5_nucleotid_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFK9_LEIMA

TriTrypDb:

LmjF.14.1250 , LMJLV39_140020300 , LMJSD75_140019800

Length:

205

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.799
CLV_NRD_NRD_1	193	195	PF00675	0.487
CLV_PCSK_KEX2_1	10	12	PF00082	0.799
CLV_PCSK_SKI1_1	141	145	PF00082	0.647
CLV_PCSK_SKI1_1	198	202	PF00082	0.696
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.590
DOC_MAPK_gen_1	10	17	PF00069	0.775
DOC_MAPK_MEF2A_6	10	19	PF00069	0.673
DOC_MAPK_MEF2A_6	83	91	PF00069	0.647
DOC_USP7_MATH_1	79	83	PF00917	0.697
DOC_USP7_UBL2_3	44	48	PF12436	0.594
DOC_WW_Pin1_4	65	70	PF00397	0.683
DOC_WW_Pin1_4	93	98	PF00397	0.611
LIG_14-3-3_CanoR_1	194	198	PF00244	0.610
LIG_APCC_ABBA_1	107	112	PF00400	0.537
LIG_Clathr_ClatBox_1	174	178	PF01394	0.409
LIG_FHA_1	132	138	PF00498	0.641
LIG_FHA_1	147	153	PF00498	0.458
LIG_FHA_1	154	160	PF00498	0.507
LIG_FHA_1	75	81	PF00498	0.614
LIG_FHA_2	37	43	PF00498	0.676
LIG_LIR_Gen_1	199	205	PF02991	0.500
LIG_LIR_Gen_1	59	69	PF02991	0.583
LIG_LIR_Nem_3	103	108	PF02991	0.522
LIG_LIR_Nem_3	199	204	PF02991	0.542
LIG_LIR_Nem_3	59	65	PF02991	0.606
LIG_LIR_Nem_3	95	101	PF02991	0.572
LIG_PDZ_Class_3	200	205	PF00595	0.697
LIG_Pex14_2	197	201	PF04695	0.683
LIG_PTB_Apo_2	46	53	PF02174	0.498
LIG_PTB_Phospho_1	46	52	PF10480	0.493
LIG_SH2_CRK	105	109	PF00017	0.536
LIG_SH2_CRK	62	66	PF00017	0.638
LIG_SH2_CRK	98	102	PF00017	0.536
LIG_SH2_STAT5	147	150	PF00017	0.539
LIG_SH2_STAT5	180	183	PF00017	0.588
LIG_SH2_STAT5	75	78	PF00017	0.607
LIG_SH3_3	112	118	PF00018	0.628
LIG_SUMO_SIM_anti_2	22	27	PF11976	0.651
MOD_CK1_1	3	9	PF00069	0.706
MOD_CK1_1	63	69	PF00069	0.689
MOD_CK1_1	93	99	PF00069	0.602
MOD_GlcNHglycan	125	128	PF01048	0.549
MOD_GlcNHglycan	138	141	PF01048	0.493
MOD_GSK3_1	132	139	PF00069	0.539
MOD_GSK3_1	56	63	PF00069	0.684
MOD_GSK3_1	74	81	PF00069	0.578
MOD_N-GLC_1	129	134	PF02516	0.662
MOD_N-GLC_1	6	11	PF02516	0.767
MOD_NEK2_1	148	153	PF00069	0.642
MOD_NEK2_1	176	181	PF00069	0.682
MOD_NEK2_1	61	66	PF00069	0.757
MOD_NEK2_2	193	198	PF00069	0.707
MOD_PKA_2	193	199	PF00069	0.609
MOD_Plk_4	110	116	PF00069	0.685
MOD_Plk_4	148	154	PF00069	0.578
MOD_Plk_4	176	182	PF00069	0.650
MOD_ProDKin_1	65	71	PF00069	0.676
MOD_ProDKin_1	93	99	PF00069	0.602
MOD_SUMO_for_1	47	50	PF00179	0.596
TRG_DiLeu_BaEn_1	104	109	PF01217	0.650
TRG_ENDOCYTIC_2	105	108	PF00928	0.547
TRG_ENDOCYTIC_2	62	65	PF00928	0.636
TRG_ENDOCYTIC_2	98	101	PF00928	0.536
TRG_ER_diArg_1	10	12	PF00400	0.799
TRG_NES_CRM1_1	166	178	PF08389	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ7	Leptomonas seymouri	43%	100%
A0A3S7WT67	Leishmania donovani	92%	100%
A4H7U5	Leishmania braziliensis	71%	100%
A4HW71	Leishmania infantum	92%	100%
E9APX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%