Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFK5_LEIMA

TriTrypDb:

LmjF.14.1290 , LMJLV39_140020700 , LMJSD75_140020200

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.589
CLV_C14_Caspase3-7	501	505	PF00656	0.620
CLV_C14_Caspase3-7	637	641	PF00656	0.679
CLV_C14_Caspase3-7	654	658	PF00656	0.620
CLV_NRD_NRD_1	131	133	PF00675	0.650
CLV_NRD_NRD_1	148	150	PF00675	0.340
CLV_NRD_NRD_1	191	193	PF00675	0.584
CLV_NRD_NRD_1	261	263	PF00675	0.607
CLV_NRD_NRD_1	336	338	PF00675	0.599
CLV_NRD_NRD_1	36	38	PF00675	0.506
CLV_NRD_NRD_1	410	412	PF00675	0.628
CLV_NRD_NRD_1	454	456	PF00675	0.711
CLV_NRD_NRD_1	475	477	PF00675	0.813
CLV_NRD_NRD_1	494	496	PF00675	0.439
CLV_NRD_NRD_1	52	54	PF00675	0.389
CLV_NRD_NRD_1	599	601	PF00675	0.826
CLV_NRD_NRD_1	61	63	PF00675	0.488
CLV_NRD_NRD_1	648	650	PF00675	0.821
CLV_NRD_NRD_1	779	781	PF00675	0.688
CLV_NRD_NRD_1	88	90	PF00675	0.412
CLV_PCSK_FUR_1	34	38	PF00082	0.534
CLV_PCSK_FUR_1	452	456	PF00082	0.708
CLV_PCSK_FUR_1	475	479	PF00082	0.727
CLV_PCSK_KEX2_1	131	133	PF00082	0.650
CLV_PCSK_KEX2_1	147	149	PF00082	0.357
CLV_PCSK_KEX2_1	191	193	PF00082	0.584
CLV_PCSK_KEX2_1	261	263	PF00082	0.607
CLV_PCSK_KEX2_1	275	277	PF00082	0.408
CLV_PCSK_KEX2_1	336	338	PF00082	0.599
CLV_PCSK_KEX2_1	36	38	PF00082	0.532
CLV_PCSK_KEX2_1	451	453	PF00082	0.703
CLV_PCSK_KEX2_1	454	456	PF00082	0.679
CLV_PCSK_KEX2_1	475	477	PF00082	0.707
CLV_PCSK_KEX2_1	494	496	PF00082	0.577
CLV_PCSK_KEX2_1	51	53	PF00082	0.571
CLV_PCSK_KEX2_1	599	601	PF00082	0.826
CLV_PCSK_KEX2_1	61	63	PF00082	0.537
CLV_PCSK_KEX2_1	778	780	PF00082	0.694
CLV_PCSK_KEX2_1	90	92	PF00082	0.663
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.585
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.670
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.707
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.558
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.826
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.663
CLV_PCSK_PC7_1	775	781	PF00082	0.718
CLV_PCSK_SKI1_1	104	108	PF00082	0.587
CLV_PCSK_SKI1_1	112	116	PF00082	0.660
CLV_PCSK_SKI1_1	149	153	PF00082	0.620
CLV_PCSK_SKI1_1	213	217	PF00082	0.532
CLV_PCSK_SKI1_1	27	31	PF00082	0.534
CLV_PCSK_SKI1_1	400	404	PF00082	0.549
CLV_PCSK_SKI1_1	411	415	PF00082	0.557
CLV_PCSK_SKI1_1	573	577	PF00082	0.649
DEG_APCC_DBOX_1	147	155	PF00400	0.599
DOC_ANK_TNKS_1	477	484	PF00023	0.732
DOC_ANK_TNKS_1	728	735	PF00023	0.816
DOC_CKS1_1	614	619	PF01111	0.790
DOC_CYCLIN_RxL_1	146	157	PF00134	0.553
DOC_CYCLIN_RxL_1	21	33	PF00134	0.534
DOC_CYCLIN_RxL_1	210	217	PF00134	0.624
DOC_MAPK_gen_1	147	153	PF00069	0.556
DOC_MAPK_gen_1	336	343	PF00069	0.597
DOC_MAPK_gen_1	34	43	PF00069	0.520
DOC_MAPK_gen_1	366	373	PF00069	0.651
DOC_MAPK_gen_1	397	405	PF00069	0.443
DOC_MAPK_gen_1	411	417	PF00069	0.657
DOC_MAPK_gen_1	51	60	PF00069	0.535
DOC_MAPK_gen_1	598	606	PF00069	0.587
DOC_PP1_RVXF_1	147	154	PF00149	0.540
DOC_USP7_MATH_1	16	20	PF00917	0.540
DOC_USP7_MATH_1	274	278	PF00917	0.626
DOC_USP7_MATH_1	286	290	PF00917	0.441
DOC_USP7_MATH_1	438	442	PF00917	0.699
DOC_USP7_MATH_1	490	494	PF00917	0.518
DOC_USP7_MATH_1	622	626	PF00917	0.813
DOC_USP7_MATH_1	629	633	PF00917	0.681
DOC_USP7_MATH_1	718	722	PF00917	0.697
DOC_USP7_MATH_1	768	772	PF00917	0.768
DOC_USP7_UBL2_3	51	55	PF12436	0.560
DOC_WW_Pin1_4	519	524	PF00397	0.690
DOC_WW_Pin1_4	549	554	PF00397	0.769
DOC_WW_Pin1_4	613	618	PF00397	0.767
DOC_WW_Pin1_4	625	630	PF00397	0.633
DOC_WW_Pin1_4	666	671	PF00397	0.740
DOC_WW_Pin1_4	724	729	PF00397	0.692
LIG_14-3-3_CanoR_1	147	152	PF00244	0.475
LIG_14-3-3_CanoR_1	159	164	PF00244	0.557
LIG_14-3-3_CanoR_1	170	179	PF00244	0.446
LIG_14-3-3_CanoR_1	213	219	PF00244	0.541
LIG_14-3-3_CanoR_1	256	264	PF00244	0.543
LIG_14-3-3_CanoR_1	411	416	PF00244	0.533
LIG_14-3-3_CanoR_1	454	459	PF00244	0.627
LIG_14-3-3_CanoR_1	467	474	PF00244	0.638
LIG_14-3-3_CanoR_1	513	517	PF00244	0.654
LIG_14-3-3_CanoR_1	519	523	PF00244	0.663
LIG_14-3-3_CanoR_1	568	573	PF00244	0.719
LIG_14-3-3_CanoR_1	6	12	PF00244	0.524
LIG_14-3-3_CanoR_1	739	747	PF00244	0.753
LIG_Actin_WH2_2	338	356	PF00022	0.602
LIG_AP2alpha_1	796	800	PF02296	0.592
LIG_APCC_ABBA_1	225	230	PF00400	0.537
LIG_BIR_II_1	1	5	PF00653	0.575
LIG_eIF4E_1	339	345	PF01652	0.587
LIG_FHA_1	156	162	PF00498	0.574
LIG_FHA_1	170	176	PF00498	0.419
LIG_FHA_1	329	335	PF00498	0.634
LIG_FHA_1	412	418	PF00498	0.531
LIG_FHA_1	540	546	PF00498	0.634
LIG_FHA_1	6	12	PF00498	0.531
LIG_FHA_1	629	635	PF00498	0.672
LIG_FHA_2	261	267	PF00498	0.625
LIG_FHA_2	288	294	PF00498	0.628
LIG_FHA_2	376	382	PF00498	0.542
LIG_LIR_Gen_1	19	30	PF02991	0.541
LIG_LIR_Gen_1	752	761	PF02991	0.805
LIG_LIR_Gen_1	793	801	PF02991	0.607
LIG_LIR_Nem_3	19	25	PF02991	0.543
LIG_LIR_Nem_3	420	425	PF02991	0.541
LIG_LIR_Nem_3	640	646	PF02991	0.811
LIG_LIR_Nem_3	752	758	PF02991	0.809
LIG_NRBOX	139	145	PF00104	0.524
LIG_NRBOX	340	346	PF00104	0.507
LIG_Pex14_1	422	426	PF04695	0.543
LIG_Pex14_2	751	755	PF04695	0.757
LIG_Pex14_2	796	800	PF04695	0.592
LIG_RPA_C_Fungi	386	398	PF08784	0.527
LIG_RPA_C_Fungi	432	444	PF08784	0.685
LIG_SH2_CRK	426	430	PF00017	0.639
LIG_SH2_NCK_1	339	343	PF00017	0.595
LIG_SH2_SRC	228	231	PF00017	0.556
LIG_SH2_STAP1	228	232	PF00017	0.650
LIG_SH2_STAP1	339	343	PF00017	0.595
LIG_SH2_STAP1	426	430	PF00017	0.639
LIG_SH2_STAP1	525	529	PF00017	0.582
LIG_SH3_1	583	589	PF00018	0.739
LIG_SH3_3	550	556	PF00018	0.696
LIG_SH3_3	583	589	PF00018	0.739
LIG_SH3_3	671	677	PF00018	0.767
LIG_SH3_3	742	748	PF00018	0.633
LIG_SH3_3	771	777	PF00018	0.704
LIG_SH3_CIN85_PxpxPR_1	670	675	PF14604	0.726
LIG_SH3_CIN85_PxpxPR_1	695	700	PF14604	0.605
LIG_SUMO_SIM_par_1	343	349	PF11976	0.519
LIG_SUMO_SIM_par_1	413	418	PF11976	0.530
LIG_TRAF2_1	263	266	PF00917	0.647
LIG_TRAF2_1	290	293	PF00917	0.564
LIG_TRAF2_1	299	302	PF00917	0.611
LIG_TRAF2_1	308	311	PF00917	0.484
LIG_TRAF2_1	524	527	PF00917	0.731
LIG_TYR_ITIM	424	429	PF00017	0.641
LIG_WRC_WIRS_1	103	108	PF05994	0.640
LIG_WW_3	472	476	PF00397	0.717
MOD_CDK_SPK_2	670	675	PF00069	0.726
MOD_CDK_SPK_2	724	729	PF00069	0.692
MOD_CDK_SPxxK_3	668	675	PF00069	0.728
MOD_CK1_1	312	318	PF00069	0.483
MOD_CK1_1	485	491	PF00069	0.682
MOD_CK1_1	511	517	PF00069	0.741
MOD_CK1_1	557	563	PF00069	0.825
MOD_CK1_1	625	631	PF00069	0.716
MOD_CK1_1	638	644	PF00069	0.667
MOD_CK1_1	651	657	PF00069	0.700
MOD_CK1_1	660	666	PF00069	0.758
MOD_CK1_1	721	727	PF00069	0.560
MOD_CK1_1	746	752	PF00069	0.712
MOD_CK2_1	17	23	PF00069	0.514
MOD_CK2_1	260	266	PF00069	0.648
MOD_CK2_1	287	293	PF00069	0.630
MOD_CK2_1	375	381	PF00069	0.545
MOD_Cter_Amidation	129	132	PF01082	0.654
MOD_Cter_Amidation	189	192	PF01082	0.543
MOD_Cter_Amidation	409	412	PF01082	0.503
MOD_GlcNHglycan	172	175	PF01048	0.516
MOD_GlcNHglycan	246	249	PF01048	0.567
MOD_GlcNHglycan	257	260	PF01048	0.567
MOD_GlcNHglycan	301	306	PF01048	0.577
MOD_GlcNHglycan	309	314	PF01048	0.489
MOD_GlcNHglycan	439	443	PF01048	0.686
MOD_GlcNHglycan	469	472	PF01048	0.784
MOD_GlcNHglycan	487	490	PF01048	0.506
MOD_GlcNHglycan	539	542	PF01048	0.786
MOD_GlcNHglycan	624	627	PF01048	0.804
MOD_GlcNHglycan	631	634	PF01048	0.680
MOD_GlcNHglycan	650	653	PF01048	0.529
MOD_GlcNHglycan	714	717	PF01048	0.692
MOD_GlcNHglycan	720	723	PF01048	0.686
MOD_GlcNHglycan	729	732	PF01048	0.675
MOD_GlcNHglycan	92	95	PF01048	0.571
MOD_GSK3_1	155	162	PF00069	0.599
MOD_GSK3_1	190	197	PF00069	0.654
MOD_GSK3_1	507	514	PF00069	0.672
MOD_GSK3_1	554	561	PF00069	0.737
MOD_GSK3_1	563	570	PF00069	0.685
MOD_GSK3_1	625	632	PF00069	0.717
MOD_GSK3_1	635	642	PF00069	0.664
MOD_GSK3_1	651	658	PF00069	0.598
MOD_GSK3_1	666	673	PF00069	0.718
MOD_GSK3_1	714	721	PF00069	0.690
MOD_LATS_1	168	174	PF00433	0.619
MOD_LATS_1	409	415	PF00433	0.580
MOD_NEK2_1	214	219	PF00069	0.535
MOD_NEK2_1	260	265	PF00069	0.524
MOD_NEK2_1	320	325	PF00069	0.622
MOD_NEK2_1	353	358	PF00069	0.639
MOD_NEK2_1	387	392	PF00069	0.587
MOD_NEK2_1	508	513	PF00069	0.670
MOD_NEK2_2	223	228	PF00069	0.552
MOD_NEK2_2	559	564	PF00069	0.828
MOD_PIKK_1	508	514	PF00454	0.667
MOD_PIKK_1	532	538	PF00454	0.763
MOD_PK_1	159	165	PF00069	0.529
MOD_PK_1	454	460	PF00069	0.588
MOD_PK_1	568	574	PF00069	0.805
MOD_PKA_1	131	137	PF00069	0.549
MOD_PKA_1	147	153	PF00069	0.353
MOD_PKA_1	411	417	PF00069	0.617
MOD_PKA_1	454	460	PF00069	0.588
MOD_PKA_1	51	57	PF00069	0.364
MOD_PKA_1	90	96	PF00069	0.580
MOD_PKA_2	131	137	PF00069	0.620
MOD_PKA_2	147	153	PF00069	0.353
MOD_PKA_2	169	175	PF00069	0.587
MOD_PKA_2	177	183	PF00069	0.548
MOD_PKA_2	190	196	PF00069	0.444
MOD_PKA_2	255	261	PF00069	0.545
MOD_PKA_2	353	359	PF00069	0.600
MOD_PKA_2	387	393	PF00069	0.646
MOD_PKA_2	454	460	PF00069	0.667
MOD_PKA_2	461	467	PF00069	0.608
MOD_PKA_2	5	11	PF00069	0.524
MOD_PKA_2	51	57	PF00069	0.380
MOD_PKA_2	512	518	PF00069	0.648
MOD_PKA_2	563	569	PF00069	0.718
MOD_PKA_2	648	654	PF00069	0.741
MOD_PKA_2	738	744	PF00069	0.723
MOD_PKA_2	90	96	PF00069	0.578
MOD_PKB_1	452	460	PF00069	0.591
MOD_Plk_1	286	292	PF00069	0.553
MOD_Plk_1	525	531	PF00069	0.585
MOD_Plk_1	639	645	PF00069	0.703
MOD_Plk_2-3	287	293	PF00069	0.586
MOD_Plk_4	223	229	PF00069	0.541
MOD_ProDKin_1	519	525	PF00069	0.690
MOD_ProDKin_1	549	555	PF00069	0.763
MOD_ProDKin_1	613	619	PF00069	0.768
MOD_ProDKin_1	625	631	PF00069	0.633
MOD_ProDKin_1	666	672	PF00069	0.737
MOD_ProDKin_1	724	730	PF00069	0.694
MOD_SUMO_for_1	218	221	PF00179	0.371
MOD_SUMO_for_1	367	370	PF00179	0.572
MOD_SUMO_rev_2	268	277	PF00179	0.632
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.373
TRG_DiLeu_BaLyEn_6	210	215	PF01217	0.507
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.541
TRG_DiLeu_BaLyEn_6	779	784	PF01217	0.673
TRG_ENDOCYTIC_2	22	25	PF00928	0.542
TRG_ENDOCYTIC_2	426	429	PF00928	0.641
TRG_ER_diArg_1	131	133	PF00400	0.650
TRG_ER_diArg_1	146	149	PF00400	0.372
TRG_ER_diArg_1	260	262	PF00400	0.570
TRG_ER_diArg_1	336	338	PF00400	0.577
TRG_ER_diArg_1	34	37	PF00400	0.528
TRG_ER_diArg_1	43	46	PF00400	0.534
TRG_ER_diArg_1	452	455	PF00400	0.711
TRG_ER_diArg_1	474	476	PF00400	0.714
TRG_ER_diArg_1	60	62	PF00400	0.395
TRG_ER_diArg_1	646	649	PF00400	0.740
TRG_ER_diArg_1	777	780	PF00400	0.739
TRG_NLS_Bipartite_1	36	55	PF00514	0.548
TRG_NLS_MonoExtC_3	450	455	PF00514	0.671
TRG_NLS_MonoExtC_3	475	480	PF00514	0.805
TRG_NLS_MonoExtC_3	50	55	PF00514	0.557
TRG_NLS_MonoExtN_4	448	455	PF00514	0.628
TRG_NLS_MonoExtN_4	473	480	PF00514	0.696
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	276	281	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	423	428	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P321	Leptomonas seymouri	40%	100%
A0A3S5H6T0	Leishmania donovani	90%	100%
A4H7U9	Leishmania braziliensis	69%	99%
A4HW75	Leishmania infantum	90%	100%
E9APX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%