LeishMANIAdb
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Ribosomal_L16 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ribosomal_L16 domain-containing protein
Gene product:
Ribosomal protein L16p/L10e, putative
Species:
Leishmania major
UniProt:
Q4QFP0_LEIMA
TriTrypDb:
LmjF.14.0950 , LMJLV39_140016200 * , LMJSD75_140015600
Length:
168

Annotations

Annotations by Jardim et al.

Ribosomal Protein, Ribosomal L16p/L10e

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0000315 organellar large ribosomal subunit 5 2
GO:0005762 mitochondrial large ribosomal subunit 3 2
GO:0015934 large ribosomal subunit 4 2
GO:0032991 protein-containing complex 1 10
GO:0044391 ribosomal subunit 3 2
GO:0098798 mitochondrial protein-containing complex 2 2
GO:1990904 ribonucleoprotein complex 2 10
GO:0005840 ribosome 5 8
GO:0043226 organelle 2 8
GO:0043228 non-membrane-bounded organelle 3 8
GO:0043229 intracellular organelle 3 8
GO:0043232 intracellular non-membrane-bounded organelle 4 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

Q4QFP0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFP0

PDB structure(s): 7aih_H , 7ane_H

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 10
GO:0006518 peptide metabolic process 4 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0009058 biosynthetic process 2 10
GO:0009059 macromolecule biosynthetic process 4 10
GO:0009987 cellular process 1 10
GO:0019538 protein metabolic process 3 10
GO:0032543 mitochondrial translation 5 2
GO:0034641 cellular nitrogen compound metabolic process 3 10
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 10
GO:0043043 peptide biosynthetic process 5 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043603 amide metabolic process 3 10
GO:0043604 amide biosynthetic process 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044238 primary metabolic process 2 10
GO:0044249 cellular biosynthetic process 3 10
GO:0044260 obsolete cellular macromolecule metabolic process 3 10
GO:0044271 cellular nitrogen compound biosynthetic process 4 10
GO:0071704 organic substance metabolic process 2 10
GO:1901564 organonitrogen compound metabolic process 3 10
GO:1901566 organonitrogen compound biosynthetic process 4 10
GO:1901576 organic substance biosynthetic process 3 10
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 10
GO:0003723 RNA binding 4 10
GO:0003735 structural constituent of ribosome 2 10
GO:0005198 structural molecule activity 1 10
GO:0005488 binding 1 10
GO:0019843 rRNA binding 5 10
GO:0097159 organic cyclic compound binding 2 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 131 133 PF00675 0.262
CLV_NRD_NRD_1 29 31 PF00675 0.478
CLV_NRD_NRD_1 73 75 PF00675 0.262
CLV_PCSK_KEX2_1 131 133 PF00082 0.262
CLV_PCSK_KEX2_1 73 75 PF00082 0.249
CLV_PCSK_SKI1_1 46 50 PF00082 0.307
DEG_Nend_UBRbox_3 1 3 PF02207 0.696
DOC_CYCLIN_RxL_1 43 53 PF00134 0.380
DOC_USP7_MATH_1 104 108 PF00917 0.502
DOC_USP7_MATH_1 127 131 PF00917 0.472
DOC_USP7_MATH_1 144 148 PF00917 0.521
DOC_USP7_MATH_1 76 80 PF00917 0.533
DOC_WW_Pin1_4 94 99 PF00397 0.462
LIG_14-3-3_CanoR_1 7 12 PF00244 0.619
LIG_APCC_ABBA_1 82 87 PF00400 0.480
LIG_FHA_1 115 121 PF00498 0.448
LIG_FHA_1 151 157 PF00498 0.462
LIG_FHA_2 84 90 PF00498 0.462
LIG_LIR_Gen_1 86 94 PF02991 0.462
LIG_LIR_Nem_3 147 151 PF02991 0.535
LIG_LIR_Nem_3 162 167 PF02991 0.418
LIG_LIR_Nem_3 53 59 PF02991 0.468
LIG_LIR_Nem_3 86 91 PF02991 0.462
LIG_Pex14_2 112 116 PF04695 0.462
LIG_SH2_CRK 15 19 PF00017 0.482
LIG_SH2_PTP2 17 20 PF00017 0.458
LIG_SH2_SRC 17 20 PF00017 0.458
LIG_SH2_STAT5 17 20 PF00017 0.458
LIG_SUMO_SIM_anti_2 41 46 PF11976 0.484
LIG_SxIP_EBH_1 146 155 PF03271 0.535
MOD_CDK_SPxxK_3 94 101 PF00069 0.462
MOD_CK1_1 97 103 PF00069 0.462
MOD_CK2_1 59 65 PF00069 0.462
MOD_CK2_1 83 89 PF00069 0.462
MOD_GlcNHglycan 3 6 PF01048 0.672
MOD_GSK3_1 123 130 PF00069 0.502
MOD_GSK3_1 76 83 PF00069 0.533
MOD_NEK2_1 1 6 PF00069 0.658
MOD_NEK2_1 123 128 PF00069 0.487
MOD_NEK2_1 80 85 PF00069 0.480
MOD_PIKK_1 57 63 PF00454 0.462
MOD_PKA_2 6 12 PF00069 0.620
MOD_PKA_2 76 82 PF00069 0.533
MOD_Plk_1 123 129 PF00069 0.496
MOD_Plk_4 7 13 PF00069 0.557
MOD_ProDKin_1 94 100 PF00069 0.462
TRG_ENDOCYTIC_2 15 18 PF00928 0.490
TRG_ENDOCYTIC_2 164 167 PF00928 0.425
TRG_ENDOCYTIC_2 88 91 PF00928 0.462
TRG_ER_diArg_1 131 133 PF00400 0.462
TRG_ER_diArg_1 157 160 PF00400 0.511
TRG_ER_diArg_1 72 74 PF00400 0.462
TRG_Pf-PMV_PEXEL_1 131 135 PF00026 0.262
TRG_Pf-PMV_PEXEL_1 24 28 PF00026 0.459

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P481 Leptomonas seymouri 92% 100%
A0A1X0NNV3 Trypanosomatidae 85% 100%
A0A3R7M6C9 Trypanosoma rangeli 82% 100%
A0A3S7WT29 Leishmania donovani 99% 100%
A1QZS1 Borrelia turicatae (strain 91E135) 29% 100%
A1VIQ7 Polaromonas naphthalenivorans (strain CJ2) 34% 100%
A4H7P8 Leishmania braziliensis 98% 100%
A4HW37 Leishmania infantum 100% 100%
A5IM90 Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1) 32% 100%
A7HBM5 Anaeromyxobacter sp. (strain Fw109-5) 30% 100%
A9BPS5 Delftia acidovorans (strain DSM 14801 / SPH-1) 32% 100%
B1LBN3 Thermotoga sp. (strain RQ2) 32% 100%
B1Y8I0 Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) 31% 100%
B2S0I8 Borrelia hermsii (strain HS1 / DAH) 30% 100%
B4UBA6 Anaeromyxobacter sp. (strain K) 31% 100%
B5RM43 Borrelia duttonii (strain Ly) 29% 100%
B5RPI9 Borrelia recurrentis (strain A1) 30% 100%
B8GV51 Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) 31% 100%
B8J867 Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258) 31% 100%
C9ZSY3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 82% 100%
E9APU0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
P38509 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 31% 100%
P46173 Buchnera aphidicola subsp. Acyrthosiphon kondoi 31% 100%
Q0SQF1 Clostridium perfringens (strain SM101 / Type A) 31% 100%
Q0TMQ3 Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) 31% 100%
Q12GW4 Polaromonas sp. (strain JS666 / ATCC BAA-500) 33% 100%
Q2IJ83 Anaeromyxobacter dehalogenans (strain 2CP-C) 31% 100%
Q6F7R9 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) 30% 100%
Q72I11 Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) 28% 100%
Q7VQE1 Blochmannia floridanus 32% 100%
Q890P5 Clostridium tetani (strain Massachusetts / E88) 31% 100%
Q8K957 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 32% 100%
Q8XHT0 Clostridium perfringens (strain 13 / Type A) 31% 100%
Q97EI5 Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS