WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFM1_LEIMA

TriTrypDb:

LmjF.14.1130 , LMJLV39_140019000 , LMJSD75_140018500

Length:

929

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005858	axonemal dynein complex	4	2
GO:0005875	microtubule associated complex	2	2
GO:0030286	dynein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

Q4QFM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFM1

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	2
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045503	dynein light chain binding	3	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.587
CLV_C14_Caspase3-7	671	675	PF00656	0.715
CLV_NRD_NRD_1	216	218	PF00675	0.666
CLV_NRD_NRD_1	257	259	PF00675	0.646
CLV_NRD_NRD_1	432	434	PF00675	0.633
CLV_NRD_NRD_1	513	515	PF00675	0.627
CLV_NRD_NRD_1	6	8	PF00675	0.558
CLV_NRD_NRD_1	728	730	PF00675	0.783
CLV_PCSK_KEX2_1	256	258	PF00082	0.660
CLV_PCSK_KEX2_1	513	515	PF00082	0.627
CLV_PCSK_KEX2_1	6	8	PF00082	0.553
CLV_PCSK_KEX2_1	728	730	PF00082	0.783
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.553
CLV_PCSK_SKI1_1	17	21	PF00082	0.546
CLV_PCSK_SKI1_1	225	229	PF00082	0.682
CLV_PCSK_SKI1_1	258	262	PF00082	0.618
CLV_PCSK_SKI1_1	365	369	PF00082	0.696
CLV_PCSK_SKI1_1	409	413	PF00082	0.576
CLV_PCSK_SKI1_1	47	51	PF00082	0.642
CLV_PCSK_SKI1_1	513	517	PF00082	0.551
CLV_PCSK_SKI1_1	634	638	PF00082	0.545
CLV_PCSK_SKI1_1	74	78	PF00082	0.661
DEG_APCC_DBOX_1	6	14	PF00400	0.552
DEG_Nend_UBRbox_2	1	3	PF02207	0.587
DEG_SCF_FBW7_1	818	824	PF00400	0.493
DEG_SPOP_SBC_1	39	43	PF00917	0.742
DEG_SPOP_SBC_1	651	655	PF00917	0.613
DEG_SPOP_SBC_1	67	71	PF00917	0.591
DEG_SPOP_SBC_1	813	817	PF00917	0.360
DOC_CKS1_1	113	118	PF01111	0.706
DOC_CKS1_1	126	131	PF01111	0.689
DOC_CKS1_1	818	823	PF01111	0.495
DOC_CYCLIN_yCln2_LP_2	422	428	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	480	486	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.724
DOC_CYCLIN_yCln2_LP_2	530	533	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	688	694	PF00134	0.657
DOC_MAPK_FxFP_2	385	388	PF00069	0.547
DOC_MAPK_gen_1	378	385	PF00069	0.521
DOC_MAPK_gen_1	409	419	PF00069	0.491
DOC_MAPK_gen_1	739	747	PF00069	0.599
DOC_MAPK_MEF2A_6	412	419	PF00069	0.500
DOC_MAPK_MEF2A_6	47	54	PF00069	0.581
DOC_MAPK_MEF2A_6	74	81	PF00069	0.587
DOC_MAPK_NFAT4_5	47	55	PF00069	0.577
DOC_MAPK_NFAT4_5	74	82	PF00069	0.588
DOC_PP1_RVXF_1	148	155	PF00149	0.567
DOC_PP1_RVXF_1	495	502	PF00149	0.458
DOC_PP2B_LxvP_1	422	425	PF13499	0.355
DOC_PP2B_LxvP_1	52	55	PF13499	0.724
DOC_PP2B_LxvP_1	529	532	PF13499	0.521
DOC_PP4_FxxP_1	385	388	PF00568	0.547
DOC_PP4_FxxP_1	541	544	PF00568	0.560
DOC_USP7_MATH_1	105	109	PF00917	0.819
DOC_USP7_MATH_1	298	302	PF00917	0.620
DOC_USP7_MATH_1	306	310	PF00917	0.675
DOC_USP7_MATH_1	388	392	PF00917	0.712
DOC_USP7_MATH_1	39	43	PF00917	0.696
DOC_USP7_MATH_1	394	398	PF00917	0.624
DOC_USP7_MATH_1	536	540	PF00917	0.525
DOC_USP7_MATH_1	585	589	PF00917	0.478
DOC_USP7_MATH_1	60	64	PF00917	0.719
DOC_USP7_MATH_1	651	655	PF00917	0.613
DOC_USP7_MATH_1	67	71	PF00917	0.802
DOC_USP7_MATH_1	678	682	PF00917	0.602
DOC_USP7_MATH_1	700	704	PF00917	0.604
DOC_USP7_MATH_1	786	790	PF00917	0.461
DOC_USP7_MATH_1	848	852	PF00917	0.612
DOC_USP7_MATH_1	897	901	PF00917	0.551
DOC_USP7_MATH_2	779	785	PF00917	0.498
DOC_WW_Pin1_4	109	114	PF00397	0.722
DOC_WW_Pin1_4	115	120	PF00397	0.725
DOC_WW_Pin1_4	125	130	PF00397	0.609
DOC_WW_Pin1_4	172	177	PF00397	0.718
DOC_WW_Pin1_4	301	306	PF00397	0.560
DOC_WW_Pin1_4	35	40	PF00397	0.739
DOC_WW_Pin1_4	411	416	PF00397	0.519
DOC_WW_Pin1_4	540	545	PF00397	0.548
DOC_WW_Pin1_4	69	74	PF00397	0.698
DOC_WW_Pin1_4	715	720	PF00397	0.767
DOC_WW_Pin1_4	790	795	PF00397	0.461
DOC_WW_Pin1_4	817	822	PF00397	0.495
LIG_14-3-3_CanoR_1	278	285	PF00244	0.545
LIG_14-3-3_CanoR_1	334	344	PF00244	0.799
LIG_14-3-3_CanoR_1	359	366	PF00244	0.572
LIG_14-3-3_CanoR_1	378	384	PF00244	0.656
LIG_14-3-3_CanoR_1	535	544	PF00244	0.542
LIG_14-3-3_CanoR_1	741	746	PF00244	0.489
LIG_14-3-3_CanoR_1	835	845	PF00244	0.614
LIG_14-3-3_CanoR_1	89	93	PF00244	0.745
LIG_APCC_ABBA_1	554	559	PF00400	0.474
LIG_APCC_ABBAyCdc20_2	553	559	PF00400	0.472
LIG_BIR_III_4	226	230	PF00653	0.671
LIG_BIR_III_4	804	808	PF00653	0.568
LIG_BRCT_BRCA1_1	150	154	PF00533	0.573
LIG_BRCT_BRCA1_1	381	385	PF00533	0.524
LIG_BRCT_BRCA1_1	898	902	PF00533	0.445
LIG_CtBP_PxDLS_1	78	82	PF00389	0.624
LIG_deltaCOP1_diTrp_1	906	911	PF00928	0.458
LIG_FHA_1	231	237	PF00498	0.626
LIG_FHA_1	262	268	PF00498	0.573
LIG_FHA_1	475	481	PF00498	0.447
LIG_FHA_1	524	530	PF00498	0.494
LIG_FHA_1	657	663	PF00498	0.620
LIG_FHA_1	683	689	PF00498	0.745
LIG_FHA_1	721	727	PF00498	0.610
LIG_FHA_1	749	755	PF00498	0.586
LIG_FHA_1	814	820	PF00498	0.540
LIG_FHA_1	822	828	PF00498	0.445
LIG_FHA_1	919	925	PF00498	0.594
LIG_FHA_2	457	463	PF00498	0.544
LIG_LIR_Apic_2	382	388	PF02991	0.538
LIG_LIR_Apic_2	539	544	PF02991	0.543
LIG_LIR_Apic_2	640	646	PF02991	0.477
LIG_LIR_Gen_1	151	160	PF02991	0.570
LIG_LIR_Nem_3	591	595	PF02991	0.473
LIG_MLH1_MIPbox_1	899	903	PF16413	0.447
LIG_NRBOX	418	424	PF00104	0.355
LIG_PCNA_yPIPBox_3	14	28	PF02747	0.558
LIG_PDZ_Class_1	924	929	PF00595	0.534
LIG_Pex14_2	385	389	PF04695	0.547
LIG_REV1ctd_RIR_1	900	909	PF16727	0.440
LIG_RPA_C_Fungi	724	736	PF08784	0.633
LIG_SH2_CRK	644	648	PF00017	0.468
LIG_SH2_STAT5	27	30	PF00017	0.658
LIG_SH2_STAT5	592	595	PF00017	0.497
LIG_SH2_STAT5	918	921	PF00017	0.507
LIG_SH3_1	123	129	PF00018	0.762
LIG_SH3_2	126	131	PF14604	0.754
LIG_SH3_3	110	116	PF00018	0.753
LIG_SH3_3	123	129	PF00018	0.665
LIG_SH3_3	229	235	PF00018	0.637
LIG_SH3_3	325	331	PF00018	0.705
LIG_SH3_3	421	427	PF00018	0.501
LIG_SH3_3	480	486	PF00018	0.588
LIG_SH3_3	530	536	PF00018	0.525
LIG_SH3_3	579	585	PF00018	0.492
LIG_SH3_3	713	719	PF00018	0.567
LIG_SUMO_SIM_anti_2	462	468	PF11976	0.483
LIG_SUMO_SIM_par_1	658	663	PF11976	0.624
LIG_SUMO_SIM_par_1	77	83	PF11976	0.585
LIG_SUMO_SIM_par_1	820	826	PF11976	0.492
LIG_TRAF2_1	202	205	PF00917	0.716
LIG_TRAF2_1	699	702	PF00917	0.587
LIG_TYR_ITIM	590	595	PF00017	0.492
LIG_WW_3	645	649	PF00397	0.549
MOD_CDC14_SPxK_1	793	796	PF00782	0.493
MOD_CDK_SPK_2	69	74	PF00069	0.638
MOD_CDK_SPxK_1	125	131	PF00069	0.760
MOD_CDK_SPxK_1	790	796	PF00069	0.478
MOD_CDK_SPxxK_3	172	179	PF00069	0.628
MOD_CK1_1	108	114	PF00069	0.739
MOD_CK1_1	130	136	PF00069	0.663
MOD_CK1_1	172	178	PF00069	0.690
MOD_CK1_1	251	257	PF00069	0.601
MOD_CK1_1	29	35	PF00069	0.666
MOD_CK1_1	301	307	PF00069	0.697
MOD_CK1_1	317	323	PF00069	0.567
MOD_CK1_1	38	44	PF00069	0.677
MOD_CK1_1	451	457	PF00069	0.613
MOD_CK1_1	474	480	PF00069	0.445
MOD_CK1_1	540	546	PF00069	0.538
MOD_CK1_1	588	594	PF00069	0.438
MOD_CK1_1	666	672	PF00069	0.644
MOD_CK1_1	717	723	PF00069	0.740
MOD_CK1_1	72	78	PF00069	0.774
MOD_CK1_1	762	768	PF00069	0.549
MOD_CK1_1	785	791	PF00069	0.467
MOD_CK1_1	80	86	PF00069	0.717
MOD_CK1_1	817	823	PF00069	0.492
MOD_CK1_1	91	97	PF00069	0.786
MOD_CK1_1	98	104	PF00069	0.804
MOD_CK2_1	456	462	PF00069	0.564
MOD_CK2_1	823	829	PF00069	0.494
MOD_CK2_1	884	890	PF00069	0.682
MOD_DYRK1A_RPxSP_1	125	129	PF00069	0.757
MOD_GlcNHglycan	107	110	PF01048	0.818
MOD_GlcNHglycan	132	135	PF01048	0.781
MOD_GlcNHglycan	171	174	PF01048	0.699
MOD_GlcNHglycan	187	190	PF01048	0.695
MOD_GlcNHglycan	28	31	PF01048	0.673
MOD_GlcNHglycan	308	311	PF01048	0.597
MOD_GlcNHglycan	337	340	PF01048	0.795
MOD_GlcNHglycan	360	363	PF01048	0.683
MOD_GlcNHglycan	390	393	PF01048	0.733
MOD_GlcNHglycan	396	399	PF01048	0.651
MOD_GlcNHglycan	405	408	PF01048	0.625
MOD_GlcNHglycan	453	456	PF01048	0.677
MOD_GlcNHglycan	47	50	PF01048	0.524
MOD_GlcNHglycan	56	59	PF01048	0.685
MOD_GlcNHglycan	62	65	PF01048	0.796
MOD_GlcNHglycan	624	627	PF01048	0.464
MOD_GlcNHglycan	701	705	PF01048	0.789
MOD_GlcNHglycan	74	77	PF01048	0.823
MOD_GlcNHglycan	761	764	PF01048	0.445
MOD_GlcNHglycan	784	787	PF01048	0.534
MOD_GlcNHglycan	804	808	PF01048	0.238
MOD_GlcNHglycan	84	87	PF01048	0.745
MOD_GlcNHglycan	858	861	PF01048	0.624
MOD_GlcNHglycan	97	100	PF01048	0.600
MOD_GSK3_1	105	112	PF00069	0.740
MOD_GSK3_1	181	188	PF00069	0.723
MOD_GSK3_1	248	255	PF00069	0.641
MOD_GSK3_1	26	33	PF00069	0.619
MOD_GSK3_1	301	308	PF00069	0.754
MOD_GSK3_1	344	351	PF00069	0.677
MOD_GSK3_1	35	42	PF00069	0.699
MOD_GSK3_1	390	397	PF00069	0.649
MOD_GSK3_1	451	458	PF00069	0.684
MOD_GSK3_1	471	478	PF00069	0.457
MOD_GSK3_1	519	526	PF00069	0.544
MOD_GSK3_1	536	543	PF00069	0.535
MOD_GSK3_1	573	580	PF00069	0.472
MOD_GSK3_1	610	617	PF00069	0.513
MOD_GSK3_1	652	659	PF00069	0.620
MOD_GSK3_1	662	669	PF00069	0.662
MOD_GSK3_1	678	685	PF00069	0.789
MOD_GSK3_1	68	75	PF00069	0.816
MOD_GSK3_1	711	718	PF00069	0.785
MOD_GSK3_1	781	788	PF00069	0.492
MOD_GSK3_1	803	810	PF00069	0.458
MOD_GSK3_1	813	820	PF00069	0.498
MOD_GSK3_1	88	95	PF00069	0.774
MOD_GSK3_1	893	900	PF00069	0.503
MOD_N-GLC_1	332	337	PF02516	0.697
MOD_N-GLC_1	836	841	PF02516	0.752
MOD_NEK2_1	185	190	PF00069	0.783
MOD_NEK2_1	261	266	PF00069	0.575
MOD_NEK2_1	344	349	PF00069	0.772
MOD_NEK2_1	45	50	PF00069	0.762
MOD_NEK2_1	490	495	PF00069	0.469
MOD_NEK2_1	520	525	PF00069	0.547
MOD_NEK2_1	620	625	PF00069	0.464
MOD_NEK2_1	660	665	PF00069	0.634
MOD_NEK2_1	684	689	PF00069	0.566
MOD_NEK2_1	773	778	PF00069	0.498
MOD_NEK2_1	90	95	PF00069	0.802
MOD_NEK2_1	910	915	PF00069	0.457
MOD_NEK2_1	924	929	PF00069	0.534
MOD_NEK2_2	558	563	PF00069	0.510
MOD_NEK2_2	897	902	PF00069	0.515
MOD_NEK2_2	918	923	PF00069	0.500
MOD_PIKK_1	133	139	PF00454	0.718
MOD_PIKK_1	230	236	PF00454	0.740
MOD_PIKK_1	353	359	PF00454	0.732
MOD_PIKK_1	566	572	PF00454	0.453
MOD_PIKK_1	577	583	PF00454	0.268
MOD_PKA_2	124	130	PF00069	0.838
MOD_PKA_2	277	283	PF00069	0.544
MOD_PKA_2	30	36	PF00069	0.727
MOD_PKA_2	358	364	PF00069	0.579
MOD_PKA_2	379	385	PF00069	0.653
MOD_PKA_2	88	94	PF00069	0.743
MOD_PKA_2	95	101	PF00069	0.648
MOD_PKB_1	739	747	PF00069	0.599
MOD_Plk_1	314	320	PF00069	0.820
MOD_Plk_1	455	461	PF00069	0.699
MOD_Plk_1	474	480	PF00069	0.324
MOD_Plk_1	773	779	PF00069	0.600
MOD_Plk_2-3	456	462	PF00069	0.447
MOD_Plk_2-3	635	641	PF00069	0.506
MOD_Plk_4	239	245	PF00069	0.701
MOD_Plk_4	286	292	PF00069	0.612
MOD_Plk_4	475	481	PF00069	0.420
MOD_Plk_4	485	491	PF00069	0.392
MOD_Plk_4	525	531	PF00069	0.530
MOD_Plk_4	588	594	PF00069	0.474
MOD_Plk_4	652	658	PF00069	0.619
MOD_Plk_4	807	813	PF00069	0.450
MOD_Plk_4	814	820	PF00069	0.503
MOD_Plk_4	897	903	PF00069	0.449
MOD_ProDKin_1	109	115	PF00069	0.723
MOD_ProDKin_1	125	131	PF00069	0.759
MOD_ProDKin_1	172	178	PF00069	0.719
MOD_ProDKin_1	301	307	PF00069	0.564
MOD_ProDKin_1	35	41	PF00069	0.739
MOD_ProDKin_1	411	417	PF00069	0.510
MOD_ProDKin_1	540	546	PF00069	0.538
MOD_ProDKin_1	69	75	PF00069	0.699
MOD_ProDKin_1	715	721	PF00069	0.764
MOD_ProDKin_1	790	796	PF00069	0.462
MOD_ProDKin_1	817	823	PF00069	0.492
MOD_SUMO_rev_2	567	574	PF00179	0.453
TRG_DiLeu_BaEn_1	413	418	PF01217	0.489
TRG_DiLeu_BaEn_1	475	480	PF01217	0.454
TRG_DiLeu_BaEn_1	511	516	PF01217	0.525
TRG_DiLeu_LyEn_5	511	516	PF01217	0.525
TRG_ENDOCYTIC_2	592	595	PF00928	0.500
TRG_ER_diArg_1	256	258	PF00400	0.658
TRG_ER_diArg_1	512	514	PF00400	0.641
TRG_ER_diArg_1	728	730	PF00400	0.783
TRG_ER_diArg_1	739	742	PF00400	0.434
TRG_ER_diArg_1	754	757	PF00400	0.423
TRG_ER_diArg_1	81	84	PF00400	0.745
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.681
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHJ0	Leptomonas seymouri	49%	92%
A0A3S7WT61	Leishmania donovani	91%	99%
A4H7R6	Leishmania braziliensis	73%	100%
A4HW59	Leishmania infantum	91%	99%
E9APV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%