishmania major 38% 100%
Q4QFR8 Leishmania major 32% 100%
Q4QFR9 Leishmania major 32% 100%
Q4QFS0 Leishmania major 31% 100%
Q4QJ85 Leishmania major 32% 100%
Q4R516 Macaca fascicularis 30% 100%
Q5M8U1 Xenopus tropicalis 27% 100%
Q5RFL5 Pongo abelii 31% 100%
Q5ZJR8 Gallus gallus 39% 100%
Q6PC64 Danio rerio 37% 100%
Q8BHI7 Mus musculus 32% 100%
Q920L5 Mus musculus 38% 100%
Q920L6 Rattus norvegicus 38% 100%
Q920L7 Rattus norvegicus 30% 100%
Q95K73 Macaca fascicularis 30% 96%
Q9BW60 Homo sapiens 28% 100%
Q9D2Y9 Mus musculus 30% 100%
Q9EQC4 Mus musculus 31% 96%
Q9GZR5 Homo sapiens 30% 96%
Q9H5J4 Homo sapiens 37% 100%
Q9HB03 Homo sapiens 30% 100%
Q9JLJ4 Mus musculus 28% 100%
Q9JLJ5 Mus musculus 29% 100%
Q9NXB9 Homo sapiens 28% 100%
Q9NYP7 Homo sapiens 30% 100%
Q9UTF7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 90%
Q9VH58 Drosophila melanogaster 30% 100%
Q9VV87 Drosophila melanogaster 38% 95%
Q9XVQ9 Caenorhabditis elegans 36% 100%
V5BE99 Trypanosoma cruzi 55% 100%
V5BIX9 Trypanosoma cruzi 39% 100%
V5BND3 Trypanosoma cruzi 45% 100%
V5DF68 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS