CUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFK8_LEIMA

TriTrypDb:

LmjF.14.1260 , LMJLV39_140020400 , LMJSD75_140019900

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFK8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	93	95	PF00675	0.380
CLV_PCSK_KEX2_1	84	86	PF00082	0.554
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.496
CLV_PCSK_SKI1_1	13	17	PF00082	0.661
DEG_APCC_DBOX_1	93	101	PF00400	0.473
DEG_Nend_UBRbox_2	1	3	PF02207	0.720
DOC_CYCLIN_yCln2_LP_2	41	47	PF00134	0.517
DOC_MAPK_gen_1	84	91	PF00069	0.485
DOC_MAPK_gen_1	94	101	PF00069	0.378
DOC_MAPK_MEF2A_6	94	101	PF00069	0.475
DOC_USP7_MATH_1	37	41	PF00917	0.485
DOC_USP7_MATH_1	63	67	PF00917	0.582
DOC_WW_Pin1_4	59	64	PF00397	0.692
LIG_14-3-3_CanoR_1	137	142	PF00244	0.539
LIG_FHA_1	100	106	PF00498	0.344
LIG_FHA_1	109	115	PF00498	0.483
LIG_FHA_1	44	50	PF00498	0.473
LIG_FHA_1	60	66	PF00498	0.440
LIG_FHA_1	88	94	PF00498	0.479
LIG_FHA_2	55	61	PF00498	0.400
LIG_LIR_Gen_1	21	32	PF02991	0.543
LIG_LIR_Gen_1	35	45	PF02991	0.539
LIG_LIR_Gen_1	66	73	PF02991	0.541
LIG_LIR_Nem_3	111	116	PF02991	0.574
LIG_LIR_Nem_3	117	121	PF02991	0.438
LIG_LIR_Nem_3	144	150	PF02991	0.582
LIG_LIR_Nem_3	21	27	PF02991	0.491
LIG_LIR_Nem_3	35	41	PF02991	0.567
LIG_LIR_Nem_3	66	70	PF02991	0.453
LIG_SH2_CRK	38	42	PF00017	0.543
LIG_SH2_CRK	67	71	PF00017	0.529
LIG_SH2_NCK_1	34	38	PF00017	0.531
LIG_SH2_NCK_1	67	71	PF00017	0.529
LIG_SH2_STAP1	34	38	PF00017	0.531
LIG_SH2_STAP1	45	49	PF00017	0.407
LIG_SH2_STAT3	119	122	PF00017	0.509
LIG_SH2_STAT5	119	122	PF00017	0.403
LIG_SH2_STAT5	45	48	PF00017	0.610
LIG_SH3_3	132	138	PF00018	0.669
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.507
LIG_SUMO_SIM_par_1	51	57	PF11976	0.464
LIG_SUMO_SIM_par_1	96	102	PF11976	0.338
LIG_TYR_ITIM	116	121	PF00017	0.412
LIG_TYR_ITIM	36	41	PF00017	0.555
LIG_TYR_ITIM	65	70	PF00017	0.555
LIG_WRC_WIRS_1	88	93	PF05994	0.432
MOD_CK1_1	104	110	PF00069	0.379
MOD_CK1_1	125	131	PF00069	0.560
MOD_CK1_1	52	58	PF00069	0.501
MOD_CK2_1	37	43	PF00069	0.618
MOD_CK2_1	54	60	PF00069	0.418
MOD_GlcNHglycan	128	131	PF01048	0.499
MOD_GlcNHglycan	2	5	PF01048	0.590
MOD_GSK3_1	104	111	PF00069	0.578
MOD_GSK3_1	122	129	PF00069	0.345
MOD_GSK3_1	133	140	PF00069	0.450
MOD_GSK3_1	28	35	PF00069	0.583
MOD_GSK3_1	39	46	PF00069	0.558
MOD_GSK3_1	48	55	PF00069	0.440
MOD_GSK3_1	59	66	PF00069	0.355
MOD_N-GLC_1	133	138	PF02516	0.611
MOD_NEK2_1	123	128	PF00069	0.477
MOD_NEK2_1	32	37	PF00069	0.382
MOD_NEK2_1	89	94	PF00069	0.516
MOD_PK_1	137	143	PF00069	0.562
MOD_Plk_1	28	34	PF00069	0.429
MOD_Plk_4	101	107	PF00069	0.419
MOD_Plk_4	114	120	PF00069	0.476
MOD_Plk_4	142	148	PF00069	0.541
MOD_Plk_4	49	55	PF00069	0.591
MOD_ProDKin_1	59	65	PF00069	0.681
TRG_ENDOCYTIC_2	118	121	PF00928	0.416
TRG_ENDOCYTIC_2	12	15	PF00928	0.628
TRG_ENDOCYTIC_2	38	41	PF00928	0.585
TRG_ENDOCYTIC_2	67	70	PF00928	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA15	Leptomonas seymouri	42%	80%
A0A3S5H6S9	Leishmania donovani	91%	100%
A4H7U6	Leishmania braziliensis	67%	100%
A4HW72	Leishmania infantum	91%	100%
E9APX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%