ADP/ATP translocase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

ADP/ATP translocase

Gene product:

ADP/ATP mitochondrial carrier-like protein

Species:

Leishmania major

UniProt:

Q4QFN6_LEIMA

TriTrypDb:

LmjF.14.0990 , LMJLV39_140016600 , LMJSD75_140016000

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005743	mitochondrial inner membrane	5	14
GO:0016020	membrane	2	14
GO:0019866	organelle inner membrane	4	14
GO:0031090	organelle membrane	3	14
GO:0031966	mitochondrial membrane	4	14
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

Q4QFN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFN6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	14
GO:0006811	monoatomic ion transport	4	14
GO:0006820	monoatomic anion transport	5	14
GO:0006862	nucleotide transport	6	14
GO:0009987	cellular process	1	14
GO:0015711	organic anion transport	5	14
GO:0015748	organophosphate ester transport	5	14
GO:0015865	purine nucleotide transport	7	14
GO:0015866	ADP transport	6	14
GO:0015867	ATP transport	6	14
GO:0015868	purine ribonucleotide transport	6	14
GO:0015931	nucleobase-containing compound transport	5	14
GO:0034220	monoatomic ion transmembrane transport	3	14
GO:0051179	localization	1	14
GO:0051234	establishment of localization	2	14
GO:0051503	adenine nucleotide transport	8	14
GO:0055085	transmembrane transport	2	14
GO:0071702	organic substance transport	4	14
GO:0071705	nitrogen compound transport	4	14
GO:0072530	purine-containing compound transmembrane transport	3	14
GO:0098656	monoatomic anion transmembrane transport	4	14
GO:0140021	mitochondrial ADP transmembrane transport	4	14
GO:1901264	carbohydrate derivative transport	5	14
GO:1901679	nucleotide transmembrane transport	3	14
GO:1990542	mitochondrial transmembrane transport	3	14
GO:1990544	mitochondrial ATP transmembrane transport	4	14

Molecular functions
Term	Name	Level	Count
GO:0000295	adenine nucleotide transmembrane transporter activity	6	14
GO:0005215	transporter activity	1	14
GO:0005346	purine ribonucleotide transmembrane transporter activity	4	14
GO:0005347	ATP transmembrane transporter activity	5	14
GO:0005471	ATP:ADP antiporter activity	5	14
GO:0008509	monoatomic anion transmembrane transporter activity	4	14
GO:0008514	organic anion transmembrane transporter activity	5	14
GO:0015075	monoatomic ion transmembrane transporter activity	3	14
GO:0015215	nucleotide transmembrane transporter activity	4	14
GO:0015216	purine nucleotide transmembrane transporter activity	5	14
GO:0015217	ADP transmembrane transporter activity	5	14
GO:0015291	secondary active transmembrane transporter activity	4	14
GO:0015297	antiporter activity	5	14
GO:0015605	organophosphate ester transmembrane transporter activity	3	14
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	14
GO:0022804	active transmembrane transporter activity	3	14
GO:0022853	active monoatomic ion transmembrane transporter activity	4	14
GO:0022857	transmembrane transporter activity	2	14
GO:0140323	obsolete solute:monoatomic anion antiporter activity	6	14
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.346
CLV_NRD_NRD_1	178	180	PF00675	0.325
CLV_NRD_NRD_1	248	250	PF00675	0.243
CLV_NRD_NRD_1	312	314	PF00675	0.226
CLV_NRD_NRD_1	325	327	PF00675	0.205
CLV_PCSK_KEX2_1	248	250	PF00082	0.256
CLV_PCSK_KEX2_1	312	314	PF00082	0.226
CLV_PCSK_KEX2_1	325	327	PF00082	0.206
CLV_PCSK_PC7_1	244	250	PF00082	0.234
CLV_PCSK_SKI1_1	313	317	PF00082	0.286
CLV_PCSK_SKI1_1	364	368	PF00082	0.429
CLV_PCSK_SKI1_1	54	58	PF00082	0.370
CLV_Separin_Metazoa	80	84	PF03568	0.503
DOC_CKS1_1	171	176	PF01111	0.311
DOC_CYCLIN_RxL_1	267	277	PF00134	0.408
DOC_CYCLIN_RxL_1	309	320	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.366
DOC_MAPK_DCC_7	257	266	PF00069	0.525
DOC_MAPK_gen_1	351	358	PF00069	0.497
DOC_MAPK_MEF2A_6	351	358	PF00069	0.525
DOC_MAPK_RevD_3	297	313	PF00069	0.366
DOC_PP2B_LxvP_1	121	124	PF13499	0.285
DOC_USP7_MATH_1	163	167	PF00917	0.392
DOC_USP7_MATH_2	306	312	PF00917	0.441
DOC_WW_Pin1_4	170	175	PF00397	0.311
DOC_WW_Pin1_4	224	229	PF00397	0.550
DOC_WW_Pin1_4	26	31	PF00397	0.686
DOC_WW_Pin1_4	4	9	PF00397	0.793
LIG_14-3-3_CanoR_1	179	183	PF00244	0.510
LIG_14-3-3_CanoR_1	283	289	PF00244	0.331
LIG_14-3-3_CanoR_1	353	359	PF00244	0.308
LIG_AP2alpha_1	127	131	PF02296	0.330
LIG_BH_BH3_1	288	304	PF00452	0.325
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_eIF4E_1	269	275	PF01652	0.349
LIG_FHA_1	131	137	PF00498	0.415
LIG_FHA_1	152	158	PF00498	0.339
LIG_FHA_1	196	202	PF00498	0.531
LIG_FHA_1	302	308	PF00498	0.414
LIG_FHA_1	363	369	PF00498	0.412
LIG_FHA_2	236	242	PF00498	0.471
LIG_FHA_2	315	321	PF00498	0.495
LIG_FHA_2	41	47	PF00498	0.554
LIG_FHA_2	73	79	PF00498	0.511
LIG_LIR_Gen_1	173	183	PF02991	0.520
LIG_LIR_Gen_1	365	374	PF02991	0.381
LIG_LIR_Nem_3	173	178	PF02991	0.520
LIG_LIR_Nem_3	268	272	PF02991	0.313
LIG_LIR_Nem_3	28	34	PF02991	0.639
LIG_LIR_Nem_3	324	330	PF02991	0.497
LIG_LIR_Nem_3	344	350	PF02991	0.428
LIG_LIR_Nem_3	365	370	PF02991	0.419
LIG_PCNA_TLS_4	105	113	PF02747	0.494
LIG_Pex14_1	252	256	PF04695	0.525
LIG_Pex14_2	127	131	PF04695	0.413
LIG_SH2_CRK	175	179	PF00017	0.531
LIG_SH2_CRK	269	273	PF00017	0.414
LIG_SH2_CRK	327	331	PF00017	0.472
LIG_SH2_NCK_1	236	240	PF00017	0.455
LIG_SH2_SRC	273	276	PF00017	0.408
LIG_SH2_STAP1	99	103	PF00017	0.499
LIG_SH2_STAT5	236	239	PF00017	0.460
LIG_SH2_STAT5	273	276	PF00017	0.367
LIG_SH3_3	168	174	PF00018	0.354
LIG_SH3_3	222	228	PF00018	0.434
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.533
LIG_SUMO_SIM_par_1	118	125	PF11976	0.336
LIG_SUMO_SIM_par_1	153	161	PF11976	0.248
LIG_SUMO_SIM_par_1	262	268	PF11976	0.460
LIG_SUMO_SIM_par_1	304	311	PF11976	0.408
LIG_SUMO_SIM_par_1	354	360	PF11976	0.377
LIG_TRAF2_1	11	14	PF00917	0.679
LIG_TRAF2_1	228	231	PF00917	0.499
LIG_TYR_ITSM	171	178	PF00017	0.408
LIG_WRC_WIRS_1	128	133	PF05994	0.330
MOD_CK1_1	130	136	PF00069	0.460
MOD_CK1_1	212	218	PF00069	0.539
MOD_CK1_1	357	363	PF00069	0.408
MOD_CK2_1	235	241	PF00069	0.438
MOD_CK2_1	72	78	PF00069	0.510
MOD_GlcNHglycan	1	4	PF01048	0.415
MOD_GlcNHglycan	124	127	PF01048	0.310
MOD_GlcNHglycan	165	168	PF01048	0.354
MOD_GlcNHglycan	211	214	PF01048	0.314
MOD_GlcNHglycan	252	255	PF01048	0.235
MOD_GlcNHglycan	347	350	PF01048	0.243
MOD_GSK3_1	158	165	PF00069	0.276
MOD_GSK3_1	235	242	PF00069	0.438
MOD_GSK3_1	274	281	PF00069	0.509
MOD_GSK3_1	341	348	PF00069	0.481
MOD_NEK2_1	127	132	PF00069	0.314
MOD_NEK2_1	152	157	PF00069	0.330
MOD_NEK2_1	162	167	PF00069	0.266
MOD_NEK2_1	274	279	PF00069	0.375
MOD_NEK2_1	314	319	PF00069	0.428
MOD_NEK2_1	354	359	PF00069	0.263
MOD_NEK2_1	40	45	PF00069	0.633
MOD_NEK2_1	60	65	PF00069	0.438
MOD_NEK2_1	72	77	PF00069	0.492
MOD_NEK2_2	362	367	PF00069	0.330
MOD_PIKK_1	301	307	PF00454	0.299
MOD_PKA_2	178	184	PF00069	0.530
MOD_PKA_2	234	240	PF00069	0.470
MOD_Plk_4	152	158	PF00069	0.408
MOD_Plk_4	178	184	PF00069	0.442
MOD_Plk_4	274	280	PF00069	0.288
MOD_ProDKin_1	170	176	PF00069	0.311
MOD_ProDKin_1	224	230	PF00069	0.550
MOD_ProDKin_1	26	32	PF00069	0.681
MOD_ProDKin_1	4	10	PF00069	0.793
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.341
TRG_ENDOCYTIC_2	175	178	PF00928	0.527
TRG_ENDOCYTIC_2	269	272	PF00928	0.329
TRG_ENDOCYTIC_2	327	330	PF00928	0.430
TRG_ENDOCYTIC_2	99	102	PF00928	0.529
TRG_ER_diArg_1	247	249	PF00400	0.457
TRG_ER_diArg_1	312	314	PF00400	0.414
TRG_ER_diArg_1	325	327	PF00400	0.420
TRG_NES_CRM1_1	305	320	PF08389	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD69	Leptomonas seymouri	67%	100%
A0A0S4J2G4	Bodo saltans	33%	100%
A0A1X0NP33	Trypanosomatidae	28%	100%
A0A1X0NQ13	Trypanosomatidae	42%	100%
A0A1X0P6F0	Trypanosomatidae	22%	100%
A0A1X0P6P9	Trypanosomatidae	22%	100%
A0A3R7K844	Trypanosoma rangeli	23%	100%
A0A3R7KEL4	Trypanosoma rangeli	25%	100%
A0A3R7NBU8	Trypanosoma rangeli	29%	100%
A0A3S7WT37	Leishmania donovani	93%	100%
A0A422N466	Trypanosoma rangeli	43%	100%
A4H7Q2	Leishmania braziliensis	81%	100%
A4HW41	Leishmania infantum	94%	100%
C9ZSY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A0D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
E9APU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
K7VYZ9	Zea mays	24%	100%
P02723	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	24%	100%
P04710	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P18239	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	100%
P27080	Chlamydomonas reinhardtii	24%	100%
P31692	Parachlorella kessleri	21%	100%
Q505J6	Rattus norvegicus	26%	100%
Q5IS35	Macaca fascicularis	20%	100%
Q7PQV7	Anopheles gambiae	23%	100%
Q9DB41	Mus musculus	27%	100%
V5BNE7	Trypanosoma cruzi	42%	100%
V5BWX9	Trypanosoma cruzi	23%	100%