C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytoskeleton associated protein, putative

Species:

Leishmania major

UniProt:

Q4QFI9_LEIMA

TriTrypDb:

LmjF.14.1440 , LMJLV39_140022300 , LMJSD75_140022000

Length:

930

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	2
GO:0030863	cortical cytoskeleton	6	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.557
CLV_NRD_NRD_1	325	327	PF00675	0.545
CLV_NRD_NRD_1	39	41	PF00675	0.616
CLV_NRD_NRD_1	422	424	PF00675	0.403
CLV_NRD_NRD_1	538	540	PF00675	0.635
CLV_NRD_NRD_1	60	62	PF00675	0.724
CLV_NRD_NRD_1	65	67	PF00675	0.715
CLV_NRD_NRD_1	851	853	PF00675	0.724
CLV_NRD_NRD_1	91	93	PF00675	0.691
CLV_NRD_NRD_1	912	914	PF00675	0.704
CLV_NRD_NRD_1	918	920	PF00675	0.715
CLV_PCSK_FUR_1	848	852	PF00082	0.741
CLV_PCSK_KEX2_1	19	21	PF00082	0.640
CLV_PCSK_KEX2_1	38	40	PF00082	0.579
CLV_PCSK_KEX2_1	422	424	PF00082	0.403
CLV_PCSK_KEX2_1	525	527	PF00082	0.570
CLV_PCSK_KEX2_1	540	542	PF00082	0.555
CLV_PCSK_KEX2_1	60	62	PF00082	0.711
CLV_PCSK_KEX2_1	65	67	PF00082	0.727
CLV_PCSK_KEX2_1	850	852	PF00082	0.738
CLV_PCSK_KEX2_1	861	863	PF00082	0.635
CLV_PCSK_KEX2_1	91	93	PF00082	0.691
CLV_PCSK_KEX2_1	912	914	PF00082	0.704
CLV_PCSK_KEX2_1	918	920	PF00082	0.715
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.482
CLV_PCSK_PC1ET2_1	525	527	PF00082	0.570
CLV_PCSK_PC1ET2_1	540	542	PF00082	0.555
CLV_PCSK_PC1ET2_1	861	863	PF00082	0.607
CLV_PCSK_PC7_1	61	67	PF00082	0.712
CLV_PCSK_SKI1_1	31	35	PF00082	0.706
CLV_PCSK_SKI1_1	91	95	PF00082	0.601
DEG_APCC_DBOX_1	37	45	PF00400	0.562
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DOC_CYCLIN_yCln2_LP_2	527	533	PF00134	0.531
DOC_CYCLIN_yCln2_LP_2	702	708	PF00134	0.725
DOC_MAPK_DCC_7	94	104	PF00069	0.577
DOC_MAPK_FxFP_2	150	153	PF00069	0.429
DOC_MAPK_gen_1	135	144	PF00069	0.379
DOC_MAPK_gen_1	173	183	PF00069	0.336
DOC_MAPK_gen_1	326	333	PF00069	0.565
DOC_MAPK_gen_1	38	46	PF00069	0.612
DOC_MAPK_gen_1	525	533	PF00069	0.508
DOC_MAPK_gen_1	94	104	PF00069	0.527
DOC_MAPK_MEF2A_6	326	335	PF00069	0.565
DOC_MAPK_MEF2A_6	38	46	PF00069	0.612
DOC_MAPK_MEF2A_6	95	104	PF00069	0.555
DOC_MAPK_NFAT4_5	39	47	PF00069	0.620
DOC_PP2B_LxvP_1	245	248	PF13499	0.594
DOC_PP2B_LxvP_1	527	530	PF13499	0.633
DOC_PP4_FxxP_1	150	153	PF00568	0.429
DOC_USP7_MATH_1	12	16	PF00917	0.612
DOC_USP7_MATH_1	203	207	PF00917	0.519
DOC_USP7_MATH_1	296	300	PF00917	0.684
DOC_USP7_MATH_1	398	402	PF00917	0.617
DOC_USP7_MATH_1	53	57	PF00917	0.633
DOC_USP7_MATH_1	706	710	PF00917	0.700
DOC_USP7_MATH_1	734	738	PF00917	0.677
DOC_USP7_MATH_1	750	754	PF00917	0.608
DOC_USP7_MATH_1	917	921	PF00917	0.720
DOC_USP7_UBL2_3	887	891	PF12436	0.605
DOC_USP7_UBL2_3	94	98	PF12436	0.591
DOC_WW_Pin1_4	298	303	PF00397	0.699
DOC_WW_Pin1_4	590	595	PF00397	0.647
DOC_WW_Pin1_4	616	621	PF00397	0.741
DOC_WW_Pin1_4	753	758	PF00397	0.620
DOC_WW_Pin1_4	854	859	PF00397	0.661
DOC_WW_Pin1_4	913	918	PF00397	0.731
DOC_WW_Pin1_4	923	928	PF00397	0.670
LIG_14-3-3_CanoR_1	119	123	PF00244	0.429
LIG_14-3-3_CanoR_1	486	491	PF00244	0.379
LIG_14-3-3_CanoR_1	912	917	PF00244	0.718
LIG_14-3-3_CanoR_1	918	927	PF00244	0.709
LIG_Actin_WH2_2	215	231	PF00022	0.471
LIG_APCC_ABBA_1	44	49	PF00400	0.636
LIG_BIR_III_2	168	172	PF00653	0.429
LIG_BRCT_BRCA1_1	408	412	PF00533	0.379
LIG_Clathr_ClatBox_1	41	45	PF01394	0.622
LIG_deltaCOP1_diTrp_1	377	388	PF00928	0.751
LIG_eIF4E_1	482	488	PF01652	0.379
LIG_FHA_1	131	137	PF00498	0.429
LIG_FHA_1	242	248	PF00498	0.594
LIG_FHA_1	250	256	PF00498	0.486
LIG_FHA_1	268	274	PF00498	0.501
LIG_FHA_1	803	809	PF00498	0.525
LIG_FHA_1	920	926	PF00498	0.711
LIG_FHA_2	292	298	PF00498	0.519
LIG_FHA_2	540	546	PF00498	0.550
LIG_FHA_2	84	90	PF00498	0.787
LIG_LIR_Apic_2	147	153	PF02991	0.429
LIG_LIR_Apic_2	307	313	PF02991	0.561
LIG_LIR_Apic_2	7	12	PF02991	0.679
LIG_LIR_Apic_2	854	858	PF02991	0.705
LIG_LIR_Apic_2	863	868	PF02991	0.698
LIG_LIR_Gen_1	357	362	PF02991	0.562
LIG_LIR_Gen_1	409	420	PF02991	0.426
LIG_LIR_Gen_1	430	440	PF02991	0.425
LIG_LIR_Gen_1	464	473	PF02991	0.429
LIG_LIR_LC3C_4	162	166	PF02991	0.429
LIG_LIR_Nem_3	151	155	PF02991	0.396
LIG_LIR_Nem_3	307	312	PF02991	0.615
LIG_LIR_Nem_3	357	361	PF02991	0.567
LIG_LIR_Nem_3	378	384	PF02991	0.600
LIG_LIR_Nem_3	408	414	PF02991	0.429
LIG_LIR_Nem_3	430	435	PF02991	0.425
LIG_LIR_Nem_3	464	470	PF02991	0.429
LIG_LIR_Nem_3	523	527	PF02991	0.557
LIG_MLH1_MIPbox_1	408	412	PF16413	0.379
LIG_MYND_1	298	302	PF01753	0.598
LIG_MYND_1	663	667	PF01753	0.643
LIG_Pex14_1	146	150	PF04695	0.429
LIG_SH2_CRK	524	528	PF00017	0.566
LIG_SH2_CRK	64	68	PF00017	0.706
LIG_SH2_GRB2like	154	157	PF00017	0.429
LIG_SH2_PTP2	432	435	PF00017	0.429
LIG_SH2_SRC	154	157	PF00017	0.379
LIG_SH2_SRC	311	314	PF00017	0.562
LIG_SH2_STAP1	607	611	PF00017	0.632
LIG_SH2_STAP1	841	845	PF00017	0.581
LIG_SH2_STAT5	154	157	PF00017	0.444
LIG_SH2_STAT5	227	230	PF00017	0.545
LIG_SH2_STAT5	269	272	PF00017	0.510
LIG_SH2_STAT5	311	314	PF00017	0.597
LIG_SH2_STAT5	432	435	PF00017	0.429
LIG_SH2_STAT5	645	648	PF00017	0.720
LIG_SH2_STAT5	747	750	PF00017	0.625
LIG_SH2_STAT5	9	12	PF00017	0.619
LIG_SH3_1	310	316	PF00018	0.566
LIG_SH3_1	865	871	PF00018	0.745
LIG_SH3_3	178	184	PF00018	0.357
LIG_SH3_3	197	203	PF00018	0.465
LIG_SH3_3	310	316	PF00018	0.566
LIG_SH3_3	330	336	PF00018	0.547
LIG_SH3_3	386	392	PF00018	0.434
LIG_SH3_3	442	448	PF00018	0.429
LIG_SH3_3	689	695	PF00018	0.692
LIG_SH3_3	709	715	PF00018	0.640
LIG_SH3_3	75	81	PF00018	0.840
LIG_SH3_3	865	871	PF00018	0.717
LIG_SH3_4	291	298	PF00018	0.571
LIG_SUMO_SIM_anti_2	117	124	PF11976	0.427
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.429
LIG_SUMO_SIM_anti_2	339	352	PF11976	0.645
LIG_SUMO_SIM_anti_2	496	506	PF11976	0.563
LIG_SUMO_SIM_par_1	162	168	PF11976	0.429
LIG_SUMO_SIM_par_1	367	373	PF11976	0.582
LIG_TRAF2_1	145	148	PF00917	0.429
LIG_TRAF2_1	213	216	PF00917	0.680
LIG_TRAF2_1	342	345	PF00917	0.658
LIG_TRAF2_1	543	546	PF00917	0.603
LIG_TRAF2_1	552	555	PF00917	0.603
LIG_TRAF2_1	632	635	PF00917	0.656
LIG_TRAF2_1	659	662	PF00917	0.681
LIG_TRAF2_1	688	691	PF00917	0.664
LIG_TRAF2_1	708	711	PF00917	0.700
LIG_TRAF2_1	715	718	PF00917	0.680
MOD_CDK_SPK_2	913	918	PF00069	0.731
MOD_CDK_SPxK_1	913	919	PF00069	0.737
MOD_CDK_SPxxK_3	854	861	PF00069	0.659
MOD_CK1_1	15	21	PF00069	0.609
MOD_CK1_1	206	212	PF00069	0.519
MOD_CK1_1	434	440	PF00069	0.429
MOD_CK1_1	753	759	PF00069	0.621
MOD_CK1_1	854	860	PF00069	0.678
MOD_CK2_1	15	21	PF00069	0.559
MOD_CK2_1	210	216	PF00069	0.622
MOD_CK2_1	291	297	PF00069	0.600
MOD_CK2_1	338	344	PF00069	0.806
MOD_CK2_1	539	545	PF00069	0.549
MOD_CK2_1	598	604	PF00069	0.760
MOD_CK2_1	622	628	PF00069	0.676
MOD_CK2_1	648	654	PF00069	0.655
MOD_CK2_1	690	696	PF00069	0.713
MOD_CK2_1	756	762	PF00069	0.639
MOD_CK2_1	901	907	PF00069	0.641
MOD_DYRK1A_RPxSP_1	913	917	PF00069	0.724
MOD_GlcNHglycan	112	115	PF01048	0.447
MOD_GlcNHglycan	185	188	PF01048	0.304
MOD_GlcNHglycan	436	439	PF01048	0.379
MOD_GlcNHglycan	55	58	PF01048	0.638
MOD_GlcNHglycan	752	755	PF01048	0.629
MOD_GlcNHglycan	862	865	PF01048	0.711
MOD_GlcNHglycan	871	874	PF01048	0.686
MOD_GSK3_1	206	213	PF00069	0.509
MOD_GSK3_1	218	225	PF00069	0.491
MOD_GSK3_1	406	413	PF00069	0.550
MOD_GSK3_1	907	914	PF00069	0.682
MOD_GSK3_1	919	926	PF00069	0.665
MOD_N-GLC_1	282	287	PF02516	0.633
MOD_NEK2_1	102	107	PF00069	0.429
MOD_NEK2_1	249	254	PF00069	0.485
MOD_NEK2_1	370	375	PF00069	0.604
MOD_NEK2_1	410	415	PF00069	0.429
MOD_NEK2_1	568	573	PF00069	0.716
MOD_NEK2_1	73	78	PF00069	0.662
MOD_NEK2_1	883	888	PF00069	0.684
MOD_PIKK_1	291	297	PF00454	0.519
MOD_PIKK_1	314	320	PF00454	0.621
MOD_PIKK_1	622	628	PF00454	0.701
MOD_PK_1	486	492	PF00069	0.379
MOD_PK_1	598	604	PF00069	0.685
MOD_PKA_1	539	545	PF00069	0.549
MOD_PKA_1	851	857	PF00069	0.738
MOD_PKA_1	912	918	PF00069	0.725
MOD_PKA_2	118	124	PF00069	0.429
MOD_PKA_2	277	283	PF00069	0.671
MOD_PKA_2	851	857	PF00069	0.738
MOD_PKA_2	911	917	PF00069	0.713
MOD_PKA_2	918	924	PF00069	0.709
MOD_Plk_1	598	604	PF00069	0.635
MOD_Plk_1	907	913	PF00069	0.678
MOD_Plk_2-3	340	346	PF00069	0.676
MOD_Plk_2-3	441	447	PF00069	0.429
MOD_Plk_2-3	648	654	PF00069	0.711
MOD_Plk_2-3	690	696	PF00069	0.695
MOD_Plk_4	218	224	PF00069	0.491
MOD_Plk_4	249	255	PF00069	0.532
MOD_Plk_4	284	290	PF00069	0.628
MOD_Plk_4	398	404	PF00069	0.684
MOD_Plk_4	406	412	PF00069	0.498
MOD_Plk_4	851	857	PF00069	0.690
MOD_ProDKin_1	298	304	PF00069	0.698
MOD_ProDKin_1	590	596	PF00069	0.647
MOD_ProDKin_1	616	622	PF00069	0.747
MOD_ProDKin_1	753	759	PF00069	0.621
MOD_ProDKin_1	854	860	PF00069	0.659
MOD_ProDKin_1	913	919	PF00069	0.737
MOD_ProDKin_1	923	929	PF00069	0.671
MOD_SUMO_for_1	336	339	PF00179	0.584
MOD_SUMO_for_1	827	830	PF00179	0.529
MOD_SUMO_rev_2	29	36	PF00179	0.596
MOD_SUMO_rev_2	822	829	PF00179	0.521
TRG_DiLeu_BaEn_1	22	27	PF01217	0.605
TRG_DiLeu_BaEn_1	344	349	PF01217	0.659
TRG_DiLeu_BaEn_1	37	42	PF01217	0.485
TRG_DiLeu_BaEn_1	483	488	PF01217	0.429
TRG_DiLeu_BaEn_1	69	74	PF01217	0.582
TRG_DiLeu_BaLyEn_6	173	178	PF01217	0.304
TRG_DiLeu_LyEn_5	22	27	PF01217	0.605
TRG_DiLeu_LyEn_5	483	488	PF01217	0.304
TRG_ENDOCYTIC_2	2	5	PF00928	0.650
TRG_ENDOCYTIC_2	309	312	PF00928	0.609
TRG_ENDOCYTIC_2	432	435	PF00928	0.429
TRG_ENDOCYTIC_2	524	527	PF00928	0.557
TRG_ENDOCYTIC_2	64	67	PF00928	0.713
TRG_ER_diArg_1	38	40	PF00400	0.619
TRG_ER_diArg_1	421	423	PF00400	0.403
TRG_ER_diArg_1	50	53	PF00400	0.563
TRG_ER_diArg_1	538	541	PF00400	0.607
TRG_ER_diArg_1	59	61	PF00400	0.638
TRG_ER_diArg_1	64	66	PF00400	0.638
TRG_ER_diArg_1	848	851	PF00400	0.736
TRG_ER_diArg_1	90	92	PF00400	0.710
TRG_ER_diArg_1	911	913	PF00400	0.694
TRG_ER_diArg_1	917	919	PF00400	0.712
TRG_NES_CRM1_1	346	359	PF08389	0.601
TRG_NES_CRM1_1	408	424	PF08389	0.403
TRG_NLS_Bipartite_1	525	543	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.759
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	653	657	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H6T3	Leishmania donovani	90%	99%
A4H7W4	Leishmania braziliensis	60%	100%
A4HW91	Leishmania infantum	90%	100%
E9APZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	96%