Protein phosphatase 2C-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein phosphatase 2C-like protein

Species:

Leishmania major

UniProt:

Q4QFP5_LEIMA

TriTrypDb:

LmjF.14.0900 , LMJLV39_140015600 , LMJSD75_140015000

Length:

854

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QFP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFP5

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.683
CLV_C14_Caspase3-7	374	378	PF00656	0.650
CLV_NRD_NRD_1	291	293	PF00675	0.788
CLV_NRD_NRD_1	479	481	PF00675	0.375
CLV_NRD_NRD_1	542	544	PF00675	0.372
CLV_NRD_NRD_1	607	609	PF00675	0.386
CLV_NRD_NRD_1	679	681	PF00675	0.399
CLV_NRD_NRD_1	73	75	PF00675	0.680
CLV_NRD_NRD_1	828	830	PF00675	0.637
CLV_NRD_NRD_1	95	97	PF00675	0.673
CLV_PCSK_FUR_1	540	544	PF00082	0.335
CLV_PCSK_KEX2_1	291	293	PF00082	0.794
CLV_PCSK_KEX2_1	479	481	PF00082	0.375
CLV_PCSK_KEX2_1	540	542	PF00082	0.375
CLV_PCSK_KEX2_1	607	609	PF00082	0.386
CLV_PCSK_KEX2_1	679	681	PF00082	0.412
CLV_PCSK_KEX2_1	73	75	PF00082	0.641
CLV_PCSK_KEX2_1	95	97	PF00082	0.673
CLV_PCSK_SKI1_1	124	128	PF00082	0.649
CLV_PCSK_SKI1_1	188	192	PF00082	0.697
CLV_PCSK_SKI1_1	292	296	PF00082	0.615
CLV_PCSK_SKI1_1	309	313	PF00082	0.606
CLV_PCSK_SKI1_1	427	431	PF00082	0.502
CLV_PCSK_SKI1_1	516	520	PF00082	0.375
CLV_PCSK_SKI1_1	582	586	PF00082	0.379
CLV_PCSK_SKI1_1	608	612	PF00082	0.386
CLV_PCSK_SKI1_1	728	732	PF00082	0.375
CLV_PCSK_SKI1_1	841	845	PF00082	0.564
DEG_SPOP_SBC_1	195	199	PF00917	0.687
DOC_MAPK_DCC_7	384	392	PF00069	0.656
DOC_MAPK_gen_1	607	618	PF00069	0.386
DOC_MAPK_MEF2A_6	384	392	PF00069	0.685
DOC_MAPK_MEF2A_6	427	435	PF00069	0.579
DOC_PP2B_LxvP_1	191	194	PF13499	0.688
DOC_USP7_MATH_1	111	115	PF00917	0.703
DOC_USP7_MATH_1	150	154	PF00917	0.647
DOC_USP7_MATH_1	164	168	PF00917	0.625
DOC_USP7_MATH_1	195	199	PF00917	0.777
DOC_USP7_MATH_1	2	6	PF00917	0.645
DOC_USP7_MATH_1	249	253	PF00917	0.638
DOC_USP7_MATH_1	373	377	PF00917	0.646
DOC_USP7_MATH_1	50	54	PF00917	0.660
DOC_USP7_MATH_1	534	538	PF00917	0.258
DOC_USP7_MATH_1	672	676	PF00917	0.403
DOC_USP7_MATH_1	809	813	PF00917	0.562
DOC_USP7_MATH_1	828	832	PF00917	0.675
DOC_WW_Pin1_4	144	149	PF00397	0.808
DOC_WW_Pin1_4	16	21	PF00397	0.661
DOC_WW_Pin1_4	203	208	PF00397	0.686
DOC_WW_Pin1_4	245	250	PF00397	0.617
DOC_WW_Pin1_4	330	335	PF00397	0.624
DOC_WW_Pin1_4	640	645	PF00397	0.330
DOC_WW_Pin1_4	670	675	PF00397	0.372
DOC_WW_Pin1_4	731	736	PF00397	0.375
DOC_WW_Pin1_4	748	753	PF00397	0.355
LIG_14-3-3_CanoR_1	112	117	PF00244	0.543
LIG_14-3-3_CanoR_1	243	249	PF00244	0.573
LIG_14-3-3_CanoR_1	42	48	PF00244	0.672
LIG_14-3-3_CanoR_1	829	833	PF00244	0.650
LIG_14-3-3_CanoR_1	87	91	PF00244	0.639
LIG_14-3-3_CanoR_1	95	103	PF00244	0.588
LIG_Actin_WH2_2	119	136	PF00022	0.749
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BIR_III_3	1	5	PF00653	0.563
LIG_BRCT_BRCA1_1	246	250	PF00533	0.573
LIG_BRCT_BRCA1_1	652	656	PF00533	0.375
LIG_FHA_1	17	23	PF00498	0.644
LIG_FHA_1	240	246	PF00498	0.648
LIG_FHA_1	283	289	PF00498	0.743
LIG_FHA_1	361	367	PF00498	0.656
LIG_FHA_1	39	45	PF00498	0.599
LIG_FHA_1	426	432	PF00498	0.581
LIG_FHA_1	722	728	PF00498	0.375
LIG_FHA_1	732	738	PF00498	0.305
LIG_FHA_1	87	93	PF00498	0.677
LIG_FHA_2	117	123	PF00498	0.666
LIG_FHA_2	446	452	PF00498	0.404
LIG_FHA_2	512	518	PF00498	0.375
LIG_FHA_2	645	651	PF00498	0.258
LIG_Integrin_isoDGR_2	282	284	PF01839	0.647
LIG_Integrin_isoDGR_2	847	849	PF01839	0.652
LIG_Integrin_isoDGR_2	93	95	PF01839	0.585
LIG_LIR_Gen_1	451	462	PF02991	0.375
LIG_LIR_Gen_1	517	524	PF02991	0.372
LIG_LIR_Gen_1	547	554	PF02991	0.296
LIG_LIR_Gen_1	704	714	PF02991	0.404
LIG_LIR_LC3C_4	41	45	PF02991	0.602
LIG_LIR_Nem_3	451	457	PF02991	0.375
LIG_LIR_Nem_3	517	522	PF02991	0.392
LIG_LIR_Nem_3	704	709	PF02991	0.404
LIG_LIR_Nem_3	712	718	PF02991	0.322
LIG_LIR_Nem_3	729	733	PF02991	0.225
LIG_MYND_1	128	132	PF01753	0.674
LIG_MYND_1	20	24	PF01753	0.704
LIG_Pex14_1	488	492	PF04695	0.475
LIG_Pex14_2	634	638	PF04695	0.375
LIG_Pex14_2	726	730	PF04695	0.375
LIG_PTAP_UEV_1	264	269	PF05743	0.611
LIG_SH2_GRB2like	36	39	PF00017	0.670
LIG_SH2_STAP1	88	92	PF00017	0.638
LIG_SH2_STAT5	36	39	PF00017	0.631
LIG_SH2_STAT5	492	495	PF00017	0.481
LIG_SH2_STAT5	574	577	PF00017	0.393
LIG_SH2_STAT5	69	72	PF00017	0.681
LIG_SH2_STAT5	733	736	PF00017	0.501
LIG_SH2_STAT5	88	91	PF00017	0.641
LIG_SH3_3	20	26	PF00018	0.696
LIG_SH3_3	262	268	PF00018	0.619
LIG_SH3_3	382	388	PF00018	0.718
LIG_SH3_3	389	395	PF00018	0.649
LIG_SH3_3	42	48	PF00018	0.633
LIG_SH3_3	666	672	PF00018	0.291
LIG_SH3_3	734	740	PF00018	0.471
LIG_SUMO_SIM_anti_2	468	474	PF11976	0.383
LIG_SUMO_SIM_anti_2	777	783	PF11976	0.418
LIG_SUMO_SIM_par_1	468	474	PF11976	0.382
LIG_SUMO_SIM_par_1	623	628	PF11976	0.404
LIG_SxIP_EBH_1	194	208	PF03271	0.686
LIG_TRAF2_1	647	650	PF00917	0.335
LIG_TRAF2_1	719	722	PF00917	0.375
LIG_UBA3_1	518	525	PF00899	0.375
LIG_WW_3	148	152	PF00397	0.650
MOD_CDK_SPK_2	203	208	PF00069	0.686
MOD_CDK_SPxxK_3	144	151	PF00069	0.681
MOD_CK1_1	13	19	PF00069	0.700
MOD_CK1_1	167	173	PF00069	0.611
MOD_CK1_1	203	209	PF00069	0.683
MOD_CK1_1	248	254	PF00069	0.606
MOD_CK1_1	368	374	PF00069	0.662
MOD_CK1_1	425	431	PF00069	0.542
MOD_CK1_1	673	679	PF00069	0.420
MOD_CK1_1	748	754	PF00069	0.355
MOD_CK1_1	812	818	PF00069	0.640
MOD_CK1_1	831	837	PF00069	0.692
MOD_CK2_1	251	257	PF00069	0.594
MOD_CK2_1	263	269	PF00069	0.607
MOD_CK2_1	368	374	PF00069	0.693
MOD_CK2_1	511	517	PF00069	0.375
MOD_CK2_1	644	650	PF00069	0.281
MOD_CK2_1	716	722	PF00069	0.381
MOD_CK2_1	831	837	PF00069	0.607
MOD_Cter_Amidation	477	480	PF01082	0.375
MOD_Cter_Amidation	538	541	PF01082	0.375
MOD_Cter_Amidation	93	96	PF01082	0.644
MOD_GlcNHglycan	103	106	PF01048	0.679
MOD_GlcNHglycan	152	155	PF01048	0.645
MOD_GlcNHglycan	191	194	PF01048	0.688
MOD_GlcNHglycan	251	254	PF01048	0.733
MOD_GlcNHglycan	265	268	PF01048	0.577
MOD_GlcNHglycan	370	373	PF01048	0.684
MOD_GlcNHglycan	403	407	PF01048	0.653
MOD_GlcNHglycan	424	427	PF01048	0.551
MOD_GlcNHglycan	438	441	PF01048	0.389
MOD_GlcNHglycan	537	540	PF01048	0.339
MOD_GlcNHglycan	554	557	PF01048	0.252
MOD_GlcNHglycan	665	669	PF01048	0.479
MOD_GlcNHglycan	702	706	PF01048	0.383
MOD_GlcNHglycan	743	746	PF01048	0.400
MOD_GlcNHglycan	796	799	PF01048	0.509
MOD_GlcNHglycan	802	805	PF01048	0.593
MOD_GlcNHglycan	811	814	PF01048	0.576
MOD_GlcNHglycan	99	102	PF01048	0.708
MOD_GSK3_1	112	119	PF00069	0.645
MOD_GSK3_1	196	203	PF00069	0.656
MOD_GSK3_1	222	229	PF00069	0.679
MOD_GSK3_1	244	251	PF00069	0.717
MOD_GSK3_1	263	270	PF00069	0.565
MOD_GSK3_1	326	333	PF00069	0.553
MOD_GSK3_1	373	380	PF00069	0.660
MOD_GSK3_1	390	397	PF00069	0.625
MOD_GSK3_1	421	428	PF00069	0.535
MOD_GSK3_1	507	514	PF00069	0.450
MOD_GSK3_1	554	561	PF00069	0.375
MOD_GSK3_1	588	595	PF00069	0.375
MOD_GSK3_1	640	647	PF00069	0.258
MOD_GSK3_1	741	748	PF00069	0.396
MOD_GSK3_1	808	815	PF00069	0.671
MOD_GSK3_1	97	104	PF00069	0.674
MOD_N-GLC_1	173	178	PF02516	0.682
MOD_N-GLC_1	457	462	PF02516	0.335
MOD_N-GLC_1	535	540	PF02516	0.335
MOD_N-GLC_1	644	649	PF02516	0.280
MOD_N-GLC_1	663	668	PF02516	0.280
MOD_N-GLC_1	777	782	PF02516	0.423
MOD_N-GLC_2	760	762	PF02516	0.375
MOD_NEK2_1	244	249	PF00069	0.571
MOD_NEK2_1	314	319	PF00069	0.622
MOD_NEK2_1	359	364	PF00069	0.658
MOD_NEK2_1	457	462	PF00069	0.455
MOD_NEK2_1	507	512	PF00069	0.419
MOD_NEK2_1	625	630	PF00069	0.404
MOD_NEK2_1	687	692	PF00069	0.375
MOD_NEK2_1	743	748	PF00069	0.264
MOD_NEK2_1	820	825	PF00069	0.693
MOD_NEK2_1	836	841	PF00069	0.629
MOD_NEK2_2	164	169	PF00069	0.626
MOD_NEK2_2	173	178	PF00069	0.517
MOD_PIKK_1	231	237	PF00454	0.591
MOD_PIKK_1	360	366	PF00454	0.654
MOD_PIKK_1	812	818	PF00454	0.629
MOD_PKA_1	95	101	PF00069	0.680
MOD_PKA_2	111	117	PF00069	0.553
MOD_PKA_2	150	156	PF00069	0.648
MOD_PKA_2	222	228	PF00069	0.678
MOD_PKA_2	445	451	PF00069	0.448
MOD_PKA_2	61	67	PF00069	0.583
MOD_PKA_2	772	778	PF00069	0.375
MOD_PKA_2	794	800	PF00069	0.494
MOD_PKA_2	828	834	PF00069	0.664
MOD_PKA_2	86	92	PF00069	0.656
MOD_PKA_2	95	101	PF00069	0.623
MOD_PKB_1	110	118	PF00069	0.650
MOD_Plk_1	38	44	PF00069	0.628
MOD_Plk_1	457	463	PF00069	0.335
MOD_Plk_1	701	707	PF00069	0.375
MOD_Plk_1	777	783	PF00069	0.422
MOD_Plk_2-3	772	778	PF00069	0.375
MOD_Plk_4	173	179	PF00069	0.644
MOD_Plk_4	196	202	PF00069	0.700
MOD_Plk_4	32	38	PF00069	0.639
MOD_Plk_4	465	471	PF00069	0.383
MOD_Plk_4	507	513	PF00069	0.375
MOD_Plk_4	559	565	PF00069	0.375
MOD_Plk_4	777	783	PF00069	0.475
MOD_Plk_4	831	837	PF00069	0.607
MOD_ProDKin_1	144	150	PF00069	0.804
MOD_ProDKin_1	16	22	PF00069	0.662
MOD_ProDKin_1	203	209	PF00069	0.683
MOD_ProDKin_1	245	251	PF00069	0.614
MOD_ProDKin_1	330	336	PF00069	0.626
MOD_ProDKin_1	640	646	PF00069	0.330
MOD_ProDKin_1	670	676	PF00069	0.372
MOD_ProDKin_1	731	737	PF00069	0.375
MOD_ProDKin_1	748	754	PF00069	0.355
MOD_SUMO_rev_2	121	126	PF00179	0.674
MOD_SUMO_rev_2	595	600	PF00179	0.399
MOD_SUMO_rev_2	633	638	PF00179	0.375
MOD_SUMO_rev_2	643	653	PF00179	0.287
TRG_DiLeu_BaEn_1	39	44	PF01217	0.597
TRG_DiLeu_BaEn_3	721	727	PF01217	0.375
TRG_DiLeu_BaLyEn_6	212	217	PF01217	0.699
TRG_ER_diArg_1	479	481	PF00400	0.393
TRG_ER_diArg_1	540	543	PF00400	0.375
TRG_ER_diArg_1	607	609	PF00400	0.386
TRG_ER_diArg_1	679	681	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	131	135	PF00026	0.674
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID61	Leishmania donovani	92%	100%
A4H7P3	Leishmania braziliensis	72%	91%
A4HKF6	Leishmania braziliensis	25%	100%
A4HW33	Leishmania infantum	92%	88%
E9APT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	88%