Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFQ6_LEIMA

TriTrypDb:

LmjF.14.0770 , LMJLV39_140014000 , LMJSD75_140013600

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 1
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QFQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFQ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.517
CLV_C14_Caspase3-7	288	292	PF00656	0.579
CLV_NRD_NRD_1	156	158	PF00675	0.732
CLV_NRD_NRD_1	164	166	PF00675	0.785
CLV_NRD_NRD_1	233	235	PF00675	0.832
CLV_NRD_NRD_1	250	252	PF00675	0.673
CLV_NRD_NRD_1	299	301	PF00675	0.746
CLV_NRD_NRD_1	58	60	PF00675	0.844
CLV_PCSK_KEX2_1	149	151	PF00082	0.747
CLV_PCSK_KEX2_1	156	158	PF00082	0.769
CLV_PCSK_KEX2_1	233	235	PF00082	0.832
CLV_PCSK_KEX2_1	250	252	PF00082	0.673
CLV_PCSK_KEX2_1	299	301	PF00082	0.755
CLV_PCSK_KEX2_1	58	60	PF00082	0.764
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.744
CLV_PCSK_SKI1_1	340	344	PF00082	0.735
CLV_PCSK_SKI1_1	44	48	PF00082	0.772
DEG_APCC_DBOX_1	188	196	PF00400	0.629
DEG_SPOP_SBC_1	159	163	PF00917	0.608
DEG_SPOP_SBC_1	317	321	PF00917	0.552
DOC_CKS1_1	124	129	PF01111	0.472
DOC_MAPK_gen_1	351	359	PF00069	0.575
DOC_PP2B_LxvP_1	4	7	PF13499	0.688
DOC_PP2B_PxIxI_1	284	290	PF00149	0.599
DOC_USP7_MATH_1	159	163	PF00917	0.533
DOC_USP7_MATH_1	174	178	PF00917	0.438
DOC_USP7_MATH_1	191	195	PF00917	0.567
DOC_USP7_MATH_1	229	233	PF00917	0.594
DOC_USP7_MATH_1	254	258	PF00917	0.623
DOC_USP7_MATH_1	308	312	PF00917	0.511
DOC_USP7_MATH_1	379	383	PF00917	0.530
DOC_WW_Pin1_4	108	113	PF00397	0.648
DOC_WW_Pin1_4	123	128	PF00397	0.469
DOC_WW_Pin1_4	184	189	PF00397	0.480
LIG_14-3-3_CanoR_1	150	160	PF00244	0.515
LIG_14-3-3_CanoR_1	224	229	PF00244	0.508
LIG_APCC_ABBA_1	25	30	PF00400	0.471
LIG_BRCT_BRCA1_1	385	389	PF00533	0.491
LIG_FHA_1	185	191	PF00498	0.474
LIG_FHA_2	179	185	PF00498	0.517
LIG_FHA_2	24	30	PF00498	0.636
LIG_FHA_2	319	325	PF00498	0.557
LIG_LIR_Nem_3	386	392	PF02991	0.378
LIG_PDZ_Class_2	391	396	PF00595	0.530
LIG_Pex14_2	392	396	PF04695	0.452
LIG_SH2_CRK	124	128	PF00017	0.498
LIG_SH2_NCK_1	124	128	PF00017	0.498
LIG_SH2_NCK_1	182	186	PF00017	0.515
LIG_SH2_SRC	182	185	PF00017	0.488
LIG_SH2_STAT5	71	74	PF00017	0.568
LIG_SH3_3	185	191	PF00018	0.585
LIG_SH3_3	86	92	PF00018	0.517
LIG_SUMO_SIM_par_1	21	30	PF11976	0.472
LIG_SUMO_SIM_par_1	285	291	PF11976	0.599
LIG_TRAF2_1	100	103	PF00917	0.599
LIG_TRAF2_1	346	349	PF00917	0.524
MOD_CDK_SPK_2	108	113	PF00069	0.720
MOD_CDK_SPK_2	184	189	PF00069	0.592
MOD_CK1_1	232	238	PF00069	0.795
MOD_CK1_1	316	322	PF00069	0.687
MOD_CK1_1	336	342	PF00069	0.740
MOD_CK2_1	23	29	PF00069	0.738
MOD_CK2_1	318	324	PF00069	0.775
MOD_Cter_Amidation	82	85	PF01082	0.759
MOD_GlcNHglycan	11	14	PF01048	0.706
MOD_GlcNHglycan	176	179	PF01048	0.595
MOD_GlcNHglycan	226	229	PF01048	0.733
MOD_GlcNHglycan	237	241	PF01048	0.816
MOD_GlcNHglycan	310	313	PF01048	0.747
MOD_GlcNHglycan	34	37	PF01048	0.778
MOD_GlcNHglycan	371	375	PF01048	0.711
MOD_GlcNHglycan	39	42	PF01048	0.726
MOD_GSK3_1	174	181	PF00069	0.769
MOD_GSK3_1	220	227	PF00069	0.712
MOD_GSK3_1	232	239	PF00069	0.722
MOD_GSK3_1	308	315	PF00069	0.745
MOD_GSK3_1	316	323	PF00069	0.734
MOD_GSK3_1	366	373	PF00069	0.728
MOD_GSK3_1	379	386	PF00069	0.365
MOD_NEK2_1	11	16	PF00069	0.553
MOD_NEK2_1	383	388	PF00069	0.530
MOD_NEK2_2	191	196	PF00069	0.714
MOD_NEK2_2	379	384	PF00069	0.530
MOD_PIKK_1	232	238	PF00454	0.639
MOD_PKA_2	232	238	PF00069	0.795
MOD_PKA_2	298	304	PF00069	0.756
MOD_PKA_2	336	342	PF00069	0.673
MOD_PKB_1	251	259	PF00069	0.646
MOD_Plk_1	101	107	PF00069	0.763
MOD_Plk_1	312	318	PF00069	0.654
MOD_Plk_4	263	269	PF00069	0.799
MOD_Plk_4	379	385	PF00069	0.374
MOD_ProDKin_1	108	114	PF00069	0.826
MOD_ProDKin_1	123	129	PF00069	0.580
MOD_ProDKin_1	184	190	PF00069	0.589
MOD_SUMO_rev_2	336	342	PF00179	0.673
MOD_SUMO_rev_2	76	86	PF00179	0.819
TRG_ER_diArg_1	245	248	PF00400	0.692
TRG_ER_diArg_1	250	253	PF00400	0.642
TRG_ER_diArg_1	57	59	PF00400	0.710
TRG_NLS_Bipartite_1	148	169	PF00514	0.775
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WT04	Leishmania donovani	86%	100%
A4H7N2	Leishmania braziliensis	55%	98%
A4HW21	Leishmania infantum	86%	100%
E9APS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	93%