Putative ras-like small GTPases

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-like small GTPases, putative

Species:

Leishmania major

UniProt:

Q4QFL7_LEIMA

TriTrypDb:

LmjF.14.1170 , LMJLV39_140019500 , LMJSD75_140019000

Length:

766

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFL7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0003924	GTPase activity	7	7
GO:0005488	binding	1	7
GO:0005525	GTP binding	5	7
GO:0016462	pyrophosphatase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7
GO:0019001	guanyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032561	guanyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.424
CLV_NRD_NRD_1	220	222	PF00675	0.633
CLV_NRD_NRD_1	359	361	PF00675	0.602
CLV_NRD_NRD_1	421	423	PF00675	0.374
CLV_NRD_NRD_1	453	455	PF00675	0.315
CLV_NRD_NRD_1	470	472	PF00675	0.315
CLV_NRD_NRD_1	52	54	PF00675	0.317
CLV_NRD_NRD_1	542	544	PF00675	0.620
CLV_NRD_NRD_1	737	739	PF00675	0.684
CLV_NRD_NRD_1	764	766	PF00675	0.633
CLV_PCSK_KEX2_1	131	133	PF00082	0.424
CLV_PCSK_KEX2_1	219	221	PF00082	0.623
CLV_PCSK_KEX2_1	340	342	PF00082	0.542
CLV_PCSK_KEX2_1	359	361	PF00082	0.493
CLV_PCSK_KEX2_1	421	423	PF00082	0.374
CLV_PCSK_KEX2_1	453	455	PF00082	0.315
CLV_PCSK_KEX2_1	542	544	PF00082	0.667
CLV_PCSK_KEX2_1	736	738	PF00082	0.690
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.542
CLV_PCSK_SKI1_1	14	18	PF00082	0.557
CLV_PCSK_SKI1_1	231	235	PF00082	0.502
CLV_PCSK_SKI1_1	377	381	PF00082	0.497
CLV_PCSK_SKI1_1	385	389	PF00082	0.361
CLV_PCSK_SKI1_1	471	475	PF00082	0.368
CLV_PCSK_SKI1_1	750	754	PF00082	0.486
DEG_APCC_DBOX_1	222	230	PF00400	0.556
DEG_SCF_FBW7_2	665	672	PF00400	0.495
DEG_SPOP_SBC_1	687	691	PF00917	0.592
DEG_SPOP_SBC_1	83	87	PF00917	0.424
DOC_CKS1_1	107	112	PF01111	0.314
DOC_CYCLIN_yCln2_LP_2	153	159	PF00134	0.258
DOC_CYCLIN_yCln2_LP_2	380	386	PF00134	0.418
DOC_MAPK_gen_1	421	428	PF00069	0.374
DOC_MAPK_MEF2A_6	421	428	PF00069	0.424
DOC_PP2B_LxvP_1	172	175	PF13499	0.258
DOC_PP2B_LxvP_1	536	539	PF13499	0.585
DOC_PP2B_LxvP_1	571	574	PF13499	0.522
DOC_USP7_MATH_1	118	122	PF00917	0.378
DOC_USP7_MATH_1	147	151	PF00917	0.409
DOC_USP7_MATH_1	158	162	PF00917	0.469
DOC_USP7_MATH_1	180	184	PF00917	0.317
DOC_USP7_MATH_1	199	203	PF00917	0.270
DOC_USP7_MATH_1	247	251	PF00917	0.526
DOC_USP7_MATH_1	290	294	PF00917	0.645
DOC_USP7_MATH_1	312	316	PF00917	0.660
DOC_USP7_MATH_1	42	46	PF00917	0.350
DOC_USP7_MATH_1	526	530	PF00917	0.632
DOC_USP7_MATH_1	551	555	PF00917	0.663
DOC_USP7_MATH_1	566	570	PF00917	0.558
DOC_USP7_MATH_1	586	590	PF00917	0.685
DOC_USP7_MATH_1	608	612	PF00917	0.566
DOC_USP7_MATH_1	688	692	PF00917	0.565
DOC_USP7_MATH_1	739	743	PF00917	0.642
DOC_USP7_MATH_1	83	87	PF00917	0.474
DOC_USP7_MATH_1	92	96	PF00917	0.457
DOC_WW_Pin1_4	106	111	PF00397	0.335
DOC_WW_Pin1_4	183	188	PF00397	0.342
DOC_WW_Pin1_4	379	384	PF00397	0.440
DOC_WW_Pin1_4	582	587	PF00397	0.725
DOC_WW_Pin1_4	588	593	PF00397	0.570
DOC_WW_Pin1_4	6	11	PF00397	0.726
DOC_WW_Pin1_4	619	624	PF00397	0.713
DOC_WW_Pin1_4	633	638	PF00397	0.545
DOC_WW_Pin1_4	665	670	PF00397	0.501
LIG_14-3-3_CanoR_1	117	127	PF00244	0.258
LIG_14-3-3_CanoR_1	196	205	PF00244	0.315
LIG_14-3-3_CanoR_1	313	317	PF00244	0.681
LIG_14-3-3_CanoR_1	341	346	PF00244	0.582
LIG_14-3-3_CanoR_1	348	357	PF00244	0.500
LIG_14-3-3_CanoR_1	377	383	PF00244	0.462
LIG_14-3-3_CanoR_1	430	438	PF00244	0.395
LIG_14-3-3_CanoR_1	471	476	PF00244	0.373
LIG_14-3-3_CanoR_1	587	592	PF00244	0.742
LIG_14-3-3_CanoR_1	655	664	PF00244	0.430
LIG_14-3-3_CanoR_1	731	739	PF00244	0.666
LIG_14-3-3_CanoR_1	750	755	PF00244	0.375
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_BIR_III_4	648	652	PF00653	0.529
LIG_BRCT_BRCA1_1	252	256	PF00533	0.483
LIG_BRCT_BRCA1_1	44	48	PF00533	0.350
LIG_deltaCOP1_diTrp_1	362	372	PF00928	0.469
LIG_FHA_1	270	276	PF00498	0.518
LIG_FHA_1	350	356	PF00498	0.494
LIG_FHA_1	688	694	PF00498	0.543
LIG_FHA_2	209	215	PF00498	0.578
LIG_FHA_2	240	246	PF00498	0.570
LIG_FHA_2	690	696	PF00498	0.604
LIG_LIR_Gen_1	239	247	PF02991	0.457
LIG_LIR_Gen_1	352	358	PF02991	0.490
LIG_LIR_Gen_1	668	679	PF02991	0.448
LIG_LIR_Gen_1	95	104	PF02991	0.258
LIG_LIR_LC3C_4	204	209	PF02991	0.526
LIG_LIR_Nem_3	239	243	PF02991	0.511
LIG_LIR_Nem_3	302	306	PF02991	0.643
LIG_LIR_Nem_3	352	357	PF02991	0.493
LIG_LIR_Nem_3	447	452	PF02991	0.317
LIG_LIR_Nem_3	45	51	PF02991	0.316
LIG_LIR_Nem_3	668	674	PF02991	0.443
LIG_MYND_1	663	667	PF01753	0.507
LIG_NRBOX	758	764	PF00104	0.516
LIG_PCNA_yPIPBox_3	261	275	PF02747	0.487
LIG_RPA_C_Fungi	425	437	PF08784	0.368
LIG_SH2_SRC	467	470	PF00017	0.374
LIG_SH2_SRC	74	77	PF00017	0.424
LIG_SH2_STAP1	203	207	PF00017	0.315
LIG_SH2_STAP1	351	355	PF00017	0.553
LIG_SH2_STAT3	203	206	PF00017	0.315
LIG_SH2_STAT5	257	260	PF00017	0.626
LIG_SH2_STAT5	351	354	PF00017	0.561
LIG_SH2_STAT5	74	77	PF00017	0.374
LIG_SH3_1	131	137	PF00018	0.314
LIG_SH3_3	104	110	PF00018	0.364
LIG_SH3_3	131	137	PF00018	0.314
LIG_SH3_3	4	10	PF00018	0.531
LIG_SH3_3	409	415	PF00018	0.424
LIG_SH3_3	594	600	PF00018	0.735
LIG_SH3_3	622	628	PF00018	0.629
LIG_SH3_3	631	637	PF00018	0.601
LIG_SH3_3	70	76	PF00018	0.424
LIG_SUMO_SIM_anti_2	677	684	PF11976	0.483
LIG_SUMO_SIM_par_1	15	20	PF11976	0.570
LIG_TRAF2_1	211	214	PF00917	0.563
LIG_WRC_WIRS_1	237	242	PF05994	0.537
LIG_WRC_WIRS_1	369	374	PF05994	0.518
MOD_CDC14_SPxK_1	382	385	PF00782	0.403
MOD_CDK_SPK_2	582	587	PF00069	0.551
MOD_CDK_SPxK_1	379	385	PF00069	0.432
MOD_CDK_SPxxK_3	633	640	PF00069	0.549
MOD_CK1_1	106	112	PF00069	0.428
MOD_CK1_1	121	127	PF00069	0.386
MOD_CK1_1	145	151	PF00069	0.433
MOD_CK1_1	176	182	PF00069	0.439
MOD_CK1_1	183	189	PF00069	0.349
MOD_CK1_1	239	245	PF00069	0.560
MOD_CK1_1	250	256	PF00069	0.496
MOD_CK1_1	285	291	PF00069	0.637
MOD_CK1_1	302	308	PF00069	0.666
MOD_CK1_1	370	376	PF00069	0.558
MOD_CK1_1	508	514	PF00069	0.718
MOD_CK1_1	529	535	PF00069	0.611
MOD_CK1_1	554	560	PF00069	0.685
MOD_CK1_1	636	642	PF00069	0.717
MOD_CK1_1	689	695	PF00069	0.626
MOD_CK1_1	711	717	PF00069	0.773
MOD_CK1_1	718	724	PF00069	0.713
MOD_CK1_1	97	103	PF00069	0.314
MOD_CK2_1	208	214	PF00069	0.562
MOD_CK2_1	219	225	PF00069	0.647
MOD_CK2_1	331	337	PF00069	0.547
MOD_CK2_1	554	560	PF00069	0.787
MOD_CK2_1	689	695	PF00069	0.588
MOD_CK2_1	82	88	PF00069	0.350
MOD_GlcNHglycan	1	4	PF01048	0.630
MOD_GlcNHglycan	122	126	PF01048	0.456
MOD_GlcNHglycan	145	148	PF01048	0.423
MOD_GlcNHglycan	149	152	PF01048	0.403
MOD_GlcNHglycan	175	178	PF01048	0.435
MOD_GlcNHglycan	252	255	PF01048	0.550
MOD_GlcNHglycan	307	310	PF01048	0.738
MOD_GlcNHglycan	322	325	PF01048	0.482
MOD_GlcNHglycan	398	401	PF01048	0.381
MOD_GlcNHglycan	432	435	PF01048	0.350
MOD_GlcNHglycan	442	446	PF01048	0.290
MOD_GlcNHglycan	486	489	PF01048	0.350
MOD_GlcNHglycan	508	511	PF01048	0.714
MOD_GlcNHglycan	528	531	PF01048	0.756
MOD_GlcNHglycan	536	539	PF01048	0.601
MOD_GlcNHglycan	553	556	PF01048	0.549
MOD_GlcNHglycan	695	699	PF01048	0.620
MOD_GlcNHglycan	704	707	PF01048	0.671
MOD_GlcNHglycan	720	723	PF01048	0.574
MOD_GlcNHglycan	96	99	PF01048	0.369
MOD_GSK3_1	142	149	PF00069	0.398
MOD_GSK3_1	166	173	PF00069	0.414
MOD_GSK3_1	176	183	PF00069	0.292
MOD_GSK3_1	281	288	PF00069	0.637
MOD_GSK3_1	307	314	PF00069	0.628
MOD_GSK3_1	42	49	PF00069	0.354
MOD_GSK3_1	467	474	PF00069	0.374
MOD_GSK3_1	504	511	PF00069	0.666
MOD_GSK3_1	582	589	PF00069	0.683
MOD_GSK3_1	619	626	PF00069	0.661
MOD_GSK3_1	683	690	PF00069	0.545
MOD_GSK3_1	694	701	PF00069	0.570
MOD_GSK3_1	704	711	PF00069	0.614
MOD_GSK3_1	727	734	PF00069	0.721
MOD_GSK3_1	99	106	PF00069	0.383
MOD_N-GLC_1	100	105	PF02516	0.224
MOD_N-GLC_1	247	252	PF02516	0.580
MOD_N-GLC_1	269	274	PF02516	0.536
MOD_N-GLC_1	349	354	PF02516	0.480
MOD_N-GLC_1	582	587	PF02516	0.699
MOD_N-GLC_1	727	732	PF02516	0.656
MOD_N-GLC_1	750	755	PF02516	0.559
MOD_N-GLC_1	83	88	PF02516	0.337
MOD_N-GLC_2	580	582	PF02516	0.637
MOD_NEK2_1	142	147	PF00069	0.323
MOD_NEK2_1	17	22	PF00069	0.463
MOD_NEK2_1	207	212	PF00069	0.542
MOD_NEK2_1	320	325	PF00069	0.644
MOD_NEK2_1	378	383	PF00069	0.514
MOD_NEK2_1	64	69	PF00069	0.374
MOD_NEK2_1	674	679	PF00069	0.403
MOD_NEK2_1	99	104	PF00069	0.286
MOD_NEK2_2	656	661	PF00069	0.485
MOD_OFUCOSY	195	201	PF10250	0.374
MOD_PIKK_1	17	23	PF00454	0.486
MOD_PIKK_1	186	192	PF00454	0.486
MOD_PIKK_1	349	355	PF00454	0.501
MOD_PIKK_1	406	412	PF00454	0.374
MOD_PKA_1	219	225	PF00069	0.647
MOD_PKA_1	471	477	PF00069	0.368
MOD_PKA_2	219	225	PF00069	0.647
MOD_PKA_2	281	287	PF00069	0.747
MOD_PKA_2	312	318	PF00069	0.723
MOD_PKA_2	413	419	PF00069	0.374
MOD_PKA_2	586	592	PF00069	0.582
MOD_Plk_1	100	106	PF00069	0.350
MOD_Plk_1	17	23	PF00069	0.433
MOD_Plk_1	247	253	PF00069	0.531
MOD_Plk_1	269	275	PF00069	0.538
MOD_Plk_1	328	334	PF00069	0.577
MOD_Plk_1	349	355	PF00069	0.473
MOD_Plk_1	642	648	PF00069	0.498
MOD_Plk_1	683	689	PF00069	0.566
MOD_Plk_1	727	733	PF00069	0.577
MOD_Plk_1	750	756	PF00069	0.563
MOD_Plk_4	103	109	PF00069	0.321
MOD_Plk_4	236	242	PF00069	0.440
MOD_Plk_4	247	253	PF00069	0.512
MOD_Plk_4	312	318	PF00069	0.681
MOD_Plk_4	471	477	PF00069	0.315
MOD_Plk_4	566	572	PF00069	0.534
MOD_Plk_4	674	680	PF00069	0.476
MOD_ProDKin_1	106	112	PF00069	0.335
MOD_ProDKin_1	183	189	PF00069	0.342
MOD_ProDKin_1	379	385	PF00069	0.432
MOD_ProDKin_1	582	588	PF00069	0.728
MOD_ProDKin_1	6	12	PF00069	0.724
MOD_ProDKin_1	619	625	PF00069	0.710
MOD_ProDKin_1	633	639	PF00069	0.539
MOD_ProDKin_1	665	671	PF00069	0.494
MOD_SUMO_rev_2	222	229	PF00179	0.625
TRG_DiLeu_BaEn_2	450	456	PF01217	0.424
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.465
TRG_DiLeu_BaLyEn_6	660	665	PF01217	0.501
TRG_ENDOCYTIC_2	351	354	PF00928	0.561
TRG_ENDOCYTIC_2	449	452	PF00928	0.374
TRG_ENDOCYTIC_2	96	99	PF00928	0.314
TRG_ER_diArg_1	130	132	PF00400	0.424
TRG_ER_diArg_1	218	221	PF00400	0.652
TRG_ER_diArg_1	424	427	PF00400	0.300
TRG_ER_diArg_1	452	454	PF00400	0.334
TRG_ER_diArg_1	541	543	PF00400	0.561
TRG_ER_diArg_1	736	738	PF00400	0.694
TRG_NES_CRM1_1	672	684	PF08389	0.462
TRG_Pf-PMV_PEXEL_1	430	435	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	743	747	PF00026	0.602
TRG_Pf-PMV_PEXEL_1	750	755	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I177	Leptomonas seymouri	62%	88%
A0A1X0NPZ6	Trypanosomatidae	42%	100%
A0A3S7WT46	Leishmania donovani	90%	100%
A4H7T7	Leishmania braziliensis	71%	88%
E9APW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%