Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFL2_LEIMA

TriTrypDb:

LmjF.14.1220 , LMJLV39_140020000 , LMJSD75_140019500

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFL2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.625
CLV_C14_Caspase3-7	267	271	PF00656	0.784
CLV_C14_Caspase3-7	440	444	PF00656	0.631
CLV_C14_Caspase3-7	490	494	PF00656	0.688
CLV_C14_Caspase3-7	536	540	PF00656	0.673
CLV_C14_Caspase3-7	694	698	PF00656	0.578
CLV_C14_Caspase3-7	80	84	PF00656	0.619
CLV_C14_Caspase3-7	803	807	PF00656	0.517
CLV_NRD_NRD_1	122	124	PF00675	0.534
CLV_NRD_NRD_1	263	265	PF00675	0.786
CLV_NRD_NRD_1	343	345	PF00675	0.661
CLV_NRD_NRD_1	359	361	PF00675	0.595
CLV_NRD_NRD_1	389	391	PF00675	0.603
CLV_NRD_NRD_1	447	449	PF00675	0.494
CLV_PCSK_FUR_1	261	265	PF00082	0.709
CLV_PCSK_KEX2_1	263	265	PF00082	0.786
CLV_PCSK_KEX2_1	343	345	PF00082	0.661
CLV_PCSK_KEX2_1	351	353	PF00082	0.600
CLV_PCSK_KEX2_1	359	361	PF00082	0.595
CLV_PCSK_KEX2_1	389	391	PF00082	0.488
CLV_PCSK_KEX2_1	447	449	PF00082	0.497
CLV_PCSK_KEX2_1	478	480	PF00082	0.552
CLV_PCSK_KEX2_1	510	512	PF00082	0.448
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.722
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.535
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.415
CLV_PCSK_SKI1_1	32	36	PF00082	0.462
CLV_PCSK_SKI1_1	325	329	PF00082	0.749
CLV_PCSK_SKI1_1	351	355	PF00082	0.646
CLV_PCSK_SKI1_1	485	489	PF00082	0.540
CLV_PCSK_SKI1_1	668	672	PF00082	0.496
DEG_APCC_DBOX_1	667	675	PF00400	0.498
DEG_APCC_KENBOX_2	42	46	PF00400	0.588
DOC_CKS1_1	378	383	PF01111	0.687
DOC_CYCLIN_RxL_1	501	509	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.639
DOC_MAPK_gen_1	261	268	PF00069	0.704
DOC_MAPK_HePTP_8	201	213	PF00069	0.603
DOC_MAPK_MEF2A_6	16	24	PF00069	0.615
DOC_MAPK_MEF2A_6	204	213	PF00069	0.607
DOC_PIKK_1	93	101	PF02985	0.612
DOC_PP2B_LxvP_1	213	216	PF13499	0.630
DOC_USP7_MATH_1	161	165	PF00917	0.828
DOC_USP7_MATH_1	175	179	PF00917	0.696
DOC_USP7_MATH_1	190	194	PF00917	0.614
DOC_USP7_MATH_1	334	338	PF00917	0.673
DOC_USP7_MATH_1	494	498	PF00917	0.630
DOC_USP7_MATH_1	514	518	PF00917	0.330
DOC_USP7_MATH_1	622	626	PF00917	0.608
DOC_USP7_MATH_1	642	646	PF00917	0.565
DOC_USP7_MATH_1	666	670	PF00917	0.472
DOC_USP7_MATH_1	875	879	PF00917	0.815
DOC_USP7_MATH_1	916	920	PF00917	0.660
DOC_USP7_UBL2_3	557	561	PF12436	0.465
DOC_WW_Pin1_4	148	153	PF00397	0.748
DOC_WW_Pin1_4	249	254	PF00397	0.716
DOC_WW_Pin1_4	286	291	PF00397	0.711
DOC_WW_Pin1_4	294	299	PF00397	0.700
DOC_WW_Pin1_4	374	379	PF00397	0.762
DOC_WW_Pin1_4	861	866	PF00397	0.742
DOC_WW_Pin1_4	912	917	PF00397	0.766
LIG_14-3-3_CanoR_1	123	133	PF00244	0.612
LIG_14-3-3_CanoR_1	174	180	PF00244	0.590
LIG_14-3-3_CanoR_1	278	284	PF00244	0.665
LIG_14-3-3_CanoR_1	343	349	PF00244	0.600
LIG_14-3-3_CanoR_1	485	492	PF00244	0.533
LIG_14-3-3_CanoR_1	702	710	PF00244	0.508
LIG_14-3-3_CanoR_1	855	860	PF00244	0.658
LIG_14-3-3_CanoR_1	922	928	PF00244	0.667
LIG_Actin_WH2_2	467	484	PF00022	0.495
LIG_Actin_WH2_2	707	724	PF00022	0.509
LIG_Actin_WH2_2	898	913	PF00022	0.662
LIG_BIR_II_1	1	5	PF00653	0.605
LIG_BIR_III_4	697	701	PF00653	0.584
LIG_BRCT_BRCA1_1	279	283	PF00533	0.783
LIG_EVH1_2	381	385	PF00568	0.657
LIG_FAT_LD_1	442	450	PF03623	0.542
LIG_FHA_1	3	9	PF00498	0.638
LIG_FHA_1	326	332	PF00498	0.779
LIG_FHA_1	500	506	PF00498	0.532
LIG_FHA_1	54	60	PF00498	0.522
LIG_FHA_1	575	581	PF00498	0.622
LIG_FHA_1	878	884	PF00498	0.583
LIG_FHA_2	113	119	PF00498	0.559
LIG_FHA_2	28	34	PF00498	0.463
LIG_FHA_2	314	320	PF00498	0.748
LIG_FHA_2	345	351	PF00498	0.628
LIG_FHA_2	534	540	PF00498	0.668
LIG_FHA_2	808	814	PF00498	0.536
LIG_FHA_2	922	928	PF00498	0.667
LIG_FXI_DFP_1	413	417	PF00024	0.441
LIG_GBD_Chelix_1	401	409	PF00786	0.478
LIG_LIR_Gen_1	214	222	PF02991	0.567
LIG_LIR_Gen_1	383	391	PF02991	0.524
LIG_LIR_Gen_1	524	532	PF02991	0.556
LIG_LIR_Nem_3	214	220	PF02991	0.563
LIG_LIR_Nem_3	23	27	PF02991	0.614
LIG_LIR_Nem_3	280	286	PF02991	0.704
LIG_LIR_Nem_3	383	388	PF02991	0.558
LIG_LIR_Nem_3	414	419	PF02991	0.526
LIG_LIR_Nem_3	524	529	PF02991	0.544
LIG_LIR_Nem_3	837	842	PF02991	0.563
LIG_NRBOX	441	447	PF00104	0.549
LIG_NRBOX	562	568	PF00104	0.493
LIG_NRBOX	683	689	PF00104	0.540
LIG_NRBOX	97	103	PF00104	0.501
LIG_RPA_C_Fungi	354	366	PF08784	0.656
LIG_SH2_GRB2like	397	400	PF00017	0.476
LIG_SH2_STAT5	397	400	PF00017	0.495
LIG_SH2_STAT5	767	770	PF00017	0.470
LIG_SH3_3	266	272	PF00018	0.776
LIG_SH3_3	278	284	PF00018	0.618
LIG_SH3_3	295	301	PF00018	0.534
LIG_SH3_3	375	381	PF00018	0.718
LIG_SH3_3	925	931	PF00018	0.656
LIG_SUMO_SIM_anti_2	207	214	PF11976	0.683
LIG_SUMO_SIM_par_1	528	534	PF11976	0.528
LIG_UBA3_1	34	43	PF00899	0.585
LIG_UBA3_1	405	410	PF00899	0.472
LIG_UBA3_1	790	796	PF00899	0.468
LIG_UBA3_1	800	808	PF00899	0.512
LIG_WW_3	888	892	PF00397	0.782
MOD_CDK_SPxxK_3	297	304	PF00069	0.663
MOD_CK1_1	138	144	PF00069	0.787
MOD_CK1_1	148	154	PF00069	0.657
MOD_CK1_1	156	162	PF00069	0.753
MOD_CK1_1	178	184	PF00069	0.742
MOD_CK1_1	191	197	PF00069	0.574
MOD_CK1_1	2	8	PF00069	0.642
MOD_CK1_1	251	257	PF00069	0.797
MOD_CK1_1	279	285	PF00069	0.812
MOD_CK1_1	377	383	PF00069	0.735
MOD_CK1_1	649	655	PF00069	0.549
MOD_CK1_1	909	915	PF00069	0.737
MOD_CK1_1	923	929	PF00069	0.546
MOD_CK2_1	112	118	PF00069	0.563
MOD_CK2_1	313	319	PF00069	0.730
MOD_CK2_1	344	350	PF00069	0.636
MOD_CK2_1	622	628	PF00069	0.626
MOD_CK2_1	649	655	PF00069	0.592
MOD_CK2_1	921	927	PF00069	0.669
MOD_GlcNHglycan	127	130	PF01048	0.593
MOD_GlcNHglycan	147	150	PF01048	0.785
MOD_GlcNHglycan	158	161	PF01048	0.737
MOD_GlcNHglycan	163	166	PF01048	0.678
MOD_GlcNHglycan	177	180	PF01048	0.680
MOD_GlcNHglycan	189	193	PF01048	0.548
MOD_GlcNHglycan	217	220	PF01048	0.704
MOD_GlcNHglycan	242	245	PF01048	0.725
MOD_GlcNHglycan	254	257	PF01048	0.747
MOD_GlcNHglycan	308	311	PF01048	0.611
MOD_GlcNHglycan	336	339	PF01048	0.650
MOD_GlcNHglycan	361	364	PF01048	0.764
MOD_GlcNHglycan	516	519	PF01048	0.457
MOD_GlcNHglycan	595	598	PF01048	0.541
MOD_GlcNHglycan	667	671	PF01048	0.462
MOD_GlcNHglycan	703	706	PF01048	0.577
MOD_GlcNHglycan	717	721	PF01048	0.433
MOD_GlcNHglycan	734	737	PF01048	0.371
MOD_GlcNHglycan	74	78	PF01048	0.636
MOD_GlcNHglycan	911	914	PF01048	0.623
MOD_GSK3_1	131	138	PF00069	0.664
MOD_GSK3_1	141	148	PF00069	0.804
MOD_GSK3_1	174	181	PF00069	0.722
MOD_GSK3_1	220	227	PF00069	0.670
MOD_GSK3_1	245	252	PF00069	0.691
MOD_GSK3_1	302	309	PF00069	0.642
MOD_GSK3_1	370	377	PF00069	0.725
MOD_GSK3_1	423	430	PF00069	0.700
MOD_GSK3_1	642	649	PF00069	0.526
MOD_GSK3_1	790	797	PF00069	0.467
MOD_GSK3_1	855	862	PF00069	0.661
MOD_GSK3_1	875	882	PF00069	0.496
MOD_GSK3_1	905	912	PF00069	0.741
MOD_GSK3_1	916	923	PF00069	0.618
MOD_N-GLC_1	454	459	PF02516	0.424
MOD_N-GLC_1	616	621	PF02516	0.555
MOD_N-GLC_1	783	788	PF02516	0.470
MOD_NEK2_1	238	243	PF00069	0.668
MOD_NEK2_1	27	32	PF00069	0.468
MOD_NEK2_1	418	423	PF00069	0.736
MOD_NEK2_1	783	788	PF00069	0.470
MOD_NEK2_1	794	799	PF00069	0.462
MOD_NEK2_1	920	925	PF00069	0.675
MOD_NEK2_2	916	921	PF00069	0.777
MOD_PIKK_1	178	184	PF00454	0.779
MOD_PIKK_1	2	8	PF00454	0.642
MOD_PIKK_1	224	230	PF00454	0.690
MOD_PIKK_1	245	251	PF00454	0.706
MOD_PIKK_1	460	466	PF00454	0.551
MOD_PK_1	264	270	PF00069	0.721
MOD_PKA_1	343	349	PF00069	0.755
MOD_PKA_1	351	357	PF00069	0.591
MOD_PKA_1	359	365	PF00069	0.517
MOD_PKA_2	112	118	PF00069	0.556
MOD_PKA_2	238	244	PF00069	0.755
MOD_PKA_2	277	283	PF00069	0.781
MOD_PKA_2	343	349	PF00069	0.711
MOD_PKA_2	351	357	PF00069	0.591
MOD_PKA_2	358	364	PF00069	0.617
MOD_PKA_2	649	655	PF00069	0.588
MOD_PKA_2	659	665	PF00069	0.521
MOD_PKA_2	701	707	PF00069	0.599
MOD_PKA_2	921	927	PF00069	0.769
MOD_Plk_1	276	282	PF00069	0.759
MOD_Plk_1	622	628	PF00069	0.703
MOD_Plk_1	666	672	PF00069	0.490
MOD_Plk_1	716	722	PF00069	0.617
MOD_Plk_1	754	760	PF00069	0.470
MOD_Plk_1	794	800	PF00069	0.467
MOD_Plk_1	93	99	PF00069	0.611
MOD_Plk_4	20	26	PF00069	0.635
MOD_Plk_4	264	270	PF00069	0.738
MOD_Plk_4	380	386	PF00069	0.575
MOD_Plk_4	622	628	PF00069	0.692
MOD_Plk_4	754	760	PF00069	0.470
MOD_ProDKin_1	148	154	PF00069	0.749
MOD_ProDKin_1	249	255	PF00069	0.717
MOD_ProDKin_1	286	292	PF00069	0.711
MOD_ProDKin_1	294	300	PF00069	0.697
MOD_ProDKin_1	374	380	PF00069	0.759
MOD_ProDKin_1	861	867	PF00069	0.744
MOD_ProDKin_1	912	918	PF00069	0.768
MOD_SUMO_rev_2	404	412	PF00179	0.472
MOD_SUMO_rev_2	607	616	PF00179	0.494
MOD_SUMO_rev_2	659	666	PF00179	0.649
MOD_SUMO_rev_2	735	742	PF00179	0.543
MOD_SUMO_rev_2	74	84	PF00179	0.716
MOD_SUMO_rev_2	803	810	PF00179	0.521
TRG_AP2beta_CARGO_1	414	423	PF09066	0.471
TRG_DiLeu_BaEn_1	207	212	PF01217	0.677
TRG_DiLeu_BaEn_4	472	478	PF01217	0.452
TRG_DiLeu_BaEn_4	93	99	PF01217	0.611
TRG_ENDOCYTIC_2	217	220	PF00928	0.598
TRG_ER_diArg_1	261	264	PF00400	0.763
TRG_ER_diArg_1	342	344	PF00400	0.798
TRG_ER_diArg_1	388	390	PF00400	0.623
TRG_ER_diArg_1	446	448	PF00400	0.499
TRG_ER_diArg_1	854	857	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	504	509	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	682	686	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	693	697	PF00026	0.643
TRG_Pf-PMV_PEXEL_1	712	717	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	881	885	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B0	Leptomonas seymouri	49%	100%
A0A3Q8I8X0	Leishmania donovani	93%	100%
A4H7U2	Leishmania braziliensis	75%	99%
A4HW68	Leishmania infantum	93%	100%
E9APW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%