Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFM7_LEIMA

TriTrypDb:

LmjF.14.1080 , LMJLV39_140017900 , LMJSD75_140017300

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.428
CLV_C14_Caspase3-7	97	101	PF00656	0.608
CLV_NRD_NRD_1	137	139	PF00675	0.426
CLV_NRD_NRD_1	180	182	PF00675	0.432
CLV_NRD_NRD_1	3	5	PF00675	0.579
CLV_NRD_NRD_1	303	305	PF00675	0.576
CLV_PCSK_KEX2_1	117	119	PF00082	0.639
CLV_PCSK_KEX2_1	137	139	PF00082	0.304
CLV_PCSK_KEX2_1	3	5	PF00082	0.579
CLV_PCSK_KEX2_1	303	305	PF00082	0.576
CLV_PCSK_KEX2_1	326	328	PF00082	0.536
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.639
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.517
CLV_PCSK_SKI1_1	10	14	PF00082	0.510
CLV_PCSK_SKI1_1	137	141	PF00082	0.439
CLV_PCSK_SKI1_1	305	309	PF00082	0.706
CLV_PCSK_SKI1_1	323	327	PF00082	0.418
CLV_PCSK_SKI1_1	338	342	PF00082	0.357
CLV_PCSK_SKI1_1	90	94	PF00082	0.602
CLV_Separin_Metazoa	231	235	PF03568	0.548
DEG_APCC_DBOX_1	136	144	PF00400	0.374
DEG_APCC_DBOX_1	180	188	PF00400	0.476
DEG_Nend_UBRbox_3	1	3	PF02207	0.507
DEG_SCF_FBW7_2	128	135	PF00400	0.525
DEG_SPOP_SBC_1	170	174	PF00917	0.614
DOC_CKS1_1	129	134	PF01111	0.441
DOC_CYCLIN_RxL_1	179	188	PF00134	0.482
DOC_MAPK_DCC_7	79	88	PF00069	0.637
DOC_MAPK_FxFP_2	29	32	PF00069	0.508
DOC_MAPK_FxFP_2	341	344	PF00069	0.443
DOC_MAPK_HePTP_8	76	88	PF00069	0.586
DOC_MAPK_MEF2A_6	79	88	PF00069	0.637
DOC_PP1_RVXF_1	336	342	PF00149	0.368
DOC_PP2B_LxvP_1	149	152	PF13499	0.598
DOC_PP2B_LxvP_1	154	157	PF13499	0.601
DOC_PP4_FxxP_1	129	132	PF00568	0.528
DOC_PP4_FxxP_1	276	279	PF00568	0.527
DOC_PP4_FxxP_1	29	32	PF00568	0.508
DOC_PP4_FxxP_1	341	344	PF00568	0.443
DOC_USP7_MATH_1	170	174	PF00917	0.591
DOC_USP7_MATH_1	195	199	PF00917	0.517
DOC_USP7_MATH_1	267	271	PF00917	0.646
DOC_USP7_MATH_1	330	334	PF00917	0.487
DOC_USP7_MATH_1	36	40	PF00917	0.675
DOC_USP7_MATH_1	94	98	PF00917	0.588
DOC_WW_Pin1_4	12	17	PF00397	0.518
DOC_WW_Pin1_4	128	133	PF00397	0.454
DOC_WW_Pin1_4	159	164	PF00397	0.629
DOC_WW_Pin1_4	166	171	PF00397	0.664
DOC_WW_Pin1_4	309	314	PF00397	0.635
LIG_14-3-3_CanoR_1	10	15	PF00244	0.509
LIG_14-3-3_CanoR_1	153	157	PF00244	0.650
LIG_14-3-3_CanoR_1	216	222	PF00244	0.497
LIG_14-3-3_CanoR_1	79	87	PF00244	0.630
LIG_BIR_III_2	167	171	PF00653	0.577
LIG_BIR_III_4	35	39	PF00653	0.506
LIG_BRCT_BRCA1_1	272	276	PF00533	0.525
LIG_deltaCOP1_diTrp_1	8	11	PF00928	0.544
LIG_FHA_1	146	152	PF00498	0.503
LIG_FHA_1	227	233	PF00498	0.527
LIG_FHA_1	282	288	PF00498	0.505
LIG_FHA_2	218	224	PF00498	0.422
LIG_HP1_1	183	187	PF01393	0.462
LIG_IBAR_NPY_1	235	237	PF08397	0.537
LIG_LIR_Apic_2	273	279	PF02991	0.526
LIG_LIR_Gen_1	211	219	PF02991	0.500
LIG_LIR_Gen_1	246	255	PF02991	0.594
LIG_LIR_Gen_1	293	302	PF02991	0.552
LIG_LIR_Gen_1	318	329	PF02991	0.544
LIG_LIR_Gen_1	366	374	PF02991	0.458
LIG_LIR_Gen_1	8	19	PF02991	0.522
LIG_LIR_Nem_3	108	114	PF02991	0.675
LIG_LIR_Nem_3	131	136	PF02991	0.435
LIG_LIR_Nem_3	211	215	PF02991	0.455
LIG_LIR_Nem_3	246	252	PF02991	0.493
LIG_LIR_Nem_3	293	298	PF02991	0.531
LIG_LIR_Nem_3	318	324	PF02991	0.556
LIG_LIR_Nem_3	366	370	PF02991	0.423
LIG_LIR_Nem_3	8	14	PF02991	0.536
LIG_MYND_1	16	20	PF01753	0.542
LIG_Pex14_1	390	394	PF04695	0.437
LIG_Pex14_2	129	133	PF04695	0.516
LIG_REV1ctd_RIR_1	368	375	PF16727	0.467
LIG_RPA_C_Fungi	299	311	PF08784	0.526
LIG_SH2_NCK_1	241	245	PF00017	0.560
LIG_SH2_SRC	241	244	PF00017	0.535
LIG_SH2_STAT5	214	217	PF00017	0.573
LIG_SH2_STAT5	295	298	PF00017	0.522
LIG_SH2_STAT5	335	338	PF00017	0.421
LIG_SH2_STAT5	367	370	PF00017	0.457
LIG_SH3_3	230	236	PF00018	0.642
LIG_SUMO_SIM_par_1	182	188	PF11976	0.456
LIG_TRAF2_1	101	104	PF00917	0.622
LIG_TYR_ITIM	239	244	PF00017	0.595
LIG_UBA3_1	296	305	PF00899	0.567
MOD_CDK_SPK_2	159	164	PF00069	0.629
MOD_CDK_SPxK_1	128	134	PF00069	0.451
MOD_CK1_1	169	175	PF00069	0.590
MOD_CK1_1	196	202	PF00069	0.517
MOD_CK1_1	270	276	PF00069	0.745
MOD_CK1_1	34	40	PF00069	0.577
MOD_CK1_1	78	84	PF00069	0.596
MOD_CK2_1	287	293	PF00069	0.550
MOD_CK2_1	98	104	PF00069	0.623
MOD_GlcNHglycan	123	126	PF01048	0.556
MOD_GlcNHglycan	187	190	PF01048	0.419
MOD_GlcNHglycan	269	272	PF01048	0.580
MOD_GlcNHglycan	35	39	PF01048	0.515
MOD_GlcNHglycan	95	99	PF01048	0.697
MOD_GSK3_1	155	162	PF00069	0.626
MOD_GSK3_1	166	173	PF00069	0.530
MOD_GSK3_1	195	202	PF00069	0.585
MOD_GSK3_1	267	274	PF00069	0.615
MOD_GSK3_1	277	284	PF00069	0.636
MOD_GSK3_1	311	318	PF00069	0.689
MOD_GSK3_1	356	363	PF00069	0.560
MOD_GSK3_1	90	97	PF00069	0.649
MOD_N-GLC_1	281	286	PF02516	0.505
MOD_N-GLC_1	345	350	PF02516	0.401
MOD_N-GLC_2	72	74	PF02516	0.565
MOD_NEK2_1	116	121	PF00069	0.487
MOD_NEK2_1	250	255	PF00069	0.602
MOD_NEK2_2	272	277	PF00069	0.527
MOD_PIKK_1	281	287	PF00454	0.524
MOD_PIKK_1	360	366	PF00454	0.575
MOD_PKA_2	152	158	PF00069	0.573
MOD_PKA_2	43	49	PF00069	0.622
MOD_PKA_2	78	84	PF00069	0.633
MOD_Plk_1	356	362	PF00069	0.532
MOD_Plk_2-3	226	232	PF00069	0.509
MOD_Plk_4	217	223	PF00069	0.430
MOD_Plk_4	345	351	PF00069	0.415
MOD_ProDKin_1	12	18	PF00069	0.516
MOD_ProDKin_1	128	134	PF00069	0.451
MOD_ProDKin_1	159	165	PF00069	0.632
MOD_ProDKin_1	166	172	PF00069	0.661
MOD_ProDKin_1	309	315	PF00069	0.636
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.526
TRG_ENDOCYTIC_2	241	244	PF00928	0.597
TRG_ENDOCYTIC_2	295	298	PF00928	0.489
TRG_ENDOCYTIC_2	367	370	PF00928	0.398
TRG_ER_diArg_1	136	138	PF00400	0.437
TRG_ER_diArg_1	3	5	PF00400	0.579
TRG_ER_diArg_1	302	304	PF00400	0.550
TRG_ER_diArg_1	41	44	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P428	Leptomonas seymouri	50%	100%
A0A3S7WT47	Leishmania donovani	92%	100%
A4H7R2	Leishmania braziliensis	71%	95%
A4HW50	Leishmania infantum	92%	100%
E9APV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	95%