Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFK3_LEIMA

TriTrypDb:

LmjF.14.1310 , LMJLV39_140020900 , LMJSD75_140020400

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFK3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.656
CLV_C14_Caspase3-7	135	139	PF00656	0.711
CLV_MEL_PAP_1	254	260	PF00089	0.548
CLV_NRD_NRD_1	21	23	PF00675	0.568
CLV_NRD_NRD_1	256	258	PF00675	0.544
CLV_NRD_NRD_1	298	300	PF00675	0.581
CLV_NRD_NRD_1	98	100	PF00675	0.655
CLV_PCSK_KEX2_1	20	22	PF00082	0.488
CLV_PCSK_KEX2_1	256	258	PF00082	0.571
CLV_PCSK_KEX2_1	298	300	PF00082	0.581
CLV_PCSK_KEX2_1	98	100	PF00082	0.682
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.491
CLV_PCSK_SKI1_1	125	129	PF00082	0.692
CLV_PCSK_SKI1_1	333	337	PF00082	0.434
CLV_PCSK_SKI1_1	89	93	PF00082	0.562
DEG_COP1_1	285	294	PF00400	0.689
DEG_Nend_Nbox_1	1	3	PF02207	0.579
DOC_CKS1_1	327	332	PF01111	0.622
DOC_MAPK_gen_1	298	306	PF00069	0.397
DOC_MAPK_gen_1	72	81	PF00069	0.493
DOC_MAPK_HePTP_8	204	216	PF00069	0.537
DOC_MAPK_MEF2A_6	207	216	PF00069	0.417
DOC_MAPK_MEF2A_6	298	306	PF00069	0.411
DOC_PP1_MyPhoNE_1	298	305	PF00149	0.536
DOC_PP1_RVXF_1	9	16	PF00149	0.592
DOC_PP2B_LxvP_1	243	246	PF13499	0.579
DOC_PP2B_LxvP_1	48	51	PF13499	0.592
DOC_USP7_MATH_1	121	125	PF00917	0.579
DOC_USP7_MATH_1	149	153	PF00917	0.699
DOC_USP7_MATH_1	164	168	PF00917	0.571
DOC_USP7_MATH_1	187	191	PF00917	0.671
DOC_USP7_MATH_1	231	235	PF00917	0.584
DOC_USP7_MATH_1	239	243	PF00917	0.545
DOC_USP7_MATH_1	317	321	PF00917	0.524
DOC_USP7_MATH_1	38	42	PF00917	0.638
DOC_USP7_MATH_1	49	53	PF00917	0.610
DOC_WW_Pin1_4	145	150	PF00397	0.680
DOC_WW_Pin1_4	217	222	PF00397	0.547
DOC_WW_Pin1_4	323	328	PF00397	0.587
DOC_WW_Pin1_4	357	362	PF00397	0.568
LIG_14-3-3_CanoR_1	107	117	PF00244	0.623
LIG_14-3-3_CanoR_1	154	160	PF00244	0.713
LIG_14-3-3_CanoR_1	174	178	PF00244	0.550
LIG_14-3-3_CanoR_1	282	292	PF00244	0.683
LIG_BRCT_BRCA1_1	156	160	PF00533	0.678
LIG_CaM_IQ_9	248	264	PF13499	0.531
LIG_FHA_1	209	215	PF00498	0.402
LIG_FHA_1	273	279	PF00498	0.561
LIG_FHA_1	55	61	PF00498	0.611
LIG_FHA_2	283	289	PF00498	0.666
LIG_Pex14_2	336	340	PF04695	0.502
LIG_PTAP_UEV_1	165	170	PF05743	0.633
LIG_SH2_CRK	10	14	PF00017	0.425
LIG_SH2_STAP1	269	273	PF00017	0.571
LIG_SH2_STAT5	18	21	PF00017	0.586
LIG_SH2_STAT5	182	185	PF00017	0.533
LIG_SH3_3	1	7	PF00018	0.586
LIG_SH3_3	143	149	PF00018	0.793
LIG_SH3_3	163	169	PF00018	0.700
LIG_SH3_3	186	192	PF00018	0.706
LIG_SH3_3	324	330	PF00018	0.680
LIG_SH3_3	53	59	PF00018	0.693
LIG_TRAF2_1	64	67	PF00917	0.512
MOD_CDK_SPxxK_3	326	333	PF00069	0.505
MOD_CK1_1	108	114	PF00069	0.609
MOD_CK1_1	147	153	PF00069	0.685
MOD_CK1_1	156	162	PF00069	0.656
MOD_CK1_1	234	240	PF00069	0.548
MOD_CK1_1	283	289	PF00069	0.660
MOD_CK1_1	326	332	PF00069	0.511
MOD_CK1_1	41	47	PF00069	0.628
MOD_CK1_1	52	58	PF00069	0.705
MOD_CK2_1	234	240	PF00069	0.637
MOD_CK2_1	282	288	PF00069	0.627
MOD_CK2_1	307	313	PF00069	0.514
MOD_CK2_1	61	67	PF00069	0.540
MOD_GlcNHglycan	130	133	PF01048	0.630
MOD_GlcNHglycan	166	169	PF01048	0.563
MOD_GlcNHglycan	201	204	PF01048	0.614
MOD_GlcNHglycan	237	240	PF01048	0.549
MOD_GlcNHglycan	285	288	PF01048	0.602
MOD_GlcNHglycan	292	295	PF01048	0.578
MOD_GlcNHglycan	347	350	PF01048	0.432
MOD_GlcNHglycan	40	43	PF01048	0.666
MOD_GlcNHglycan	63	66	PF01048	0.510
MOD_GlcNHglycan	75	78	PF01048	0.479
MOD_GSK3_1	101	108	PF00069	0.691
MOD_GSK3_1	121	128	PF00069	0.565
MOD_GSK3_1	144	151	PF00069	0.716
MOD_GSK3_1	152	159	PF00069	0.670
MOD_GSK3_1	195	202	PF00069	0.707
MOD_GSK3_1	231	238	PF00069	0.574
MOD_GSK3_1	282	289	PF00069	0.638
MOD_NEK2_1	172	177	PF00069	0.570
MOD_NEK2_1	195	200	PF00069	0.744
MOD_NEK2_1	260	265	PF00069	0.535
MOD_NEK2_1	345	350	PF00069	0.445
MOD_NEK2_1	43	48	PF00069	0.649
MOD_PIKK_1	149	155	PF00454	0.750
MOD_PIKK_1	246	252	PF00454	0.444
MOD_PIKK_1	280	286	PF00454	0.643
MOD_PK_1	307	313	PF00069	0.475
MOD_PKA_2	108	114	PF00069	0.622
MOD_PKA_2	153	159	PF00069	0.555
MOD_PKA_2	173	179	PF00069	0.550
MOD_PKB_1	107	115	PF00069	0.627
MOD_PKB_1	280	288	PF00069	0.659
MOD_Plk_1	231	237	PF00069	0.512
MOD_Plk_1	239	245	PF00069	0.483
MOD_Plk_4	208	214	PF00069	0.403
MOD_ProDKin_1	145	151	PF00069	0.681
MOD_ProDKin_1	217	223	PF00069	0.548
MOD_ProDKin_1	323	329	PF00069	0.584
MOD_ProDKin_1	357	363	PF00069	0.587
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.713
TRG_ENDOCYTIC_2	10	13	PF00928	0.542
TRG_ER_diArg_1	107	110	PF00400	0.591
TRG_ER_diArg_1	19	22	PF00400	0.592
TRG_ER_diArg_1	256	258	PF00400	0.544
TRG_ER_diArg_1	297	299	PF00400	0.581
TRG_NLS_MonoCore_2	96	101	PF00514	0.598
TRG_NLS_MonoExtC_3	96	102	PF00514	0.599
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHA6	Leptomonas seymouri	56%	100%
A0A1X0NNF4	Trypanosomatidae	28%	90%
A0A3S7WT74	Leishmania donovani	90%	100%
A0A422NFP0	Trypanosoma rangeli	36%	100%
A4H7V1	Leishmania braziliensis	81%	100%
A4HW77	Leishmania infantum	90%	100%
C9ZST9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9APX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AW09	Trypanosoma cruzi	39%	100%