Delta-4 fatty acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

delta-4 fatty acid desaturase

Species:

Leishmania major

UniProt:

Q4QFK0_LEIMA

TriTrypDb:

LmjF.14.1340 , LMJLV39_140021200 , LMJSD75_140020700

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QFK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFK0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	2
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.479
CLV_NRD_NRD_1	424	426	PF00675	0.398
CLV_NRD_NRD_1	64	66	PF00675	0.262
CLV_PCSK_FUR_1	422	426	PF00082	0.365
CLV_PCSK_KEX2_1	103	105	PF00082	0.330
CLV_PCSK_KEX2_1	142	144	PF00082	0.479
CLV_PCSK_KEX2_1	424	426	PF00082	0.469
CLV_PCSK_KEX2_1	63	65	PF00082	0.264
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.283
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.469
CLV_PCSK_PC7_1	420	426	PF00082	0.347
CLV_PCSK_SKI1_1	123	127	PF00082	0.293
CLV_PCSK_SKI1_1	20	24	PF00082	0.350
CLV_PCSK_SKI1_1	268	272	PF00082	0.295
CLV_PCSK_SKI1_1	34	38	PF00082	0.287
CLV_PCSK_SKI1_1	394	398	PF00082	0.302
DEG_APCC_KENBOX_2	404	408	PF00400	0.421
DEG_MDM2_SWIB_1	351	359	PF02201	0.516
DEG_Nend_UBRbox_3	1	3	PF02207	0.546
DEG_ODPH_VHL_1	109	122	PF01847	0.412
DOC_CYCLIN_RxL_1	176	186	PF00134	0.486
DOC_MAPK_gen_1	142	149	PF00069	0.242
DOC_MAPK_gen_1	19	25	PF00069	0.551
DOC_MAPK_gen_1	268	278	PF00069	0.484
DOC_MAPK_MEF2A_6	123	132	PF00069	0.337
DOC_MAPK_MEF2A_6	212	220	PF00069	0.277
DOC_MAPK_MEF2A_6	222	231	PF00069	0.272
DOC_MAPK_MEF2A_6	271	280	PF00069	0.513
DOC_MAPK_RevD_3	128	143	PF00069	0.286
DOC_PP2B_LxvP_1	216	219	PF13499	0.235
LIG_14-3-3_CanoR_1	268	278	PF00244	0.459
LIG_14-3-3_CanoR_1	394	399	PF00244	0.498
LIG_14-3-3_CterR_2	425	428	PF00244	0.624
LIG_APCC_ABBAyCdc20_2	78	84	PF00400	0.504
LIG_BRCT_BRCA1_1	322	326	PF00533	0.422
LIG_BRCT_BRCA1_1	347	351	PF00533	0.497
LIG_CaM_NSCaTE_8	118	125	PF13499	0.314
LIG_FHA_1	270	276	PF00498	0.424
LIG_FHA_1	30	36	PF00498	0.458
LIG_FHA_2	401	407	PF00498	0.474
LIG_GBD_Chelix_1	128	136	PF00786	0.238
LIG_Integrin_isoDGR_2	50	52	PF01839	0.340
LIG_LIR_Apic_2	72	77	PF02991	0.536
LIG_LIR_Gen_1	126	134	PF02991	0.303
LIG_LIR_Gen_1	135	145	PF02991	0.352
LIG_LIR_Gen_1	399	409	PF02991	0.474
LIG_LIR_Gen_1	96	105	PF02991	0.468
LIG_LIR_Nem_3	126	130	PF02991	0.303
LIG_LIR_Nem_3	135	140	PF02991	0.349
LIG_LIR_Nem_3	244	250	PF02991	0.236
LIG_LIR_Nem_3	397	401	PF02991	0.458
LIG_LIR_Nem_3	55	61	PF02991	0.447
LIG_LIR_Nem_3	94	98	PF02991	0.458
LIG_Pex14_2	238	242	PF04695	0.267
LIG_Pex14_2	254	258	PF04695	0.180
LIG_Pex14_2	351	355	PF04695	0.516
LIG_PTB_Apo_2	195	202	PF02174	0.316
LIG_PTB_Apo_2	252	259	PF02174	0.302
LIG_PTB_Phospho_1	195	201	PF10480	0.316
LIG_SH2_CRK	286	290	PF00017	0.390
LIG_SH2_CRK	380	384	PF00017	0.453
LIG_SH2_CRK	401	405	PF00017	0.556
LIG_SH2_CRK	74	78	PF00017	0.584
LIG_SH2_GRB2like	206	209	PF00017	0.235
LIG_SH2_SRC	201	204	PF00017	0.316
LIG_SH2_STAP1	137	141	PF00017	0.454
LIG_SH2_STAP1	380	384	PF00017	0.476
LIG_SH2_STAP1	95	99	PF00017	0.545
LIG_SH2_STAT5	119	122	PF00017	0.303
LIG_SH2_STAT5	145	148	PF00017	0.321
LIG_SH2_STAT5	201	204	PF00017	0.248
LIG_SH2_STAT5	206	209	PF00017	0.222
LIG_SH2_STAT5	239	242	PF00017	0.250
LIG_SH2_STAT5	315	318	PF00017	0.261
LIG_SH2_STAT5	382	385	PF00017	0.437
LIG_SH2_STAT5	398	401	PF00017	0.443
LIG_SH2_STAT5	98	101	PF00017	0.448
LIG_SH3_3	243	249	PF00018	0.210
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.292
LIG_SUMO_SIM_anti_2	31	39	PF11976	0.477
LIG_SUMO_SIM_par_1	21	26	PF11976	0.544
LIG_SxIP_EBH_1	220	230	PF03271	0.316
LIG_SxIP_EBH_1	277	287	PF03271	0.321
LIG_TYR_ITIM	284	289	PF00017	0.390
LIG_TYR_ITIM	316	321	PF00017	0.371
LIG_TYR_ITSM	397	404	PF00017	0.442
LIG_UBA3_1	253	261	PF00899	0.398
LIG_WRC_WIRS_1	409	414	PF05994	0.513
MOD_CK1_1	191	197	PF00069	0.325
MOD_CK1_1	7	13	PF00069	0.599
MOD_CK1_1	94	100	PF00069	0.493
MOD_CK2_1	400	406	PF00069	0.573
MOD_CK2_1	7	13	PF00069	0.548
MOD_CK2_1	82	88	PF00069	0.560
MOD_GlcNHglycan	224	227	PF01048	0.516
MOD_GSK3_1	145	152	PF00069	0.272
MOD_GSK3_1	396	403	PF00069	0.508
MOD_GSK3_1	4	11	PF00069	0.614
MOD_N-GLC_2	2	4	PF02516	0.342
MOD_NEK2_1	188	193	PF00069	0.315
MOD_NEK2_1	269	274	PF00069	0.508
MOD_NEK2_1	293	298	PF00069	0.336
MOD_NEK2_1	320	325	PF00069	0.251
MOD_NEK2_1	396	401	PF00069	0.468
MOD_NEK2_1	408	413	PF00069	0.494
MOD_OFUCOSY	299	305	PF10250	0.424
MOD_OFUCOSY	343	349	PF10250	0.316
MOD_PIKK_1	181	187	PF00454	0.302
MOD_PIKK_1	269	275	PF00454	0.502
MOD_Plk_1	52	58	PF00069	0.472
MOD_Plk_2-3	21	27	PF00069	0.548
MOD_Plk_4	123	129	PF00069	0.277
MOD_Plk_4	135	141	PF00069	0.334
MOD_Plk_4	145	151	PF00069	0.306
MOD_Plk_4	279	285	PF00069	0.315
MOD_Plk_4	82	88	PF00069	0.600
MOD_Plk_4	94	100	PF00069	0.531
TRG_DiLeu_BaEn_1	265	270	PF01217	0.535
TRG_DiLeu_BaEn_1	33	38	PF01217	0.486
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.235
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.472
TRG_DiLeu_LyEn_5	265	270	PF01217	0.476
TRG_ENDOCYTIC_2	119	122	PF00928	0.290
TRG_ENDOCYTIC_2	137	140	PF00928	0.373
TRG_ENDOCYTIC_2	239	242	PF00928	0.285
TRG_ENDOCYTIC_2	286	289	PF00928	0.390
TRG_ENDOCYTIC_2	318	321	PF00928	0.255
TRG_ENDOCYTIC_2	380	383	PF00928	0.422
TRG_ENDOCYTIC_2	401	404	PF00928	0.478
TRG_ENDOCYTIC_2	98	101	PF00928	0.448
TRG_ER_diArg_1	141	143	PF00400	0.285
TRG_ER_diArg_1	63	65	PF00400	0.478
TRG_ER_diLys_1	424	428	PF00400	0.706
TRG_NES_CRM1_1	151	165	PF08389	0.279

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0C5PRW9	Tachysurus fulvidraco	24%	96%
A0A0N1HZP4	Leptomonas seymouri	82%	100%
A0A0N1IMB2	Leptomonas seymouri	22%	100%
A0A0N1PAQ6	Leptomonas seymouri	25%	100%
A0A0S4IVF3	Bodo saltans	51%	100%
A0A0S4KLP1	Bodo saltans	22%	100%
A0A1X0NMZ1	Trypanosomatidae	22%	100%
A0A1X0NPK3	Trypanosomatidae	21%	100%
A0A1X0P7J5	Trypanosomatidae	57%	100%
A0A3Q8I9Z6	Leishmania donovani	95%	100%
A0A3Q8IK71	Leishmania donovani	23%	100%
A0A3S5H618	Leishmania donovani	25%	100%
A0A422NCE1	Trypanosoma rangeli	56%	100%
A0PJ29	Rebecca salina	36%	96%
A4H558	Leishmania braziliensis	25%	100%
A4H7V4	Leishmania braziliensis	85%	100%
A4HQL7	Leishmania braziliensis	24%	100%
A4HTD5	Leishmania infantum	25%	100%
A4HW80	Leishmania infantum	95%	100%
A4IFP3	Bos taurus	22%	97%
A4UVI1	Papio anubis	23%	96%
A8MWK0	Homo sapiens	25%	89%
A9SIZ6	Physcomitrium patens	27%	89%
B2KKL4	Siganus canaliculatus	22%	97%
D0A3D4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D8X2C5	Siganus canaliculatus	24%	96%
E9AI08	Leishmania infantum	24%	100%
E9ALC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9APY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AUD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
I2CYZ4	Chlamydomonas reinhardtii	29%	83%
O04353	Borago officinalis	24%	96%
O60427	Homo sapiens	22%	96%
O74212	Mortierella alpina	26%	96%
O95864	Homo sapiens	20%	96%
O96099	Dictyostelium discoideum	25%	92%
Q08871	Synechocystis sp. (strain PCC 6803 / Kazusa)	29%	100%
Q0VAX3	Mus musculus	22%	88%
Q1ZXQ5	Dictyostelium discoideum	27%	93%
Q4G2T3	Thalassiosira pseudonana	21%	83%
Q4Q058	Leishmania major	23%	100%
Q4QIH7	Leishmania major	25%	100%
Q6DDK2	Xenopus laevis	22%	96%
Q6VPV2	Diacronema lutheri	37%	96%
Q6WNG7	Euglena gracilis	29%	79%
Q8K1P9	Rattus norvegicus	24%	95%
Q8S3C0	Thraustochytrium sp.	25%	82%
Q920L1	Mus musculus	22%	96%
Q920R3	Rattus norvegicus	21%	96%
Q9DEX7	Danio rerio	23%	96%
Q9FR82	Borago officinalis	22%	96%
Q9JJE7	Mus musculus	24%	95%
Q9LEM9	Ceratodon purpureus	24%	82%
Q9LEN0	Ceratodon purpureus	26%	89%
Q9Y1W0	Dictyostelium discoideum	25%	92%
Q9Y5Q0	Homo sapiens	24%	96%
Q9ZNW2	Physcomitrium patens	25%	82%