Guanine nucleotide-binding protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanine nucleotide-binding protein-like protein

Species:

Leishmania major

UniProt:

Q4QFQ7_LEIMA

TriTrypDb:

LmjF.14.0760 , LMJLV39_140013800 , LMJSD75_140013400

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFQ7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0016192	vesicle-mediated transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.340
CLV_C14_Caspase3-7	334	338	PF00656	0.609
CLV_C14_Caspase3-7	6	10	PF00656	0.630
CLV_NRD_NRD_1	197	199	PF00675	0.317
CLV_PCSK_KEX2_1	197	199	PF00082	0.320
CLV_PCSK_SKI1_1	101	105	PF00082	0.401
CLV_PCSK_SKI1_1	272	276	PF00082	0.361
DEG_APCC_DBOX_1	197	205	PF00400	0.265
DEG_Nend_UBRbox_2	1	3	PF02207	0.661
DEG_SCF_FBW7_1	358	365	PF00400	0.593
DEG_SPOP_SBC_1	236	240	PF00917	0.356
DEG_SPOP_SBC_1	30	34	PF00917	0.626
DEG_SPOP_SBC_1	74	78	PF00917	0.655
DOC_ANK_TNKS_1	23	30	PF00023	0.620
DOC_ANK_TNKS_1	342	349	PF00023	0.637
DOC_CKS1_1	359	364	PF01111	0.592
DOC_MAPK_gen_1	101	112	PF00069	0.326
DOC_MAPK_gen_1	197	204	PF00069	0.291
DOC_MAPK_MEF2A_6	216	224	PF00069	0.291
DOC_PP2B_LxvP_1	91	94	PF13499	0.574
DOC_USP7_MATH_1	134	138	PF00917	0.409
DOC_USP7_MATH_1	236	240	PF00917	0.381
DOC_USP7_MATH_1	31	35	PF00917	0.627
DOC_USP7_MATH_1	329	333	PF00917	0.725
DOC_USP7_MATH_1	351	355	PF00917	0.592
DOC_USP7_MATH_1	362	366	PF00917	0.602
DOC_USP7_MATH_1	370	374	PF00917	0.600
DOC_USP7_MATH_1	41	45	PF00917	0.544
DOC_USP7_MATH_1	52	56	PF00917	0.593
DOC_WW_Pin1_4	358	363	PF00397	0.649
DOC_WW_Pin1_4	368	373	PF00397	0.575
DOC_WW_Pin1_4	404	409	PF00397	0.671
DOC_WW_Pin1_4	60	65	PF00397	0.664
DOC_WW_Pin1_4	68	73	PF00397	0.680
LIG_14-3-3_CanoR_1	24	31	PF00244	0.652
LIG_14-3-3_CanoR_1	254	261	PF00244	0.388
LIG_14-3-3_CanoR_1	327	335	PF00244	0.618
LIG_14-3-3_CanoR_1	357	362	PF00244	0.699
LIG_14-3-3_CanoR_1	379	389	PF00244	0.654
LIG_BRCT_BRCA1_1	178	182	PF00533	0.312
LIG_BRCT_BRCA1_1	80	84	PF00533	0.583
LIG_FHA_1	104	110	PF00498	0.375
LIG_FHA_1	136	142	PF00498	0.312
LIG_FHA_1	156	162	PF00498	0.312
LIG_FHA_1	264	270	PF00498	0.402
LIG_FHA_1	277	283	PF00498	0.242
LIG_FHA_1	359	365	PF00498	0.593
LIG_FHA_1	386	392	PF00498	0.631
LIG_FHA_1	56	62	PF00498	0.534
LIG_FHA_2	52	58	PF00498	0.614
LIG_LIR_Gen_1	276	285	PF02991	0.312
LIG_LIR_Nem_3	276	281	PF02991	0.333
LIG_PTB_Apo_2	177	184	PF02174	0.312
LIG_PTB_Phospho_1	177	183	PF10480	0.312
LIG_SH2_SRC	131	134	PF00017	0.340
LIG_SH2_STAT5	126	129	PF00017	0.312
LIG_SH2_STAT5	367	370	PF00017	0.640
LIG_SH3_3	130	136	PF00018	0.312
LIG_SH3_3	145	151	PF00018	0.312
LIG_SH3_3	356	362	PF00018	0.596
LIG_SH3_3	58	64	PF00018	0.594
LIG_SH3_3	66	72	PF00018	0.591
LIG_SUMO_SIM_par_1	108	114	PF11976	0.312
LIG_SUMO_SIM_par_1	281	286	PF11976	0.312
LIG_TRAF2_1	169	172	PF00917	0.312
MOD_CDK_SPK_2	68	73	PF00069	0.629
MOD_CK1_1	18	24	PF00069	0.635
MOD_CK1_1	200	206	PF00069	0.424
MOD_CK1_1	241	247	PF00069	0.282
MOD_CK1_1	267	273	PF00069	0.312
MOD_CK1_1	309	315	PF00069	0.648
MOD_CK1_1	353	359	PF00069	0.616
MOD_CK1_1	365	371	PF00069	0.591
MOD_CK1_1	45	51	PF00069	0.572
MOD_CK1_1	55	61	PF00069	0.599
MOD_CK1_1	63	69	PF00069	0.520
MOD_CK1_1	78	84	PF00069	0.559
MOD_CK2_1	312	318	PF00069	0.632
MOD_GlcNHglycan	151	154	PF01048	0.291
MOD_GlcNHglycan	240	243	PF01048	0.312
MOD_GlcNHglycan	25	28	PF01048	0.548
MOD_GlcNHglycan	266	269	PF01048	0.326
MOD_GlcNHglycan	299	302	PF01048	0.565
MOD_GlcNHglycan	311	314	PF01048	0.660
MOD_GlcNHglycan	331	334	PF01048	0.478
MOD_GlcNHglycan	364	367	PF01048	0.599
MOD_GlcNHglycan	372	375	PF01048	0.754
MOD_GlcNHglycan	65	68	PF01048	0.569
MOD_GSK3_1	237	244	PF00069	0.363
MOD_GSK3_1	263	270	PF00069	0.490
MOD_GSK3_1	302	309	PF00069	0.553
MOD_GSK3_1	329	336	PF00069	0.711
MOD_GSK3_1	349	356	PF00069	0.694
MOD_GSK3_1	358	365	PF00069	0.523
MOD_GSK3_1	41	48	PF00069	0.650
MOD_GSK3_1	51	58	PF00069	0.594
MOD_GSK3_1	74	81	PF00069	0.775
MOD_NEK2_1	103	108	PF00069	0.443
MOD_NEK2_1	165	170	PF00069	0.388
MOD_NEK2_1	264	269	PF00069	0.352
MOD_NEK2_1	75	80	PF00069	0.663
MOD_PIKK_1	306	312	PF00454	0.527
MOD_PIKK_1	318	324	PF00454	0.512
MOD_PKA_1	197	203	PF00069	0.291
MOD_PKA_2	197	203	PF00069	0.265
MOD_PKA_2	23	29	PF00069	0.622
MOD_PKA_2	253	259	PF00069	0.388
MOD_Plk_4	157	163	PF00069	0.316
MOD_Plk_4	197	203	PF00069	0.312
MOD_Plk_4	31	37	PF00069	0.569
MOD_Plk_4	42	48	PF00069	0.484
MOD_Plk_4	92	98	PF00069	0.477
MOD_ProDKin_1	358	364	PF00069	0.649
MOD_ProDKin_1	368	374	PF00069	0.578
MOD_ProDKin_1	404	410	PF00069	0.671
MOD_ProDKin_1	60	66	PF00069	0.663
MOD_ProDKin_1	68	74	PF00069	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKL4	Leptomonas seymouri	50%	100%
A0A3S7WT13	Leishmania donovani	89%	100%
A4HW20	Leishmania infantum	89%	100%
E9AI46	Leishmania braziliensis	67%	100%
E9APS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%