Inositol-3-phosphate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol-3-phosphate synthase

Species:

Leishmania major

UniProt:

Q4QFJ8_LEIMA

TriTrypDb:

LmjF.14.1360 , LMJLV39_140021400 , LMJSD75_140021100

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFJ8

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0006020	inositol metabolic process	4	11
GO:0006021	inositol biosynthetic process	5	11
GO:0006066	alcohol metabolic process	3	11
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016051	carbohydrate biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019751	polyol metabolic process	4	11
GO:0034637	obsolete cellular carbohydrate biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044262	obsolete cellular carbohydrate metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046165	alcohol biosynthetic process	4	11
GO:0046173	polyol biosynthetic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004512	inositol-3-phosphate synthase activity	4	11
GO:0016853	isomerase activity	2	11
GO:0016872	intramolecular lyase activity	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.502
CLV_NRD_NRD_1	150	152	PF00675	0.284
CLV_NRD_NRD_1	206	208	PF00675	0.286
CLV_NRD_NRD_1	30	32	PF00675	0.423
CLV_NRD_NRD_1	375	377	PF00675	0.286
CLV_PCSK_FUR_1	28	32	PF00082	0.422
CLV_PCSK_KEX2_1	150	152	PF00082	0.284
CLV_PCSK_KEX2_1	252	254	PF00082	0.284
CLV_PCSK_KEX2_1	30	32	PF00082	0.423
CLV_PCSK_KEX2_1	394	396	PF00082	0.286
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.284
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.286
CLV_PCSK_SKI1_1	211	215	PF00082	0.284
CLV_PCSK_SKI1_1	293	297	PF00082	0.407
CLV_PCSK_SKI1_1	312	316	PF00082	0.216
CLV_PCSK_SKI1_1	352	356	PF00082	0.271
CLV_PCSK_SKI1_1	394	398	PF00082	0.385
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.527
DOC_MAPK_DCC_7	49	59	PF00069	0.477
DOC_MAPK_gen_1	150	157	PF00069	0.484
DOC_MAPK_gen_1	310	318	PF00069	0.514
DOC_MAPK_gen_1	376	384	PF00069	0.496
DOC_MAPK_gen_1	49	59	PF00069	0.368
DOC_MAPK_MEF2A_6	112	121	PF00069	0.552
DOC_MAPK_MEF2A_6	150	159	PF00069	0.471
DOC_MAPK_MEF2A_6	52	61	PF00069	0.471
DOC_PP2B_LxvP_1	423	426	PF13499	0.501
DOC_PP2B_LxvP_1	471	474	PF13499	0.471
DOC_USP7_UBL2_3	352	356	PF12436	0.471
DOC_USP7_UBL2_3	80	84	PF12436	0.462
DOC_WW_Pin1_4	11	16	PF00397	0.407
DOC_WW_Pin1_4	126	131	PF00397	0.566
DOC_WW_Pin1_4	448	453	PF00397	0.555
DOC_WW_Pin1_4	477	482	PF00397	0.471
LIG_14-3-3_CanoR_1	232	240	PF00244	0.484
LIG_14-3-3_CanoR_1	30	39	PF00244	0.600
LIG_EVH1_2	453	457	PF00568	0.454
LIG_FHA_1	103	109	PF00498	0.486
LIG_FHA_1	12	18	PF00498	0.445
LIG_FHA_1	24	30	PF00498	0.417
LIG_FHA_1	34	40	PF00498	0.485
LIG_FHA_1	399	405	PF00498	0.501
LIG_FHA_1	409	415	PF00498	0.484
LIG_FHA_1	478	484	PF00498	0.471
LIG_FHA_1	71	77	PF00498	0.460
LIG_FHA_2	415	421	PF00498	0.475
LIG_LIR_Gen_1	161	172	PF02991	0.484
LIG_LIR_Gen_1	198	206	PF02991	0.517
LIG_LIR_Gen_1	331	339	PF02991	0.497
LIG_LIR_Gen_1	399	406	PF02991	0.471
LIG_LIR_Gen_1	456	464	PF02991	0.485
LIG_LIR_Nem_3	115	121	PF02991	0.503
LIG_LIR_Nem_3	198	203	PF02991	0.552
LIG_LIR_Nem_3	331	335	PF02991	0.495
LIG_LIR_Nem_3	399	405	PF02991	0.471
LIG_NRBOX	466	472	PF00104	0.471
LIG_Pex14_2	177	181	PF04695	0.471
LIG_Rb_pABgroove_1	16	24	PF01858	0.364
LIG_SH2_NCK_1	264	268	PF00017	0.471
LIG_SH2_SRC	22	25	PF00017	0.380
LIG_SH2_STAP1	264	268	PF00017	0.484
LIG_SH2_STAP1	400	404	PF00017	0.471
LIG_SH2_STAT5	13	16	PF00017	0.407
LIG_SH2_STAT5	386	389	PF00017	0.483
LIG_SH2_STAT5	400	403	PF00017	0.473
LIG_SH2_STAT5	469	472	PF00017	0.533
LIG_SH2_STAT5	96	99	PF00017	0.460
LIG_SH3_3	114	120	PF00018	0.468
LIG_SH3_3	366	372	PF00018	0.566
LIG_SH3_3	471	477	PF00018	0.471
LIG_SUMO_SIM_anti_2	220	227	PF11976	0.471
LIG_SUMO_SIM_anti_2	430	436	PF11976	0.480
LIG_SUMO_SIM_anti_2	461	468	PF11976	0.471
LIG_SUMO_SIM_par_1	220	227	PF11976	0.471
LIG_SUMO_SIM_par_1	33	40	PF11976	0.432
LIG_SUMO_SIM_par_1	425	430	PF11976	0.471
LIG_SUMO_SIM_par_1	461	468	PF11976	0.485
LIG_UBA3_1	466	472	PF00899	0.471
MOD_CK1_1	306	312	PF00069	0.471
MOD_CK1_1	446	452	PF00069	0.476
MOD_CK1_1	465	471	PF00069	0.468
MOD_CK2_1	212	218	PF00069	0.463
MOD_GlcNHglycan	214	217	PF01048	0.342
MOD_GlcNHglycan	305	308	PF01048	0.251
MOD_GlcNHglycan	312	315	PF01048	0.276
MOD_GlcNHglycan	443	446	PF01048	0.359
MOD_GlcNHglycan	92	95	PF01048	0.336
MOD_GSK3_1	227	234	PF00069	0.499
MOD_GSK3_1	306	313	PF00069	0.471
MOD_GSK3_1	348	355	PF00069	0.471
MOD_GSK3_1	35	42	PF00069	0.471
MOD_GSK3_1	414	421	PF00069	0.471
MOD_GSK3_1	439	446	PF00069	0.542
MOD_GSK3_1	96	103	PF00069	0.460
MOD_N-GLC_1	253	258	PF02516	0.366
MOD_N-GLC_1	341	346	PF02516	0.327
MOD_N-GLC_1	67	72	PF02516	0.260
MOD_N-GLC_2	416	418	PF02516	0.271
MOD_NEK2_1	363	368	PF00069	0.501
MOD_NEK2_1	47	52	PF00069	0.329
MOD_NEK2_2	400	405	PF00069	0.504
MOD_PIKK_1	446	452	PF00454	0.423
MOD_PIKK_1	98	104	PF00454	0.460
MOD_PKA_1	30	36	PF00069	0.540
MOD_PKA_2	231	237	PF00069	0.484
MOD_PKA_2	30	36	PF00069	0.525
MOD_PKA_2	439	445	PF00069	0.501
MOD_PKB_1	28	36	PF00069	0.433
MOD_Plk_1	398	404	PF00069	0.471
MOD_Plk_1	418	424	PF00069	0.544
MOD_Plk_4	17	23	PF00069	0.352
MOD_Plk_4	259	265	PF00069	0.508
MOD_Plk_4	271	277	PF00069	0.443
MOD_Plk_4	408	414	PF00069	0.471
MOD_Plk_4	418	424	PF00069	0.471
MOD_Plk_4	459	465	PF00069	0.478
MOD_ProDKin_1	11	17	PF00069	0.404
MOD_ProDKin_1	126	132	PF00069	0.566
MOD_ProDKin_1	448	454	PF00069	0.555
MOD_ProDKin_1	477	483	PF00069	0.471
MOD_SUMO_for_1	324	327	PF00179	0.471
MOD_SUMO_rev_2	209	216	PF00179	0.622
MOD_SUMO_rev_2	290	298	PF00179	0.514
MOD_SUMO_rev_2	302	306	PF00179	0.441
TRG_DiLeu_BaEn_2	270	276	PF01217	0.566
TRG_DiLeu_BaEn_2	293	299	PF01217	0.486
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.471
TRG_ENDOCYTIC_2	164	167	PF00928	0.484
TRG_ENDOCYTIC_2	332	335	PF00928	0.483
TRG_ER_diArg_1	149	151	PF00400	0.484
TRG_ER_diArg_1	28	31	PF00400	0.429
TRG_ER_diArg_1	85	88	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I042	Leptomonas seymouri	82%	100%
A0A0S4JLI5	Bodo saltans	66%	100%
A0A1X0P7U4	Trypanosomatidae	72%	99%
A0A3R7LTQ6	Trypanosoma rangeli	68%	100%
A0A3S5H6T1	Leishmania donovani	97%	100%
A4H7V6	Leishmania braziliensis	84%	100%
A4HW82	Leishmania infantum	97%	100%
E9APY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O64437	Oryza sativa subsp. japonica	56%	100%
O65195	Hordeum vulgare	56%	100%
O97477	Drosophila melanogaster	57%	93%
P11986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	99%
P42800	Candida albicans (strain SC5314 / ATCC MYA-2876)	49%	100%
P42801	Arabidopsis thaliana	56%	100%
P42802	Citrus paradisi	54%	100%
P42803	Spirodela polyrhiza	56%	100%
Q2NL29	Bos taurus	57%	94%
Q38862	Arabidopsis thaliana	56%	100%
Q40271	Mesembryanthemum crystallinum	55%	100%
Q41107	Phaseolus vulgaris	55%	100%
Q4R6E3	Macaca fascicularis	58%	94%
Q54N49	Dictyostelium discoideum	59%	100%
Q6AYK3	Rattus norvegicus	57%	94%
Q6DDT1	Xenopus laevis	56%	93%
Q6FQI1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	50%	98%
Q7ZXY0	Xenopus laevis	56%	93%
Q8A7J8	Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50)	32%	100%
Q8I3Y8	Plasmodium falciparum (isolate 3D7)	37%	87%
Q8S5N2	Oryza sativa subsp. japonica	57%	100%
Q96348	Brassica napus	56%	100%
Q9FPK7	Zea mays	56%	100%
Q9FYV1	Sesamum indicum	57%	100%
Q9JHU9	Mus musculus	58%	94%
Q9LW96	Nicotiana tabacum	56%	100%
Q9LX12	Arabidopsis thaliana	55%	100%
Q9NPH2	Homo sapiens	58%	94%
Q9S7U0	Triticum aestivum	57%	100%
Q9SSV4	Nicotiana paniculata	56%	100%
V5B836	Trypanosoma cruzi	69%	99%