J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QFK1_LEIMA

TriTrypDb:

LmjF.14.1330 , LMJLV39_140021100 , LMJSD75_140020600

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 2
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QFK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.494
CLV_NRD_NRD_1	226	228	PF00675	0.423
CLV_NRD_NRD_1	266	268	PF00675	0.466
CLV_NRD_NRD_1	279	281	PF00675	0.375
CLV_NRD_NRD_1	428	430	PF00675	0.500
CLV_NRD_NRD_1	448	450	PF00675	0.122
CLV_NRD_NRD_1	451	453	PF00675	0.305
CLV_NRD_NRD_1	50	52	PF00675	0.316
CLV_PCSK_FUR_1	224	228	PF00082	0.443
CLV_PCSK_KEX2_1	226	228	PF00082	0.443
CLV_PCSK_KEX2_1	266	268	PF00082	0.460
CLV_PCSK_KEX2_1	279	281	PF00082	0.355
CLV_PCSK_KEX2_1	310	312	PF00082	0.501
CLV_PCSK_KEX2_1	424	426	PF00082	0.484
CLV_PCSK_KEX2_1	448	450	PF00082	0.305
CLV_PCSK_KEX2_1	495	497	PF00082	0.337
CLV_PCSK_KEX2_1	50	52	PF00082	0.316
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.501
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.485
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.337
CLV_PCSK_SKI1_1	245	249	PF00082	0.524
CLV_PCSK_SKI1_1	453	457	PF00082	0.428
CLV_PCSK_SKI1_1	466	470	PF00082	0.431
CLV_PCSK_SKI1_1	487	491	PF00082	0.305
CLV_PCSK_SKI1_1	50	54	PF00082	0.394
DEG_APCC_DBOX_1	90	98	PF00400	0.378
DEG_SPOP_SBC_1	3	7	PF00917	0.545
DOC_CYCLIN_RxL_1	277	287	PF00134	0.415
DOC_CYCLIN_RxL_1	429	441	PF00134	0.452
DOC_CYCLIN_RxL_1	47	57	PF00134	0.457
DOC_MAPK_gen_1	140	148	PF00069	0.528
DOC_MAPK_gen_1	200	208	PF00069	0.503
DOC_MAPK_gen_1	315	323	PF00069	0.506
DOC_MAPK_MEF2A_6	412	420	PF00069	0.450
DOC_USP7_MATH_1	155	159	PF00917	0.554
DOC_USP7_MATH_1	347	351	PF00917	0.389
DOC_USP7_MATH_1	455	459	PF00917	0.438
DOC_USP7_UBL2_3	150	154	PF12436	0.486
DOC_USP7_UBL2_3	306	310	PF12436	0.522
DOC_USP7_UBL2_3	430	434	PF12436	0.305
DOC_WW_Pin1_4	248	253	PF00397	0.564
LIG_14-3-3_CanoR_1	125	129	PF00244	0.411
LIG_14-3-3_CanoR_1	17	27	PF00244	0.480
LIG_14-3-3_CanoR_1	170	174	PF00244	0.481
LIG_14-3-3_CanoR_1	352	360	PF00244	0.528
LIG_14-3-3_CanoR_1	4	13	PF00244	0.674
LIG_Actin_WH2_2	409	426	PF00022	0.524
LIG_FHA_1	19	25	PF00498	0.526
LIG_FHA_1	239	245	PF00498	0.529
LIG_FHA_1	303	309	PF00498	0.337
LIG_FHA_1	73	79	PF00498	0.366
LIG_FHA_2	373	379	PF00498	0.533
LIG_FHA_2	467	473	PF00498	0.454
LIG_GBD_Chelix_1	23	31	PF00786	0.520
LIG_LIR_Apic_2	179	185	PF02991	0.565
LIG_LIR_Gen_1	172	181	PF02991	0.454
LIG_LIR_Gen_1	314	325	PF02991	0.476
LIG_LIR_Gen_1	72	82	PF02991	0.448
LIG_LIR_Gen_1	93	103	PF02991	0.499
LIG_LIR_LC3C_4	26	30	PF02991	0.655
LIG_LIR_Nem_3	172	178	PF02991	0.379
LIG_LIR_Nem_3	314	320	PF02991	0.427
LIG_LIR_Nem_3	431	436	PF02991	0.305
LIG_LIR_Nem_3	477	483	PF02991	0.305
LIG_LIR_Nem_3	72	77	PF02991	0.512
LIG_NRBOX	107	113	PF00104	0.349
LIG_PCNA_yPIPBox_3	125	136	PF02747	0.509
LIG_Pex14_2	517	521	PF04695	0.689
LIG_Pex14_2	525	529	PF04695	0.668
LIG_Pex14_2	533	537	PF04695	0.665
LIG_Pex14_2	541	545	PF04695	0.643
LIG_REV1ctd_RIR_1	556	564	PF16727	0.624
LIG_SH2_CRK	149	153	PF00017	0.553
LIG_SH2_CRK	433	437	PF00017	0.305
LIG_SH2_CRK	451	455	PF00017	0.305
LIG_SH2_CRK	74	78	PF00017	0.500
LIG_SH2_NCK_1	189	193	PF00017	0.573
LIG_SH2_NCK_1	89	93	PF00017	0.358
LIG_SH2_STAP1	15	19	PF00017	0.581
LIG_SH2_STAP1	171	175	PF00017	0.417
LIG_SH2_STAP1	336	340	PF00017	0.505
LIG_SH2_STAP1	74	78	PF00017	0.330
LIG_SH2_STAT3	246	249	PF00017	0.429
LIG_SH2_STAT3	336	339	PF00017	0.427
LIG_SH2_STAT5	171	174	PF00017	0.403
LIG_SH2_STAT5	189	192	PF00017	0.472
LIG_SH2_STAT5	246	249	PF00017	0.429
LIG_SH2_STAT5	74	77	PF00017	0.355
LIG_SH3_3	329	335	PF00018	0.553
LIG_SH3_3	502	508	PF00018	0.544
LIG_SH3_5	428	432	PF00018	0.366
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.382
LIG_SUMO_SIM_anti_2	26	32	PF11976	0.617
LIG_SUMO_SIM_par_1	346	356	PF11976	0.289
LIG_TRAF2_1	240	243	PF00917	0.395
LIG_TRAF2_1	335	338	PF00917	0.517
LIG_TRAF2_1	443	446	PF00917	0.353
LIG_UBA3_1	435	440	PF00899	0.426
MOD_CK1_1	127	133	PF00069	0.512
MOD_CK1_1	158	164	PF00069	0.458
MOD_CK1_1	217	223	PF00069	0.525
MOD_CK1_1	350	356	PF00069	0.303
MOD_CK1_1	5	11	PF00069	0.561
MOD_CK1_1	72	78	PF00069	0.510
MOD_CK2_1	271	277	PF00069	0.524
MOD_CK2_1	350	356	PF00069	0.409
MOD_CK2_1	440	446	PF00069	0.353
MOD_CK2_1	466	472	PF00069	0.321
MOD_CK2_1	87	93	PF00069	0.351
MOD_GlcNHglycan	36	39	PF01048	0.568
MOD_GlcNHglycan	442	445	PF01048	0.375
MOD_GlcNHglycan	500	503	PF01048	0.524
MOD_GSK3_1	155	162	PF00069	0.567
MOD_GSK3_1	169	176	PF00069	0.532
MOD_GSK3_1	2	9	PF00069	0.639
MOD_GSK3_1	347	354	PF00069	0.399
MOD_GSK3_1	462	469	PF00069	0.305
MOD_NEK2_1	124	129	PF00069	0.390
MOD_NEK2_1	2	7	PF00069	0.634
MOD_NEK2_1	23	28	PF00069	0.606
MOD_NEK2_1	271	276	PF00069	0.525
MOD_NEK2_1	423	428	PF00069	0.584
MOD_NEK2_1	438	443	PF00069	0.373
MOD_NEK2_1	454	459	PF00069	0.217
MOD_NEK2_1	516	521	PF00069	0.744
MOD_NEK2_2	347	352	PF00069	0.399
MOD_PIKK_1	127	133	PF00454	0.447
MOD_PIKK_1	155	161	PF00454	0.538
MOD_PIKK_1	180	186	PF00454	0.561
MOD_PIKK_1	238	244	PF00454	0.470
MOD_PIKK_1	245	251	PF00454	0.382
MOD_PKA_2	124	130	PF00069	0.392
MOD_PKA_2	169	175	PF00069	0.539
MOD_PKA_2	3	9	PF00069	0.641
MOD_PKA_2	302	308	PF00069	0.332
MOD_PKA_2	351	357	PF00069	0.408
MOD_PKB_1	496	504	PF00069	0.219
MOD_Plk_1	214	220	PF00069	0.451
MOD_Plk_1	271	277	PF00069	0.524
MOD_Plk_1	45	51	PF00069	0.474
MOD_Plk_4	23	29	PF00069	0.599
MOD_Plk_4	372	378	PF00069	0.478
MOD_Plk_4	93	99	PF00069	0.391
MOD_ProDKin_1	248	254	PF00069	0.561
MOD_SUMO_for_1	418	421	PF00179	0.575
MOD_SUMO_for_1	82	85	PF00179	0.533
MOD_SUMO_rev_2	137	145	PF00179	0.481
MOD_SUMO_rev_2	309	317	PF00179	0.516
MOD_SUMO_rev_2	405	413	PF00179	0.584
MOD_SUMO_rev_2	482	489	PF00179	0.310
MOD_SUMO_rev_2	492	497	PF00179	0.298
TRG_DiLeu_BaEn_1	204	209	PF01217	0.445
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.444
TRG_ENDOCYTIC_2	149	152	PF00928	0.483
TRG_ENDOCYTIC_2	432	435	PF00928	0.292
TRG_ENDOCYTIC_2	451	454	PF00928	0.280
TRG_ENDOCYTIC_2	74	77	PF00928	0.502
TRG_ENDOCYTIC_2	95	98	PF00928	0.494
TRG_ER_diArg_1	223	226	PF00400	0.443
TRG_ER_diArg_1	265	267	PF00400	0.457
TRG_ER_diArg_1	278	280	PF00400	0.370
TRG_ER_diArg_1	447	449	PF00400	0.305
TRG_ER_diArg_1	49	51	PF00400	0.307
TRG_ER_diArg_1	496	499	PF00400	0.362
TRG_NES_CRM1_1	207	222	PF08389	0.438
TRG_NES_CRM1_1	273	287	PF08389	0.455
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0D1E2P6	Ustilago maydis (strain 521 / FGSC 9021)	25%	97%
A0A0D2XVZ5	Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)	28%	100%
A0A0N1PCC0	Leptomonas seymouri	65%	99%
A0A0N1PF59	Leptomonas seymouri	25%	100%
A0A0S4JQ76	Bodo saltans	44%	100%
A0A1X0NP19	Trypanosomatidae	42%	100%
A0A3S7WTD0	Leishmania donovani	93%	99%
A0A422NFP3	Trypanosoma rangeli	48%	100%
A4H7V3	Leishmania braziliensis	83%	100%
A4HW79	Leishmania infantum	92%	98%
C9ZST7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9APY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
J9VKM5	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	25%	100%
Q13217	Homo sapiens	29%	100%
Q27968	Bos taurus	28%	100%
Q54M21	Dictyostelium discoideum	26%	100%
Q5JNB5	Oryza sativa subsp. japonica	28%	100%
Q5R8D8	Pongo abelii	23%	100%
Q5ZI13	Gallus gallus	28%	100%
Q91YW3	Mus musculus	28%	100%
Q99615	Homo sapiens	24%	100%
Q9QYI3	Mus musculus	23%	100%
Q9R0T3	Rattus norvegicus	28%	100%
V5BKH0	Trypanosoma cruzi	48%	100%