Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

STE/STE11 serine/threonine-protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QFK4_LEIMA

TriTrypDb:

LmjF.14.1300 , LMJLV39_140020800 , LMJSD75_140020300

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QFK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFK4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.326
CLV_NRD_NRD_1	226	228	PF00675	0.265
CLV_NRD_NRD_1	451	453	PF00675	0.582
CLV_NRD_NRD_1	46	48	PF00675	0.597
CLV_NRD_NRD_1	463	465	PF00675	0.532
CLV_NRD_NRD_1	479	481	PF00675	0.565
CLV_NRD_NRD_1	525	527	PF00675	0.597
CLV_PCSK_FUR_1	456	460	PF00082	0.582
CLV_PCSK_KEX2_1	156	158	PF00082	0.371
CLV_PCSK_KEX2_1	226	228	PF00082	0.265
CLV_PCSK_KEX2_1	455	457	PF00082	0.583
CLV_PCSK_KEX2_1	458	460	PF00082	0.577
CLV_PCSK_KEX2_1	46	48	PF00082	0.583
CLV_PCSK_KEX2_1	463	465	PF00082	0.559
CLV_PCSK_KEX2_1	479	481	PF00082	0.556
CLV_PCSK_KEX2_1	524	526	PF00082	0.604
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.265
CLV_PCSK_PC1ET2_1	455	457	PF00082	0.578
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.581
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.586
CLV_PCSK_PC7_1	459	465	PF00082	0.583
CLV_PCSK_SKI1_1	157	161	PF00082	0.424
CLV_PCSK_SKI1_1	232	236	PF00082	0.416
CLV_PCSK_SKI1_1	256	260	PF00082	0.233
CLV_PCSK_SKI1_1	403	407	PF00082	0.548
CLV_PCSK_SKI1_1	573	577	PF00082	0.595
CLV_PCSK_SKI1_1	602	606	PF00082	0.556
DOC_CKS1_1	384	389	PF01111	0.537
DOC_CKS1_1	393	398	PF01111	0.517
DOC_CYCLIN_yClb5_NLxxxL_5	417	426	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.565
DOC_MAPK_gen_1	232	241	PF00069	0.423
DOC_PP4_FxxP_1	205	208	PF00568	0.238
DOC_PP4_FxxP_1	274	277	PF00568	0.265
DOC_USP7_MATH_1	129	133	PF00917	0.504
DOC_USP7_MATH_1	138	142	PF00917	0.488
DOC_USP7_MATH_1	198	202	PF00917	0.265
DOC_USP7_MATH_1	382	386	PF00917	0.495
DOC_USP7_MATH_1	440	444	PF00917	0.575
DOC_USP7_MATH_1	58	62	PF00917	0.466
DOC_USP7_MATH_1	64	68	PF00917	0.429
DOC_WW_Pin1_4	124	129	PF00397	0.482
DOC_WW_Pin1_4	130	135	PF00397	0.504
DOC_WW_Pin1_4	36	41	PF00397	0.541
DOC_WW_Pin1_4	383	388	PF00397	0.696
DOC_WW_Pin1_4	392	397	PF00397	0.690
DOC_WW_Pin1_4	405	410	PF00397	0.562
DOC_WW_Pin1_4	412	417	PF00397	0.549
DOC_WW_Pin1_4	424	429	PF00397	0.582
DOC_WW_Pin1_4	486	491	PF00397	0.597
DOC_WW_Pin1_4	554	559	PF00397	0.552
DOC_WW_Pin1_4	586	591	PF00397	0.555
DOC_WW_Pin1_4	7	12	PF00397	0.560
LIG_14-3-3_CanoR_1	403	408	PF00244	0.575
LIG_14-3-3_CanoR_1	46	51	PF00244	0.570
LIG_14-3-3_CanoR_1	510	515	PF00244	0.590
LIG_14-3-3_CanoR_1	542	552	PF00244	0.591
LIG_14-3-3_CanoR_1	599	605	PF00244	0.566
LIG_APCC_ABBA_1	183	188	PF00400	0.265
LIG_APCC_ABBAyCdc20_2	227	233	PF00400	0.301
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BIR_III_1	1	5	PF00653	0.482
LIG_BIR_III_3	1	5	PF00653	0.482
LIG_deltaCOP1_diTrp_1	338	348	PF00928	0.265
LIG_FHA_1	180	186	PF00498	0.274
LIG_FHA_1	194	200	PF00498	0.202
LIG_FHA_1	263	269	PF00498	0.351
LIG_FHA_1	326	332	PF00498	0.300
LIG_FHA_1	421	427	PF00498	0.606
LIG_FHA_1	572	578	PF00498	0.547
LIG_FHA_2	287	293	PF00498	0.265
LIG_FHA_2	338	344	PF00498	0.262
LIG_FHA_2	360	366	PF00498	0.310
LIG_FHA_2	446	452	PF00498	0.583
LIG_FHA_2	619	625	PF00498	0.525
LIG_LIR_Apic_2	204	208	PF02991	0.238
LIG_LIR_Apic_2	271	277	PF02991	0.409
LIG_LIR_Apic_2	427	433	PF02991	0.520
LIG_LIR_Gen_1	370	379	PF02991	0.411
LIG_LIR_Nem_3	201	205	PF02991	0.297
LIG_LIR_Nem_3	370	375	PF02991	0.435
LIG_LIR_Nem_3	84	88	PF02991	0.433
LIG_Pex14_1	371	375	PF04695	0.309
LIG_PTAP_UEV_1	395	400	PF05743	0.493
LIG_SH2_CRK	430	434	PF00017	0.549
LIG_SH2_CRK	85	89	PF00017	0.470
LIG_SH2_GRB2like	173	176	PF00017	0.265
LIG_SH2_SRC	334	337	PF00017	0.265
LIG_SH2_STAP1	593	597	PF00017	0.515
LIG_SH2_STAT5	173	176	PF00017	0.342
LIG_SH2_STAT5	189	192	PF00017	0.274
LIG_SH2_STAT5	273	276	PF00017	0.367
LIG_SH2_STAT5	334	337	PF00017	0.265
LIG_SH2_STAT5	619	622	PF00017	0.509
LIG_SH3_3	128	134	PF00018	0.506
LIG_SH3_3	276	282	PF00018	0.364
LIG_SH3_3	393	399	PF00018	0.550
LIG_SH3_3	8	14	PF00018	0.527
LIG_SUMO_SIM_anti_2	158	163	PF11976	0.417
LIG_SUMO_SIM_anti_2	362	368	PF11976	0.305
LIG_TRAF2_1	204	207	PF00917	0.265
LIG_TRFH_1	405	409	PF08558	0.525
LIG_UBA3_1	300	307	PF00899	0.193
LIG_UBA3_1	99	103	PF00899	0.327
LIG_WRC_WIRS_1	202	207	PF05994	0.265
MOD_CDC14_SPxK_1	408	411	PF00782	0.512
MOD_CDK_SPxK_1	405	411	PF00069	0.522
MOD_CK1_1	191	197	PF00069	0.265
MOD_CK1_1	201	207	PF00069	0.193
MOD_CK1_1	23	29	PF00069	0.505
MOD_CK1_1	257	263	PF00069	0.265
MOD_CK1_1	383	389	PF00069	0.588
MOD_CK1_1	392	398	PF00069	0.591
MOD_CK1_1	442	448	PF00069	0.614
MOD_CK1_1	471	477	PF00069	0.661
MOD_CK1_1	478	484	PF00069	0.654
MOD_CK1_1	485	491	PF00069	0.627
MOD_CK1_1	493	499	PF00069	0.581
MOD_CK1_1	502	508	PF00069	0.586
MOD_CK1_1	541	547	PF00069	0.617
MOD_CK1_1	598	604	PF00069	0.543
MOD_CK1_1	607	613	PF00069	0.532
MOD_CK1_1	67	73	PF00069	0.385
MOD_CK2_1	201	207	PF00069	0.270
MOD_CK2_1	445	451	PF00069	0.592
MOD_CK2_1	606	612	PF00069	0.567
MOD_CK2_1	618	624	PF00069	0.505
MOD_Cter_Amidation	453	456	PF01082	0.592
MOD_GlcNHglycan	145	148	PF01048	0.423
MOD_GlcNHglycan	190	193	PF01048	0.265
MOD_GlcNHglycan	22	25	PF01048	0.554
MOD_GlcNHglycan	260	263	PF01048	0.238
MOD_GlcNHglycan	282	285	PF01048	0.211
MOD_GlcNHglycan	325	328	PF01048	0.281
MOD_GlcNHglycan	42	45	PF01048	0.585
MOD_GlcNHglycan	436	439	PF01048	0.645
MOD_GlcNHglycan	441	445	PF01048	0.572
MOD_GlcNHglycan	460	463	PF01048	0.649
MOD_GlcNHglycan	470	473	PF01048	0.694
MOD_GlcNHglycan	474	477	PF01048	0.666
MOD_GlcNHglycan	493	496	PF01048	0.627
MOD_GlcNHglycan	500	504	PF01048	0.616
MOD_GlcNHglycan	52	56	PF01048	0.551
MOD_GlcNHglycan	559	562	PF01048	0.595
MOD_GlcNHglycan	565	569	PF01048	0.536
MOD_GlcNHglycan	606	609	PF01048	0.569
MOD_GlcNHglycan	62	65	PF01048	0.450
MOD_GSK3_1	23	30	PF00069	0.515
MOD_GSK3_1	254	261	PF00069	0.405
MOD_GSK3_1	264	271	PF00069	0.341
MOD_GSK3_1	36	43	PF00069	0.521
MOD_GSK3_1	382	389	PF00069	0.663
MOD_GSK3_1	412	419	PF00069	0.642
MOD_GSK3_1	420	427	PF00069	0.559
MOD_GSK3_1	439	446	PF00069	0.599
MOD_GSK3_1	467	474	PF00069	0.653
MOD_GSK3_1	478	485	PF00069	0.698
MOD_GSK3_1	486	493	PF00069	0.631
MOD_GSK3_1	495	502	PF00069	0.542
MOD_GSK3_1	504	511	PF00069	0.620
MOD_GSK3_1	578	585	PF00069	0.569
MOD_GSK3_1	591	598	PF00069	0.493
MOD_GSK3_1	60	67	PF00069	0.562
MOD_GSK3_1	600	607	PF00069	0.552
MOD_GSK3_1	620	627	PF00069	0.462
MOD_LATS_1	465	471	PF00433	0.542
MOD_N-GLC_1	420	425	PF02516	0.516
MOD_N-GLC_1	569	574	PF02516	0.561
MOD_N-GLC_1	582	587	PF02516	0.523
MOD_NEK2_1	121	126	PF00069	0.467
MOD_NEK2_1	20	25	PF00069	0.560
MOD_NEK2_1	240	245	PF00069	0.269
MOD_NEK2_1	264	269	PF00069	0.270
MOD_NEK2_1	34	39	PF00069	0.523
MOD_NEK2_1	367	372	PF00069	0.297
MOD_NEK2_1	595	600	PF00069	0.517
MOD_NEK2_1	604	609	PF00069	0.547
MOD_NEK2_1	92	97	PF00069	0.344
MOD_NEK2_2	138	143	PF00069	0.504
MOD_NEK2_2	600	605	PF00069	0.550
MOD_PIKK_1	242	248	PF00454	0.265
MOD_PIKK_1	347	353	PF00454	0.265
MOD_PIKK_1	478	484	PF00454	0.588
MOD_PKA_1	458	464	PF00069	0.579
MOD_PKA_1	46	52	PF00069	0.521
MOD_PKA_2	115	121	PF00069	0.387
MOD_PKA_2	359	365	PF00069	0.409
MOD_PKA_2	458	464	PF00069	0.548
MOD_PKA_2	46	52	PF00069	0.522
MOD_PKA_2	466	472	PF00069	0.563
MOD_PKA_2	478	484	PF00069	0.638
MOD_PKA_2	541	547	PF00069	0.622
MOD_PKA_2	598	604	PF00069	0.557
MOD_PKA_2	67	73	PF00069	0.386
MOD_PKB_1	497	505	PF00069	0.565
MOD_Plk_1	157	163	PF00069	0.373
MOD_Plk_1	337	343	PF00069	0.326
MOD_Plk_4	157	163	PF00069	0.265
MOD_Plk_4	254	260	PF00069	0.234
MOD_Plk_4	264	270	PF00069	0.245
MOD_Plk_4	367	373	PF00069	0.275
MOD_Plk_4	389	395	PF00069	0.583
MOD_ProDKin_1	124	130	PF00069	0.484
MOD_ProDKin_1	36	42	PF00069	0.545
MOD_ProDKin_1	383	389	PF00069	0.697
MOD_ProDKin_1	392	398	PF00069	0.688
MOD_ProDKin_1	405	411	PF00069	0.561
MOD_ProDKin_1	412	418	PF00069	0.549
MOD_ProDKin_1	424	430	PF00069	0.586
MOD_ProDKin_1	486	492	PF00069	0.597
MOD_ProDKin_1	554	560	PF00069	0.554
MOD_ProDKin_1	586	592	PF00069	0.555
MOD_ProDKin_1	7	13	PF00069	0.560
MOD_SUMO_for_1	142	145	PF00179	0.500
MOD_SUMO_for_1	155	158	PF00179	0.184
MOD_SUMO_for_1	75	78	PF00179	0.378
MOD_SUMO_rev_2	565	572	PF00179	0.541
MOD_SUMO_rev_2	622	627	PF00179	0.492
TRG_DiLeu_BaEn_2	343	349	PF01217	0.265
TRG_ENDOCYTIC_2	202	205	PF00928	0.301
TRG_ENDOCYTIC_2	85	88	PF00928	0.415
TRG_ENDOCYTIC_2	89	92	PF00928	0.354
TRG_NLS_MonoExtN_4	521	528	PF00514	0.572
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFW0	Leishmania donovani	27%	100%
A0A3Q8IRT6	Leishmania donovani	25%	100%
A0A3Q8IVR8	Leishmania donovani	26%	100%
A0A3S5H5G0	Leishmania donovani	21%	100%
A0A3S7WY10	Leishmania donovani	22%	100%
A0A3S7XAX0	Leishmania donovani	25%	100%
A4H459	Leishmania braziliensis	22%	100%
A4H7V0	Leishmania braziliensis	77%	88%
A4HCD7	Leishmania braziliensis	29%	100%
A4HHP8	Leishmania braziliensis	24%	100%
A4HI35	Leishmania braziliensis	24%	100%
A4HJW2	Leishmania braziliensis	27%	100%
A4HNT2	Leishmania braziliensis	27%	100%
A4HNU6	Leishmania braziliensis	28%	100%
A4HSE2	Leishmania infantum	21%	100%
A4HW76	Leishmania infantum	90%	78%
A4I5B1	Leishmania infantum	25%	100%
A4I7C4	Leishmania infantum	27%	100%
A4ICR2	Leishmania infantum	26%	100%
A4IDK3	Leishmania infantum	25%	100%
E9AH34	Leishmania infantum	23%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9APX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	88%
E9ASJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ASK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AT06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q1J2	Leishmania major	25%	100%
Q4Q1Z0	Leishmania major	26%	100%
Q4Q204	Leishmania major	26%	100%
Q4Q5T9	Leishmania major	26%	100%
Q4Q7M5	Leishmania major	25%	100%
Q4QJJ0	Leishmania major	21%	100%
Q5R4L1	Pongo abelii	24%	92%
Q9FGW5	Arabidopsis thaliana	27%	100%
Q9NYY3	Homo sapiens	24%	92%
Q9R012	Rattus norvegicus	24%	92%
V5BCN4	Trypanosoma cruzi	23%	100%