Excreted/secreted protein 9.1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4201), putative

Species:

Leishmania major

UniProt:

Q4QFQ1_LEIMA

TriTrypDb:

LmjF.14.0820 , LMJLV39_140014500 , LMJSD75_140014100

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005815	microtubule organizing center	2	2
GO:0005930	axoneme	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	10
GO:0005856	cytoskeleton	5	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8

Expansion

Sequence features

Q4QFQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFQ1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.514
CLV_NRD_NRD_1	103	105	PF00675	0.669
CLV_NRD_NRD_1	175	177	PF00675	0.566
CLV_NRD_NRD_1	182	184	PF00675	0.518
CLV_NRD_NRD_1	236	238	PF00675	0.542
CLV_NRD_NRD_1	268	270	PF00675	0.727
CLV_NRD_NRD_1	298	300	PF00675	0.474
CLV_NRD_NRD_1	331	333	PF00675	0.282
CLV_NRD_NRD_1	463	465	PF00675	0.246
CLV_NRD_NRD_1	481	483	PF00675	0.446
CLV_NRD_NRD_1	532	534	PF00675	0.588
CLV_PCSK_FUR_1	329	333	PF00082	0.331
CLV_PCSK_FUR_1	394	398	PF00082	0.317
CLV_PCSK_KEX2_1	103	105	PF00082	0.669
CLV_PCSK_KEX2_1	175	177	PF00082	0.569
CLV_PCSK_KEX2_1	181	183	PF00082	0.534
CLV_PCSK_KEX2_1	235	237	PF00082	0.514
CLV_PCSK_KEX2_1	268	270	PF00082	0.628
CLV_PCSK_KEX2_1	298	300	PF00082	0.414
CLV_PCSK_KEX2_1	331	333	PF00082	0.292
CLV_PCSK_KEX2_1	396	398	PF00082	0.292
CLV_PCSK_KEX2_1	481	483	PF00082	0.516
CLV_PCSK_KEX2_1	532	534	PF00082	0.575
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.317
CLV_PCSK_PC7_1	178	184	PF00082	0.654
CLV_PCSK_PC7_1	294	300	PF00082	0.418
CLV_PCSK_PC7_1	477	483	PF00082	0.538
CLV_PCSK_SKI1_1	197	201	PF00082	0.511
CLV_PCSK_SKI1_1	214	218	PF00082	0.423
CLV_PCSK_SKI1_1	249	253	PF00082	0.448
CLV_PCSK_SKI1_1	276	280	PF00082	0.588
CLV_PCSK_SKI1_1	397	401	PF00082	0.292
CLV_PCSK_SKI1_1	426	430	PF00082	0.238
CLV_PCSK_SKI1_1	457	461	PF00082	0.331
CLV_PCSK_SKI1_1	526	530	PF00082	0.558
CLV_Separin_Metazoa	250	254	PF03568	0.461
CLV_Separin_Metazoa	291	295	PF03568	0.533
DEG_APCC_DBOX_1	181	189	PF00400	0.556
DEG_Nend_UBRbox_2	1	3	PF02207	0.693
DEG_SPOP_SBC_1	167	171	PF00917	0.577
DOC_MAPK_gen_1	235	242	PF00069	0.429
DOC_MAPK_MEF2A_6	235	244	PF00069	0.452
DOC_MAPK_NFAT4_5	237	245	PF00069	0.426
DOC_USP7_MATH_1	109	113	PF00917	0.728
DOC_USP7_MATH_1	127	131	PF00917	0.539
DOC_USP7_MATH_1	15	19	PF00917	0.726
DOC_USP7_MATH_1	262	266	PF00917	0.595
DOC_USP7_MATH_1	508	512	PF00917	0.671
DOC_USP7_MATH_1	514	518	PF00917	0.668
DOC_USP7_MATH_1	521	525	PF00917	0.663
DOC_USP7_MATH_1	546	550	PF00917	0.603
DOC_USP7_MATH_1	572	576	PF00917	0.712
DOC_USP7_UBL2_3	396	400	PF12436	0.531
DOC_WW_Pin1_4	133	138	PF00397	0.698
LIG_14-3-3_CanoR_1	175	181	PF00244	0.627
LIG_14-3-3_CanoR_1	182	186	PF00244	0.531
LIG_14-3-3_CanoR_1	298	307	PF00244	0.472
LIG_14-3-3_CanoR_1	487	493	PF00244	0.560
LIG_Actin_WH2_2	238	255	PF00022	0.441
LIG_CaM_IQ_9	418	433	PF13499	0.451
LIG_FHA_1	108	114	PF00498	0.438
LIG_FHA_1	139	145	PF00498	0.634
LIG_FHA_1	203	209	PF00498	0.523
LIG_FHA_1	259	265	PF00498	0.503
LIG_FHA_1	370	376	PF00498	0.448
LIG_FHA_1	569	575	PF00498	0.525
LIG_FHA_1	88	94	PF00498	0.497
LIG_FHA_2	208	214	PF00498	0.592
LIG_FHA_2	227	233	PF00498	0.335
LIG_FHA_2	285	291	PF00498	0.577
LIG_FHA_2	36	42	PF00498	0.697
LIG_LIR_Gen_1	189	199	PF02991	0.429
LIG_LIR_Gen_1	336	346	PF02991	0.440
LIG_LIR_Gen_1	40	50	PF02991	0.520
LIG_LIR_Nem_3	189	194	PF02991	0.462
LIG_LIR_Nem_3	336	341	PF02991	0.436
LIG_LIR_Nem_3	40	45	PF02991	0.537
LIG_PCNA_yPIPBox_3	43	52	PF02747	0.547
LIG_SH2_CRK	50	54	PF00017	0.427
LIG_SH2_GRB2like	493	496	PF00017	0.700
LIG_SH2_NCK_1	50	54	PF00017	0.449
LIG_SH2_STAP1	149	153	PF00017	0.526
LIG_SH2_STAP1	50	54	PF00017	0.507
LIG_SH2_STAT3	445	448	PF00017	0.436
LIG_SH2_STAT5	295	298	PF00017	0.446
LIG_SH2_STAT5	306	309	PF00017	0.402
LIG_SH2_STAT5	405	408	PF00017	0.436
LIG_SH2_STAT5	50	53	PF00017	0.406
LIG_SH3_3	108	114	PF00018	0.648
LIG_SH3_3	434	440	PF00018	0.449
LIG_SH3_3	540	546	PF00018	0.609
LIG_TRAF2_1	210	213	PF00917	0.554
LIG_TRAF2_1	229	232	PF00917	0.300
LIG_TRAF2_1	432	435	PF00917	0.531
LIG_TRAF2_1	85	88	PF00917	0.587
MOD_CK1_1	152	158	PF00069	0.613
MOD_CK1_1	27	33	PF00069	0.593
MOD_CK1_1	371	377	PF00069	0.436
MOD_CK1_1	390	396	PF00069	0.436
MOD_CK1_1	500	506	PF00069	0.652
MOD_CK1_1	6	12	PF00069	0.737
MOD_CK2_1	207	213	PF00069	0.522
MOD_CK2_1	226	232	PF00069	0.348
MOD_CK2_1	285	291	PF00069	0.573
MOD_CK2_1	398	404	PF00069	0.467
MOD_CK2_1	541	547	PF00069	0.714
MOD_Cter_Amidation	173	176	PF01082	0.629
MOD_GlcNHglycan	118	121	PF01048	0.681
MOD_GlcNHglycan	128	132	PF01048	0.598
MOD_GlcNHglycan	15	18	PF01048	0.657
MOD_GlcNHglycan	158	161	PF01048	0.619
MOD_GlcNHglycan	170	173	PF01048	0.602
MOD_GlcNHglycan	24	27	PF01048	0.582
MOD_GlcNHglycan	263	267	PF01048	0.595
MOD_GlcNHglycan	281	284	PF01048	0.616
MOD_GlcNHglycan	30	33	PF01048	0.511
MOD_GlcNHglycan	488	491	PF01048	0.480
MOD_GlcNHglycan	510	513	PF01048	0.717
MOD_GlcNHglycan	523	526	PF01048	0.649
MOD_GlcNHglycan	55	58	PF01048	0.502
MOD_GlcNHglycan	554	558	PF01048	0.662
MOD_GlcNHglycan	82	86	PF01048	0.480
MOD_GSK3_1	129	136	PF00069	0.643
MOD_GSK3_1	149	156	PF00069	0.638
MOD_GSK3_1	163	170	PF00069	0.605
MOD_GSK3_1	24	31	PF00069	0.530
MOD_GSK3_1	258	265	PF00069	0.520
MOD_GSK3_1	298	305	PF00069	0.611
MOD_GSK3_1	367	374	PF00069	0.436
MOD_GSK3_1	400	407	PF00069	0.512
MOD_GSK3_1	422	429	PF00069	0.404
MOD_GSK3_1	497	504	PF00069	0.553
MOD_GSK3_1	5	12	PF00069	0.768
MOD_GSK3_1	508	515	PF00069	0.549
MOD_GSK3_1	568	575	PF00069	0.526
MOD_GSK3_1	70	77	PF00069	0.542
MOD_GSK3_1	92	99	PF00069	0.473
MOD_N-GLC_1	114	119	PF02516	0.656
MOD_N-GLC_1	27	32	PF02516	0.584
MOD_N-GLC_1	501	506	PF02516	0.605
MOD_NEK2_1	153	158	PF00069	0.546
MOD_NEK2_1	278	283	PF00069	0.539
MOD_NEK2_1	367	372	PF00069	0.436
MOD_PIKK_1	207	213	PF00454	0.522
MOD_PIKK_1	299	305	PF00454	0.486
MOD_PKA_1	181	187	PF00069	0.654
MOD_PKA_1	276	282	PF00069	0.555
MOD_PKA_1	298	304	PF00069	0.524
MOD_PKA_2	156	162	PF00069	0.601
MOD_PKA_2	181	187	PF00069	0.564
MOD_PKA_2	22	28	PF00069	0.609
MOD_PKA_2	298	304	PF00069	0.524
MOD_PKA_2	486	492	PF00069	0.522
MOD_PKA_2	500	506	PF00069	0.570
MOD_Plk_1	138	144	PF00069	0.603
MOD_Plk_1	149	155	PF00069	0.658
MOD_Plk_1	390	396	PF00069	0.465
MOD_Plk_1	546	552	PF00069	0.605
MOD_Plk_1	81	87	PF00069	0.574
MOD_Plk_2-3	547	553	PF00069	0.610
MOD_Plk_4	138	144	PF00069	0.655
MOD_Plk_4	302	308	PF00069	0.292
MOD_Plk_4	41	47	PF00069	0.652
MOD_ProDKin_1	133	139	PF00069	0.699
MOD_SUMO_for_1	395	398	PF00179	0.517
MOD_SUMO_for_1	440	443	PF00179	0.446
MOD_SUMO_rev_2	189	199	PF00179	0.558
MOD_SUMO_rev_2	344	353	PF00179	0.471
MOD_SUMO_rev_2	363	370	PF00179	0.362
MOD_SUMO_rev_2	419	428	PF00179	0.453
TRG_DiLeu_BaEn_4	88	94	PF01217	0.473
TRG_ENDOCYTIC_2	50	53	PF00928	0.426
TRG_ER_diArg_1	103	105	PF00400	0.601
TRG_ER_diArg_1	175	178	PF00400	0.581
TRG_ER_diArg_1	180	183	PF00400	0.565
TRG_ER_diArg_1	234	237	PF00400	0.510
TRG_ER_diArg_1	328	331	PF00400	0.449
TRG_ER_diArg_1	481	483	PF00400	0.507
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	481	486	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.722

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T9	Leptomonas seymouri	62%	100%
A0A1X0NNL2	Trypanosomatidae	42%	100%
A0A3Q8IIC4	Leishmania donovani	93%	100%
A0A422N1M9	Trypanosoma rangeli	42%	100%
A4H7N6	Leishmania braziliensis	76%	100%
A4HW26	Leishmania infantum	94%	100%
C9ZT07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9APS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BEA4	Trypanosoma cruzi	43%	100%