FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QFL3_LEIMA

TriTrypDb:

LmjF.14.1210 , LMJLV39_140019900 , LMJSD75_140019400

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFL3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016791	phosphatase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.721
CLV_NRD_NRD_1	167	169	PF00675	0.326
CLV_NRD_NRD_1	257	259	PF00675	0.533
CLV_PCSK_KEX2_1	123	125	PF00082	0.755
CLV_PCSK_KEX2_1	167	169	PF00082	0.325
CLV_PCSK_KEX2_1	257	259	PF00082	0.533
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.755
CLV_PCSK_PC7_1	119	125	PF00082	0.725
CLV_PCSK_SKI1_1	252	256	PF00082	0.447
CLV_PCSK_SKI1_1	5	9	PF00082	0.370
DEG_SCF_SKP2-CKS1_1	202	209	PF00560	0.344
DOC_ANK_TNKS_1	22	29	PF00023	0.571
DOC_PP1_RVXF_1	147	153	PF00149	0.444
DOC_USP7_MATH_1	102	106	PF00917	0.787
DOC_USP7_MATH_1	110	114	PF00917	0.777
DOC_WW_Pin1_4	203	208	PF00397	0.372
LIG_14-3-3_CanoR_1	69	73	PF00244	0.473
LIG_BRCT_BRCA1_1	116	120	PF00533	0.558
LIG_BRCT_BRCA1_1	184	188	PF00533	0.444
LIG_EH1_1	239	247	PF00400	0.396
LIG_FHA_1	198	204	PF00498	0.344
LIG_FHA_1	33	39	PF00498	0.481
LIG_FHA_1	69	75	PF00498	0.457
LIG_FHA_2	125	131	PF00498	0.684
LIG_FHA_2	13	19	PF00498	0.366
LIG_FHA_2	159	165	PF00498	0.338
LIG_FHA_2	178	184	PF00498	0.344
LIG_GBD_Chelix_1	8	16	PF00786	0.392
LIG_Integrin_isoDGR_2	114	116	PF01839	0.704
LIG_LIR_Gen_1	185	195	PF02991	0.403
LIG_LIR_Gen_1	215	221	PF02991	0.429
LIG_LIR_Nem_3	164	169	PF02991	0.403
LIG_LIR_Nem_3	185	191	PF02991	0.352
LIG_LIR_Nem_3	215	220	PF02991	0.429
LIG_MYND_1	2	6	PF01753	0.587
LIG_Pex14_2	152	156	PF04695	0.344
LIG_PTB_Apo_2	73	80	PF02174	0.510
LIG_SH2_STAT5	217	220	PF00017	0.410
LIG_SUMO_SIM_par_1	199	206	PF11976	0.345
LIG_TRAF2_1	132	135	PF00917	0.717
LIG_TRAF2_1	97	100	PF00917	0.670
MOD_CDK_SPxK_1	203	209	PF00069	0.344
MOD_CK1_1	177	183	PF00069	0.330
MOD_CK1_1	64	70	PF00069	0.434
MOD_CK1_1	81	87	PF00069	0.628
MOD_CK2_1	12	18	PF00069	0.375
MOD_CK2_1	124	130	PF00069	0.769
MOD_CK2_1	133	139	PF00069	0.494
MOD_GlcNHglycan	102	105	PF01048	0.780
MOD_GlcNHglycan	110	113	PF01048	0.753
MOD_GlcNHglycan	116	119	PF01048	0.800
MOD_GlcNHglycan	133	138	PF01048	0.638
MOD_GSK3_1	110	117	PF00069	0.625
MOD_GSK3_1	154	161	PF00069	0.321
MOD_GSK3_1	64	71	PF00069	0.412
MOD_N-GLC_1	81	86	PF02516	0.632
MOD_NEK2_1	12	17	PF00069	0.372
MOD_PIKK_1	182	188	PF00454	0.441
MOD_PKA_1	124	130	PF00069	0.686
MOD_PKA_2	12	18	PF00069	0.375
MOD_PKA_2	124	130	PF00069	0.686
MOD_PKA_2	68	74	PF00069	0.438
MOD_Plk_1	158	164	PF00069	0.444
MOD_Plk_1	182	188	PF00069	0.429
MOD_Plk_1	229	235	PF00069	0.343
MOD_Plk_1	32	38	PF00069	0.541
MOD_Plk_1	81	87	PF00069	0.723
MOD_Plk_4	12	18	PF00069	0.375
MOD_Plk_4	197	203	PF00069	0.392
MOD_Plk_4	230	236	PF00069	0.343
MOD_ProDKin_1	203	209	PF00069	0.372
MOD_SUMO_for_1	228	231	PF00179	0.399
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.460
TRG_ENDOCYTIC_2	217	220	PF00928	0.444
TRG_ER_diArg_1	124	126	PF00400	0.721
TRG_ER_diArg_1	166	168	PF00400	0.325
TRG_ER_diArg_1	235	238	PF00400	0.366
TRG_ER_diArg_1	256	258	PF00400	0.552

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q2	Leptomonas seymouri	59%	94%
A0A0S4IS02	Bodo saltans	42%	100%
A0A1X0NNH3	Trypanosomatidae	39%	100%
A0A3R7R775	Trypanosoma rangeli	42%	100%
A0A3S7WT65	Leishmania donovani	91%	100%
A4H7U1	Leishmania braziliensis	71%	94%
A4HW67	Leishmania infantum	91%	100%
E9APW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%