CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFM0_LEIMA

TriTrypDb:

LmjF.14.1140 , LMJLV39_140019100 , LMJSD75_140018600

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QFM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFM0

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.669
CLV_NRD_NRD_1	163	165	PF00675	0.573
CLV_NRD_NRD_1	252	254	PF00675	0.568
CLV_NRD_NRD_1	336	338	PF00675	0.518
CLV_NRD_NRD_1	453	455	PF00675	0.734
CLV_NRD_NRD_1	460	462	PF00675	0.712
CLV_NRD_NRD_1	68	70	PF00675	0.509
CLV_PCSK_KEX2_1	154	156	PF00082	0.728
CLV_PCSK_KEX2_1	252	254	PF00082	0.568
CLV_PCSK_KEX2_1	336	338	PF00082	0.508

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L8	Leptomonas seymouri	51%	87%
A0A1X0NNT6	Trypanosomatidae	39%	100%
A0A3R7R786	Trypanosoma rangeli	39%	100%
A0A3S7WTB0	Leishmania donovani	92%	100%
A4H7R7	Leishmania braziliensis	72%	98%
A4HW60	Leishmania infantum	92%	100%
C9ZSW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9APW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5DC73	Trypanosoma cruzi	38%	100%

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