Tub family protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tub family protein-like protein

Species:

Leishmania major

UniProt:

Q4QFL9_LEIMA

TriTrypDb:

LmjF.14.1150 , LMJLV39_140019200 , LMJSD75_140018700

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFL9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.377
CLV_C14_Caspase3-7	6	10	PF00656	0.614
CLV_NRD_NRD_1	131	133	PF00675	0.342
CLV_NRD_NRD_1	148	150	PF00675	0.335
CLV_NRD_NRD_1	268	270	PF00675	0.453
CLV_NRD_NRD_1	3	5	PF00675	0.772
CLV_NRD_NRD_1	355	357	PF00675	0.468
CLV_NRD_NRD_1	44	46	PF00675	0.461
CLV_PCSK_FUR_1	44	48	PF00082	0.530
CLV_PCSK_KEX2_1	131	133	PF00082	0.348
CLV_PCSK_KEX2_1	268	270	PF00082	0.322
CLV_PCSK_KEX2_1	44	46	PF00082	0.461
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.530
CLV_PCSK_SKI1_1	150	154	PF00082	0.504
CLV_PCSK_SKI1_1	256	260	PF00082	0.313
CLV_PCSK_SKI1_1	331	335	PF00082	0.335
CLV_PCSK_SKI1_1	80	84	PF00082	0.567
DEG_APCC_DBOX_1	336	344	PF00400	0.335
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.453
DOC_MAPK_FxFP_2	336	339	PF00069	0.335
DOC_MAPK_gen_1	131	141	PF00069	0.389
DOC_MAPK_gen_1	146	155	PF00069	0.335
DOC_MAPK_gen_1	44	52	PF00069	0.506
DOC_MAPK_MEF2A_6	149	157	PF00069	0.335
DOC_MAPK_MEF2A_6	269	278	PF00069	0.335
DOC_PP1_RVXF_1	292	298	PF00149	0.335
DOC_PP2B_PxIxI_1	273	279	PF00149	0.335
DOC_PP4_FxxP_1	336	339	PF00568	0.335
DOC_USP7_MATH_1	237	241	PF00917	0.374
DOC_USP7_MATH_1	243	247	PF00917	0.369
DOC_USP7_UBL2_3	146	150	PF12436	0.335
DOC_USP7_UBL2_3	303	307	PF12436	0.453
DOC_WW_Pin1_4	224	229	PF00397	0.389
DOC_WW_Pin1_4	233	238	PF00397	0.296
DOC_WW_Pin1_4	270	275	PF00397	0.332
LIG_14-3-3_CanoR_1	165	171	PF00244	0.396
LIG_14-3-3_CanoR_1	197	204	PF00244	0.320
LIG_14-3-3_CanoR_1	59	64	PF00244	0.542
LIG_Actin_RPEL_3	37	56	PF02755	0.480
LIG_APCC_ABBA_1	138	143	PF00400	0.335
LIG_BRCT_BRCA1_1	61	65	PF00533	0.416
LIG_FHA_1	167	173	PF00498	0.341
LIG_FHA_1	348	354	PF00498	0.284
LIG_FHA_2	1	7	PF00498	0.659
LIG_FHA_2	84	90	PF00498	0.583
LIG_LIR_Apic_2	178	184	PF02991	0.334
LIG_LIR_Apic_2	27	33	PF02991	0.422
LIG_LIR_Apic_2	335	339	PF02991	0.335
LIG_LIR_Gen_1	166	175	PF02991	0.313
LIG_LIR_Gen_1	217	228	PF02991	0.358
LIG_LIR_Gen_1	306	317	PF02991	0.319
LIG_LIR_Gen_1	62	67	PF02991	0.384
LIG_LIR_Nem_3	166	171	PF02991	0.313
LIG_LIR_Nem_3	227	233	PF02991	0.321
LIG_LIR_Nem_3	283	289	PF02991	0.453
LIG_LIR_Nem_3	306	312	PF02991	0.325
LIG_LIR_Nem_3	62	66	PF02991	0.384
LIG_NRBOX	152	158	PF00104	0.453
LIG_Pex14_2	332	336	PF04695	0.335
LIG_SH2_NCK_1	14	18	PF00017	0.530
LIG_SH2_PTP2	181	184	PF00017	0.335
LIG_SH2_STAT5	181	184	PF00017	0.335
LIG_SH2_STAT5	41	44	PF00017	0.400
LIG_SH3_1	268	274	PF00018	0.335
LIG_SH3_3	167	173	PF00018	0.354
LIG_SH3_3	19	25	PF00018	0.478
LIG_SH3_3	268	274	PF00018	0.335
LIG_SH3_3	311	317	PF00018	0.334
LIG_SUMO_SIM_anti_2	151	157	PF11976	0.453
LIG_SUMO_SIM_par_1	275	281	PF11976	0.453
LIG_SUMO_SIM_par_1	310	316	PF11976	0.313
LIG_UBA3_1	276	282	PF00899	0.313
MOD_CK1_1	12	18	PF00069	0.605
MOD_CK1_1	142	148	PF00069	0.351
MOD_CK1_1	166	172	PF00069	0.342
MOD_CK1_1	221	227	PF00069	0.389
MOD_CK1_1	81	87	PF00069	0.719
MOD_CK2_1	243	249	PF00069	0.389
MOD_CK2_1	83	89	PF00069	0.648
MOD_GlcNHglycan	178	181	PF01048	0.335
MOD_GlcNHglycan	239	242	PF01048	0.357
MOD_GlcNHglycan	9	12	PF01048	0.661
MOD_GlcNHglycan	92	95	PF01048	0.697
MOD_GSK3_1	160	167	PF00069	0.335
MOD_GSK3_1	233	240	PF00069	0.388
MOD_GSK3_1	243	250	PF00069	0.370
MOD_GSK3_1	298	305	PF00069	0.412
MOD_GSK3_1	347	354	PF00069	0.353
MOD_GSK3_1	5	12	PF00069	0.613
MOD_N-GLC_1	163	168	PF02516	0.358
MOD_N-GLC_1	209	214	PF02516	0.389
MOD_NEK2_1	16	21	PF00069	0.546
MOD_NEK2_1	160	165	PF00069	0.325
MOD_PIKK_1	100	106	PF00454	0.560
MOD_PKA_2	164	170	PF00069	0.431
MOD_PKA_2	196	202	PF00069	0.453
MOD_PKA_2	299	305	PF00069	0.341
MOD_Plk_1	163	169	PF00069	0.389
MOD_Plk_4	16	22	PF00069	0.555
MOD_Plk_4	348	354	PF00069	0.335
MOD_Plk_4	51	57	PF00069	0.571
MOD_Plk_4	9	15	PF00069	0.593
MOD_ProDKin_1	224	230	PF00069	0.389
MOD_ProDKin_1	233	239	PF00069	0.296
MOD_ProDKin_1	270	276	PF00069	0.332
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.467
TRG_ENDOCYTIC_2	220	223	PF00928	0.421
TRG_ER_diArg_1	267	269	PF00400	0.453
TRG_ER_diArg_1	31	34	PF00400	0.417
TRG_ER_diArg_1	44	47	PF00400	0.466
TRG_NLS_MonoCore_2	44	49	PF00514	0.502
TRG_NLS_MonoExtN_4	44	50	PF00514	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC07	Leptomonas seymouri	71%	74%
A0A3Q8I9W0	Leishmania donovani	94%	100%
A4H7R8	Leishmania braziliensis	77%	89%
A4HW61	Leishmania infantum	94%	70%
E9APW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%