Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFJ9_LEIMA

TriTrypDb:

LmjF.14.1350 , LMJLV39_140021300 , LMJSD75_140020800

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005868	cytoplasmic dynein complex	4	4
GO:0005874	microtubule	6	4
GO:0005875	microtubule associated complex	2	4
GO:0030286	dynein complex	3	4
GO:0032991	protein-containing complex	1	4
GO:0099080	supramolecular complex	2	4
GO:0099081	supramolecular polymer	3	4
GO:0099512	supramolecular fiber	4	4
GO:0099513	polymeric cytoskeletal fiber	5	4
GO:0110165	cellular anatomical entity	1	4
GO:1902494	catalytic complex	2	4

Expansion

Sequence features

Q4QFJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFJ9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	4
GO:0007018	microtubule-based movement	3	4
GO:0009987	cellular process	1	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0005488	binding	1	4
GO:0005524	ATP binding	5	4
GO:0017076	purine nucleotide binding	4	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.783
CLV_C14_Caspase3-7	563	567	PF00656	0.767
CLV_MEL_PAP_1	467	473	PF00089	0.626
CLV_NRD_NRD_1	102	104	PF00675	0.529
CLV_NRD_NRD_1	237	239	PF00675	0.509
CLV_NRD_NRD_1	308	310	PF00675	0.501
CLV_NRD_NRD_1	85	87	PF00675	0.464
CLV_PCSK_KEX2_1	102	104	PF00082	0.467
CLV_PCSK_KEX2_1	237	239	PF00082	0.509
CLV_PCSK_KEX2_1	308	310	PF00082	0.501
CLV_PCSK_KEX2_1	85	87	PF00082	0.476
CLV_PCSK_KEX2_1	97	99	PF00082	0.448
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.448
CLV_PCSK_PC7_1	98	104	PF00082	0.545
CLV_PCSK_SKI1_1	461	465	PF00082	0.510
CLV_PCSK_SKI1_1	86	90	PF00082	0.514
DEG_APCC_DBOX_1	441	449	PF00400	0.497
DEG_APCC_DBOX_1	460	468	PF00400	0.519
DEG_Nend_Nbox_1	1	3	PF02207	0.568
DEG_SPOP_SBC_1	375	379	PF00917	0.529
DOC_CKS1_1	228	233	PF01111	0.658
DOC_CKS1_1	576	581	PF01111	0.671
DOC_CYCLIN_RxL_1	406	416	PF00134	0.547
DOC_CYCLIN_RxL_1	97	109	PF00134	0.501
DOC_CYCLIN_yCln2_LP_2	428	434	PF00134	0.509
DOC_MAPK_gen_1	39	47	PF00069	0.720
DOC_MAPK_gen_1	439	448	PF00069	0.515
DOC_MAPK_HePTP_8	424	436	PF00069	0.512
DOC_MAPK_MEF2A_6	357	365	PF00069	0.631
DOC_MAPK_MEF2A_6	427	436	PF00069	0.512
DOC_PP1_RVXF_1	100	107	PF00149	0.543
DOC_PP2B_LxvP_1	428	431	PF13499	0.582
DOC_PP2B_LxvP_1	70	73	PF13499	0.691
DOC_PP4_FxxP_1	365	368	PF00568	0.631
DOC_PP4_FxxP_1	380	383	PF00568	0.625
DOC_USP7_MATH_1	164	168	PF00917	0.695
DOC_USP7_MATH_1	335	339	PF00917	0.606
DOC_USP7_MATH_1	38	42	PF00917	0.809
DOC_USP7_MATH_1	46	50	PF00917	0.714
DOC_USP7_MATH_1	463	467	PF00917	0.408
DOC_USP7_MATH_1	509	513	PF00917	0.585
DOC_WW_Pin1_4	10	15	PF00397	0.579
DOC_WW_Pin1_4	227	232	PF00397	0.662
DOC_WW_Pin1_4	31	36	PF00397	0.775
DOC_WW_Pin1_4	349	354	PF00397	0.535
DOC_WW_Pin1_4	557	562	PF00397	0.769
DOC_WW_Pin1_4	575	580	PF00397	0.612
LIG_14-3-3_CanoR_1	222	229	PF00244	0.761
LIG_14-3-3_CanoR_1	237	243	PF00244	0.503
LIG_14-3-3_CanoR_1	381	389	PF00244	0.607
LIG_14-3-3_CanoR_1	442	446	PF00244	0.546
LIG_14-3-3_CanoR_1	470	474	PF00244	0.625
LIG_14-3-3_CanoR_1	519	527	PF00244	0.548
LIG_14-3-3_CanoR_1	570	579	PF00244	0.677
LIG_Actin_WH2_2	421	437	PF00022	0.589
LIG_BRCT_BRCA1_1	223	227	PF00533	0.761
LIG_BRCT_BRCA1_1	350	354	PF00533	0.610
LIG_BRCT_BRCA1_1	376	380	PF00533	0.576
LIG_Clathr_ClatBox_1	267	271	PF01394	0.399
LIG_EH_1	488	492	PF12763	0.519
LIG_eIF4E_1	482	488	PF01652	0.641
LIG_FHA_1	201	207	PF00498	0.610
LIG_FHA_1	377	383	PF00498	0.584
LIG_FHA_2	397	403	PF00498	0.399
LIG_FHA_2	557	563	PF00498	0.720
LIG_FHA_2	569	575	PF00498	0.689
LIG_LIR_Apic_2	362	368	PF02991	0.636
LIG_LIR_Apic_2	377	383	PF02991	0.624
LIG_LIR_Gen_1	283	294	PF02991	0.517
LIG_LIR_Nem_3	283	289	PF02991	0.514
LIG_PTB_Apo_2	486	493	PF02174	0.545
LIG_PTB_Phospho_1	486	492	PF10480	0.546
LIG_SH2_CRK	194	198	PF00017	0.548
LIG_SH2_GRB2like	482	485	PF00017	0.713
LIG_SH2_SRC	194	197	PF00017	0.549
LIG_SH2_SRC	482	485	PF00017	0.713
LIG_SH2_STAP1	194	198	PF00017	0.548
LIG_SH2_STAP1	482	486	PF00017	0.674
LIG_SH2_STAT3	196	199	PF00017	0.549
LIG_SH2_STAT3	589	592	PF00017	0.565
LIG_SH2_STAT5	196	199	PF00017	0.533
LIG_SH2_STAT5	284	287	PF00017	0.434
LIG_SH2_STAT5	292	295	PF00017	0.392
LIG_SH2_STAT5	498	501	PF00017	0.382
LIG_SH2_STAT5	589	592	PF00017	0.565
LIG_SH3_3	32	38	PF00018	0.768
LIG_SH3_3	550	556	PF00018	0.669
LIG_SH3_3	573	579	PF00018	0.683
LIG_SH3_3	87	93	PF00018	0.352
LIG_SUMO_SIM_anti_2	262	269	PF11976	0.379
LIG_SUMO_SIM_anti_2	536	542	PF11976	0.434
LIG_SUMO_SIM_par_1	265	271	PF11976	0.392
LIG_TRAF2_1	315	318	PF00917	0.541
LIG_TRAF2_1	606	609	PF00917	0.710
LIG_TYR_ITIM	192	197	PF00017	0.553
LIG_WW_3	36	40	PF00397	0.745
MOD_CDK_SPK_2	10	15	PF00069	0.567
MOD_CK1_1	187	193	PF00069	0.652
MOD_CK1_1	273	279	PF00069	0.514
MOD_CK1_1	31	37	PF00069	0.771
MOD_CK1_1	336	342	PF00069	0.685
MOD_CK1_1	352	358	PF00069	0.743
MOD_CK1_1	385	391	PF00069	0.554
MOD_CK1_1	441	447	PF00069	0.461
MOD_CK1_1	466	472	PF00069	0.532
MOD_CK1_1	512	518	PF00069	0.574
MOD_CK1_1	557	563	PF00069	0.792
MOD_CK1_1	77	83	PF00069	0.640
MOD_CK2_1	284	290	PF00069	0.526
MOD_CK2_1	352	358	PF00069	0.714
MOD_CK2_1	396	402	PF00069	0.481
MOD_CK2_1	545	551	PF00069	0.572
MOD_CK2_1	556	562	PF00069	0.742
MOD_CK2_1	568	574	PF00069	0.657
MOD_CK2_1	603	609	PF00069	0.745
MOD_Cter_Amidation	95	98	PF01082	0.416
MOD_GlcNHglycan	166	169	PF01048	0.700
MOD_GlcNHglycan	189	192	PF01048	0.648
MOD_GlcNHglycan	20	25	PF01048	0.728
MOD_GlcNHglycan	217	220	PF01048	0.635
MOD_GlcNHglycan	223	226	PF01048	0.607
MOD_GlcNHglycan	262	265	PF01048	0.548
MOD_GlcNHglycan	335	338	PF01048	0.666
MOD_GlcNHglycan	340	343	PF01048	0.728
MOD_GlcNHglycan	384	387	PF01048	0.603
MOD_GlcNHglycan	415	418	PF01048	0.593
MOD_GlcNHglycan	484	487	PF01048	0.627
MOD_GlcNHglycan	504	507	PF01048	0.242
MOD_GlcNHglycan	521	524	PF01048	0.463
MOD_GlcNHglycan	599	602	PF01048	0.677
MOD_GlcNHglycan	94	97	PF01048	0.472
MOD_GSK3_1	213	220	PF00069	0.667
MOD_GSK3_1	232	239	PF00069	0.532
MOD_GSK3_1	25	32	PF00069	0.807
MOD_GSK3_1	270	277	PF00069	0.498
MOD_GSK3_1	284	291	PF00069	0.478
MOD_GSK3_1	329	336	PF00069	0.552
MOD_GSK3_1	340	347	PF00069	0.646
MOD_GSK3_1	348	355	PF00069	0.694
MOD_GSK3_1	411	418	PF00069	0.544
MOD_GSK3_1	557	564	PF00069	0.705
MOD_GSK3_1	77	84	PF00069	0.667
MOD_GSK3_1	92	99	PF00069	0.406
MOD_N-GLC_1	375	380	PF02516	0.613
MOD_N-GLC_1	509	514	PF02516	0.611
MOD_NEK2_1	232	237	PF00069	0.628
MOD_NEK2_1	296	301	PF00069	0.546
MOD_NEK2_1	413	418	PF00069	0.636
MOD_NEK2_1	438	443	PF00069	0.459
MOD_NEK2_1	544	549	PF00069	0.644
MOD_NEK2_1	597	602	PF00069	0.660
MOD_NEK2_2	581	586	PF00069	0.594
MOD_PIKK_1	217	223	PF00454	0.689
MOD_PIKK_1	3	9	PF00454	0.651
MOD_PIKK_1	447	453	PF00454	0.458
MOD_PIKK_1	46	52	PF00454	0.769
MOD_PIKK_1	608	614	PF00454	0.650
MOD_PIKK_1	77	83	PF00454	0.672
MOD_PKA_1	237	243	PF00069	0.526
MOD_PKA_2	172	178	PF00069	0.705
MOD_PKA_2	221	227	PF00069	0.766
MOD_PKA_2	236	242	PF00069	0.533
MOD_PKA_2	38	44	PF00069	0.750
MOD_PKA_2	405	411	PF00069	0.555
MOD_PKA_2	438	444	PF00069	0.442
MOD_PKA_2	469	475	PF00069	0.626
MOD_PKA_2	569	575	PF00069	0.694
MOD_Plk_1	273	279	PF00069	0.487
MOD_Plk_1	375	381	PF00069	0.588
MOD_Plk_1	509	515	PF00069	0.614
MOD_Plk_4	288	294	PF00069	0.491
MOD_Plk_4	441	447	PF00069	0.413
MOD_Plk_4	564	570	PF00069	0.711
MOD_ProDKin_1	10	16	PF00069	0.580
MOD_ProDKin_1	227	233	PF00069	0.654
MOD_ProDKin_1	31	37	PF00069	0.771
MOD_ProDKin_1	349	355	PF00069	0.531
MOD_ProDKin_1	557	563	PF00069	0.771
MOD_ProDKin_1	575	581	PF00069	0.602
MOD_SUMO_rev_2	318	327	PF00179	0.544
TRG_DiLeu_BaEn_1	420	425	PF01217	0.601
TRG_ENDOCYTIC_2	194	197	PF00928	0.549
TRG_ENDOCYTIC_2	286	289	PF00928	0.393
TRG_ENDOCYTIC_2	492	495	PF00928	0.385
TRG_ER_diArg_1	102	104	PF00400	0.527
TRG_ER_diArg_1	236	238	PF00400	0.498
TRG_ER_diArg_1	307	309	PF00400	0.501
TRG_ER_diArg_1	85	87	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	588	592	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ5	Leptomonas seymouri	56%	100%
A0A1X0NMR8	Trypanosomatidae	26%	100%
A0A3Q8I9X0	Leishmania donovani	92%	100%
A0A422NDE3	Trypanosoma rangeli	28%	87%
A4H7V5	Leishmania braziliensis	75%	83%
A4HW81	Leishmania infantum	92%	100%
D0A9A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9APY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BID0	Trypanosoma cruzi	26%	100%