GOLD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

emp24/gp25L/p24 family/GOLD, putative

Species:

Leishmania major

UniProt:

Q4QFJ5_LEIMA

TriTrypDb:

LmjF.14.1390 , LMJLV39_140021700 , LMJSD75_140021400

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 1
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	12
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	2
GO:0030135	coated vesicle	7	2
GO:0031410	cytoplasmic vesicle	6	2
GO:0031982	vesicle	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097708	intracellular vesicle	5	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QFJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFJ5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	2
GO:0006996	organelle organization	4	2
GO:0007030	Golgi organization	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0016192	vesicle-mediated transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.315
CLV_NRD_NRD_1	140	142	PF00675	0.546
CLV_NRD_NRD_1	206	208	PF00675	0.396
CLV_PCSK_KEX2_1	131	133	PF00082	0.498
CLV_PCSK_KEX2_1	206	208	PF00082	0.400
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.498
CLV_PCSK_SKI1_1	119	123	PF00082	0.489
CLV_PCSK_SKI1_1	142	146	PF00082	0.462
CLV_PCSK_SKI1_1	174	178	PF00082	0.460
CLV_PCSK_SKI1_1	212	216	PF00082	0.443
DOC_MAPK_gen_1	119	127	PF00069	0.275
DOC_MAPK_MEF2A_6	119	127	PF00069	0.260
DOC_MAPK_MEF2A_6	174	183	PF00069	0.315
DOC_PP1_RVXF_1	92	98	PF00149	0.246
LIG_14-3-3_CanoR_1	206	211	PF00244	0.633
LIG_APCC_ABBA_1	152	157	PF00400	0.257
LIG_deltaCOP1_diTrp_1	170	176	PF00928	0.346
LIG_FHA_1	178	184	PF00498	0.262
LIG_FHA_1	33	39	PF00498	0.294
LIG_FHA_2	143	149	PF00498	0.315
LIG_HCF-1_HBM_1	104	107	PF13415	0.346
LIG_LIR_Gen_1	173	184	PF02991	0.346
LIG_LIR_Gen_1	57	66	PF02991	0.329
LIG_LIR_Gen_1	68	76	PF02991	0.354
LIG_LIR_Nem_3	173	179	PF02991	0.344
LIG_LIR_Nem_3	51	56	PF02991	0.313
LIG_LIR_Nem_3	66	72	PF02991	0.206
LIG_NRP_CendR_1	220	221	PF00754	0.485
LIG_PTB_Apo_2	108	115	PF02174	0.257
LIG_PTB_Phospho_1	108	114	PF10480	0.257
LIG_SH2_STAP1	82	86	PF00017	0.346
LIG_SH2_STAT5	107	110	PF00017	0.290
LIG_SH2_STAT5	203	206	PF00017	0.518
LIG_SH2_STAT5	9	12	PF00017	0.477
LIG_SH2_STAT5	96	99	PF00017	0.262
LIG_SUMO_SIM_par_1	197	202	PF11976	0.302
LIG_UBA3_1	159	164	PF00899	0.346
MOD_GlcNHglycan	113	117	PF01048	0.473
MOD_NEK2_1	199	204	PF00069	0.359
MOD_NEK2_1	214	219	PF00069	0.645
MOD_NEK2_2	126	131	PF00069	0.290
MOD_PKA_1	206	212	PF00069	0.671
MOD_PKA_2	206	212	PF00069	0.639
MOD_SUMO_for_1	121	124	PF00179	0.340
MOD_SUMO_rev_2	113	121	PF00179	0.315
TRG_ENDOCYTIC_2	53	56	PF00928	0.278
TRG_ENDOCYTIC_2	60	63	PF00928	0.236
TRG_ER_diArg_1	205	207	PF00400	0.554
TRG_NES_CRM1_1	173	186	PF08389	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ0	Leptomonas seymouri	81%	100%
A0A0S4JYK0	Bodo saltans	26%	100%
A0A1X0NPX7	Trypanosomatidae	49%	100%
A0A3Q8IC43	Leishmania donovani	96%	100%
A0A422NFM3	Trypanosoma rangeli	49%	98%
A4H7V9	Leishmania braziliensis	91%	100%
A4HW85	Leishmania infantum	96%	100%
C9ZST1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
E9APY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BKG3	Trypanosoma cruzi	49%	98%