Putative phosphatidylserine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylserine synthase, putative

Species:

Leishmania major

UniProt:

Q4QFL4_LEIMA

TriTrypDb:

LmjF.14.1200 , LMJLV39_140019800 , LMJSD75_140019300

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QFL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFL4

Function

Biological processes
Term	Name	Level	Count
GO:0006575	cellular modified amino acid metabolic process	3	12
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006658	phosphatidylserine metabolic process	4	12
GO:0006659	phosphatidylserine biosynthetic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0042398	cellular modified amino acid biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003882	CDP-diacylglycerol-serine O-phosphatidyltransferase activity	6	5
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	4	12
GO:0017169	CDP-alcohol phosphatidyltransferase activity	5	5
GO:0106245	L-serine-phosphatidylethanolamine phosphatidyltransferase activity	5	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.571
CLV_NRD_NRD_1	2	4	PF00675	0.419
CLV_NRD_NRD_1	48	50	PF00675	0.489
CLV_NRD_NRD_1	480	482	PF00675	0.349
CLV_NRD_NRD_1	55	57	PF00675	0.437
CLV_PCSK_FUR_1	409	413	PF00082	0.294
CLV_PCSK_FUR_1	477	481	PF00082	0.398
CLV_PCSK_KEX2_1	15	17	PF00082	0.548
CLV_PCSK_KEX2_1	2	4	PF00082	0.593
CLV_PCSK_KEX2_1	325	327	PF00082	0.284
CLV_PCSK_KEX2_1	37	39	PF00082	0.532
CLV_PCSK_KEX2_1	411	413	PF00082	0.270
CLV_PCSK_KEX2_1	479	481	PF00082	0.340
CLV_PCSK_KEX2_1	55	57	PF00082	0.494
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.305
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.532
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.270
CLV_PCSK_SKI1_1	165	169	PF00082	0.297
CLV_PCSK_SKI1_1	251	255	PF00082	0.313
CLV_PCSK_SKI1_1	325	329	PF00082	0.278
CLV_PCSK_SKI1_1	371	375	PF00082	0.445
CLV_PCSK_SKI1_1	386	390	PF00082	0.297
CLV_PCSK_SKI1_1	514	518	PF00082	0.530
CLV_PCSK_SKI1_1	526	530	PF00082	0.493
CLV_PCSK_SKI1_1	80	84	PF00082	0.526
DEG_APCC_DBOX_1	385	393	PF00400	0.354
DEG_MDM2_SWIB_1	274	282	PF02201	0.245
DEG_Nend_UBRbox_1	1	4	PF02207	0.621
DOC_CDC14_PxL_1	504	512	PF14671	0.433
DOC_CYCLIN_RxL_1	240	249	PF00134	0.354
DOC_CYCLIN_yCln2_LP_2	81	87	PF00134	0.669
DOC_MAPK_gen_1	248	258	PF00069	0.445
DOC_MAPK_gen_1	479	488	PF00069	0.593
DOC_MAPK_gen_1	55	62	PF00069	0.716
DOC_MAPK_MEF2A_6	165	172	PF00069	0.313
DOC_MAPK_MEF2A_6	251	260	PF00069	0.297
DOC_MAPK_MEF2A_6	481	490	PF00069	0.550
DOC_MAPK_MEF2A_6	55	64	PF00069	0.698
DOC_MAPK_NFAT4_5	165	173	PF00069	0.364
DOC_PP1_RVXF_1	384	391	PF00149	0.251
DOC_PP1_RVXF_1	524	531	PF00149	0.263
DOC_PP1_RVXF_1	88	95	PF00149	0.633
DOC_PP4_FxxP_1	344	347	PF00568	0.456
DOC_USP7_MATH_1	516	520	PF00917	0.392
DOC_USP7_MATH_1	68	72	PF00917	0.665
DOC_USP7_MATH_2	68	74	PF00917	0.674
DOC_WW_Pin1_4	26	31	PF00397	0.704
DOC_WW_Pin1_4	343	348	PF00397	0.499
DOC_WW_Pin1_4	83	88	PF00397	0.637
DOC_WW_Pin1_4	97	102	PF00397	0.546
LIG_14-3-3_CanoR_1	214	223	PF00244	0.245
LIG_14-3-3_CanoR_1	251	260	PF00244	0.297
LIG_14-3-3_CanoR_1	412	422	PF00244	0.470
LIG_14-3-3_CanoR_1	55	64	PF00244	0.694
LIG_AP2alpha_2	220	222	PF02296	0.331
LIG_APCC_ABBA_1	180	185	PF00400	0.417
LIG_BRCT_BRCA1_1	112	116	PF00533	0.348
LIG_BRCT_BRCA1_1	256	260	PF00533	0.297
LIG_deltaCOP1_diTrp_1	218	229	PF00928	0.332
LIG_EH1_1	239	247	PF00400	0.332
LIG_EH1_1	350	358	PF00400	0.384
LIG_EH1_1	367	375	PF00400	0.198
LIG_eIF4E_1	195	201	PF01652	0.328
LIG_eIF4E_1	240	246	PF01652	0.354
LIG_eIF4E_1	485	491	PF01652	0.363
LIG_FHA_1	101	107	PF00498	0.458
LIG_FHA_1	177	183	PF00498	0.417
LIG_FHA_1	352	358	PF00498	0.392
LIG_FHA_1	377	383	PF00498	0.275
LIG_FHA_1	393	399	PF00498	0.259
LIG_FHA_1	414	420	PF00498	0.321
LIG_FHA_1	426	432	PF00498	0.288
LIG_FHA_1	52	58	PF00498	0.714
LIG_FHA_2	215	221	PF00498	0.256
LIG_FHA_2	225	231	PF00498	0.227
LIG_FHA_2	46	52	PF00498	0.636
LIG_GBD_Chelix_1	496	504	PF00786	0.210
LIG_LIR_Gen_1	103	112	PF02991	0.395
LIG_LIR_Gen_1	179	186	PF02991	0.299
LIG_LIR_Gen_1	227	235	PF02991	0.270
LIG_LIR_Gen_1	257	267	PF02991	0.297
LIG_LIR_Gen_1	276	287	PF02991	0.245
LIG_LIR_Gen_1	400	410	PF02991	0.466
LIG_LIR_Gen_1	415	426	PF02991	0.212
LIG_LIR_Nem_3	103	108	PF02991	0.395
LIG_LIR_Nem_3	179	183	PF02991	0.328
LIG_LIR_Nem_3	219	225	PF02991	0.240
LIG_LIR_Nem_3	227	232	PF02991	0.239
LIG_LIR_Nem_3	249	253	PF02991	0.464
LIG_LIR_Nem_3	257	263	PF02991	0.265
LIG_LIR_Nem_3	264	270	PF02991	0.235
LIG_LIR_Nem_3	276	282	PF02991	0.245
LIG_LIR_Nem_3	335	339	PF02991	0.447
LIG_LIR_Nem_3	348	353	PF02991	0.438
LIG_LIR_Nem_3	415	421	PF02991	0.422
LIG_LIR_Nem_3	525	530	PF02991	0.358
LIG_LYPXL_yS_3	123	126	PF13949	0.351
LIG_NRBOX	357	363	PF00104	0.362
LIG_NRBOX	388	394	PF00104	0.417
LIG_Pex14_1	464	468	PF04695	0.297
LIG_Pex14_2	274	278	PF04695	0.245
LIG_PTB_Apo_2	486	493	PF02174	0.332
LIG_REV1ctd_RIR_1	527	532	PF16727	0.362
LIG_SH2_CRK	121	125	PF00017	0.257
LIG_SH2_CRK	493	497	PF00017	0.257
LIG_SH2_SRC	121	124	PF00017	0.254
LIG_SH2_STAP1	196	200	PF00017	0.322
LIG_SH2_STAP1	493	497	PF00017	0.417
LIG_SH2_STAP1	524	528	PF00017	0.323
LIG_SH2_STAT5	240	243	PF00017	0.349
LIG_SH2_STAT5	440	443	PF00017	0.320
LIG_SH2_STAT5	468	471	PF00017	0.377
LIG_SH2_STAT5	485	488	PF00017	0.213
LIG_SH2_STAT5	527	530	PF00017	0.352
LIG_SH2_STAT5	99	102	PF00017	0.541
LIG_SH3_3	146	152	PF00018	0.417
LIG_SH3_3	447	453	PF00018	0.322
LIG_SH3_3	81	87	PF00018	0.683
LIG_SUMO_SIM_anti_2	354	360	PF11976	0.418
LIG_SUMO_SIM_par_1	243	249	PF11976	0.297
LIG_SUMO_SIM_par_1	261	266	PF11976	0.297
LIG_SUMO_SIM_par_1	358	364	PF11976	0.268
LIG_SUMO_SIM_par_1	470	475	PF11976	0.530
LIG_TRAF2_1	216	219	PF00917	0.324
LIG_TYR_ITIM	466	471	PF00017	0.382
LIG_UBA3_1	182	191	PF00899	0.397
LIG_UBA3_1	300	307	PF00899	0.382
LIG_WRC_WIRS_1	177	182	PF05994	0.299
MOD_CDC14_SPxK_1	346	349	PF00782	0.505
MOD_CDK_SPxK_1	343	349	PF00069	0.505
MOD_CDK_SPxxK_3	83	90	PF00069	0.652
MOD_CK1_1	45	51	PF00069	0.755
MOD_CK1_1	71	77	PF00069	0.708
MOD_CK2_1	213	219	PF00069	0.281
MOD_CK2_1	30	36	PF00069	0.762
MOD_CK2_1	45	51	PF00069	0.563
MOD_GlcNHglycan	136	139	PF01048	0.338
MOD_GlcNHglycan	518	521	PF01048	0.597
MOD_GSK3_1	106	113	PF00069	0.415
MOD_GSK3_1	26	33	PF00069	0.743
MOD_GSK3_1	425	432	PF00069	0.384
MOD_GSK3_1	51	58	PF00069	0.711
MOD_GSK3_1	68	75	PF00069	0.621
MOD_NEK2_1	224	229	PF00069	0.245
MOD_NEK2_1	234	239	PF00069	0.297
MOD_NEK2_1	351	356	PF00069	0.350
MOD_NEK2_1	392	397	PF00069	0.408
MOD_PIKK_1	55	61	PF00454	0.724
MOD_PKA_1	55	61	PF00069	0.690
MOD_PKA_2	213	219	PF00069	0.264
MOD_PKA_2	55	61	PF00069	0.602
MOD_Plk_1	196	202	PF00069	0.317
MOD_Plk_1	205	211	PF00069	0.298
MOD_Plk_1	263	269	PF00069	0.297
MOD_Plk_4	100	106	PF00069	0.475
MOD_Plk_4	110	116	PF00069	0.278
MOD_Plk_4	151	157	PF00069	0.521
MOD_Plk_4	176	182	PF00069	0.347
MOD_Plk_4	196	202	PF00069	0.114
MOD_Plk_4	425	431	PF00069	0.313
MOD_ProDKin_1	26	32	PF00069	0.705
MOD_ProDKin_1	343	349	PF00069	0.499
MOD_ProDKin_1	83	89	PF00069	0.631
MOD_ProDKin_1	97	103	PF00069	0.541
TRG_DiLeu_BaLyEn_6	323	328	PF01217	0.531
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.675
TRG_ENDOCYTIC_2	123	126	PF00928	0.324
TRG_ENDOCYTIC_2	174	177	PF00928	0.297
TRG_ENDOCYTIC_2	309	312	PF00928	0.463
TRG_ENDOCYTIC_2	402	405	PF00928	0.445
TRG_ENDOCYTIC_2	468	471	PF00928	0.377
TRG_ENDOCYTIC_2	485	488	PF00928	0.382
TRG_ENDOCYTIC_2	493	496	PF00928	0.417
TRG_ENDOCYTIC_2	527	530	PF00928	0.359
TRG_ER_diArg_1	1	3	PF00400	0.622
TRG_ER_diArg_1	477	480	PF00400	0.537
TRG_ER_diArg_1	55	57	PF00400	0.607
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.243
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIC0	Leptomonas seymouri	72%	100%
A0A0S4ILR0	Bodo saltans	49%	100%
A0A1X0NNG6	Trypanosomatidae	57%	100%
A0A3R7N202	Trypanosoma rangeli	52%	100%
A0A3S7WT59	Leishmania donovani	94%	100%
A4H7U0	Leishmania braziliensis	86%	100%
A4HW66	Leishmania infantum	94%	100%
B2GV22	Rattus norvegicus	34%	100%
C9ZSV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E1BYA3	Gallus gallus	34%	100%
E7EY42	Danio rerio	34%	100%
E9APW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O08888	Cricetulus griseus	34%	100%
P48651	Homo sapiens	32%	100%
Q00576	Cricetulus griseus	32%	100%
Q08D11	Xenopus tropicalis	35%	100%
Q0JR55	Oryza sativa subsp. japonica	33%	100%
Q2KHY9	Bos taurus	32%	100%
Q5PQL5	Rattus norvegicus	32%	100%
Q5ZM65	Gallus gallus	32%	100%
Q6I628	Oryza sativa subsp. japonica	34%	100%
Q803C9	Danio rerio	32%	100%
Q99LH2	Mus musculus	32%	100%
Q9VPD3	Drosophila melanogaster	31%	100%
Q9Z1X2	Mus musculus	34%	100%
V5DC50	Trypanosoma cruzi	50%	100%