CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFM0_LEIMA

TriTrypDb:

LmjF.14.1140 , LMJLV39_140019100 , LMJSD75_140018600

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFM0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003677	DNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.669
CLV_NRD_NRD_1	163	165	PF00675	0.573
CLV_NRD_NRD_1	252	254	PF00675	0.568
CLV_NRD_NRD_1	336	338	PF00675	0.518
CLV_NRD_NRD_1	453	455	PF00675	0.734
CLV_NRD_NRD_1	460	462	PF00675	0.712
CLV_NRD_NRD_1	68	70	PF00675	0.509
CLV_PCSK_KEX2_1	154	156	PF00082	0.728
CLV_PCSK_KEX2_1	252	254	PF00082	0.568
CLV_PCSK_KEX2_1	336	338	PF00082	0.508
CLV_PCSK_KEX2_1	460	462	PF00082	0.775
CLV_PCSK_KEX2_1	68	70	PF00082	0.511
CLV_PCSK_SKI1_1	118	122	PF00082	0.486
CLV_PCSK_SKI1_1	124	128	PF00082	0.408
CLV_PCSK_SKI1_1	338	342	PF00082	0.532
CLV_PCSK_SKI1_1	366	370	PF00082	0.443
DOC_CYCLIN_RxL_1	337	349	PF00134	0.661
DOC_MAPK_DCC_7	221	230	PF00069	0.442
DOC_MAPK_gen_1	417	425	PF00069	0.415
DOC_MAPK_gen_1	463	473	PF00069	0.584
DOC_PP1_RVXF_1	136	142	PF00149	0.505
DOC_PP1_RVXF_1	231	238	PF00149	0.513
DOC_PP1_RVXF_1	279	286	PF00149	0.406
DOC_PP4_FxxP_1	341	344	PF00568	0.556
DOC_PP4_FxxP_1	40	43	PF00568	0.595
DOC_USP7_MATH_1	196	200	PF00917	0.713
DOC_USP7_MATH_1	6	10	PF00917	0.656
DOC_USP7_UBL2_3	413	417	PF12436	0.460
DOC_WW_Pin1_4	157	162	PF00397	0.714
DOC_WW_Pin1_4	16	21	PF00397	0.645
DOC_WW_Pin1_4	182	187	PF00397	0.727
DOC_WW_Pin1_4	220	225	PF00397	0.453
DOC_WW_Pin1_4	303	308	PF00397	0.555
LIG_14-3-3_CanoR_1	138	142	PF00244	0.458
LIG_14-3-3_CanoR_1	207	213	PF00244	0.518
LIG_14-3-3_CanoR_1	22	30	PF00244	0.691
LIG_14-3-3_CanoR_1	261	267	PF00244	0.455
LIG_14-3-3_CanoR_1	401	405	PF00244	0.490
LIG_Actin_WH2_2	262	280	PF00022	0.449
LIG_Actin_WH2_2	72	89	PF00022	0.576
LIG_BIR_III_2	349	353	PF00653	0.635
LIG_BRCT_BRCA1_1	118	122	PF00533	0.407
LIG_BRCT_BRCA1_1	383	387	PF00533	0.391
LIG_FHA_1	401	407	PF00498	0.495
LIG_FHA_1	6	12	PF00498	0.645
LIG_FHA_2	132	138	PF00498	0.535
LIG_FHA_2	161	167	PF00498	0.541
LIG_FHA_2	217	223	PF00498	0.482
LIG_FHA_2	462	468	PF00498	0.624
LIG_LIR_Apic_2	38	43	PF02991	0.560
LIG_LIR_Gen_1	140	148	PF02991	0.538
LIG_LIR_Gen_1	279	290	PF02991	0.423
LIG_LIR_Gen_1	470	476	PF02991	0.555
LIG_LIR_Gen_1	89	98	PF02991	0.587
LIG_LIR_Nem_3	140	144	PF02991	0.499
LIG_LIR_Nem_3	229	234	PF02991	0.410
LIG_LIR_Nem_3	279	285	PF02991	0.408
LIG_LIR_Nem_3	358	364	PF02991	0.478
LIG_LIR_Nem_3	371	376	PF02991	0.349
LIG_LIR_Nem_3	383	389	PF02991	0.410
LIG_LIR_Nem_3	470	476	PF02991	0.555
LIG_LIR_Nem_3	89	93	PF02991	0.584
LIG_MLH1_MIPbox_1	118	122	PF16413	0.407
LIG_MLH1_MIPbox_1	383	387	PF16413	0.391
LIG_PDZ_Class_3	471	476	PF00595	0.600
LIG_REV1ctd_RIR_1	118	128	PF16727	0.513
LIG_SH2_CRK	231	235	PF00017	0.488
LIG_SH2_CRK	71	75	PF00017	0.370
LIG_SH2_PTP2	90	93	PF00017	0.672
LIG_SH2_STAT5	132	135	PF00017	0.438
LIG_SH2_STAT5	282	285	PF00017	0.420
LIG_SH2_STAT5	404	407	PF00017	0.516
LIG_SH2_STAT5	90	93	PF00017	0.697
LIG_SH3_1	221	227	PF00018	0.484
LIG_SH3_3	141	147	PF00018	0.552
LIG_SH3_3	221	227	PF00018	0.484
LIG_SH3_3	257	263	PF00018	0.564
LIG_SUMO_SIM_anti_2	318	325	PF11976	0.503
LIG_SUMO_SIM_par_1	343	349	PF11976	0.677
LIG_TRAF2_1	108	111	PF00917	0.578
LIG_TRFH_1	285	289	PF08558	0.535
LIG_TYR_ITSM	227	234	PF00017	0.476
MOD_CDK_SPxK_1	16	22	PF00069	0.638
MOD_CDK_SPxxK_3	157	164	PF00069	0.567
MOD_CK1_1	160	166	PF00069	0.672
MOD_CK1_1	195	201	PF00069	0.624
MOD_CK1_1	226	232	PF00069	0.532
MOD_CK1_1	265	271	PF00069	0.381
MOD_CK1_1	359	365	PF00069	0.456
MOD_CK1_1	381	387	PF00069	0.530
MOD_CK1_1	390	396	PF00069	0.550
MOD_CK1_1	9	15	PF00069	0.683
MOD_CK2_1	131	137	PF00069	0.531
MOD_CK2_1	216	222	PF00069	0.481
MOD_CK2_1	306	312	PF00069	0.752
MOD_CK2_1	329	335	PF00069	0.453
MOD_Cter_Amidation	415	418	PF01082	0.449
MOD_GlcNHglycan	124	127	PF01048	0.535
MOD_GlcNHglycan	191	197	PF01048	0.693
MOD_GlcNHglycan	278	281	PF01048	0.556
MOD_GlcNHglycan	308	311	PF01048	0.739
MOD_GlcNHglycan	361	364	PF01048	0.595
MOD_GlcNHglycan	37	40	PF01048	0.744
MOD_GlcNHglycan	378	383	PF01048	0.467
MOD_GlcNHglycan	442	445	PF01048	0.622
MOD_GlcNHglycan	8	11	PF01048	0.697
MOD_GlcNHglycan	81	84	PF01048	0.648
MOD_GSK3_1	1	8	PF00069	0.691
MOD_GSK3_1	116	123	PF00069	0.442
MOD_GSK3_1	191	198	PF00069	0.647
MOD_GSK3_1	216	223	PF00069	0.496
MOD_GSK3_1	272	279	PF00069	0.614
MOD_GSK3_1	387	394	PF00069	0.516
MOD_N-GLC_1	390	395	PF02516	0.568
MOD_NEK2_1	1	6	PF00069	0.698
MOD_NEK2_1	116	121	PF00069	0.529
MOD_NEK2_1	122	127	PF00069	0.463
MOD_NEK2_1	30	35	PF00069	0.639
MOD_NEK2_1	387	392	PF00069	0.425
MOD_NEK2_1	58	63	PF00069	0.483
MOD_NEK2_1	86	91	PF00069	0.648
MOD_NMyristoyl	1	7	PF02799	0.570
MOD_PIKK_1	198	204	PF00454	0.765
MOD_PKA_2	137	143	PF00069	0.497
MOD_PKA_2	21	27	PF00069	0.607
MOD_PKA_2	359	365	PF00069	0.456
MOD_PKA_2	400	406	PF00069	0.493
MOD_PKA_2	459	465	PF00069	0.767
MOD_Plk_1	330	336	PF00069	0.534
MOD_Plk_1	425	431	PF00069	0.398
MOD_Plk_4	116	122	PF00069	0.446
MOD_Plk_4	226	232	PF00069	0.507
MOD_Plk_4	381	387	PF00069	0.402
MOD_Plk_4	400	406	PF00069	0.434
MOD_Plk_4	86	92	PF00069	0.583
MOD_ProDKin_1	157	163	PF00069	0.715
MOD_ProDKin_1	16	22	PF00069	0.646
MOD_ProDKin_1	182	188	PF00069	0.728
MOD_ProDKin_1	220	226	PF00069	0.464
MOD_ProDKin_1	303	309	PF00069	0.553
MOD_SUMO_rev_2	211	219	PF00179	0.433
MOD_SUMO_rev_2	362	370	PF00179	0.532
TRG_DiLeu_BaEn_1	319	324	PF01217	0.504
TRG_DiLeu_BaEn_2	176	182	PF01217	0.509
TRG_ENDOCYTIC_2	231	234	PF00928	0.476
TRG_ENDOCYTIC_2	282	285	PF00928	0.420
TRG_ENDOCYTIC_2	71	74	PF00928	0.365
TRG_ENDOCYTIC_2	90	93	PF00928	0.697
TRG_ER_diArg_1	154	156	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L8	Leptomonas seymouri	51%	87%
A0A1X0NNT6	Trypanosomatidae	39%	100%
A0A3R7R786	Trypanosoma rangeli	39%	100%
A0A3S7WTB0	Leishmania donovani	92%	100%
A4H7R7	Leishmania braziliensis	72%	98%
A4HW60	Leishmania infantum	92%	100%
C9ZSW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9APW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5DC73	Trypanosoma cruzi	38%	100%