LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QFP6_LEIMA
TriTrypDb:
LmjF.14.0890 , LMJLV39_140015500 * , LMJSD75_140014900
Length:
661

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFP6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFP6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 569 573 PF00656 0.622
CLV_C14_Caspase3-7 578 582 PF00656 0.559
CLV_C14_Caspase3-7 602 606 PF00656 0.535
CLV_NRD_NRD_1 274 276 PF00675 0.669
CLV_NRD_NRD_1 472 474 PF00675 0.548
CLV_NRD_NRD_1 479 481 PF00675 0.564
CLV_NRD_NRD_1 482 484 PF00675 0.549
CLV_NRD_NRD_1 519 521 PF00675 0.726
CLV_NRD_NRD_1 621 623 PF00675 0.640
CLV_NRD_NRD_1 625 627 PF00675 0.648
CLV_NRD_NRD_1 65 67 PF00675 0.530
CLV_PCSK_FUR_1 469 473 PF00082 0.600
CLV_PCSK_FUR_1 63 67 PF00082 0.426
CLV_PCSK_KEX2_1 36 38 PF00082 0.517
CLV_PCSK_KEX2_1 461 463 PF00082 0.556
CLV_PCSK_KEX2_1 471 473 PF00082 0.474
CLV_PCSK_KEX2_1 479 481 PF00082 0.594
CLV_PCSK_KEX2_1 621 623 PF00082 0.640
CLV_PCSK_KEX2_1 625 627 PF00082 0.648
CLV_PCSK_KEX2_1 65 67 PF00082 0.530
CLV_PCSK_KEX2_1 656 658 PF00082 0.537
CLV_PCSK_PC1ET2_1 36 38 PF00082 0.517
CLV_PCSK_PC1ET2_1 461 463 PF00082 0.593
CLV_PCSK_PC1ET2_1 656 658 PF00082 0.537
CLV_PCSK_PC7_1 621 627 PF00082 0.644
CLV_PCSK_SKI1_1 262 266 PF00082 0.585
CLV_PCSK_SKI1_1 282 286 PF00082 0.714
CLV_PCSK_SKI1_1 359 363 PF00082 0.631
CLV_PCSK_SKI1_1 625 629 PF00082 0.646
CLV_PCSK_SKI1_1 65 69 PF00082 0.439
CLV_PCSK_SKI1_1 653 657 PF00082 0.581
CLV_Separin_Metazoa 221 225 PF03568 0.488
DEG_APCC_DBOX_1 330 338 PF00400 0.638
DEG_Nend_Nbox_1 1 3 PF02207 0.538
DEG_SCF_FBW7_2 404 411 PF00400 0.681
DEG_SCF_TRCP1_1 173 179 PF00400 0.510
DEG_SPOP_SBC_1 108 112 PF00917 0.598
DOC_CDC14_PxL_1 124 132 PF14671 0.458
DOC_CKS1_1 214 219 PF01111 0.509
DOC_CYCLIN_RxL_1 63 72 PF00134 0.438
DOC_MAPK_gen_1 248 256 PF00069 0.518
DOC_MAPK_gen_1 63 70 PF00069 0.430
DOC_MAPK_gen_1 93 101 PF00069 0.363
DOC_MAPK_MEF2A_6 37 46 PF00069 0.462
DOC_PP1_RVXF_1 562 568 PF00149 0.542
DOC_PP1_RVXF_1 93 99 PF00149 0.398
DOC_USP7_MATH_1 108 112 PF00917 0.623
DOC_USP7_MATH_1 312 316 PF00917 0.530
DOC_USP7_MATH_1 317 321 PF00917 0.688
DOC_USP7_MATH_1 370 374 PF00917 0.635
DOC_USP7_MATH_1 395 399 PF00917 0.599
DOC_USP7_MATH_1 414 418 PF00917 0.732
DOC_USP7_MATH_1 436 440 PF00917 0.463
DOC_USP7_MATH_1 513 517 PF00917 0.632
DOC_USP7_MATH_2 381 387 PF00917 0.594
DOC_USP7_UBL2_3 16 20 PF12436 0.446
DOC_WW_Pin1_4 213 218 PF00397 0.630
DOC_WW_Pin1_4 338 343 PF00397 0.639
DOC_WW_Pin1_4 348 353 PF00397 0.572
DOC_WW_Pin1_4 404 409 PF00397 0.634
DOC_WW_Pin1_4 595 600 PF00397 0.674
DOC_WW_Pin1_4 603 608 PF00397 0.683
DOC_WW_Pin1_4 635 640 PF00397 0.727
DOC_WW_Pin1_4 84 89 PF00397 0.497
LIG_14-3-3_CanoR_1 109 116 PF00244 0.744
LIG_14-3-3_CanoR_1 250 255 PF00244 0.557
LIG_14-3-3_CanoR_1 262 267 PF00244 0.599
LIG_14-3-3_CanoR_1 331 339 PF00244 0.650
LIG_14-3-3_CanoR_1 564 568 PF00244 0.550
LIG_14-3-3_CanoR_1 631 639 PF00244 0.588
LIG_14-3-3_CanoR_1 649 653 PF00244 0.482
LIG_Actin_WH2_2 419 436 PF00022 0.550
LIG_BIR_III_2 596 600 PF00653 0.519
LIG_BRCT_BRCA1_1 572 576 PF00533 0.608
LIG_deltaCOP1_diTrp_1 91 98 PF00928 0.455
LIG_DLG_GKlike_1 250 258 PF00625 0.438
LIG_FHA_1 226 232 PF00498 0.345
LIG_FHA_1 256 262 PF00498 0.548
LIG_FHA_1 293 299 PF00498 0.569
LIG_FHA_1 608 614 PF00498 0.591
LIG_FHA_1 636 642 PF00498 0.530
LIG_FHA_1 79 85 PF00498 0.558
LIG_FHA_2 117 123 PF00498 0.683
LIG_FHA_2 2 8 PF00498 0.460
LIG_FHA_2 235 241 PF00498 0.520
LIG_FHA_2 564 570 PF00498 0.626
LIG_LIR_Gen_1 396 404 PF02991 0.551
LIG_LIR_Gen_1 40 50 PF02991 0.448
LIG_LIR_Gen_1 438 447 PF02991 0.524
LIG_LIR_Gen_1 60 69 PF02991 0.423
LIG_LIR_Nem_3 396 402 PF02991 0.544
LIG_LIR_Nem_3 40 46 PF02991 0.478
LIG_LIR_Nem_3 437 443 PF02991 0.448
LIG_LIR_Nem_3 554 559 PF02991 0.478
LIG_LIR_Nem_3 60 64 PF02991 0.406
LIG_MYND_3 189 193 PF01753 0.521
LIG_Pex14_2 43 47 PF04695 0.395
LIG_Pex14_2 552 556 PF04695 0.508
LIG_Pex14_2 97 101 PF04695 0.404
LIG_REV1ctd_RIR_1 44 53 PF16727 0.349
LIG_SH2_CRK 399 403 PF00017 0.537
LIG_SH2_CRK 441 445 PF00017 0.506
LIG_SH2_GRB2like 452 455 PF00017 0.503
LIG_SH2_SRC 156 159 PF00017 0.621
LIG_SH2_SRC 441 444 PF00017 0.507
LIG_SH2_STAP1 21 25 PF00017 0.440
LIG_SH2_STAT3 21 24 PF00017 0.437
LIG_SH2_STAT3 226 229 PF00017 0.484
LIG_SH2_STAT3 560 563 PF00017 0.526
LIG_SH2_STAT5 251 254 PF00017 0.555
LIG_SH2_STAT5 443 446 PF00017 0.437
LIG_SH2_STAT5 452 455 PF00017 0.486
LIG_SH2_STAT5 508 511 PF00017 0.571
LIG_SH3_3 102 108 PF00018 0.389
LIG_SH3_3 122 128 PF00018 0.412
LIG_SH3_3 162 168 PF00018 0.630
LIG_SH3_3 211 217 PF00018 0.532
LIG_SH3_3 336 342 PF00018 0.663
LIG_SH3_3 349 355 PF00018 0.656
LIG_SH3_3 82 88 PF00018 0.557
LIG_Sin3_3 590 597 PF02671 0.508
LIG_SUMO_SIM_anti_2 386 393 PF11976 0.668
LIG_SUMO_SIM_par_1 168 174 PF11976 0.691
LIG_SUMO_SIM_par_1 386 393 PF11976 0.668
LIG_SUMO_SIM_par_1 66 72 PF11976 0.396
LIG_TRAF2_1 4 7 PF00917 0.407
LIG_TRAF2_1 658 661 PF00917 0.569
MOD_CDK_SPK_2 213 218 PF00069 0.630
MOD_CK1_1 110 116 PF00069 0.689
MOD_CK1_1 332 338 PF00069 0.716
MOD_CK1_1 340 346 PF00069 0.690
MOD_CK1_1 400 406 PF00069 0.698
MOD_CK1_1 445 451 PF00069 0.496
MOD_CK1_1 516 522 PF00069 0.655
MOD_CK1_1 598 604 PF00069 0.654
MOD_CK1_1 606 612 PF00069 0.637
MOD_CK2_1 1 7 PF00069 0.485
MOD_CK2_1 116 122 PF00069 0.679
MOD_CK2_1 234 240 PF00069 0.520
MOD_CK2_1 500 506 PF00069 0.560
MOD_Cter_Amidation 273 276 PF01082 0.509
MOD_Cter_Amidation 34 37 PF01082 0.449
MOD_Cter_Amidation 619 622 PF01082 0.660
MOD_GlcNHglycan 112 115 PF01048 0.714
MOD_GlcNHglycan 146 149 PF01048 0.503
MOD_GlcNHglycan 173 176 PF01048 0.738
MOD_GlcNHglycan 178 181 PF01048 0.655
MOD_GlcNHglycan 289 292 PF01048 0.627
MOD_GlcNHglycan 319 322 PF01048 0.669
MOD_GlcNHglycan 334 337 PF01048 0.737
MOD_GlcNHglycan 342 345 PF01048 0.678
MOD_GlcNHglycan 346 349 PF01048 0.667
MOD_GlcNHglycan 370 373 PF01048 0.694
MOD_GlcNHglycan 395 398 PF01048 0.608
MOD_GlcNHglycan 449 452 PF01048 0.483
MOD_GlcNHglycan 529 532 PF01048 0.666
MOD_GlcNHglycan 546 549 PF01048 0.487
MOD_GlcNHglycan 560 563 PF01048 0.557
MOD_GSK3_1 326 333 PF00069 0.691
MOD_GSK3_1 340 347 PF00069 0.718
MOD_GSK3_1 393 400 PF00069 0.687
MOD_GSK3_1 424 431 PF00069 0.506
MOD_GSK3_1 457 464 PF00069 0.538
MOD_GSK3_1 523 530 PF00069 0.648
MOD_GSK3_1 603 610 PF00069 0.636
MOD_GSK3_1 631 638 PF00069 0.589
MOD_N-GLC_1 116 121 PF02516 0.624
MOD_N-GLC_1 298 303 PF02516 0.634
MOD_NEK2_1 130 135 PF00069 0.431
MOD_NEK2_1 285 290 PF00069 0.655
MOD_NEK2_1 298 303 PF00069 0.624
MOD_NEK2_1 324 329 PF00069 0.752
MOD_NEK2_1 402 407 PF00069 0.654
MOD_NEK2_1 487 492 PF00069 0.557
MOD_NEK2_2 116 121 PF00069 0.577
MOD_NEK2_2 414 419 PF00069 0.537
MOD_NEK2_2 436 441 PF00069 0.502
MOD_PIKK_1 225 231 PF00454 0.367
MOD_PIKK_1 298 304 PF00454 0.678
MOD_PIKK_1 326 332 PF00454 0.707
MOD_PIKK_1 397 403 PF00454 0.669
MOD_PIKK_1 424 430 PF00454 0.506
MOD_PKA_1 461 467 PF00069 0.533
MOD_PKA_2 108 114 PF00069 0.608
MOD_PKA_2 150 156 PF00069 0.573
MOD_PKA_2 330 336 PF00069 0.635
MOD_PKA_2 461 467 PF00069 0.521
MOD_PKA_2 500 506 PF00069 0.554
MOD_PKA_2 563 569 PF00069 0.559
MOD_PKA_2 648 654 PF00069 0.523
MOD_PKB_1 248 256 PF00069 0.518
MOD_Plk_1 116 122 PF00069 0.608
MOD_Plk_1 436 442 PF00069 0.471
MOD_Plk_1 523 529 PF00069 0.611
MOD_Plk_4 262 268 PF00069 0.592
MOD_Plk_4 384 390 PF00069 0.720
MOD_Plk_4 436 442 PF00069 0.461
MOD_ProDKin_1 213 219 PF00069 0.625
MOD_ProDKin_1 338 344 PF00069 0.641
MOD_ProDKin_1 348 354 PF00069 0.567
MOD_ProDKin_1 404 410 PF00069 0.631
MOD_ProDKin_1 595 601 PF00069 0.676
MOD_ProDKin_1 603 609 PF00069 0.683
MOD_ProDKin_1 635 641 PF00069 0.725
MOD_ProDKin_1 84 90 PF00069 0.483
MOD_SUMO_for_1 120 123 PF00179 0.506
MOD_SUMO_rev_2 238 247 PF00179 0.512
TRG_DiLeu_BaEn_4 122 128 PF01217 0.461
TRG_DiLeu_BaEn_4 242 248 PF01217 0.525
TRG_DiLeu_BaLyEn_6 583 588 PF01217 0.624
TRG_DiLeu_BaLyEn_6 623 628 PF01217 0.642
TRG_ENDOCYTIC_2 251 254 PF00928 0.519
TRG_ENDOCYTIC_2 399 402 PF00928 0.534
TRG_ENDOCYTIC_2 441 444 PF00928 0.507
TRG_ER_diArg_1 247 250 PF00400 0.501
TRG_ER_diArg_1 469 472 PF00400 0.586
TRG_ER_diArg_1 479 481 PF00400 0.634
TRG_ER_diArg_1 621 623 PF00400 0.654
TRG_ER_diArg_1 624 626 PF00400 0.632
TRG_ER_diArg_1 63 66 PF00400 0.432
TRG_Pf-PMV_PEXEL_1 66 71 PF00026 0.439

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IKL8 Leptomonas seymouri 54% 99%
A0A3S7WT20 Leishmania donovani 92% 100%
A0A422N7R9 Trypanosoma rangeli 27% 100%
A4H7P2 Leishmania braziliensis 72% 100%
A4HW32 Leishmania infantum 92% 100%
E9APT4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS