PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFP1_LEIMA

TriTrypDb:

LmjF.14.0940 , LMJLV39_140016100 , LMJSD75_140015500

Length:

874

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.755
CLV_C14_Caspase3-7	525	529	PF00656	0.722
CLV_NRD_NRD_1	538	540	PF00675	0.769
CLV_PCSK_FUR_1	536	540	PF00082	0.846
CLV_PCSK_KEX2_1	535	537	PF00082	0.842
CLV_PCSK_KEX2_1	538	540	PF00082	0.794
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.842
CLV_PCSK_SKI1_1	358	362	PF00082	0.705
CLV_PCSK_SKI1_1	784	788	PF00082	0.571
DEG_Nend_Nbox_1	1	3	PF02207	0.791
DEG_SCF_FBW7_1	64	71	PF00400	0.826
DEG_SCF_FBW7_1	714	721	PF00400	0.551
DEG_SCF_TRCP1_1	655	660	PF00400	0.679
DEG_SPOP_SBC_1	265	269	PF00917	0.746
DEG_SPOP_SBC_1	32	36	PF00917	0.561
DEG_SPOP_SBC_1	582	586	PF00917	0.686
DOC_CKS1_1	365	370	PF01111	0.799
DOC_CKS1_1	715	720	PF01111	0.742
DOC_CYCLIN_RxL_1	94	103	PF00134	0.668
DOC_MAPK_DCC_7	292	302	PF00069	0.675
DOC_MAPK_MEF2A_6	463	470	PF00069	0.670
DOC_PP1_RVXF_1	95	102	PF00149	0.539
DOC_PP2B_LxvP_1	524	527	PF13499	0.776
DOC_PP2B_LxvP_1	558	561	PF13499	0.790
DOC_PP2B_LxvP_1	786	789	PF13499	0.754
DOC_PP4_FxxP_1	715	718	PF00568	0.737
DOC_PP4_MxPP_1	855	858	PF00568	0.733
DOC_USP7_MATH_1	106	110	PF00917	0.677
DOC_USP7_MATH_1	143	147	PF00917	0.788
DOC_USP7_MATH_1	264	268	PF00917	0.743
DOC_USP7_MATH_1	37	41	PF00917	0.662
DOC_USP7_MATH_1	378	382	PF00917	0.794
DOC_USP7_MATH_1	436	440	PF00917	0.581
DOC_USP7_MATH_1	457	461	PF00917	0.693
DOC_USP7_MATH_1	551	555	PF00917	0.837
DOC_USP7_MATH_1	625	629	PF00917	0.581
DOC_USP7_MATH_1	662	666	PF00917	0.668
DOC_USP7_MATH_1	824	828	PF00917	0.800
DOC_USP7_MATH_1	829	833	PF00917	0.748
DOC_USP7_MATH_1	861	865	PF00917	0.531
DOC_WW_Pin1_4	151	156	PF00397	0.821
DOC_WW_Pin1_4	202	207	PF00397	0.799
DOC_WW_Pin1_4	222	227	PF00397	0.779
DOC_WW_Pin1_4	232	237	PF00397	0.641
DOC_WW_Pin1_4	252	257	PF00397	0.528
DOC_WW_Pin1_4	292	297	PF00397	0.783
DOC_WW_Pin1_4	302	307	PF00397	0.678
DOC_WW_Pin1_4	33	38	PF00397	0.790
DOC_WW_Pin1_4	341	346	PF00397	0.822
DOC_WW_Pin1_4	350	355	PF00397	0.695
DOC_WW_Pin1_4	360	365	PF00397	0.518
DOC_WW_Pin1_4	441	446	PF00397	0.654
DOC_WW_Pin1_4	64	69	PF00397	0.826
DOC_WW_Pin1_4	664	669	PF00397	0.680
DOC_WW_Pin1_4	672	677	PF00397	0.560
DOC_WW_Pin1_4	714	719	PF00397	0.737
DOC_WW_Pin1_4	766	771	PF00397	0.725
DOC_WW_Pin1_4	779	784	PF00397	0.694
DOC_WW_Pin1_4	840	845	PF00397	0.675
LIG_14-3-3_CanoR_1	172	181	PF00244	0.721
LIG_14-3-3_CanoR_1	250	256	PF00244	0.583
LIG_14-3-3_CanoR_1	347	354	PF00244	0.696
LIG_14-3-3_CanoR_1	358	365	PF00244	0.591
LIG_14-3-3_CanoR_1	97	102	PF00244	0.684
LIG_BIR_III_2	103	107	PF00653	0.670
LIG_BRCT_BRCA1_1	584	588	PF00533	0.657
LIG_Clathr_ClatBox_1	309	313	PF01394	0.678
LIG_deltaCOP1_diTrp_1	751	759	PF00928	0.660
LIG_DLG_GKlike_1	97	105	PF00625	0.540
LIG_EVH1_1	558	562	PF00568	0.782
LIG_FHA_1	267	273	PF00498	0.754
LIG_FHA_1	323	329	PF00498	0.687
LIG_FHA_1	37	43	PF00498	0.786
LIG_FHA_1	449	455	PF00498	0.566
LIG_FHA_1	598	604	PF00498	0.647
LIG_FHA_1	88	94	PF00498	0.553
LIG_FHA_2	114	120	PF00498	0.580
LIG_FHA_2	197	203	PF00498	0.751
LIG_FHA_2	223	229	PF00498	0.773
LIG_FHA_2	33	39	PF00498	0.544
LIG_FHA_2	451	457	PF00498	0.711
LIG_FHA_2	507	513	PF00498	0.716
LIG_FHA_2	523	529	PF00498	0.562
LIG_FHA_2	614	620	PF00498	0.504
LIG_IBAR_NPY_1	59	61	PF08397	0.799
LIG_KLC1_Yacidic_2	197	202	PF13176	0.693
LIG_LIR_Apic_2	197	203	PF02991	0.744
LIG_LIR_Apic_2	554	560	PF02991	0.819
LIG_LIR_Gen_1	175	186	PF02991	0.844
LIG_LIR_Gen_1	40	51	PF02991	0.674
LIG_LIR_Gen_1	589	599	PF02991	0.702
LIG_LIR_Gen_1	606	615	PF02991	0.493
LIG_LIR_Nem_3	291	297	PF02991	0.730
LIG_LIR_Nem_3	40	46	PF02991	0.674
LIG_LIR_Nem_3	585	591	PF02991	0.723
LIG_LIR_Nem_3	606	612	PF02991	0.695
LIG_LIR_Nem_3	751	757	PF02991	0.708
LIG_MYND_1	186	190	PF01753	0.752
LIG_Pex14_1	230	234	PF04695	0.699
LIG_Pex14_1	753	757	PF04695	0.708
LIG_Pex14_2	755	759	PF04695	0.716
LIG_PROFILIN_1	559	565	PF00235	0.713
LIG_PTB_Apo_2	796	803	PF02174	0.538
LIG_PTB_Phospho_1	796	802	PF10480	0.539
LIG_SH2_CRK	43	47	PF00017	0.812
LIG_SH2_CRK	592	596	PF00017	0.691
LIG_SH2_CRK	599	603	PF00017	0.587
LIG_SH2_PTP2	61	64	PF00017	0.813
LIG_SH2_PTP2	757	760	PF00017	0.669
LIG_SH2_SRC	142	145	PF00017	0.710
LIG_SH2_SRC	200	203	PF00017	0.648
LIG_SH2_SRC	557	560	PF00017	0.800
LIG_SH2_STAP1	258	262	PF00017	0.687
LIG_SH2_STAP1	592	596	PF00017	0.691
LIG_SH2_STAP1	599	603	PF00017	0.587
LIG_SH2_STAT3	102	105	PF00017	0.674
LIG_SH2_STAT3	407	410	PF00017	0.727
LIG_SH2_STAT3	498	501	PF00017	0.779
LIG_SH2_STAT5	200	203	PF00017	0.648
LIG_SH2_STAT5	557	560	PF00017	0.800
LIG_SH2_STAT5	599	602	PF00017	0.545
LIG_SH2_STAT5	61	64	PF00017	0.813
LIG_SH2_STAT5	678	681	PF00017	0.825
LIG_SH2_STAT5	757	760	PF00017	0.723
LIG_SH3_1	200	206	PF00018	0.757
LIG_SH3_1	556	562	PF00018	0.800
LIG_SH3_3	200	206	PF00018	0.757
LIG_SH3_3	351	357	PF00018	0.719
LIG_SH3_3	429	435	PF00018	0.785
LIG_SH3_3	480	486	PF00018	0.762
LIG_SH3_3	556	562	PF00018	0.800
LIG_SH3_3	563	569	PF00018	0.689
LIG_SH3_3	691	697	PF00018	0.804
LIG_SH3_3	838	844	PF00018	0.664
LIG_SH3_3	853	859	PF00018	0.613
LIG_TRAF2_2	650	655	PF00917	0.687
LIG_WW_1	368	371	PF00397	0.792
MOD_CDC14_SPxK_1	344	347	PF00782	0.807
MOD_CDC14_SPxK_1	353	356	PF00782	0.696
MOD_CDC14_SPxK_1	444	447	PF00782	0.648
MOD_CDK_SPK_2	779	784	PF00069	0.585
MOD_CDK_SPxK_1	341	347	PF00069	0.817
MOD_CDK_SPxK_1	350	356	PF00069	0.697
MOD_CDK_SPxK_1	441	447	PF00069	0.656
MOD_CDK_SPxxK_3	766	773	PF00069	0.576
MOD_CK1_1	109	115	PF00069	0.704
MOD_CK1_1	146	152	PF00069	0.838
MOD_CK1_1	168	174	PF00069	0.609
MOD_CK1_1	218	224	PF00069	0.794
MOD_CK1_1	235	241	PF00069	0.554
MOD_CK1_1	251	257	PF00069	0.582
MOD_CK1_1	320	326	PF00069	0.748
MOD_CK1_1	381	387	PF00069	0.690
MOD_CK1_1	398	404	PF00069	0.538
MOD_CK1_1	45	51	PF00069	0.812
MOD_CK1_1	5	11	PF00069	0.800
MOD_CK1_1	54	60	PF00069	0.655
MOD_CK1_1	583	589	PF00069	0.609
MOD_CK1_1	664	670	PF00069	0.704
MOD_CK1_1	672	678	PF00069	0.607
MOD_CK1_1	864	870	PF00069	0.525
MOD_CK2_1	113	119	PF00069	0.583
MOD_CK2_1	196	202	PF00069	0.754
MOD_CK2_1	222	228	PF00069	0.779
MOD_CK2_1	450	456	PF00069	0.665
MOD_CK2_1	635	641	PF00069	0.566
MOD_CK2_1	685	691	PF00069	0.680
MOD_CK2_1	814	820	PF00069	0.540
MOD_DYRK1A_RPxSP_1	840	844	PF00069	0.676
MOD_GlcNHglycan	167	170	PF01048	0.730
MOD_GlcNHglycan	20	23	PF01048	0.593
MOD_GlcNHglycan	237	240	PF01048	0.729
MOD_GlcNHglycan	26	29	PF01048	0.733
MOD_GlcNHglycan	275	278	PF01048	0.614
MOD_GlcNHglycan	284	287	PF01048	0.596
MOD_GlcNHglycan	393	396	PF01048	0.615
MOD_GlcNHglycan	4	7	PF01048	0.801
MOD_GlcNHglycan	478	482	PF01048	0.785
MOD_GlcNHglycan	53	56	PF01048	0.605
MOD_GlcNHglycan	585	588	PF01048	0.619
MOD_GlcNHglycan	627	630	PF01048	0.648
MOD_GlcNHglycan	646	649	PF01048	0.654
MOD_GlcNHglycan	655	658	PF01048	0.665
MOD_GlcNHglycan	681	684	PF01048	0.825
MOD_GlcNHglycan	741	744	PF01048	0.708
MOD_GlcNHglycan	792	795	PF01048	0.731
MOD_GlcNHglycan	82	85	PF01048	0.756
MOD_GlcNHglycan	826	829	PF01048	0.696
MOD_GlcNHglycan	831	834	PF01048	0.730
MOD_GlcNHglycan	863	866	PF01048	0.575
MOD_GSK3_1	109	116	PF00069	0.579
MOD_GSK3_1	146	153	PF00069	0.834
MOD_GSK3_1	168	175	PF00069	0.633
MOD_GSK3_1	202	209	PF00069	0.613
MOD_GSK3_1	218	225	PF00069	0.738
MOD_GSK3_1	248	255	PF00069	0.657
MOD_GSK3_1	264	271	PF00069	0.768
MOD_GSK3_1	278	285	PF00069	0.590
MOD_GSK3_1	288	295	PF00069	0.687
MOD_GSK3_1	318	325	PF00069	0.819
MOD_GSK3_1	32	39	PF00069	0.708
MOD_GSK3_1	360	367	PF00069	0.820
MOD_GSK3_1	381	388	PF00069	0.815
MOD_GSK3_1	391	398	PF00069	0.658
MOD_GSK3_1	45	52	PF00069	0.665
MOD_GSK3_1	473	480	PF00069	0.759
MOD_GSK3_1	5	12	PF00069	0.800
MOD_GSK3_1	64	71	PF00069	0.519
MOD_GSK3_1	653	660	PF00069	0.668
MOD_GSK3_1	662	669	PF00069	0.639
MOD_GSK3_1	714	721	PF00069	0.551
MOD_GSK3_1	762	769	PF00069	0.657
MOD_GSK3_1	784	791	PF00069	0.755
MOD_GSK3_1	829	836	PF00069	0.545
MOD_N-GLC_1	222	227	PF02516	0.698
MOD_N-GLC_1	49	54	PF02516	0.810
MOD_N-GLC_1	685	690	PF02516	0.545
MOD_N-GLC_1	718	723	PF02516	0.559
MOD_NEK2_1	107	112	PF00069	0.751
MOD_NEK2_1	130	135	PF00069	0.545
MOD_NEK2_1	2	7	PF00069	0.679
MOD_NEK2_1	324	329	PF00069	0.822
MOD_NEK2_1	379	384	PF00069	0.801
MOD_NEK2_1	42	47	PF00069	0.799
MOD_NEK2_1	51	56	PF00069	0.645
MOD_NEK2_1	679	684	PF00069	0.823
MOD_NEK2_1	814	819	PF00069	0.636
MOD_NEK2_1	9	14	PF00069	0.619
MOD_NEK2_2	551	556	PF00069	0.839
MOD_NEK2_2	869	874	PF00069	0.577
MOD_PIKK_1	206	212	PF00454	0.576
MOD_PIKK_1	358	364	PF00454	0.560
MOD_PIKK_1	379	385	PF00454	0.805
MOD_PIKK_1	448	454	PF00454	0.614
MOD_PIKK_1	457	463	PF00454	0.680
MOD_PIKK_1	567	573	PF00454	0.717
MOD_PIKK_1	720	726	PF00454	0.648
MOD_PIKK_1	9	15	PF00454	0.816
MOD_PKA_2	112	118	PF00069	0.661
MOD_PKA_2	146	152	PF00069	0.838
MOD_PKA_2	272	278	PF00069	0.708
MOD_PKA_2	9	15	PF00069	0.816
MOD_PKB_1	356	364	PF00069	0.698
MOD_Plk_1	107	113	PF00069	0.696
MOD_Plk_1	196	202	PF00069	0.693
MOD_Plk_1	49	55	PF00069	0.757
MOD_Plk_1	68	74	PF00069	0.600
MOD_Plk_4	188	194	PF00069	0.704
MOD_Plk_4	336	342	PF00069	0.559
MOD_Plk_4	666	672	PF00069	0.808
MOD_Plk_4	68	74	PF00069	0.749
MOD_Plk_4	97	103	PF00069	0.674
MOD_ProDKin_1	151	157	PF00069	0.825
MOD_ProDKin_1	202	208	PF00069	0.801
MOD_ProDKin_1	222	228	PF00069	0.779
MOD_ProDKin_1	232	238	PF00069	0.643
MOD_ProDKin_1	252	258	PF00069	0.526
MOD_ProDKin_1	292	298	PF00069	0.777
MOD_ProDKin_1	302	308	PF00069	0.674
MOD_ProDKin_1	33	39	PF00069	0.789
MOD_ProDKin_1	341	347	PF00069	0.817
MOD_ProDKin_1	350	356	PF00069	0.697
MOD_ProDKin_1	360	366	PF00069	0.515
MOD_ProDKin_1	441	447	PF00069	0.656
MOD_ProDKin_1	64	70	PF00069	0.826
MOD_ProDKin_1	664	670	PF00069	0.680
MOD_ProDKin_1	672	678	PF00069	0.562
MOD_ProDKin_1	714	720	PF00069	0.739
MOD_ProDKin_1	766	772	PF00069	0.728
MOD_ProDKin_1	779	785	PF00069	0.691
MOD_ProDKin_1	840	846	PF00069	0.676
MOD_SUMO_rev_2	636	646	PF00179	0.747
TRG_DiLeu_BaLyEn_6	598	603	PF01217	0.698
TRG_ENDOCYTIC_2	178	181	PF00928	0.855
TRG_ENDOCYTIC_2	43	46	PF00928	0.765
TRG_ENDOCYTIC_2	591	594	PF00928	0.702
TRG_ENDOCYTIC_2	599	602	PF00928	0.573
TRG_ENDOCYTIC_2	61	64	PF00928	0.571
TRG_ER_diArg_1	536	539	PF00400	0.842
TRG_NLS_MonoCore_2	540	545	PF00514	0.708
TRG_NLS_MonoExtC_3	533	538	PF00514	0.818
TRG_NLS_MonoExtN_4	532	539	PF00514	0.839
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IID6	Leishmania donovani	84%	100%
A4H7P7	Leishmania braziliensis	59%	98%
A4HW36	Leishmania infantum	85%	100%
E9APT9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%