Ubiquinone biosynthesis protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COQ9, putative

Species:

Leishmania major

UniProt:

Q4QFN0_LEIMA

TriTrypDb:

LmjF.14.1050 , LMJLV39_140017400 , LMJSD75_140016800

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	2
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9

Expansion

Sequence features

Q4QFN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFN0

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	11
GO:0006744	ubiquinone biosynthetic process	6	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0042180	cellular ketone metabolic process	3	11
GO:0042181	ketone biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901661	quinone metabolic process	4	11
GO:1901663	quinone biosynthetic process	5	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008289	lipid binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.381
CLV_NRD_NRD_1	176	178	PF00675	0.474
CLV_PCSK_KEX2_1	176	178	PF00082	0.471
CLV_PCSK_KEX2_1	232	234	PF00082	0.282
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.317
CLV_PCSK_SKI1_1	103	107	PF00082	0.532
CLV_PCSK_SKI1_1	115	119	PF00082	0.341
CLV_PCSK_SKI1_1	176	180	PF00082	0.500
CLV_PCSK_SKI1_1	206	210	PF00082	0.455
CLV_PCSK_SKI1_1	259	263	PF00082	0.288
DEG_Nend_UBRbox_4	1	3	PF02207	0.587
DEG_SPOP_SBC_1	242	246	PF00917	0.298
DOC_CYCLIN_RxL_1	100	109	PF00134	0.517
DOC_MAPK_gen_1	232	238	PF00069	0.283
DOC_MAPK_MEF2A_6	120	127	PF00069	0.248
DOC_PP2B_LxvP_1	104	107	PF13499	0.388
DOC_PP2B_LxvP_1	123	126	PF13499	0.336
DOC_USP7_MATH_1	183	187	PF00917	0.544
DOC_USP7_MATH_1	220	224	PF00917	0.267
DOC_USP7_UBL2_3	206	210	PF12436	0.353
DOC_WW_Pin1_4	196	201	PF00397	0.482
DOC_WW_Pin1_4	3	8	PF00397	0.508
LIG_14-3-3_CanoR_1	164	169	PF00244	0.465
LIG_BRCT_BRCA1_1	51	55	PF00533	0.428
LIG_FHA_1	242	248	PF00498	0.447
LIG_FHA_1	256	262	PF00498	0.373
LIG_FHA_2	165	171	PF00498	0.370
LIG_LIR_Apic_2	216	222	PF02991	0.263
LIG_NRBOX	167	173	PF00104	0.447
LIG_PAM2_1	130	142	PF00658	0.361
LIG_PCNA_yPIPBox_3	69	83	PF02747	0.244
LIG_PDZ_Class_1	265	270	PF00595	0.263
LIG_Pex14_2	204	208	PF04695	0.322
LIG_Pex14_2	55	59	PF04695	0.301
LIG_PTB_Apo_2	53	60	PF02174	0.350
LIG_SH2_CRK	219	223	PF00017	0.353
LIG_SH2_CRK	240	244	PF00017	0.270
LIG_SH2_SRC	139	142	PF00017	0.521
LIG_SH2_STAT5	139	142	PF00017	0.443
LIG_SH2_STAT5	146	149	PF00017	0.457
LIG_SH2_STAT5	230	233	PF00017	0.298
LIG_SUMO_SIM_anti_2	119	125	PF11976	0.392
LIG_SUMO_SIM_par_1	59	65	PF11976	0.275
LIG_TYR_ITIM	238	243	PF00017	0.316
LIG_Vh1_VBS_1	144	162	PF01044	0.349
LIG_WRC_WIRS_1	205	210	PF05994	0.438
MOD_CK1_1	199	205	PF00069	0.543
MOD_CK1_1	213	219	PF00069	0.487
MOD_CK1_1	37	43	PF00069	0.489
MOD_CK1_1	81	87	PF00069	0.410
MOD_CK1_1	91	97	PF00069	0.436
MOD_CK2_1	116	122	PF00069	0.344
MOD_CK2_1	164	170	PF00069	0.453
MOD_GlcNHglycan	132	135	PF01048	0.396
MOD_GlcNHglycan	189	192	PF01048	0.629
MOD_GlcNHglycan	215	218	PF01048	0.319
MOD_GlcNHglycan	222	225	PF01048	0.250
MOD_GSK3_1	183	190	PF00069	0.589
MOD_GSK3_1	192	199	PF00069	0.561
MOD_GSK3_1	255	262	PF00069	0.326
MOD_NEK2_1	154	159	PF00069	0.286
MOD_NEK2_1	204	209	PF00069	0.318
MOD_NEK2_1	34	39	PF00069	0.335
MOD_NEK2_2	265	270	PF00069	0.311
MOD_PIKK_1	249	255	PF00454	0.239
MOD_PIKK_1	49	55	PF00454	0.310
MOD_PKA_2	163	169	PF00069	0.353
MOD_Plk_1	155	161	PF00069	0.296
MOD_Plk_1	47	53	PF00069	0.412
MOD_Plk_4	144	150	PF00069	0.345
MOD_Plk_4	155	161	PF00069	0.435
MOD_Plk_4	204	210	PF00069	0.487
MOD_Plk_4	243	249	PF00069	0.314
MOD_Plk_4	78	84	PF00069	0.443
MOD_ProDKin_1	196	202	PF00069	0.470
MOD_ProDKin_1	3	9	PF00069	0.500
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.371
TRG_ENDOCYTIC_2	146	149	PF00928	0.480
TRG_ENDOCYTIC_2	240	243	PF00928	0.270
TRG_ER_diArg_1	176	178	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P430	Leptomonas seymouri	63%	100%
A0A1X0NP57	Trypanosomatidae	37%	97%
A0A3Q8IC23	Leishmania donovani	92%	100%
A0A422MQP2	Trypanosoma rangeli	40%	96%
A4H7Q9	Leishmania braziliensis	76%	100%
A4HW47	Leishmania infantum	92%	100%
C9ZSX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	88%
E9APV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q8MKN0	Drosophila melanogaster	27%	83%
V5BEC0	Trypanosoma cruzi	38%	96%