Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CMGC/DYRK protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QFM8_LEIMA

TriTrypDb:

LmjF.14.1070 , LMJLV39_140017800 , LMJSD75_140017200

Length:

908

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFM8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018107	peptidyl-threonine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0018210	peptidyl-threonine modification	6	2
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004713	protein tyrosine kinase activity	4	2
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.770
CLV_C14_Caspase3-7	43	47	PF00656	0.754
CLV_NRD_NRD_1	10	12	PF00675	0.592
CLV_NRD_NRD_1	201	203	PF00675	0.788
CLV_NRD_NRD_1	255	257	PF00675	0.663
CLV_NRD_NRD_1	414	416	PF00675	0.554
CLV_NRD_NRD_1	568	570	PF00675	0.532
CLV_NRD_NRD_1	659	661	PF00675	0.289
CLV_NRD_NRD_1	777	779	PF00675	0.330
CLV_NRD_NRD_1	839	841	PF00675	0.412
CLV_PCSK_FUR_1	423	427	PF00082	0.647
CLV_PCSK_FUR_1	657	661	PF00082	0.287
CLV_PCSK_KEX2_1	201	203	PF00082	0.791
CLV_PCSK_KEX2_1	255	257	PF00082	0.663
CLV_PCSK_KEX2_1	364	366	PF00082	0.684
CLV_PCSK_KEX2_1	414	416	PF00082	0.551
CLV_PCSK_KEX2_1	425	427	PF00082	0.539
CLV_PCSK_KEX2_1	568	570	PF00082	0.496
CLV_PCSK_KEX2_1	659	661	PF00082	0.287
CLV_PCSK_KEX2_1	777	779	PF00082	0.330
CLV_PCSK_KEX2_1	890	892	PF00082	0.330
CLV_PCSK_KEX2_1	9	11	PF00082	0.593
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.684
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.654
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.496
CLV_PCSK_PC1ET2_1	890	892	PF00082	0.330
CLV_PCSK_PC7_1	564	570	PF00082	0.581
CLV_PCSK_SKI1_1	45	49	PF00082	0.643
CLV_PCSK_SKI1_1	569	573	PF00082	0.521
CLV_PCSK_SKI1_1	586	590	PF00082	0.196
CLV_PCSK_SKI1_1	597	601	PF00082	0.310
CLV_PCSK_SKI1_1	659	663	PF00082	0.422
CLV_PCSK_SKI1_1	777	781	PF00082	0.310
CLV_Separin_Metazoa	631	635	PF03568	0.433
DEG_COP1_1	756	763	PF00400	0.310
DEG_Nend_Nbox_1	1	3	PF02207	0.532
DEG_SCF_FBW7_1	824	830	PF00400	0.433
DEG_SPOP_SBC_1	37	41	PF00917	0.620
DEG_SPOP_SBC_1	852	856	PF00917	0.377
DOC_CDC14_PxL_1	652	660	PF14671	0.330
DOC_CKS1_1	824	829	PF01111	0.310
DOC_MAPK_gen_1	719	728	PF00069	0.310
DOC_MAPK_HePTP_8	716	728	PF00069	0.310
DOC_MAPK_MEF2A_6	719	728	PF00069	0.310
DOC_PP1_RVXF_1	399	406	PF00149	0.557
DOC_PP1_RVXF_1	696	703	PF00149	0.310
DOC_PP4_FxxP_1	319	322	PF00568	0.532
DOC_PP4_FxxP_1	653	656	PF00568	0.330
DOC_USP7_MATH_1	192	196	PF00917	0.770
DOC_USP7_MATH_1	373	377	PF00917	0.669
DOC_USP7_MATH_1	47	51	PF00917	0.781
DOC_USP7_MATH_1	560	564	PF00917	0.702
DOC_USP7_UBL2_3	551	555	PF12436	0.746
DOC_USP7_UBL2_3	562	566	PF12436	0.567
DOC_WW_Pin1_4	279	284	PF00397	0.772
DOC_WW_Pin1_4	388	393	PF00397	0.561
DOC_WW_Pin1_4	514	519	PF00397	0.697
DOC_WW_Pin1_4	770	775	PF00397	0.433
DOC_WW_Pin1_4	823	828	PF00397	0.310
DOC_WW_Pin1_4	95	100	PF00397	0.743
LIG_14-3-3_CanoR_1	104	112	PF00244	0.712
LIG_14-3-3_CanoR_1	136	144	PF00244	0.710
LIG_14-3-3_CanoR_1	18	22	PF00244	0.631
LIG_14-3-3_CanoR_1	255	264	PF00244	0.541
LIG_14-3-3_CanoR_1	302	307	PF00244	0.671
LIG_14-3-3_CanoR_1	426	432	PF00244	0.658
LIG_14-3-3_CanoR_1	597	602	PF00244	0.330
LIG_14-3-3_CanoR_1	784	793	PF00244	0.310
LIG_14-3-3_CanoR_1	853	858	PF00244	0.402
LIG_14-3-3_CanoR_1	891	898	PF00244	0.433
LIG_AP2alpha_2	441	443	PF02296	0.612
LIG_BRCT_BRCA1_1	703	707	PF00533	0.310
LIG_EH1_1	464	472	PF00400	0.382
LIG_FHA_1	10	16	PF00498	0.582
LIG_FHA_1	204	210	PF00498	0.787
LIG_FHA_1	226	232	PF00498	0.608
LIG_FHA_1	252	258	PF00498	0.630
LIG_FHA_1	37	43	PF00498	0.669
LIG_FHA_1	431	437	PF00498	0.605
LIG_FHA_1	628	634	PF00498	0.325
LIG_FHA_1	660	666	PF00498	0.422
LIG_FHA_1	71	77	PF00498	0.717
LIG_FHA_1	748	754	PF00498	0.310
LIG_FHA_1	85	91	PF00498	0.619
LIG_FHA_2	129	135	PF00498	0.564
LIG_FHA_2	219	225	PF00498	0.724
LIG_FHA_2	38	44	PF00498	0.779
LIG_FHA_2	443	449	PF00498	0.498
LIG_FHA_2	634	640	PF00498	0.433
LIG_FHA_2	757	763	PF00498	0.313
LIG_FHA_2	891	897	PF00498	0.447
LIG_LIR_Apic_2	650	656	PF02991	0.330
LIG_LIR_Apic_2	718	724	PF02991	0.310
LIG_LIR_Gen_1	20	28	PF02991	0.572
LIG_LIR_Gen_1	369	380	PF02991	0.669
LIG_LIR_Gen_1	390	399	PF02991	0.551
LIG_LIR_Gen_1	402	410	PF02991	0.540
LIG_LIR_Gen_1	856	867	PF02991	0.355
LIG_LIR_Gen_1	873	884	PF02991	0.310
LIG_LIR_Nem_3	20	24	PF02991	0.557
LIG_LIR_Nem_3	221	226	PF02991	0.626
LIG_LIR_Nem_3	369	375	PF02991	0.551
LIG_LIR_Nem_3	390	396	PF02991	0.570
LIG_LIR_Nem_3	402	408	PF02991	0.560
LIG_LIR_Nem_3	450	456	PF02991	0.504
LIG_LIR_Nem_3	639	643	PF02991	0.310
LIG_LIR_Nem_3	650	655	PF02991	0.310
LIG_LIR_Nem_3	819	825	PF02991	0.313
LIG_LIR_Nem_3	856	862	PF02991	0.330
LIG_LIR_Nem_3	873	879	PF02991	0.310
LIG_MAD2	766	774	PF02301	0.310
LIG_NRBOX	597	603	PF00104	0.433
LIG_PDZ_Class_2	903	908	PF00595	0.568
LIG_Pex14_2	443	447	PF04695	0.628
LIG_SH2_CRK	223	227	PF00017	0.630
LIG_SH2_CRK	574	578	PF00017	0.433
LIG_SH2_CRK	825	829	PF00017	0.310
LIG_SH2_CRK	859	863	PF00017	0.310
LIG_SH2_GRB2like	789	792	PF00017	0.433
LIG_SH2_NCK_1	372	376	PF00017	0.647
LIG_SH2_NCK_1	465	469	PF00017	0.496
LIG_SH2_NCK_1	54	58	PF00017	0.680
LIG_SH2_NCK_1	825	829	PF00017	0.306
LIG_SH2_SRC	372	375	PF00017	0.610
LIG_SH2_SRC	465	468	PF00017	0.365
LIG_SH2_SRC	638	641	PF00017	0.310
LIG_SH2_SRC	671	674	PF00017	0.310
LIG_SH2_SRC	797	800	PF00017	0.433
LIG_SH2_STAP1	21	25	PF00017	0.594
LIG_SH2_STAP1	393	397	PF00017	0.651
LIG_SH2_STAP1	692	696	PF00017	0.433
LIG_SH2_STAT3	483	486	PF00017	0.524
LIG_SH2_STAT5	652	655	PF00017	0.310
LIG_SH2_STAT5	671	674	PF00017	0.310
LIG_SH2_STAT5	715	718	PF00017	0.310
LIG_SH2_STAT5	769	772	PF00017	0.310
LIG_SH2_STAT5	789	792	PF00017	0.150
LIG_SH2_STAT5	822	825	PF00017	0.314
LIG_SH3_1	280	286	PF00018	0.760
LIG_SH3_1	451	457	PF00018	0.571
LIG_SH3_3	280	286	PF00018	0.760
LIG_SH3_3	319	325	PF00018	0.523
LIG_SH3_3	386	392	PF00018	0.566
LIG_SH3_3	451	457	PF00018	0.571
LIG_SH3_3	846	852	PF00018	0.403
LIG_SH3_4	566	573	PF00018	0.426
LIG_SUMO_SIM_anti_2	624	631	PF11976	0.433
LIG_SUMO_SIM_par_1	394	400	PF11976	0.511
LIG_TRAF2_1	410	413	PF00917	0.526
LIG_TYR_ITIM	572	577	PF00017	0.456
LIG_TYR_ITSM	219	226	PF00017	0.739
LIG_UBA3_1	467	473	PF00899	0.416
LIG_WRC_WIRS_1	431	436	PF05994	0.498
LIG_WW_3	850	854	PF00397	0.447
MOD_CDK_SPxxK_3	770	777	PF00069	0.433
MOD_CK1_1	269	275	PF00069	0.751
MOD_CK1_1	376	382	PF00069	0.625
MOD_CK1_1	41	47	PF00069	0.780
MOD_CK1_1	839	845	PF00069	0.420
MOD_CK1_1	98	104	PF00069	0.752
MOD_CK2_1	10	16	PF00069	0.646
MOD_CK2_1	272	278	PF00069	0.687
MOD_CK2_1	37	43	PF00069	0.773
MOD_CK2_1	388	394	PF00069	0.601
MOD_CK2_1	442	448	PF00069	0.493
MOD_CK2_1	589	595	PF00069	0.315
MOD_CK2_1	74	80	PF00069	0.738
MOD_CK2_1	756	762	PF00069	0.313
MOD_CK2_1	890	896	PF00069	0.447
MOD_GlcNHglycan	261	264	PF01048	0.808
MOD_GlcNHglycan	274	277	PF01048	0.590
MOD_GlcNHglycan	287	290	PF01048	0.566
MOD_GlcNHglycan	368	371	PF01048	0.663
MOD_GlcNHglycan	374	378	PF01048	0.636
MOD_GlcNHglycan	512	515	PF01048	0.732
MOD_GlcNHglycan	547	550	PF01048	0.734
MOD_GlcNHglycan	82	85	PF01048	0.654
MOD_GlcNHglycan	893	896	PF01048	0.447
MOD_GSK3_1	266	273	PF00069	0.643
MOD_GSK3_1	298	305	PF00069	0.713
MOD_GSK3_1	33	40	PF00069	0.672
MOD_GSK3_1	383	390	PF00069	0.550
MOD_GSK3_1	41	48	PF00069	0.733
MOD_GSK3_1	510	517	PF00069	0.732
MOD_GSK3_1	534	541	PF00069	0.731
MOD_GSK3_1	556	563	PF00069	0.644
MOD_GSK3_1	56	63	PF00069	0.521
MOD_GSK3_1	667	674	PF00069	0.348
MOD_GSK3_1	70	77	PF00069	0.707
MOD_GSK3_1	702	709	PF00069	0.311
MOD_GSK3_1	711	718	PF00069	0.313
MOD_GSK3_1	80	87	PF00069	0.655
MOD_GSK3_1	823	830	PF00069	0.427
MOD_GSK3_1	832	839	PF00069	0.483
MOD_GSK3_1	853	860	PF00069	0.480
MOD_LATS_1	810	816	PF00433	0.237
MOD_LATS_1	888	894	PF00433	0.439
MOD_N-GLC_1	266	271	PF02516	0.749
MOD_N-GLC_1	302	307	PF02516	0.781
MOD_N-GLC_1	37	42	PF02516	0.737
MOD_N-GLC_1	582	587	PF02516	0.310
MOD_NEK2_1	2	7	PF00069	0.632
MOD_NEK2_1	382	387	PF00069	0.647
MOD_NEK2_1	633	638	PF00069	0.417
MOD_NEK2_1	651	656	PF00069	0.320
MOD_NEK2_1	688	693	PF00069	0.310
MOD_NEK2_1	702	707	PF00069	0.310
MOD_PIKK_1	104	110	PF00454	0.779
MOD_PIKK_1	135	141	PF00454	0.728
MOD_PIKK_1	142	148	PF00454	0.701
MOD_PIKK_1	192	198	PF00454	0.767
MOD_PIKK_1	225	231	PF00454	0.631
MOD_PIKK_1	74	80	PF00454	0.738
MOD_PK_1	11	17	PF00069	0.648
MOD_PKA_1	659	665	PF00069	0.417
MOD_PKA_1	890	896	PF00069	0.433
MOD_PKA_1	9	15	PF00069	0.591
MOD_PKA_2	135	141	PF00069	0.665
MOD_PKA_2	17	23	PF00069	0.578
MOD_PKA_2	267	273	PF00069	0.669
MOD_PKA_2	538	544	PF00069	0.736
MOD_PKA_2	633	639	PF00069	0.433
MOD_PKA_2	659	665	PF00069	0.417
MOD_PKA_2	783	789	PF00069	0.310
MOD_PKA_2	839	845	PF00069	0.433
MOD_PKA_2	852	858	PF00069	0.434
MOD_PKA_2	890	896	PF00069	0.438
MOD_PKA_2	9	15	PF00069	0.591
MOD_PKB_1	657	665	PF00069	0.433
MOD_PKB_1	9	17	PF00069	0.647
MOD_Plk_1	302	308	PF00069	0.660
MOD_Plk_1	37	43	PF00069	0.720
MOD_Plk_1	382	388	PF00069	0.683
MOD_Plk_1	589	595	PF00069	0.310
MOD_Plk_2-3	167	173	PF00069	0.751
MOD_Plk_2-3	493	499	PF00069	0.696
MOD_Plk_4	456	462	PF00069	0.425
MOD_Plk_4	597	603	PF00069	0.329
MOD_Plk_4	633	639	PF00069	0.376
MOD_Plk_4	667	673	PF00069	0.330
MOD_Plk_4	711	717	PF00069	0.310
MOD_Plk_4	857	863	PF00069	0.349
MOD_ProDKin_1	279	285	PF00069	0.773
MOD_ProDKin_1	388	394	PF00069	0.558
MOD_ProDKin_1	514	520	PF00069	0.698
MOD_ProDKin_1	770	776	PF00069	0.433
MOD_ProDKin_1	823	829	PF00069	0.310
MOD_ProDKin_1	95	101	PF00069	0.745
MOD_SUMO_for_1	682	685	PF00179	0.310
MOD_SUMO_rev_2	272	282	PF00179	0.773
MOD_SUMO_rev_2	41	47	PF00179	0.755
MOD_SUMO_rev_2	448	453	PF00179	0.462
MOD_SUMO_rev_2	646	651	PF00179	0.377
TRG_DiLeu_BaEn_1	624	629	PF01217	0.310
TRG_DiLeu_BaEn_2	684	690	PF01217	0.310
TRG_DiLeu_BaEn_3	874	880	PF01217	0.377
TRG_DiLeu_BaEn_4	819	825	PF01217	0.433
TRG_DiLeu_BaLyEn_6	594	599	PF01217	0.310
TRG_DiLeu_BaLyEn_6	612	617	PF01217	0.310
TRG_ENDOCYTIC_2	21	24	PF00928	0.552
TRG_ENDOCYTIC_2	223	226	PF00928	0.634
TRG_ENDOCYTIC_2	240	243	PF00928	0.390
TRG_ENDOCYTIC_2	372	375	PF00928	0.636
TRG_ENDOCYTIC_2	393	396	PF00928	0.649
TRG_ENDOCYTIC_2	465	468	PF00928	0.365
TRG_ENDOCYTIC_2	574	577	PF00928	0.367
TRG_ENDOCYTIC_2	652	655	PF00928	0.310
TRG_ENDOCYTIC_2	825	828	PF00928	0.330
TRG_ENDOCYTIC_2	859	862	PF00928	0.310
TRG_ER_diArg_1	255	257	PF00400	0.586
TRG_ER_diArg_1	414	417	PF00400	0.573
TRG_ER_diArg_1	656	659	PF00400	0.311
TRG_ER_diArg_1	776	778	PF00400	0.330
TRG_ER_diArg_1	9	11	PF00400	0.595
TRG_NES_CRM1_1	667	681	PF08389	0.310
TRG_NES_CRM1_1	875	887	PF08389	0.433
TRG_NLS_MonoExtN_4	566	572	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	419	424	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	659	664	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G9	Leptomonas seymouri	73%	88%
A0A1X0NNI0	Trypanosomatidae	53%	100%
A0A3Q8IIF0	Leishmania donovani	94%	87%
A0A422MWR8	Trypanosoma rangeli	47%	100%
A4H7R1	Leishmania braziliensis	80%	88%
A4HW49	Leishmania infantum	94%	100%
C9ZSX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9APV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AZ01	Trypanosoma cruzi	47%	100%