Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFL1_LEIMA

TriTrypDb:

LmjF.14.1230 , LMJLV39_140020100 , LMJSD75_140019600

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.455
CLV_C14_Caspase3-7	261	265	PF00656	0.355
CLV_NRD_NRD_1	34	36	PF00675	0.399
CLV_NRD_NRD_1	568	570	PF00675	0.471
CLV_PCSK_KEX2_1	34	36	PF00082	0.392
CLV_PCSK_KEX2_1	568	570	PF00082	0.471
CLV_PCSK_SKI1_1	153	157	PF00082	0.416
CLV_PCSK_SKI1_1	241	245	PF00082	0.434
CLV_PCSK_SKI1_1	34	38	PF00082	0.424
CLV_PCSK_SKI1_1	388	392	PF00082	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.489
DEG_SCF_FBW7_1	312	319	PF00400	0.639
DEG_SPOP_SBC_1	323	327	PF00917	0.591
DOC_CKS1_1	313	318	PF01111	0.599
DOC_CYCLIN_RxL_1	238	245	PF00134	0.396
DOC_CYCLIN_yCln2_LP_2	197	203	PF00134	0.364
DOC_CYCLIN_yCln2_LP_2	469	475	PF00134	0.483
DOC_PP2B_LxvP_1	197	200	PF13499	0.374
DOC_PP4_FxxP_1	423	426	PF00568	0.524
DOC_USP7_MATH_1	129	133	PF00917	0.469
DOC_USP7_MATH_1	155	159	PF00917	0.524
DOC_USP7_MATH_1	192	196	PF00917	0.504
DOC_USP7_MATH_1	239	243	PF00917	0.465
DOC_USP7_MATH_1	432	436	PF00917	0.609
DOC_USP7_MATH_1	448	452	PF00917	0.465
DOC_USP7_MATH_1	45	49	PF00917	0.549
DOC_USP7_MATH_1	536	540	PF00917	0.613
DOC_WW_Pin1_4	158	163	PF00397	0.622
DOC_WW_Pin1_4	299	304	PF00397	0.546
DOC_WW_Pin1_4	308	313	PF00397	0.630
DOC_WW_Pin1_4	319	324	PF00397	0.520
DOC_WW_Pin1_4	393	398	PF00397	0.564
DOC_WW_Pin1_4	422	427	PF00397	0.602
DOC_WW_Pin1_4	430	435	PF00397	0.607
DOC_WW_Pin1_4	486	491	PF00397	0.670
LIG_14-3-3_CanoR_1	112	118	PF00244	0.573
LIG_14-3-3_CanoR_1	208	214	PF00244	0.403
LIG_14-3-3_CanoR_1	219	224	PF00244	0.355
LIG_14-3-3_CanoR_1	228	233	PF00244	0.264
LIG_14-3-3_CanoR_1	79	89	PF00244	0.390
LIG_BRCT_BRCA1_1	131	135	PF00533	0.471
LIG_BRCT_BRCA1_1	187	191	PF00533	0.561
LIG_BRCT_BRCA1_1	287	291	PF00533	0.412
LIG_BRCT_BRCA1_1	439	443	PF00533	0.514
LIG_EVH1_1	300	304	PF00568	0.430
LIG_FAT_LD_1	25	33	PF03623	0.451
LIG_FHA_1	163	169	PF00498	0.523
LIG_FHA_1	174	180	PF00498	0.378
LIG_FHA_1	294	300	PF00498	0.367
LIG_FHA_1	407	413	PF00498	0.496
LIG_FHA_1	54	60	PF00498	0.591
LIG_FHA_1	542	548	PF00498	0.455
LIG_FHA_2	259	265	PF00498	0.391
LIG_FHA_2	79	85	PF00498	0.460
LIG_LIR_Gen_1	231	240	PF02991	0.284
LIG_LIR_Nem_3	132	138	PF02991	0.381
LIG_LIR_Nem_3	145	151	PF02991	0.416
LIG_LIR_Nem_3	231	235	PF02991	0.291
LIG_LIR_Nem_3	353	358	PF02991	0.428
LIG_NRBOX	239	245	PF00104	0.470
LIG_Pex14_1	207	211	PF04695	0.353
LIG_Pex14_2	135	139	PF04695	0.451
LIG_PTAP_UEV_1	303	308	PF05743	0.605
LIG_SH2_CRK	211	215	PF00017	0.436
LIG_SH2_STAP1	136	140	PF00017	0.346
LIG_SH2_STAT5	204	207	PF00017	0.346
LIG_SH2_STAT5	295	298	PF00017	0.384
LIG_SH2_STAT5	360	363	PF00017	0.458
LIG_SH2_STAT5	369	372	PF00017	0.403
LIG_SH2_STAT5	545	548	PF00017	0.352
LIG_SH3_3	156	162	PF00018	0.544
LIG_SH3_3	254	260	PF00018	0.455
LIG_SH3_3	298	304	PF00018	0.496
LIG_SH3_3	35	41	PF00018	0.473
LIG_SH3_3	423	429	PF00018	0.557
LIG_SH3_3	90	96	PF00018	0.466
LIG_SUMO_SIM_par_1	219	227	PF11976	0.345
LIG_TRAF2_1	505	508	PF00917	0.629
LIG_WW_1	397	400	PF00397	0.430
MOD_CK1_1	123	129	PF00069	0.531
MOD_CK1_1	158	164	PF00069	0.488
MOD_CK1_1	212	218	PF00069	0.547
MOD_CK1_1	302	308	PF00069	0.611
MOD_CK1_1	318	324	PF00069	0.567
MOD_CK1_1	341	347	PF00069	0.512
MOD_CK1_1	435	441	PF00069	0.643
MOD_CK1_1	48	54	PF00069	0.561
MOD_CK1_1	539	545	PF00069	0.408
MOD_CK1_1	80	86	PF00069	0.426
MOD_CK2_1	501	507	PF00069	0.625
MOD_CK2_1	78	84	PF00069	0.402
MOD_CMANNOS	67	70	PF00535	0.539
MOD_GlcNHglycan	124	128	PF01048	0.558
MOD_GlcNHglycan	168	171	PF01048	0.596
MOD_GlcNHglycan	20	24	PF01048	0.497
MOD_GlcNHglycan	236	239	PF01048	0.372
MOD_GlcNHglycan	254	257	PF01048	0.527
MOD_GlcNHglycan	304	307	PF01048	0.585
MOD_GlcNHglycan	338	341	PF01048	0.652
MOD_GlcNHglycan	391	394	PF01048	0.453
MOD_GlcNHglycan	430	433	PF01048	0.602
MOD_GlcNHglycan	434	437	PF01048	0.621
MOD_GlcNHglycan	47	50	PF01048	0.577
MOD_GlcNHglycan	496	499	PF01048	0.638
MOD_GlcNHglycan	59	62	PF01048	0.547
MOD_GSK3_1	107	114	PF00069	0.667
MOD_GSK3_1	119	126	PF00069	0.541
MOD_GSK3_1	147	154	PF00069	0.380
MOD_GSK3_1	158	165	PF00069	0.496
MOD_GSK3_1	209	216	PF00069	0.434
MOD_GSK3_1	308	315	PF00069	0.646
MOD_GSK3_1	318	325	PF00069	0.540
MOD_GSK3_1	336	343	PF00069	0.509
MOD_GSK3_1	389	396	PF00069	0.399
MOD_GSK3_1	428	435	PF00069	0.765
MOD_GSK3_1	48	55	PF00069	0.632
MOD_GSK3_1	489	496	PF00069	0.704
MOD_GSK3_1	517	524	PF00069	0.709
MOD_GSK3_1	539	546	PF00069	0.389
MOD_GSK3_1	559	566	PF00069	0.430
MOD_N-GLC_1	52	57	PF02516	0.545
MOD_NEK2_1	111	116	PF00069	0.574
MOD_NEK2_1	213	218	PF00069	0.379
MOD_NEK2_1	233	238	PF00069	0.303
MOD_NEK2_1	28	33	PF00069	0.346
MOD_NEK2_1	345	350	PF00069	0.714
MOD_NEK2_1	370	375	PF00069	0.422
MOD_NEK2_1	389	394	PF00069	0.534
MOD_NEK2_1	443	448	PF00069	0.421
MOD_NEK2_1	523	528	PF00069	0.590
MOD_NEK2_2	107	112	PF00069	0.521
MOD_NEK2_2	129	134	PF00069	0.495
MOD_PIKK_1	523	529	PF00454	0.616
MOD_PIKK_1	536	542	PF00454	0.434
MOD_PK_1	219	225	PF00069	0.340
MOD_PK_1	416	422	PF00069	0.350
MOD_PK_1	559	565	PF00069	0.473
MOD_PKA_2	111	117	PF00069	0.586
MOD_PKA_2	78	84	PF00069	0.429
MOD_Plk_1	123	129	PF00069	0.490
MOD_Plk_1	173	179	PF00069	0.483
MOD_Plk_1	185	191	PF00069	0.480
MOD_Plk_1	416	422	PF00069	0.350
MOD_Plk_4	155	161	PF00069	0.496
MOD_Plk_4	173	179	PF00069	0.552
MOD_Plk_4	186	192	PF00069	0.490
MOD_Plk_4	209	215	PF00069	0.476
MOD_Plk_4	228	234	PF00069	0.279
MOD_Plk_4	285	291	PF00069	0.432
MOD_Plk_4	370	376	PF00069	0.380
MOD_Plk_4	448	454	PF00069	0.458
MOD_Plk_4	559	565	PF00069	0.437
MOD_ProDKin_1	158	164	PF00069	0.626
MOD_ProDKin_1	299	305	PF00069	0.563
MOD_ProDKin_1	308	314	PF00069	0.632
MOD_ProDKin_1	319	325	PF00069	0.518
MOD_ProDKin_1	393	399	PF00069	0.570
MOD_ProDKin_1	422	428	PF00069	0.618
MOD_ProDKin_1	430	436	PF00069	0.607
MOD_ProDKin_1	486	492	PF00069	0.672
TRG_DiLeu_BaEn_1	84	89	PF01217	0.403
TRG_DiLeu_BaEn_2	552	558	PF01217	0.370
TRG_ENDOCYTIC_2	136	139	PF00928	0.353
TRG_ENDOCYTIC_2	211	214	PF00928	0.432
TRG_ENDOCYTIC_2	355	358	PF00928	0.472
TRG_ER_diArg_1	1	4	PF00400	0.489
TRG_ER_diArg_1	34	36	PF00400	0.392
TRG_ER_diArg_1	567	569	PF00400	0.434
TRG_ER_diArg_1	94	97	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	552	556	PF00026	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAA7	Leptomonas seymouri	28%	99%
A0A3S7WTC0	Leishmania donovani	84%	100%
A4H7U3	Leishmania braziliensis	63%	100%
A4HW69	Leishmania infantum	84%	100%
E9APX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%