LeishMANIAdb
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Putative immunodominant antigen

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative immunodominant antigen
Gene product:
tc40 antigen-like
Species:
Leishmania major
UniProt:
Q4QFP2_LEIMA
TriTrypDb:
LmjF.14.0930 , LMJLV39_140016000 , LMJSD75_140015400 *
Length:
861

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0020022 acidocalcisome 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0051286 cell tip 3 2
GO:0060187 cell pole 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QFP2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFP2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 597 601 PF00656 0.602
CLV_C14_Caspase3-7 845 849 PF00656 0.488
CLV_NRD_NRD_1 495 497 PF00675 0.627
CLV_NRD_NRD_1 50 52 PF00675 0.479
CLV_NRD_NRD_1 621 623 PF00675 0.652
CLV_NRD_NRD_1 668 670 PF00675 0.581
CLV_NRD_NRD_1 850 852 PF00675 0.599
CLV_PCSK_KEX2_1 495 497 PF00082 0.627
CLV_PCSK_KEX2_1 50 52 PF00082 0.456
CLV_PCSK_KEX2_1 620 622 PF00082 0.641
CLV_PCSK_KEX2_1 850 852 PF00082 0.632
CLV_PCSK_SKI1_1 113 117 PF00082 0.781
CLV_PCSK_SKI1_1 16 20 PF00082 0.616
CLV_PCSK_SKI1_1 290 294 PF00082 0.496
CLV_PCSK_SKI1_1 350 354 PF00082 0.565
CLV_PCSK_SKI1_1 467 471 PF00082 0.609
CLV_PCSK_SKI1_1 506 510 PF00082 0.579
CLV_PCSK_SKI1_1 616 620 PF00082 0.562
CLV_PCSK_SKI1_1 63 67 PF00082 0.500
CLV_PCSK_SKI1_1 733 737 PF00082 0.600
CLV_PCSK_SKI1_1 784 788 PF00082 0.542
CLV_PCSK_SKI1_1 822 826 PF00082 0.698
CLV_PCSK_SKI1_1 850 854 PF00082 0.545
CLV_Separin_Metazoa 617 621 PF03568 0.627
DEG_APCC_DBOX_1 690 698 PF00400 0.559
DEG_APCC_DBOX_1 849 857 PF00400 0.570
DEG_SPOP_SBC_1 260 264 PF00917 0.631
DEG_SPOP_SBC_1 446 450 PF00917 0.694
DOC_CKS1_1 513 518 PF01111 0.558
DOC_CKS1_1 628 633 PF01111 0.687
DOC_MAPK_gen_1 48 55 PF00069 0.445
DOC_MAPK_RevD_3 607 622 PF00069 0.437
DOC_PP1_RVXF_1 75 82 PF00149 0.530
DOC_PP2B_LxvP_1 575 578 PF13499 0.626
DOC_PP4_FxxP_1 141 144 PF00568 0.545
DOC_PP4_FxxP_1 403 406 PF00568 0.689
DOC_USP7_MATH_1 2 6 PF00917 0.577
DOC_USP7_MATH_1 209 213 PF00917 0.475
DOC_USP7_MATH_1 251 255 PF00917 0.711
DOC_USP7_MATH_1 259 263 PF00917 0.591
DOC_USP7_MATH_1 268 272 PF00917 0.377
DOC_USP7_MATH_1 372 376 PF00917 0.707
DOC_USP7_MATH_1 417 421 PF00917 0.711
DOC_USP7_MATH_1 429 433 PF00917 0.604
DOC_USP7_MATH_1 436 440 PF00917 0.715
DOC_USP7_MATH_1 446 450 PF00917 0.724
DOC_USP7_MATH_1 462 466 PF00917 0.577
DOC_USP7_MATH_1 542 546 PF00917 0.660
DOC_USP7_MATH_1 558 562 PF00917 0.737
DOC_USP7_MATH_1 566 570 PF00917 0.645
DOC_USP7_MATH_1 578 582 PF00917 0.451
DOC_USP7_MATH_1 659 663 PF00917 0.559
DOC_USP7_MATH_1 700 704 PF00917 0.651
DOC_USP7_MATH_1 87 91 PF00917 0.419
DOC_USP7_UBL2_3 124 128 PF12436 0.457
DOC_USP7_UBL2_3 16 20 PF12436 0.588
DOC_USP7_UBL2_3 821 825 PF12436 0.713
DOC_USP7_UBL2_3 854 858 PF12436 0.562
DOC_WW_Pin1_4 224 229 PF00397 0.496
DOC_WW_Pin1_4 370 375 PF00397 0.691
DOC_WW_Pin1_4 398 403 PF00397 0.682
DOC_WW_Pin1_4 438 443 PF00397 0.774
DOC_WW_Pin1_4 512 517 PF00397 0.591
DOC_WW_Pin1_4 627 632 PF00397 0.692
DOC_WW_Pin1_4 68 73 PF00397 0.535
DOC_WW_Pin1_4 718 723 PF00397 0.636
LIG_14-3-3_CanoR_1 120 124 PF00244 0.467
LIG_14-3-3_CanoR_1 223 228 PF00244 0.542
LIG_14-3-3_CanoR_1 290 295 PF00244 0.506
LIG_14-3-3_CanoR_1 339 344 PF00244 0.519
LIG_14-3-3_CanoR_1 350 355 PF00244 0.494
LIG_14-3-3_CanoR_1 397 402 PF00244 0.713
LIG_14-3-3_CanoR_1 416 426 PF00244 0.658
LIG_14-3-3_CanoR_1 562 570 PF00244 0.659
LIG_14-3-3_CanoR_1 656 662 PF00244 0.607
LIG_14-3-3_CanoR_1 739 747 PF00244 0.589
LIG_14-3-3_CanoR_1 762 768 PF00244 0.597
LIG_Actin_WH2_2 480 497 PF00022 0.666
LIG_Actin_WH2_2 683 700 PF00022 0.559
LIG_APCC_ABBA_1 23 28 PF00400 0.514
LIG_APCC_ABBA_1 307 312 PF00400 0.432
LIG_BIR_II_1 1 5 PF00653 0.586
LIG_BRCT_BRCA1_1 347 351 PF00533 0.592
LIG_BRCT_BRCA1_1 38 42 PF00533 0.476
LIG_BRCT_BRCA1_1 399 403 PF00533 0.601
LIG_BRCT_BRCA1_1 563 567 PF00533 0.628
LIG_BRCT_BRCA1_1 805 809 PF00533 0.602
LIG_BRCT_BRCA1_1 90 94 PF00533 0.549
LIG_eIF4E_1 570 576 PF01652 0.635
LIG_FHA_1 156 162 PF00498 0.478
LIG_FHA_1 171 177 PF00498 0.402
LIG_FHA_1 262 268 PF00498 0.393
LIG_FHA_1 351 357 PF00498 0.511
LIG_FHA_1 399 405 PF00498 0.636
LIG_FHA_1 507 513 PF00498 0.480
LIG_FHA_1 586 592 PF00498 0.626
LIG_FHA_2 328 334 PF00498 0.505
LIG_FHA_2 595 601 PF00498 0.622
LIG_FHA_2 631 637 PF00498 0.597
LIG_FHA_2 724 730 PF00498 0.615
LIG_FHA_2 795 801 PF00498 0.554
LIG_GBD_Chelix_1 804 812 PF00786 0.519
LIG_Integrin_RGD_1 322 324 PF01839 0.564
LIG_LIR_Apic_2 400 406 PF02991 0.700
LIG_LIR_Gen_1 137 145 PF02991 0.480
LIG_LIR_Gen_1 204 214 PF02991 0.546
LIG_LIR_Gen_1 348 359 PF02991 0.505
LIG_LIR_Gen_1 745 753 PF02991 0.527
LIG_LIR_Gen_1 75 86 PF02991 0.507
LIG_LIR_Gen_1 779 789 PF02991 0.553
LIG_LIR_Gen_1 806 816 PF02991 0.610
LIG_LIR_Gen_1 92 101 PF02991 0.279
LIG_LIR_Nem_3 137 141 PF02991 0.489
LIG_LIR_Nem_3 204 210 PF02991 0.438
LIG_LIR_Nem_3 293 297 PF02991 0.482
LIG_LIR_Nem_3 348 354 PF02991 0.568
LIG_LIR_Nem_3 39 45 PF02991 0.420
LIG_LIR_Nem_3 564 570 PF02991 0.584
LIG_LIR_Nem_3 75 81 PF02991 0.435
LIG_LIR_Nem_3 779 785 PF02991 0.559
LIG_LIR_Nem_3 806 812 PF02991 0.598
LIG_LIR_Nem_3 92 98 PF02991 0.311
LIG_LYPXL_SIV_4 462 470 PF13949 0.667
LIG_NRBOX 571 577 PF00104 0.629
LIG_Pex14_1 641 645 PF04695 0.628
LIG_Pex14_1 97 101 PF04695 0.534
LIG_Pex14_2 203 207 PF04695 0.545
LIG_SH2_NCK_1 422 426 PF00017 0.699
LIG_SH2_PTP2 95 98 PF00017 0.508
LIG_SH2_STAP1 171 175 PF00017 0.546
LIG_SH2_STAT5 126 129 PF00017 0.382
LIG_SH2_STAT5 45 48 PF00017 0.446
LIG_SH2_STAT5 645 648 PF00017 0.586
LIG_SH2_STAT5 746 749 PF00017 0.434
LIG_SH2_STAT5 95 98 PF00017 0.508
LIG_SH3_3 280 286 PF00018 0.554
LIG_SH3_3 373 379 PF00018 0.692
LIG_SH3_3 411 417 PF00018 0.727
LIG_SH3_3 548 554 PF00018 0.724
LIG_SH3_4 124 131 PF00018 0.509
LIG_SUMO_SIM_anti_2 150 155 PF11976 0.358
LIG_SUMO_SIM_anti_2 509 515 PF11976 0.486
LIG_SUMO_SIM_par_1 261 271 PF11976 0.547
LIG_SUMO_SIM_par_1 352 357 PF11976 0.502
LIG_SUMO_SIM_par_1 509 515 PF11976 0.656
LIG_SxIP_EBH_1 406 416 PF03271 0.729
LIG_TRAF2_1 626 629 PF00917 0.619
LIG_TRAF2_1 663 666 PF00917 0.595
LIG_TRAF2_1 683 686 PF00917 0.558
LIG_TRAF2_1 797 800 PF00917 0.543
LIG_UBA3_1 151 157 PF00899 0.508
LIG_WRC_WIRS_1 135 140 PF05994 0.489
LIG_WRC_WIRS_1 291 296 PF05994 0.500
LIG_WRC_WIRS_1 804 809 PF05994 0.598
MOD_CDK_SPK_2 627 632 PF00069 0.692
MOD_CK1_1 169 175 PF00069 0.573
MOD_CK1_1 181 187 PF00069 0.481
MOD_CK1_1 195 201 PF00069 0.380
MOD_CK1_1 212 218 PF00069 0.489
MOD_CK1_1 270 276 PF00069 0.529
MOD_CK1_1 296 302 PF00069 0.355
MOD_CK1_1 375 381 PF00069 0.750
MOD_CK1_1 398 404 PF00069 0.766
MOD_CK1_1 407 413 PF00069 0.524
MOD_CK1_1 430 436 PF00069 0.721
MOD_CK1_1 449 455 PF00069 0.715
MOD_CK1_1 465 471 PF00069 0.474
MOD_CK1_1 5 11 PF00069 0.637
MOD_CK1_1 561 567 PF00069 0.727
MOD_CK1_1 723 729 PF00069 0.584
MOD_CK1_1 88 94 PF00069 0.522
MOD_CK2_1 171 177 PF00069 0.594
MOD_CK2_1 228 234 PF00069 0.463
MOD_CK2_1 630 636 PF00069 0.637
MOD_CK2_1 659 665 PF00069 0.552
MOD_CK2_1 723 729 PF00069 0.622
MOD_CK2_1 770 776 PF00069 0.567
MOD_CK2_1 794 800 PF00069 0.550
MOD_GlcNHglycan 180 183 PF01048 0.632
MOD_GlcNHglycan 203 206 PF01048 0.479
MOD_GlcNHglycan 230 233 PF01048 0.529
MOD_GlcNHglycan 253 256 PF01048 0.738
MOD_GlcNHglycan 380 383 PF01048 0.742
MOD_GlcNHglycan 433 436 PF01048 0.783
MOD_GlcNHglycan 438 441 PF01048 0.722
MOD_GlcNHglycan 464 467 PF01048 0.721
MOD_GlcNHglycan 484 487 PF01048 0.610
MOD_GlcNHglycan 542 545 PF01048 0.711
MOD_GlcNHglycan 661 664 PF01048 0.596
MOD_GlcNHglycan 680 683 PF01048 0.400
MOD_GlcNHglycan 702 705 PF01048 0.641
MOD_GlcNHglycan 87 90 PF01048 0.423
MOD_GSK3_1 14 21 PF00069 0.507
MOD_GSK3_1 162 169 PF00069 0.433
MOD_GSK3_1 191 198 PF00069 0.566
MOD_GSK3_1 199 206 PF00069 0.475
MOD_GSK3_1 2 9 PF00069 0.574
MOD_GSK3_1 208 215 PF00069 0.308
MOD_GSK3_1 218 225 PF00069 0.382
MOD_GSK3_1 239 246 PF00069 0.504
MOD_GSK3_1 296 303 PF00069 0.402
MOD_GSK3_1 346 353 PF00069 0.540
MOD_GSK3_1 366 373 PF00069 0.601
MOD_GSK3_1 374 381 PF00069 0.706
MOD_GSK3_1 404 411 PF00069 0.708
MOD_GSK3_1 427 434 PF00069 0.656
MOD_GSK3_1 445 452 PF00069 0.750
MOD_GSK3_1 471 478 PF00069 0.680
MOD_GSK3_1 538 545 PF00069 0.581
MOD_GSK3_1 578 585 PF00069 0.665
MOD_GSK3_1 723 730 PF00069 0.551
MOD_GSK3_1 738 745 PF00069 0.533
MOD_GSK3_1 770 777 PF00069 0.586
MOD_GSK3_1 85 92 PF00069 0.455
MOD_N-GLC_1 223 228 PF02516 0.543
MOD_N-GLC_1 398 403 PF02516 0.745
MOD_N-GLC_1 444 449 PF02516 0.658
MOD_N-GLC_1 471 476 PF02516 0.636
MOD_N-GLC_1 5 10 PF02516 0.603
MOD_N-GLC_1 506 511 PF02516 0.585
MOD_N-GLC_1 607 612 PF02516 0.568
MOD_N-GLC_1 657 662 PF02516 0.557
MOD_NEK2_1 162 167 PF00069 0.413
MOD_NEK2_1 199 204 PF00069 0.502
MOD_NEK2_1 218 223 PF00069 0.578
MOD_NEK2_1 243 248 PF00069 0.537
MOD_NEK2_1 267 272 PF00069 0.495
MOD_NEK2_1 300 305 PF00069 0.566
MOD_NEK2_1 327 332 PF00069 0.490
MOD_NEK2_1 482 487 PF00069 0.674
MOD_NEK2_1 538 543 PF00069 0.600
MOD_NEK2_1 607 612 PF00069 0.612
MOD_NEK2_1 650 655 PF00069 0.586
MOD_NEK2_1 657 662 PF00069 0.607
MOD_NEK2_1 856 861 PF00069 0.647
MOD_NEK2_2 119 124 PF00069 0.549
MOD_PIKK_1 506 512 PF00454 0.564
MOD_PIKK_1 673 679 PF00454 0.627
MOD_PIKK_1 738 744 PF00454 0.607
MOD_PIKK_1 784 790 PF00454 0.646
MOD_PK_1 339 345 PF00069 0.555
MOD_PKA_2 119 125 PF00069 0.468
MOD_PKA_2 222 228 PF00069 0.592
MOD_PKA_2 338 344 PF00069 0.524
MOD_PKA_2 561 567 PF00069 0.666
MOD_PKA_2 591 597 PF00069 0.633
MOD_PKA_2 738 744 PF00069 0.599
MOD_PKA_2 761 767 PF00069 0.598
MOD_Plk_1 192 198 PF00069 0.593
MOD_Plk_1 327 333 PF00069 0.561
MOD_Plk_1 346 352 PF00069 0.582
MOD_Plk_1 471 477 PF00069 0.619
MOD_Plk_1 506 512 PF00069 0.646
MOD_Plk_1 607 613 PF00069 0.567
MOD_Plk_1 657 663 PF00069 0.577
MOD_Plk_1 778 784 PF00069 0.581
MOD_Plk_2-3 761 767 PF00069 0.641
MOD_Plk_2-3 810 816 PF00069 0.502
MOD_Plk_4 14 20 PF00069 0.624
MOD_Plk_4 171 177 PF00069 0.573
MOD_Plk_4 203 209 PF00069 0.553
MOD_Plk_4 239 245 PF00069 0.521
MOD_Plk_4 293 299 PF00069 0.444
MOD_Plk_4 305 311 PF00069 0.449
MOD_Plk_4 327 333 PF00069 0.575
MOD_Plk_4 350 356 PF00069 0.461
MOD_Plk_4 404 410 PF00069 0.697
MOD_Plk_4 723 729 PF00069 0.526
MOD_Plk_4 742 748 PF00069 0.459
MOD_Plk_4 778 784 PF00069 0.580
MOD_Plk_4 803 809 PF00069 0.605
MOD_ProDKin_1 224 230 PF00069 0.489
MOD_ProDKin_1 370 376 PF00069 0.697
MOD_ProDKin_1 398 404 PF00069 0.681
MOD_ProDKin_1 438 444 PF00069 0.776
MOD_ProDKin_1 512 518 PF00069 0.591
MOD_ProDKin_1 627 633 PF00069 0.687
MOD_ProDKin_1 68 74 PF00069 0.532
MOD_ProDKin_1 718 724 PF00069 0.628
MOD_SUMO_for_1 26 29 PF00179 0.575
MOD_SUMO_rev_2 172 181 PF00179 0.591
TRG_DiLeu_BaEn_1 163 168 PF01217 0.548
TRG_DiLeu_BaEn_2 37 43 PF01217 0.517
TRG_DiLeu_BaEn_4 666 672 PF01217 0.552
TRG_DiLeu_BaLyEn_6 51 56 PF01217 0.513
TRG_ENDOCYTIC_2 126 129 PF00928 0.382
TRG_ENDOCYTIC_2 746 749 PF00928 0.511
TRG_ENDOCYTIC_2 95 98 PF00928 0.508
TRG_ER_diArg_1 494 496 PF00400 0.619
TRG_ER_diArg_1 619 622 PF00400 0.644
TRG_ER_diArg_1 850 852 PF00400 0.630
TRG_Pf-PMV_PEXEL_1 185 189 PF00026 0.573
TRG_Pf-PMV_PEXEL_1 34 38 PF00026 0.450
TRG_Pf-PMV_PEXEL_1 621 625 PF00026 0.648
TRG_Pf-PMV_PEXEL_1 632 636 PF00026 0.628
TRG_Pf-PMV_PEXEL_1 648 652 PF00026 0.355
TRG_Pf-PMV_PEXEL_1 851 855 PF00026 0.605

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P333 Leptomonas seymouri 71% 99%
A0A0S4JBI5 Bodo saltans 28% 100%
A0A3R7NEG9 Trypanosoma rangeli 32% 95%
A0A3S5H6S3 Leishmania donovani 95% 100%
A4H7P6 Leishmania braziliensis 84% 100%
A4HW35 Leishmania infantum 95% 100%
C9ZSY9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 95%
E9APT8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS