HEAT repeat-containing protein 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFJ1_LEIMA

TriTrypDb:

LmjF.14.1420 , LMJLV39_140022100 , LMJSD75_140021800

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.596
CLV_NRD_NRD_1	118	120	PF00675	0.425
CLV_NRD_NRD_1	304	306	PF00675	0.482
CLV_NRD_NRD_1	348	350	PF00675	0.539
CLV_NRD_NRD_1	427	429	PF00675	0.500
CLV_NRD_NRD_1	473	475	PF00675	0.516
CLV_NRD_NRD_1	564	566	PF00675	0.531
CLV_NRD_NRD_1	60	62	PF00675	0.544
CLV_NRD_NRD_1	665	667	PF00675	0.523
CLV_PCSK_FUR_1	58	62	PF00082	0.654
CLV_PCSK_KEX2_1	304	306	PF00082	0.482
CLV_PCSK_KEX2_1	348	350	PF00082	0.539
CLV_PCSK_KEX2_1	427	429	PF00082	0.453
CLV_PCSK_KEX2_1	473	475	PF00082	0.516
CLV_PCSK_KEX2_1	58	60	PF00082	0.564
CLV_PCSK_KEX2_1	665	667	PF00082	0.477
CLV_PCSK_SKI1_1	181	185	PF00082	0.445
CLV_PCSK_SKI1_1	325	329	PF00082	0.524
CLV_PCSK_SKI1_1	451	455	PF00082	0.557
CLV_PCSK_SKI1_1	484	488	PF00082	0.465
CLV_PCSK_SKI1_1	635	639	PF00082	0.353
CLV_PCSK_SKI1_1	665	669	PF00082	0.483
CLV_PCSK_SKI1_1	83	87	PF00082	0.495
CLV_Separin_Metazoa	20	24	PF03568	0.579
DEG_APCC_DBOX_1	386	394	PF00400	0.518
DEG_Nend_UBRbox_2	1	3	PF02207	0.618
DEG_ODPH_VHL_1	334	345	PF01847	0.471
DEG_SIAH_1	510	518	PF03145	0.467
DOC_CDC14_PxL_1	121	129	PF14671	0.518
DOC_CDC14_PxL_1	406	414	PF14671	0.540
DOC_CKS1_1	365	370	PF01111	0.379
DOC_CYCLIN_RxL_1	387	399	PF00134	0.491
DOC_MAPK_DCC_7	650	659	PF00069	0.541
DOC_MAPK_gen_1	178	186	PF00069	0.516
DOC_MAPK_gen_1	348	357	PF00069	0.514
DOC_MAPK_gen_1	565	572	PF00069	0.496
DOC_MAPK_MEF2A_6	178	186	PF00069	0.514
DOC_MAPK_MEF2A_6	23	31	PF00069	0.661
DOC_MAPK_MEF2A_6	239	248	PF00069	0.504
DOC_MAPK_MEF2A_6	325	334	PF00069	0.519
DOC_MAPK_MEF2A_6	350	359	PF00069	0.427
DOC_PP2B_LxvP_1	212	215	PF13499	0.572
DOC_PP2B_LxvP_1	386	389	PF13499	0.373
DOC_PP2B_LxvP_1	502	505	PF13499	0.531
DOC_PP4_FxxP_1	36	39	PF00568	0.619
DOC_PP4_FxxP_1	582	585	PF00568	0.510
DOC_SPAK_OSR1_1	114	118	PF12202	0.518
DOC_USP7_MATH_1	171	175	PF00917	0.556
DOC_USP7_MATH_1	208	212	PF00917	0.574
DOC_USP7_MATH_1	22	26	PF00917	0.617
DOC_USP7_MATH_1	231	235	PF00917	0.539
DOC_USP7_MATH_1	416	420	PF00917	0.623
DOC_USP7_MATH_1	47	51	PF00917	0.617
DOC_USP7_MATH_1	511	515	PF00917	0.693
DOC_USP7_MATH_1	529	533	PF00917	0.469
DOC_USP7_MATH_2	416	422	PF00917	0.585
DOC_WW_Pin1_4	364	369	PF00397	0.390
DOC_WW_Pin1_4	412	417	PF00397	0.574
DOC_WW_Pin1_4	507	512	PF00397	0.654
LIG_14-3-3_CanoR_1	105	112	PF00244	0.540
LIG_14-3-3_CanoR_1	132	137	PF00244	0.471
LIG_14-3-3_CanoR_1	181	187	PF00244	0.429
LIG_14-3-3_CanoR_1	23	31	PF00244	0.620
LIG_14-3-3_CanoR_1	239	246	PF00244	0.509
LIG_14-3-3_CanoR_1	308	317	PF00244	0.497
LIG_14-3-3_CanoR_1	32	37	PF00244	0.549
LIG_14-3-3_CanoR_1	46	52	PF00244	0.671
LIG_14-3-3_CanoR_1	466	475	PF00244	0.352
LIG_14-3-3_CanoR_1	590	596	PF00244	0.447
LIG_14-3-3_CanoR_1	83	91	PF00244	0.599
LIG_14-3-3_CanoR_1	94	100	PF00244	0.506
LIG_Clathr_ClatBox_1	572	576	PF01394	0.402
LIG_Clathr_ClatBox_1	657	661	PF01394	0.428
LIG_eIF4E_1	353	359	PF01652	0.493
LIG_FHA_1	12	18	PF00498	0.686
LIG_FHA_1	155	161	PF00498	0.517
LIG_FHA_1	235	241	PF00498	0.530
LIG_FHA_1	312	318	PF00498	0.533
LIG_FHA_1	365	371	PF00498	0.372
LIG_FHA_1	424	430	PF00498	0.497
LIG_FHA_1	519	525	PF00498	0.534
LIG_FHA_1	627	633	PF00498	0.509
LIG_FHA_1	642	648	PF00498	0.322
LIG_FHA_2	105	111	PF00498	0.556
LIG_FHA_2	615	621	PF00498	0.498
LIG_FHA_2	650	656	PF00498	0.476
LIG_LIR_Apic_2	35	39	PF02991	0.682
LIG_LIR_Apic_2	580	585	PF02991	0.482
LIG_LIR_Gen_1	219	230	PF02991	0.507
LIG_LIR_Gen_1	531	542	PF02991	0.486
LIG_LIR_Gen_1	553	563	PF02991	0.409
LIG_LIR_Gen_1	598	609	PF02991	0.446
LIG_LIR_Gen_1	98	103	PF02991	0.531
LIG_LIR_LC3C_4	241	246	PF02991	0.475
LIG_LIR_Nem_3	198	203	PF02991	0.396
LIG_LIR_Nem_3	219	225	PF02991	0.415
LIG_LIR_Nem_3	30	36	PF02991	0.560
LIG_LIR_Nem_3	53	57	PF02991	0.648
LIG_LIR_Nem_3	531	537	PF02991	0.503
LIG_LIR_Nem_3	598	604	PF02991	0.457
LIG_LIR_Nem_3	98	102	PF02991	0.523
LIG_LYPXL_yS_3	409	412	PF13949	0.531
LIG_NRBOX	289	295	PF00104	0.466
LIG_NRBOX	369	375	PF00104	0.494
LIG_Pex14_2	222	226	PF04695	0.420
LIG_SH2_CRK	413	417	PF00017	0.597
LIG_SH2_CRK	534	538	PF00017	0.344
LIG_SH2_STAP1	326	330	PF00017	0.461
LIG_SH2_STAT5	16	19	PF00017	0.734
LIG_SH2_STAT5	534	537	PF00017	0.426
LIG_SH2_STAT5	55	58	PF00017	0.684
LIG_SH3_1	170	176	PF00018	0.525
LIG_SH3_2	173	178	PF14604	0.530
LIG_SH3_3	170	176	PF00018	0.525
LIG_SH3_3	502	508	PF00018	0.595
LIG_SH3_3	74	80	PF00018	0.527
LIG_SUMO_SIM_anti_2	133	138	PF11976	0.516
LIG_SUMO_SIM_anti_2	369	375	PF11976	0.494
LIG_SUMO_SIM_anti_2	600	606	PF11976	0.497
LIG_SUMO_SIM_anti_2	655	661	PF11976	0.516
LIG_SUMO_SIM_par_1	144	152	PF11976	0.479
LIG_SUMO_SIM_par_1	340	347	PF11976	0.473
LIG_SUMO_SIM_par_1	375	381	PF11976	0.462
LIG_SUMO_SIM_par_1	655	661	PF11976	0.403
LIG_TRAF2_1	437	440	PF00917	0.495
LIG_UBA3_1	165	170	PF00899	0.422
LIG_UBA3_1	449	457	PF00899	0.398
LIG_WRC_WIRS_1	33	38	PF05994	0.677
LIG_WW_3	20	24	PF00397	0.579
MOD_CK1_1	189	195	PF00069	0.488
MOD_CK1_1	234	240	PF00069	0.553
MOD_CK1_1	272	278	PF00069	0.591
MOD_CK1_1	311	317	PF00069	0.545
MOD_CK1_1	366	372	PF00069	0.364
MOD_CK1_1	506	512	PF00069	0.651
MOD_CK2_1	104	110	PF00069	0.554
MOD_CK2_1	412	418	PF00069	0.583
MOD_CK2_1	438	444	PF00069	0.455
MOD_CK2_1	614	620	PF00069	0.512
MOD_CK2_1	639	645	PF00069	0.470
MOD_CK2_1	649	655	PF00069	0.428
MOD_DYRK1A_RPxSP_1	507	511	PF00069	0.585
MOD_GlcNHglycan	233	236	PF01048	0.538
MOD_GlcNHglycan	24	27	PF01048	0.588
MOD_GlcNHglycan	259	262	PF01048	0.436
MOD_GlcNHglycan	271	274	PF01048	0.413
MOD_GlcNHglycan	310	313	PF01048	0.530
MOD_GlcNHglycan	468	471	PF01048	0.427
MOD_GSK3_1	182	189	PF00069	0.464
MOD_GSK3_1	191	198	PF00069	0.428
MOD_GSK3_1	234	241	PF00069	0.529
MOD_GSK3_1	253	260	PF00069	0.300
MOD_GSK3_1	311	318	PF00069	0.515
MOD_GSK3_1	412	419	PF00069	0.551
MOD_GSK3_1	503	510	PF00069	0.541
MOD_GSK3_1	529	536	PF00069	0.480
MOD_N-GLC_1	130	135	PF02516	0.533
MOD_N-GLC_1	396	401	PF02516	0.399
MOD_N-GLC_1	518	523	PF02516	0.351
MOD_NEK2_1	154	159	PF00069	0.535
MOD_NEK2_1	186	191	PF00069	0.470
MOD_NEK2_1	240	245	PF00069	0.420
MOD_NEK2_1	252	257	PF00069	0.330
MOD_NEK2_1	358	363	PF00069	0.429
MOD_NEK2_1	396	401	PF00069	0.313
MOD_NEK2_1	559	564	PF00069	0.494
MOD_NEK2_1	591	596	PF00069	0.425
MOD_NEK2_1	607	612	PF00069	0.255
MOD_NEK2_1	626	631	PF00069	0.518
MOD_NEK2_1	85	90	PF00069	0.553
MOD_NEK2_2	47	52	PF00069	0.681
MOD_NEK2_2	529	534	PF00069	0.558
MOD_PIKK_1	189	195	PF00454	0.555
MOD_PIKK_1	378	384	PF00454	0.506
MOD_PIKK_1	416	422	PF00454	0.626
MOD_PIKK_1	626	632	PF00454	0.435
MOD_PK_1	132	138	PF00069	0.519
MOD_PKA_2	104	110	PF00069	0.568
MOD_PKA_2	22	28	PF00069	0.657
MOD_PKA_2	238	244	PF00069	0.527
MOD_PKA_2	506	512	PF00069	0.671
MOD_PKB_1	59	67	PF00069	0.632
MOD_Plk_1	11	17	PF00069	0.678
MOD_Plk_1	130	136	PF00069	0.518
MOD_Plk_1	518	524	PF00069	0.344
MOD_Plk_1	597	603	PF00069	0.520
MOD_Plk_1	62	68	PF00069	0.422
MOD_Plk_4	132	138	PF00069	0.519
MOD_Plk_4	161	167	PF00069	0.400
MOD_Plk_4	195	201	PF00069	0.412
MOD_Plk_4	240	246	PF00069	0.408
MOD_Plk_4	366	372	PF00069	0.434
MOD_Plk_4	458	464	PF00069	0.545
MOD_Plk_4	529	535	PF00069	0.439
MOD_Plk_4	597	603	PF00069	0.523
MOD_Plk_4	73	79	PF00069	0.656
MOD_ProDKin_1	364	370	PF00069	0.388
MOD_ProDKin_1	412	418	PF00069	0.579
MOD_ProDKin_1	507	513	PF00069	0.657
TRG_DiLeu_BaEn_1	523	528	PF01217	0.524
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.495
TRG_DiLeu_BaLyEn_6	653	658	PF01217	0.467
TRG_DiLeu_BaLyEn_6	663	668	PF01217	0.336
TRG_DiLeu_LyEn_5	523	528	PF01217	0.508
TRG_ENDOCYTIC_2	33	36	PF00928	0.652
TRG_ENDOCYTIC_2	352	355	PF00928	0.369
TRG_ENDOCYTIC_2	409	412	PF00928	0.462
TRG_ENDOCYTIC_2	534	537	PF00928	0.349
TRG_ENDOCYTIC_2	99	102	PF00928	0.531
TRG_ER_diArg_1	427	429	PF00400	0.418
TRG_ER_diArg_1	472	474	PF00400	0.513
TRG_ER_diArg_1	57	60	PF00400	0.575
TRG_ER_diArg_1	664	666	PF00400	0.469
TRG_NLS_MonoCore_2	304	309	PF00514	0.468
TRG_NLS_MonoExtN_4	304	309	PF00514	0.468
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	665	670	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAI6	Leptomonas seymouri	63%	100%
A0A1X0NND4	Trypanosomatidae	32%	85%
A0A3R7NL73	Trypanosoma rangeli	31%	95%
A0A3S7WT73	Leishmania donovani	94%	100%
A4H7W2	Leishmania braziliensis	86%	100%
A4HW89	Leishmania infantum	93%	100%
C9ZSS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9APZ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5AW01	Trypanosoma cruzi	32%	95%