COMM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFJ6_LEIMA

TriTrypDb:

LmjF.14.1380 , LMJLV39_140021600 , LMJSD75_140021300

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	151	157	PF00089	0.467
CLV_NRD_NRD_1	167	169	PF00675	0.469
CLV_NRD_NRD_1	188	190	PF00675	0.497
CLV_NRD_NRD_1	310	312	PF00675	0.567
CLV_PCSK_KEX2_1	167	169	PF00082	0.469
CLV_PCSK_KEX2_1	188	190	PF00082	0.497
CLV_PCSK_KEX2_1	310	312	PF00082	0.567
CLV_PCSK_PC7_1	163	169	PF00082	0.447
CLV_PCSK_SKI1_1	125	129	PF00082	0.495
CLV_PCSK_SKI1_1	247	251	PF00082	0.523
CLV_PCSK_SKI1_1	84	88	PF00082	0.403
CLV_PCSK_SKI1_1	99	103	PF00082	0.420
CLV_Separin_Metazoa	205	209	PF03568	0.566
DEG_Nend_UBRbox_2	1	3	PF02207	0.494
DOC_CYCLIN_RxL_1	78	91	PF00134	0.418
DOC_CYCLIN_RxL_1	96	104	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.473
DOC_MAPK_DCC_7	270	280	PF00069	0.479
DOC_MAPK_RevD_3	155	168	PF00069	0.476
DOC_PP1_RVXF_1	176	183	PF00149	0.524
DOC_PP2B_LxvP_1	278	281	PF13499	0.499
DOC_PP4_FxxP_1	155	158	PF00568	0.513
DOC_SPAK_OSR1_1	154	158	PF12202	0.476
DOC_USP7_MATH_1	172	176	PF00917	0.495
DOC_WW_Pin1_4	297	302	PF00397	0.481
LIG_14-3-3_CanoR_1	154	158	PF00244	0.477
LIG_14-3-3_CanoR_1	167	173	PF00244	0.444
LIG_14-3-3_CanoR_1	82	87	PF00244	0.391
LIG_Actin_WH2_2	158	176	PF00022	0.404
LIG_BIR_III_4	211	215	PF00653	0.447
LIG_FHA_1	102	108	PF00498	0.446
LIG_FHA_1	159	165	PF00498	0.418
LIG_FHA_1	215	221	PF00498	0.499
LIG_FHA_2	217	223	PF00498	0.599
LIG_FHA_2	83	89	PF00498	0.457
LIG_LIR_Gen_1	108	117	PF02991	0.473
LIG_LIR_Gen_1	22	30	PF02991	0.366
LIG_LIR_Gen_1	38	48	PF02991	0.369
LIG_LIR_Gen_1	58	69	PF02991	0.348
LIG_LIR_Nem_3	108	112	PF02991	0.526
LIG_LIR_Nem_3	161	165	PF02991	0.486
LIG_LIR_Nem_3	22	26	PF02991	0.384
LIG_LIR_Nem_3	38	43	PF02991	0.385
LIG_LIR_Nem_3	58	64	PF02991	0.343
LIG_LIR_Nem_3	85	90	PF02991	0.475
LIG_NRBOX	123	129	PF00104	0.482
LIG_NRBOX	97	103	PF00104	0.475
LIG_SH2_CRK	109	113	PF00017	0.491
LIG_SH2_STAT5	109	112	PF00017	0.498
LIG_SH3_3	126	132	PF00018	0.461
LIG_SH3_3	154	160	PF00018	0.512
LIG_SH3_3	200	206	PF00018	0.609
LIG_SH3_3	284	290	PF00018	0.546
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.441
LIG_SUMO_SIM_par_1	130	136	PF11976	0.465
LIG_TYR_ITIM	107	112	PF00017	0.490
LIG_WRC_WIRS_1	159	164	PF05994	0.431
MOD_CK1_1	216	222	PF00069	0.683
MOD_CK1_1	28	34	PF00069	0.438
MOD_CK2_1	110	116	PF00069	0.417
MOD_CK2_1	216	222	PF00069	0.550
MOD_CK2_1	82	88	PF00069	0.422
MOD_GlcNHglycan	168	171	PF01048	0.516
MOD_GlcNHglycan	174	177	PF01048	0.450
MOD_GlcNHglycan	231	235	PF01048	0.536
MOD_GlcNHglycan	237	240	PF01048	0.482
MOD_GlcNHglycan	282	285	PF01048	0.632
MOD_GlcNHglycan	69	72	PF01048	0.596
MOD_GSK3_1	22	29	PF00069	0.373
MOD_GSK3_1	270	277	PF00069	0.561
MOD_N-GLC_1	110	115	PF02516	0.449
MOD_NEK2_1	101	106	PF00069	0.445
MOD_NEK2_1	26	31	PF00069	0.407
MOD_NEK2_1	304	309	PF00069	0.437
MOD_PKA_2	153	159	PF00069	0.476
MOD_PKA_2	166	172	PF00069	0.441
MOD_PKA_2	67	73	PF00069	0.437
MOD_Plk_1	110	116	PF00069	0.424
MOD_Plk_1	38	44	PF00069	0.401
MOD_Plk_4	251	257	PF00069	0.522
MOD_ProDKin_1	297	303	PF00069	0.480
TRG_AP2beta_CARGO_1	58	68	PF09066	0.416
TRG_DiLeu_BaEn_2	37	43	PF01217	0.405
TRG_DiLeu_BaEn_4	38	44	PF01217	0.377
TRG_DiLeu_BaLyEn_6	160	165	PF01217	0.465
TRG_ENDOCYTIC_2	109	112	PF00928	0.498
TRG_ER_diArg_1	166	168	PF00400	0.466
TRG_ER_diArg_1	188	190	PF00400	0.497
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	178	183	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q5	Leptomonas seymouri	41%	76%
A0A3Q8I8Y2	Leishmania donovani	90%	100%
A4H7V8	Leishmania braziliensis	70%	76%
A4HW84	Leishmania infantum	91%	100%
E9APY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%