DEK_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFL0_LEIMA

TriTrypDb:

LmjF.14.1240 , LMJLV39_140020200 , LMJSD75_140019700

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFL0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFL0

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	4
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	4
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0003824	catalytic activity	1	1
GO:0005488	binding	1	4
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.541
CLV_C14_Caspase3-7	287	291	PF00656	0.579
CLV_NRD_NRD_1	197	199	PF00675	0.502
CLV_NRD_NRD_1	60	62	PF00675	0.421
CLV_PCSK_KEX2_1	144	146	PF00082	0.613
CLV_PCSK_KEX2_1	197	199	PF00082	0.410
CLV_PCSK_KEX2_1	59	61	PF00082	0.410
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.613
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.576
CLV_PCSK_SKI1_1	197	201	PF00082	0.408
CLV_PCSK_SKI1_1	207	211	PF00082	0.477
CLV_PCSK_SKI1_1	246	250	PF00082	0.488
CLV_PCSK_SKI1_1	61	65	PF00082	0.473
CLV_PCSK_SKI1_1	81	85	PF00082	0.267
DEG_COP1_1	276	285	PF00400	0.500
DEG_SCF_FBW7_1	267	273	PF00400	0.487
DOC_CKS1_1	267	272	PF01111	0.484
DOC_MAPK_MEF2A_6	95	103	PF00069	0.507
DOC_PP2B_LxvP_1	118	121	PF13499	0.489
DOC_USP7_MATH_1	134	138	PF00917	0.766
DOC_USP7_MATH_1	166	170	PF00917	0.656
DOC_USP7_MATH_1	174	178	PF00917	0.587
DOC_USP7_MATH_1	184	188	PF00917	0.397
DOC_USP7_MATH_1	259	263	PF00917	0.450
DOC_USP7_MATH_1	281	285	PF00917	0.728
DOC_WW_Pin1_4	138	143	PF00397	0.617
DOC_WW_Pin1_4	200	205	PF00397	0.519
DOC_WW_Pin1_4	266	271	PF00397	0.758
DOC_WW_Pin1_4	296	301	PF00397	0.612
LIG_14-3-3_CanoR_1	216	220	PF00244	0.467
LIG_Actin_WH2_2	75	93	PF00022	0.471
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_FHA_1	113	119	PF00498	0.416
LIG_FHA_2	201	207	PF00498	0.503
LIG_FHA_2	215	221	PF00498	0.370
LIG_FHA_2	271	277	PF00498	0.599
LIG_LIR_Nem_3	194	199	PF02991	0.450
LIG_PTAP_UEV_1	282	287	PF05743	0.509
LIG_SH2_CRK	196	200	PF00017	0.416
LIG_SH3_1	145	151	PF00018	0.616
LIG_SH3_1	159	165	PF00018	0.609
LIG_SH3_3	140	146	PF00018	0.761
LIG_SH3_3	159	165	PF00018	0.676
LIG_SH3_3	280	286	PF00018	0.593
LIG_SH3_3	294	300	PF00018	0.547
LIG_TRAF2_1	2	5	PF00917	0.619
LIG_TRAF2_1	218	221	PF00917	0.507
MOD_CDC14_SPxK_1	141	144	PF00782	0.695
MOD_CDK_SPxK_1	138	144	PF00069	0.664
MOD_CDK_SPxxK_3	138	145	PF00069	0.653
MOD_CDK_SPxxK_3	200	207	PF00069	0.480
MOD_CK1_1	177	183	PF00069	0.562
MOD_CK1_1	268	274	PF00069	0.657
MOD_CK2_1	103	109	PF00069	0.514
MOD_CK2_1	157	163	PF00069	0.623
MOD_CK2_1	214	220	PF00069	0.454
MOD_CK2_1	270	276	PF00069	0.635
MOD_CK2_1	281	287	PF00069	0.584
MOD_Cter_Amidation	57	60	PF01082	0.533
MOD_GlcNHglycan	131	134	PF01048	0.659
MOD_GlcNHglycan	168	171	PF01048	0.652
MOD_GlcNHglycan	179	182	PF01048	0.552
MOD_GlcNHglycan	273	276	PF01048	0.783
MOD_GlcNHglycan	283	286	PF01048	0.590
MOD_GSK3_1	134	141	PF00069	0.617
MOD_GSK3_1	180	187	PF00069	0.669
MOD_GSK3_1	235	242	PF00069	0.429
MOD_GSK3_1	24	31	PF00069	0.479
MOD_GSK3_1	261	268	PF00069	0.561
MOD_GSK3_1	271	278	PF00069	0.654
MOD_NEK2_1	127	132	PF00069	0.672
MOD_NEK2_1	288	293	PF00069	0.493
MOD_PKA_2	215	221	PF00069	0.449
MOD_ProDKin_1	138	144	PF00069	0.618
MOD_ProDKin_1	200	206	PF00069	0.521
MOD_ProDKin_1	266	272	PF00069	0.609
MOD_ProDKin_1	296	302	PF00069	0.614
MOD_SUMO_rev_2	152	160	PF00179	0.762
TRG_DiLeu_BaEn_4	220	226	PF01217	0.547
TRG_ENDOCYTIC_2	196	199	PF00928	0.412
TRG_ER_diArg_1	196	198	PF00400	0.521
TRG_NLS_Bipartite_1	144	162	PF00514	0.689
TRG_NLS_MonoExtC_3	157	162	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C3	Leptomonas seymouri	60%	88%
A0A3Q8IC32	Leishmania donovani	95%	100%
A0A422MT09	Trypanosoma rangeli	44%	81%
A4H7U4	Leishmania braziliensis	78%	100%
A4HW70	Leishmania infantum	95%	100%
C9ZSU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
E9APX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	98%
V5AW13	Trypanosoma cruzi	40%	83%