LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
Serine/threonine-protein kinase NEK11, putative
Species:
Leishmania major
UniProt:
Q4QFJ2_LEIMA
TriTrypDb:
LmjF.14.1410 , LMJLV39_140022000 * , LMJSD75_140021700 *
Length:
555

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 20
NetGPI no yes: 0, no: 20
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

Q4QFJ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFJ2

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 21
GO:0006793 phosphorus metabolic process 3 21
GO:0006796 phosphate-containing compound metabolic process 4 21
GO:0006807 nitrogen compound metabolic process 2 21
GO:0008152 metabolic process 1 21
GO:0009987 cellular process 1 21
GO:0016310 phosphorylation 5 21
GO:0019538 protein metabolic process 3 21
GO:0036211 protein modification process 4 21
GO:0043170 macromolecule metabolic process 3 21
GO:0043412 macromolecule modification 4 21
GO:0044237 cellular metabolic process 2 21
GO:0044238 primary metabolic process 2 21
GO:0071704 organic substance metabolic process 2 21
GO:1901564 organonitrogen compound metabolic process 3 21
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 21
GO:0003824 catalytic activity 1 21
GO:0004672 protein kinase activity 3 21
GO:0005488 binding 1 21
GO:0005524 ATP binding 5 21
GO:0016301 kinase activity 4 21
GO:0016740 transferase activity 2 21
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 21
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 21
GO:0017076 purine nucleotide binding 4 21
GO:0030554 adenyl nucleotide binding 5 21
GO:0032553 ribonucleotide binding 3 21
GO:0032555 purine ribonucleotide binding 4 21
GO:0032559 adenyl ribonucleotide binding 5 21
GO:0035639 purine ribonucleoside triphosphate binding 4 21
GO:0036094 small molecule binding 2 21
GO:0043167 ion binding 2 21
GO:0043168 anion binding 3 21
GO:0097159 organic cyclic compound binding 2 21
GO:0097367 carbohydrate derivative binding 2 21
GO:0140096 catalytic activity, acting on a protein 2 21
GO:1901265 nucleoside phosphate binding 3 21
GO:1901363 heterocyclic compound binding 2 21
GO:0004674 protein serine/threonine kinase activity 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 370 374 PF00656 0.588
CLV_NRD_NRD_1 123 125 PF00675 0.229
CLV_NRD_NRD_1 333 335 PF00675 0.502
CLV_NRD_NRD_1 494 496 PF00675 0.527
CLV_NRD_NRD_1 502 504 PF00675 0.563
CLV_NRD_NRD_1 72 74 PF00675 0.240
CLV_PCSK_KEX2_1 502 504 PF00082 0.581
CLV_PCSK_SKI1_1 124 128 PF00082 0.312
CLV_PCSK_SKI1_1 129 133 PF00082 0.318
CLV_PCSK_SKI1_1 208 212 PF00082 0.358
CLV_PCSK_SKI1_1 542 546 PF00082 0.441
DEG_APCC_DBOX_1 247 255 PF00400 0.350
DEG_Nend_UBRbox_2 1 3 PF02207 0.388
DEG_SPOP_SBC_1 362 366 PF00917 0.534
DOC_CDC14_PxL_1 385 393 PF14671 0.512
DOC_CKS1_1 166 171 PF01111 0.280
DOC_CKS1_1 398 403 PF01111 0.510
DOC_CKS1_1 427 432 PF01111 0.514
DOC_CYCLIN_yCln2_LP_2 178 184 PF00134 0.229
DOC_CYCLIN_yCln2_LP_2 201 207 PF00134 0.229
DOC_CYCLIN_yCln2_LP_2 345 351 PF00134 0.486
DOC_CYCLIN_yCln2_LP_2 531 534 PF00134 0.503
DOC_MAPK_DCC_7 383 393 PF00069 0.527
DOC_MAPK_gen_1 129 138 PF00069 0.448
DOC_MAPK_gen_1 248 257 PF00069 0.297
DOC_MAPK_gen_1 73 80 PF00069 0.248
DOC_MAPK_gen_1 93 102 PF00069 0.280
DOC_MAPK_MEF2A_6 250 259 PF00069 0.285
DOC_MAPK_MEF2A_6 73 82 PF00069 0.306
DOC_MAPK_RevD_3 112 125 PF00069 0.229
DOC_PP2B_LxvP_1 255 258 PF13499 0.237
DOC_PP2B_LxvP_1 531 534 PF13499 0.503
DOC_PP2B_LxvP_1 535 538 PF13499 0.455
DOC_PP4_FxxP_1 349 352 PF00568 0.567
DOC_PP4_FxxP_1 423 426 PF00568 0.535
DOC_PP4_FxxP_1 427 430 PF00568 0.519
DOC_PP4_FxxP_1 518 521 PF00568 0.500
DOC_USP7_MATH_1 297 301 PF00917 0.548
DOC_USP7_MATH_1 527 531 PF00917 0.478
DOC_USP7_MATH_1 72 76 PF00917 0.238
DOC_USP7_UBL2_3 8 12 PF12436 0.229
DOC_WW_Pin1_4 165 170 PF00397 0.311
DOC_WW_Pin1_4 392 397 PF00397 0.500
DOC_WW_Pin1_4 415 420 PF00397 0.549
DOC_WW_Pin1_4 422 427 PF00397 0.518
DOC_WW_Pin1_4 449 454 PF00397 0.542
DOC_WW_Pin1_4 480 485 PF00397 0.488
LIG_14-3-3_CanoR_1 340 346 PF00244 0.494
LIG_14-3-3_CanoR_1 415 419 PF00244 0.550
LIG_14-3-3_CanoR_1 424 430 PF00244 0.490
LIG_14-3-3_CanoR_1 45 50 PF00244 0.248
LIG_14-3-3_CanoR_1 502 512 PF00244 0.521
LIG_14-3-3_CanoR_1 53 59 PF00244 0.205
LIG_14-3-3_CanoR_1 73 81 PF00244 0.167
LIG_Actin_RPEL_3 236 255 PF02755 0.215
LIG_APCC_ABBA_1 218 223 PF00400 0.215
LIG_APCC_ABBAyCdc20_2 124 130 PF00400 0.280
LIG_BRCT_BRCA1_1 419 423 PF00533 0.529
LIG_eIF4E_1 171 177 PF01652 0.229
LIG_EVH1_1 535 539 PF00568 0.441
LIG_FHA_1 131 137 PF00498 0.282
LIG_FHA_1 15 21 PF00498 0.273
LIG_FHA_1 398 404 PF00498 0.509
LIG_FHA_1 427 433 PF00498 0.521
LIG_FHA_2 316 322 PF00498 0.491
LIG_FHA_2 325 331 PF00498 0.514
LIG_LIR_Apic_2 168 174 PF02991 0.323
LIG_LIR_Apic_2 420 426 PF02991 0.539
LIG_LIR_Apic_2 469 475 PF02991 0.525
LIG_LIR_Apic_2 510 516 PF02991 0.534
LIG_LIR_Gen_1 2 10 PF02991 0.336
LIG_LIR_Nem_3 2 7 PF02991 0.342
LIG_LIR_Nem_3 26 32 PF02991 0.224
LIG_MAD2 216 224 PF02301 0.220
LIG_MAD2 53 61 PF02301 0.229
LIG_MYND_1 380 384 PF01753 0.521
LIG_MYND_1 480 484 PF01753 0.485
LIG_MYND_1 512 516 PF01753 0.526
LIG_MYND_1 533 537 PF01753 0.468
LIG_NRP_CendR_1 552 555 PF00754 0.480
LIG_Pex14_2 423 427 PF04695 0.513
LIG_PTB_Apo_2 512 519 PF02174 0.561
LIG_SH2_CRK 222 226 PF00017 0.220
LIG_SH2_CRK 385 389 PF00017 0.534
LIG_SH2_CRK 4 8 PF00017 0.237
LIG_SH2_CRK 472 476 PF00017 0.544
LIG_SH2_CRK 528 532 PF00017 0.553
LIG_SH2_GRB2like 385 388 PF00017 0.533
LIG_SH2_GRB2like 513 516 PF00017 0.531
LIG_SH2_NCK_1 159 163 PF00017 0.231
LIG_SH2_NCK_1 472 476 PF00017 0.534
LIG_SH2_SRC 513 516 PF00017 0.531
LIG_SH2_SRC 66 69 PF00017 0.229
LIG_SH2_SRC 84 87 PF00017 0.287
LIG_SH2_STAP1 229 233 PF00017 0.339
LIG_SH2_STAT3 120 123 PF00017 0.229
LIG_SH2_STAT3 399 402 PF00017 0.555
LIG_SH2_STAT3 476 479 PF00017 0.534
LIG_SH2_STAT5 120 123 PF00017 0.229
LIG_SH2_STAT5 171 174 PF00017 0.331
LIG_SH2_STAT5 278 281 PF00017 0.311
LIG_SH2_STAT5 30 33 PF00017 0.230
LIG_SH2_STAT5 399 402 PF00017 0.536
LIG_SH2_STAT5 4 7 PF00017 0.292
LIG_SH2_STAT5 476 479 PF00017 0.520
LIG_SH2_STAT5 488 491 PF00017 0.515
LIG_SH2_STAT5 513 516 PF00017 0.535
LIG_SH2_STAT5 66 69 PF00017 0.288
LIG_SH3_3 163 169 PF00018 0.335
LIG_SH3_3 239 245 PF00018 0.229
LIG_SH3_3 374 380 PF00018 0.540
LIG_SH3_3 398 404 PF00018 0.524
LIG_SH3_3 465 471 PF00018 0.515
LIG_SH3_3 474 480 PF00018 0.490
LIG_SH3_3 506 512 PF00018 0.512
LIG_SH3_3 530 536 PF00018 0.491
LIG_SH3_3 97 103 PF00018 0.265
LIG_SUMO_SIM_par_1 114 119 PF11976 0.229
LIG_TRAF2_1 312 315 PF00917 0.456
LIG_TRAF2_1 367 370 PF00917 0.547
LIG_TRFH_1 170 174 PF08558 0.287
LIG_TYR_ITIM 194 199 PF00017 0.282
LIG_TYR_ITIM 220 225 PF00017 0.276
LIG_UBA3_1 198 202 PF00899 0.215
LIG_WRC_WIRS_1 67 72 PF05994 0.270
LIG_WW_2 533 536 PF00397 0.459
MOD_CDC14_SPxK_1 418 421 PF00782 0.519
MOD_CDK_SPxK_1 415 421 PF00069 0.528
MOD_CK1_1 300 306 PF00069 0.580
MOD_CK1_1 320 326 PF00069 0.604
MOD_CK1_1 350 356 PF00069 0.565
MOD_CK1_1 417 423 PF00069 0.538
MOD_CK1_1 425 431 PF00069 0.582
MOD_CK1_1 449 455 PF00069 0.518
MOD_CK1_1 507 513 PF00069 0.535
MOD_CK2_1 315 321 PF00069 0.503
MOD_CK2_1 363 369 PF00069 0.514
MOD_CK2_1 45 51 PF00069 0.384
MOD_DYRK1A_RPxSP_1 415 419 PF00069 0.530
MOD_GlcNHglycan 229 232 PF01048 0.467
MOD_GlcNHglycan 302 305 PF01048 0.503
MOD_GlcNHglycan 323 326 PF01048 0.553
MOD_GlcNHglycan 365 368 PF01048 0.529
MOD_GlcNHglycan 434 437 PF01048 0.751
MOD_GlcNHglycan 509 512 PF01048 0.520
MOD_GlcNHglycan 86 89 PF01048 0.229
MOD_GSK3_1 151 158 PF00069 0.263
MOD_GSK3_1 161 168 PF00069 0.377
MOD_GSK3_1 293 300 PF00069 0.564
MOD_GSK3_1 316 323 PF00069 0.549
MOD_GSK3_1 347 354 PF00069 0.556
MOD_GSK3_1 422 429 PF00069 0.555
MOD_GSK3_1 503 510 PF00069 0.525
MOD_LATS_1 407 413 PF00433 0.538
MOD_N-GLC_2 77 79 PF02516 0.229
MOD_PIKK_1 130 136 PF00454 0.229
MOD_PIKK_1 446 452 PF00454 0.511
MOD_PKA_1 334 340 PF00069 0.488
MOD_PKA_2 316 322 PF00069 0.518
MOD_PKA_2 375 381 PF00069 0.567
MOD_PKA_2 38 44 PF00069 0.229
MOD_PKA_2 414 420 PF00069 0.507
MOD_PKA_2 507 513 PF00069 0.520
MOD_PKA_2 72 78 PF00069 0.233
MOD_Plk_1 293 299 PF00069 0.472
MOD_Plk_1 35 41 PF00069 0.230
MOD_Plk_4 161 167 PF00069 0.291
MOD_Plk_4 224 230 PF00069 0.273
MOD_Plk_4 66 72 PF00069 0.229
MOD_ProDKin_1 165 171 PF00069 0.311
MOD_ProDKin_1 392 398 PF00069 0.501
MOD_ProDKin_1 415 421 PF00069 0.549
MOD_ProDKin_1 422 428 PF00069 0.517
MOD_ProDKin_1 449 455 PF00069 0.535
MOD_ProDKin_1 480 486 PF00069 0.487
TRG_ENDOCYTIC_2 196 199 PF00928 0.308
TRG_ENDOCYTIC_2 222 225 PF00928 0.250
TRG_ENDOCYTIC_2 29 32 PF00928 0.229
TRG_ENDOCYTIC_2 385 388 PF00928 0.533
TRG_ENDOCYTIC_2 4 7 PF00928 0.272
TRG_ENDOCYTIC_2 528 531 PF00928 0.559
TRG_ER_diArg_1 552 555 PF00400 0.493
TRG_NES_CRM1_1 209 223 PF08389 0.229
TRG_NES_CRM1_1 232 244 PF08389 0.222
TRG_Pf-PMV_PEXEL_1 239 244 PF00026 0.311

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9A0 Leptomonas seymouri 28% 85%
A0A0S4JIJ6 Bodo saltans 29% 98%
A0A3Q8IC87 Leishmania donovani 30% 100%
A0A3Q8IFK8 Leishmania donovani 38% 100%
A0A3Q8IIH5 Leishmania donovani 92% 100%
A0A3Q8INQ4 Leishmania donovani 29% 100%
A0A3S5H789 Leishmania donovani 23% 100%
A0A3S7X2W3 Leishmania donovani 28% 100%
A0A3S7X5M4 Leishmania donovani 27% 85%
A0A3S7X7Y2 Leishmania donovani 28% 100%
A4H7W1 Leishmania braziliensis 77% 100%
A4HAS1 Leishmania braziliensis 29% 100%
A4HED7 Leishmania braziliensis 28% 100%
A4HH03 Leishmania braziliensis 31% 100%
A4HHN1 Leishmania braziliensis 27% 100%
A4HJT5 Leishmania braziliensis 37% 100%
A4HKG9 Leishmania braziliensis 27% 85%
A4HW88 Leishmania infantum 92% 100%
A4HYX6 Leishmania infantum 23% 100%
A4HZV1 Leishmania infantum 30% 100%
A4I1T4 Leishmania infantum 29% 100%
A4I4U6 Leishmania infantum 28% 100%
A4I7A1 Leishmania infantum 38% 100%
A4I7Z6 Leishmania infantum 27% 85%
A4I9Y5 Leishmania infantum 28% 100%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9APY9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
O08678 Rattus norvegicus 27% 70%
O08679 Rattus norvegicus 29% 77%
Q05512 Mus musculus 29% 72%
Q4Q2Z2 Leishmania major 28% 100%
Q4Q3K6 Leishmania major 25% 100%
Q4Q598 Leishmania major 27% 85%
Q4Q5W2 Leishmania major 38% 100%
Q4Q7W2 Leishmania major 30% 100%
Q4Q9K2 Leishmania major 29% 100%
Q4QBR6 Leishmania major 30% 100%
Q4QCR3 Leishmania major 23% 100%
Q9P0L2 Homo sapiens 27% 70%
Q9Y077 Leishmania major 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS