F420_oxidored domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADP oxidoreductase coenzyme F420-dependent, putative

Species:

Leishmania major

UniProt:

Q4QFK6_LEIMA

TriTrypDb:

LmjF.14.1280 , LMJLV39_140020600 , LMJSD75_140020100

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFK6

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006520	amino acid metabolic process	3	7
GO:0006560	proline metabolic process	6	7
GO:0006561	proline biosynthetic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008652	amino acid biosynthetic process	4	7
GO:0009058	biosynthetic process	2	7
GO:0009064	glutamine family amino acid metabolic process	5	7
GO:0009084	glutamine family amino acid biosynthetic process	6	7
GO:0009987	cellular process	1	7
GO:0016053	organic acid biosynthetic process	4	7
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019752	carboxylic acid metabolic process	5	7
GO:0043436	oxoacid metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0044283	small molecule biosynthetic process	3	7
GO:0046394	carboxylic acid biosynthetic process	5	7
GO:0046483	heterocycle metabolic process	3	2
GO:0055129	L-proline biosynthetic process	5	2
GO:0071704	organic substance metabolic process	2	7
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:1901605	alpha-amino acid metabolic process	4	7
GO:1901607	alpha-amino acid biosynthetic process	5	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004735	pyrroline-5-carboxylate reductase activity	5	7
GO:0016491	oxidoreductase activity	2	7
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	3	7
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	468	472	PF00656	0.539
CLV_NRD_NRD_1	259	261	PF00675	0.488
CLV_NRD_NRD_1	463	465	PF00675	0.781
CLV_PCSK_KEX2_1	462	464	PF00082	0.687
CLV_PCSK_KEX2_1	487	489	PF00082	0.745
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.655
CLV_PCSK_SKI1_1	204	208	PF00082	0.329
CLV_PCSK_SKI1_1	224	228	PF00082	0.566
CLV_PCSK_SKI1_1	371	375	PF00082	0.526
CLV_PCSK_SKI1_1	384	388	PF00082	0.594
CLV_PCSK_SKI1_1	432	436	PF00082	0.592
CLV_PCSK_SKI1_1	52	56	PF00082	0.462
CLV_PCSK_SKI1_1	570	574	PF00082	0.570
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DEG_SPOP_SBC_1	482	486	PF00917	0.637
DOC_CDC14_PxL_1	388	396	PF14671	0.524
DOC_CKS1_1	274	279	PF01111	0.542
DOC_CKS1_1	80	85	PF01111	0.676
DOC_CYCLIN_RxL_1	46	59	PF00134	0.407
DOC_CYCLIN_RxL_1	567	577	PF00134	0.572
DOC_CYCLIN_yCln2_LP_2	501	507	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.627
DOC_MAPK_gen_1	163	172	PF00069	0.495
DOC_PP1_RVXF_1	512	518	PF00149	0.590
DOC_PP4_FxxP_1	363	366	PF00568	0.658
DOC_USP7_MATH_1	100	104	PF00917	0.506
DOC_USP7_MATH_1	218	222	PF00917	0.620
DOC_USP7_MATH_1	348	352	PF00917	0.688
DOC_USP7_MATH_1	372	376	PF00917	0.642
DOC_USP7_MATH_1	38	42	PF00917	0.430
DOC_USP7_MATH_1	452	456	PF00917	0.684
DOC_WW_Pin1_4	228	233	PF00397	0.648
DOC_WW_Pin1_4	238	243	PF00397	0.415
DOC_WW_Pin1_4	273	278	PF00397	0.567
DOC_WW_Pin1_4	305	310	PF00397	0.622
DOC_WW_Pin1_4	79	84	PF00397	0.623
DOC_WW_Pin1_4	88	93	PF00397	0.604
LIG_14-3-3_CanoR_1	384	389	PF00244	0.544
LIG_14-3-3_CanoR_1	416	422	PF00244	0.714
LIG_14-3-3_CanoR_1	488	494	PF00244	0.675
LIG_14-3-3_CanoR_1	553	561	PF00244	0.602
LIG_Actin_WH2_2	547	564	PF00022	0.605
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.545
LIG_BIR_III_2	534	538	PF00653	0.601
LIG_BRCT_BRCA1_1	282	286	PF00533	0.572
LIG_BRCT_BRCA1_1	359	363	PF00533	0.572
LIG_eIF4E_1	2	8	PF01652	0.554
LIG_FHA_1	239	245	PF00498	0.511
LIG_FHA_1	27	33	PF00498	0.572
LIG_FHA_1	274	280	PF00498	0.551
LIG_FHA_1	359	365	PF00498	0.653
LIG_FHA_1	511	517	PF00498	0.588
LIG_FHA_2	113	119	PF00498	0.516
LIG_FHA_2	141	147	PF00498	0.525
LIG_FHA_2	34	40	PF00498	0.529
LIG_FHA_2	421	427	PF00498	0.627
LIG_FHA_2	439	445	PF00498	0.534
LIG_HCF-1_HBM_1	39	42	PF13415	0.508
LIG_LIR_Apic_2	360	366	PF02991	0.654
LIG_LIR_Gen_1	105	111	PF02991	0.297
LIG_LIR_Gen_1	3	13	PF02991	0.633
LIG_LIR_Gen_1	39	50	PF02991	0.440
LIG_LIR_Gen_1	426	434	PF02991	0.529
LIG_LIR_Gen_1	59	70	PF02991	0.517
LIG_LIR_Nem_3	105	110	PF02991	0.303
LIG_LIR_Nem_3	3	8	PF02991	0.638
LIG_LIR_Nem_3	39	45	PF02991	0.432
LIG_LIR_Nem_3	426	430	PF02991	0.525
LIG_LIR_Nem_3	471	476	PF02991	0.747
LIG_LIR_Nem_3	59	65	PF02991	0.517
LIG_MYND_1	537	541	PF01753	0.616
LIG_NRBOX	568	574	PF00104	0.447
LIG_Pex14_2	282	286	PF04695	0.500
LIG_SH2_CRK	34	38	PF00017	0.527
LIG_SH2_CRK	42	46	PF00017	0.427
LIG_SH2_CRK	473	477	PF00017	0.639
LIG_SH2_CRK	5	9	PF00017	0.522
LIG_SH2_NCK_1	555	559	PF00017	0.608
LIG_SH2_STAP1	2	6	PF00017	0.599
LIG_SH2_STAP1	555	559	PF00017	0.608
LIG_SH2_STAT5	107	110	PF00017	0.288
LIG_SH2_STAT5	2	5	PF00017	0.564
LIG_SH2_STAT5	42	45	PF00017	0.431
LIG_SH2_STAT5	427	430	PF00017	0.587
LIG_SH2_STAT5	437	440	PF00017	0.475
LIG_SH2_STAT5	555	558	PF00017	0.607
LIG_SH3_2	313	318	PF14604	0.538
LIG_SH3_3	229	235	PF00018	0.679
LIG_SH3_3	303	309	PF00018	0.770
LIG_SH3_3	310	316	PF00018	0.684
LIG_SH3_3	389	395	PF00018	0.766
LIG_SH3_3	476	482	PF00018	0.618
LIG_SH3_3	503	509	PF00018	0.532
LIG_SH3_3	534	540	PF00018	0.622
LIG_SH3_3	80	86	PF00018	0.613
LIG_SH3_3	91	97	PF00018	0.644
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.475
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.475
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.540
LIG_SUMO_SIM_par_1	86	91	PF11976	0.528
LIG_TRAF2_1	22	25	PF00917	0.465
LIG_TRAF2_1	329	332	PF00917	0.616
LIG_TRAF2_1	334	337	PF00917	0.538
LIG_TYR_ITIM	32	37	PF00017	0.550
LIG_UBA3_1	44	52	PF00899	0.366
LIG_WRC_WIRS_1	279	284	PF05994	0.557
LIG_WW_2	313	316	PF00397	0.643
LIG_WW_2	392	395	PF00397	0.597
LIG_WW_2	537	540	PF00397	0.619
LIG_WW_3	405	409	PF00397	0.683
LIG_WW_3	459	463	PF00397	0.570
MOD_CDC14_SPxK_1	308	311	PF00782	0.614
MOD_CDK_SPxK_1	305	311	PF00069	0.624
MOD_CDK_SPxxK_3	238	245	PF00069	0.524
MOD_CK1_1	152	158	PF00069	0.467
MOD_CK1_1	16	22	PF00069	0.540
MOD_CK1_1	217	223	PF00069	0.642
MOD_CK1_1	230	236	PF00069	0.656
MOD_CK1_1	278	284	PF00069	0.750
MOD_CK1_1	292	298	PF00069	0.535
MOD_CK1_1	305	311	PF00069	0.667
MOD_CK1_1	359	365	PF00069	0.677
MOD_CK1_1	557	563	PF00069	0.502
MOD_CK2_1	112	118	PF00069	0.380
MOD_CK2_1	19	25	PF00069	0.476
MOD_CK2_1	326	332	PF00069	0.622
MOD_CK2_1	33	39	PF00069	0.530
MOD_CK2_1	420	426	PF00069	0.629
MOD_CK2_1	438	444	PF00069	0.530
MOD_CMANNOS	517	520	PF00535	0.528
MOD_GlcNHglycan	15	18	PF01048	0.584
MOD_GlcNHglycan	208	211	PF01048	0.330
MOD_GlcNHglycan	216	219	PF01048	0.591
MOD_GlcNHglycan	236	239	PF01048	0.710
MOD_GlcNHglycan	350	353	PF01048	0.686
MOD_GlcNHglycan	374	377	PF01048	0.665
MOD_GlcNHglycan	454	457	PF01048	0.655
MOD_GlcNHglycan	523	526	PF01048	0.597
MOD_GlcNHglycan	556	559	PF01048	0.616
MOD_GSK3_1	19	26	PF00069	0.539
MOD_GSK3_1	213	220	PF00069	0.611
MOD_GSK3_1	224	231	PF00069	0.612
MOD_GSK3_1	234	241	PF00069	0.554
MOD_GSK3_1	292	299	PF00069	0.509
MOD_GSK3_1	348	355	PF00069	0.604
MOD_GSK3_1	416	423	PF00069	0.655
MOD_GSK3_1	553	560	PF00069	0.524
MOD_GSK3_1	86	93	PF00069	0.594
MOD_N-GLC_1	222	227	PF02516	0.554
MOD_NEK2_1	106	111	PF00069	0.360
MOD_NEK2_1	123	128	PF00069	0.548
MOD_NEK2_1	139	144	PF00069	0.549
MOD_NEK2_1	206	211	PF00069	0.529
MOD_NEK2_1	243	248	PF00069	0.471
MOD_NEK2_1	266	271	PF00069	0.541
MOD_NEK2_1	357	362	PF00069	0.568
MOD_NEK2_1	447	452	PF00069	0.496
MOD_NEK2_1	8	13	PF00069	0.509
MOD_OFUCOSY	288	293	PF10250	0.539
MOD_PIKK_1	218	224	PF00454	0.679
MOD_PIKK_1	317	323	PF00454	0.635
MOD_PKA_2	352	358	PF00069	0.564
MOD_PKA_2	407	413	PF00069	0.682
MOD_PKA_2	452	458	PF00069	0.715
MOD_PKA_2	489	495	PF00069	0.623
MOD_Plk_1	19	25	PF00069	0.591
MOD_Plk_1	326	332	PF00069	0.619
MOD_Plk_1	38	44	PF00069	0.437
MOD_Plk_2-3	331	337	PF00069	0.582
MOD_Plk_4	106	112	PF00069	0.361
MOD_Plk_4	302	308	PF00069	0.599
MOD_Plk_4	359	365	PF00069	0.653
MOD_Plk_4	475	481	PF00069	0.682
MOD_Plk_4	8	14	PF00069	0.511
MOD_ProDKin_1	228	234	PF00069	0.647
MOD_ProDKin_1	238	244	PF00069	0.398
MOD_ProDKin_1	273	279	PF00069	0.567
MOD_ProDKin_1	305	311	PF00069	0.624
MOD_ProDKin_1	79	85	PF00069	0.623
MOD_ProDKin_1	88	94	PF00069	0.605
TRG_DiLeu_BaEn_4	444	450	PF01217	0.614
TRG_DiLeu_BaLyEn_6	119	124	PF01217	0.391
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.469
TRG_ENDOCYTIC_2	107	110	PF00928	0.288
TRG_ENDOCYTIC_2	167	170	PF00928	0.529
TRG_ENDOCYTIC_2	34	37	PF00928	0.464
TRG_ENDOCYTIC_2	42	45	PF00928	0.429
TRG_ENDOCYTIC_2	427	430	PF00928	0.604
TRG_ENDOCYTIC_2	473	476	PF00928	0.637
TRG_ENDOCYTIC_2	5	8	PF00928	0.644
TRG_ER_diArg_1	461	464	PF00400	0.689
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.651
TRG_Pf-PMV_PEXEL_1	35	39	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	514	518	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	570	575	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F8	Leptomonas seymouri	40%	100%
A0A3S7WT63	Leishmania donovani	90%	100%
A4H7U8	Leishmania braziliensis	71%	100%
A4HW74	Leishmania infantum	89%	100%
E9APX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%