LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
Serine/threonine-protein kinase NEK11, putative
Species:
Leishmania major
UniProt:
Q4QFJ2_LEIMA
TriTrypDb:
LmjF.14.1410 , LMJLV39_140022000 * , LMJSD75_140021700 *
Length:
555

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 20
NetGPI no yes: 0, no: 20
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

Q4QFJ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFJ2

Function

Biological processes
TermNameLevelCount
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0006468 protein phosphorylation 5 21
GO:0006793 phosphorus metabolic process 3 21
GO:0006796 phosphate-containing compound metabolic process 4 21
GO:0006807 nitrogen compound metabolic process 2 21
GO:0007165 signal transduction 2 1
GO:0008152 metabolic process 1 21
GO:0009987 cellular process 1 21
GO:0016310 phosphorylation 5 21
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 21
GO:0003824 catalytic activity 1 21
GO:0004672 protein kinase activity 3 21
GO:0004674 protein serine/threonine kinase activity 4 12
GO:0005488 binding 1 21
GO:0005524 ATP binding 5 21
GO:0016301 kinase activity 4 21
GO:0016740 transferase activity 2 21
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 21
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 21
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 370 374 PF00656 0.588
CLV_NRD_NRD_1 123 125 PF00675 0.229
CLV_NRD_NRD_1 333 335 PF00675 0.502
CLV_NRD_NRD_1 494 496 PF00675 0.527
CLV_NRD_NRD_1 502 504 PF00675 0.563
CLV_NRD_NRD_1 72 74 PF00675 0.240
CLV_PCSK_KEX2_1 502 504 PF00082 0.581
CLV_PCSK_SKI1_1 124 128 PF00082 0.312
CLV_PCSK_SKI1_1 129 133 PF00082 0.318
CLV_PCSK_SKI1_1 208 212 PF00082 0.358
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I9A0 Leptomonas seymouri 28% 85%
A0A0S4JIJ6 Bodo saltans 29% 98%
A0A3Q8IC87 Leishmania donovani 30% 100%
A0A3Q8IFK8 Leishmania donovani 38% 100%
A0A3Q8IIH5 Leishmania donovani 92% 100%
A0A3Q8INQ4 Leishmania donovani 29% 100%
A0A3S5H789 Leishmania donovani 23% 100%
A0A3S7X2W3 Leishmania donovani 28% 100%
A0A3S7X5M4 Leishmania donovani 27% 85%
A0A3S7X7Y2 Leishmania donovani 28% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS