Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFN5_LEIMA

TriTrypDb:

LmjF.14.1000 , LMJLV39_140016800 , LMJSD75_140016200

Length:

436

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QFN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.593
CLV_NRD_NRD_1	243	245	PF00675	0.554
CLV_NRD_NRD_1	26	28	PF00675	0.370
CLV_NRD_NRD_1	378	380	PF00675	0.471
CLV_NRD_NRD_1	90	92	PF00675	0.411
CLV_PCSK_KEX2_1	11	13	PF00082	0.596
CLV_PCSK_KEX2_1	243	245	PF00082	0.552
CLV_PCSK_KEX2_1	25	27	PF00082	0.386
CLV_PCSK_KEX2_1	378	380	PF00082	0.471
CLV_PCSK_SKI1_1	26	30	PF00082	0.462
CLV_PCSK_SKI1_1	265	269	PF00082	0.375
CLV_PCSK_SKI1_1	34	38	PF00082	0.375
CLV_PCSK_SKI1_1	351	355	PF00082	0.409
CLV_PCSK_SKI1_1	74	78	PF00082	0.491
CLV_PCSK_SKI1_1	92	96	PF00082	0.351
DEG_APCC_DBOX_1	350	358	PF00400	0.563
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.589
DOC_MAPK_gen_1	138	146	PF00069	0.611
DOC_MAPK_gen_1	208	216	PF00069	0.585
DOC_MAPK_gen_1	349	357	PF00069	0.555
DOC_MAPK_MEF2A_6	324	332	PF00069	0.356
DOC_USP7_MATH_1	160	164	PF00917	0.500
DOC_USP7_MATH_1	220	224	PF00917	0.609
DOC_USP7_MATH_1	301	305	PF00917	0.432
DOC_USP7_MATH_1	43	47	PF00917	0.710
DOC_USP7_MATH_1	65	69	PF00917	0.635
DOC_USP7_MATH_1	97	101	PF00917	0.700
DOC_WW_Pin1_4	106	111	PF00397	0.776
DOC_WW_Pin1_4	370	375	PF00397	0.793
LIG_14-3-3_CanoR_1	116	123	PF00244	0.629
LIG_14-3-3_CanoR_1	208	218	PF00244	0.554
LIG_14-3-3_CanoR_1	247	255	PF00244	0.676
LIG_14-3-3_CanoR_1	25	33	PF00244	0.681
LIG_14-3-3_CanoR_1	279	284	PF00244	0.601
LIG_14-3-3_CanoR_1	45	51	PF00244	0.638
LIG_14-3-3_CanoR_1	96	104	PF00244	0.667
LIG_Actin_WH2_2	195	210	PF00022	0.402
LIG_BIR_II_1	1	5	PF00653	0.705
LIG_Clathr_ClatBox_1	77	81	PF01394	0.682
LIG_FHA_1	211	217	PF00498	0.543
LIG_FHA_1	410	416	PF00498	0.405
LIG_FHA_1	52	58	PF00498	0.710
LIG_FHA_2	47	53	PF00498	0.669
LIG_FHA_2	82	88	PF00498	0.498
LIG_Integrin_isoDGR_2	176	178	PF01839	0.599
LIG_LIR_Nem_3	118	123	PF02991	0.657
LIG_LIR_Nem_3	252	258	PF02991	0.615
LIG_LIR_Nem_3	421	425	PF02991	0.419
LIG_MYND_1	229	233	PF01753	0.643
LIG_NRBOX	327	333	PF00104	0.356
LIG_PCNA_yPIPBox_3	395	403	PF02747	0.560
LIG_PTAP_UEV_1	425	430	PF05743	0.452
LIG_SH2_GRB2like	383	386	PF00017	0.567
LIG_SH2_NCK_1	248	252	PF00017	0.647
LIG_SH2_SRC	383	386	PF00017	0.567
LIG_SH2_STAT5	248	251	PF00017	0.610
LIG_SH3_1	167	173	PF00018	0.382
LIG_SH3_3	167	173	PF00018	0.382
LIG_SH3_3	223	229	PF00018	0.699
LIG_SH3_3	286	292	PF00018	0.621
LIG_SH3_3	423	429	PF00018	0.530
LIG_WRC_WIRS_1	148	153	PF05994	0.405
LIG_WRC_WIRS_1	419	424	PF05994	0.408
MOD_CDK_SPK_2	108	113	PF00069	0.644
MOD_CDK_SPxxK_3	106	113	PF00069	0.733
MOD_CK1_1	201	207	PF00069	0.502
MOD_CK1_1	304	310	PF00069	0.279
MOD_CK1_1	46	52	PF00069	0.742
MOD_CK1_1	63	69	PF00069	0.514
MOD_CK2_1	147	153	PF00069	0.417
MOD_CK2_1	247	253	PF00069	0.649
MOD_CK2_1	81	87	PF00069	0.506
MOD_GlcNHglycan	1	4	PF01048	0.556
MOD_GlcNHglycan	117	120	PF01048	0.451
MOD_GlcNHglycan	249	252	PF01048	0.474
MOD_GlcNHglycan	303	306	PF01048	0.298
MOD_GlcNHglycan	311	314	PF01048	0.320
MOD_GlcNHglycan	399	402	PF01048	0.264
MOD_GlcNHglycan	431	434	PF01048	0.688
MOD_GlcNHglycan	54	57	PF01048	0.433
MOD_GlcNHglycan	67	70	PF01048	0.368
MOD_GSK3_1	102	109	PF00069	0.723
MOD_GSK3_1	190	197	PF00069	0.441
MOD_GSK3_1	275	282	PF00069	0.559
MOD_GSK3_1	92	99	PF00069	0.679
MOD_NEK2_1	190	195	PF00069	0.359
MOD_NEK2_1	198	203	PF00069	0.336
MOD_NEK2_1	219	224	PF00069	0.694
MOD_NEK2_1	28	33	PF00069	0.688
MOD_NEK2_1	285	290	PF00069	0.615
MOD_NEK2_1	303	308	PF00069	0.377
MOD_NEK2_1	410	415	PF00069	0.477
MOD_NEK2_1	418	423	PF00069	0.477
MOD_NEK2_1	60	65	PF00069	0.648
MOD_PKA_1	26	32	PF00069	0.686
MOD_PKA_2	102	108	PF00069	0.705
MOD_PKA_2	112	118	PF00069	0.623
MOD_PKA_2	210	216	PF00069	0.589
MOD_PKA_2	246	252	PF00069	0.631
MOD_PKA_2	26	32	PF00069	0.691
MOD_PKA_2	44	50	PF00069	0.645
MOD_PKA_2	95	101	PF00069	0.653
MOD_Plk_1	220	226	PF00069	0.632
MOD_Plk_1	29	35	PF00069	0.758
MOD_Plk_4	147	153	PF00069	0.405
MOD_Plk_4	194	200	PF00069	0.379
MOD_Plk_4	411	417	PF00069	0.513
MOD_ProDKin_1	106	112	PF00069	0.774
MOD_ProDKin_1	370	376	PF00069	0.789
TRG_DiLeu_BaEn_4	23	29	PF01217	0.672
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.362
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.514
TRG_ER_diArg_1	10	12	PF00400	0.794
TRG_ER_diArg_1	25	27	PF00400	0.576
TRG_ER_diArg_1	348	351	PF00400	0.577
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I9V0	Leishmania donovani	89%	100%
A4H7Q3	Leishmania braziliensis	72%	98%
A4HW42	Leishmania infantum	89%	100%
E9APU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%