LeishMANIAdb
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Vac14_Fig4_bd domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Vac14_Fig4_bd domain-containing protein
Gene product:
Vacuolar 14 Fab1-binding region/Vacuolar protein 14 C-terminal Fig4p binding, putative
Species:
Leishmania major
UniProt:
Q4QFI8_LEIMA
TriTrypDb:
LmjF.14.1450 , LMJLV39_140022400 * , LMJSD75_140022100 *
Length:
685

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005942 phosphatidylinositol 3-kinase complex 3 11
GO:0010008 endosome membrane 5 2
GO:0012506 vesicle membrane 4 2
GO:0016020 membrane 2 2
GO:0030659 cytoplasmic vesicle membrane 5 2
GO:0031090 organelle membrane 3 2
GO:0032991 protein-containing complex 1 11
GO:0035032 phosphatidylinositol 3-kinase complex, class III 4 11
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 11
GO:0070772 PAS complex 5 11
GO:0098588 bounding membrane of organelle 4 2
GO:0098796 membrane protein complex 2 11
GO:0110165 cellular anatomical entity 1 2
GO:1902494 catalytic complex 2 11
GO:1990234 transferase complex 3 11

Expansion

Sequence features

Q4QFI8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFI8

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 11
GO:0006644 phospholipid metabolic process 4 11
GO:0006650 glycerophospholipid metabolic process 5 11
GO:0006661 phosphatidylinositol biosynthetic process 6 11
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0008152 metabolic process 1 11
GO:0008610 lipid biosynthetic process 4 11
GO:0008654 phospholipid biosynthetic process 5 11
GO:0009058 biosynthetic process 2 11
GO:0009893 positive regulation of metabolic process 4 2
GO:0009987 cellular process 1 11
GO:0010562 positive regulation of phosphorus metabolic process 6 2
GO:0019220 regulation of phosphate metabolic process 6 2
GO:0019222 regulation of metabolic process 3 2
GO:0019637 organophosphate metabolic process 3 11
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031325 positive regulation of cellular metabolic process 5 2
GO:0033674 positive regulation of kinase activity 6 2
GO:0042325 regulation of phosphorylation 7 2
GO:0042327 positive regulation of phosphorylation 8 2
GO:0043085 positive regulation of catalytic activity 4 2
GO:0043549 regulation of kinase activity 5 2
GO:0044093 positive regulation of molecular function 3 2
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044255 cellular lipid metabolic process 3 11
GO:0045017 glycerolipid biosynthetic process 4 11
GO:0045937 positive regulation of phosphate metabolic process 7 2
GO:0046474 glycerophospholipid biosynthetic process 5 11
GO:0046486 glycerolipid metabolic process 4 11
GO:0046488 phosphatidylinositol metabolic process 6 11
GO:0048518 positive regulation of biological process 3 2
GO:0048522 positive regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 2
GO:0050790 regulation of catalytic activity 3 2
GO:0050794 regulation of cellular process 3 2
GO:0051174 regulation of phosphorus metabolic process 5 2
GO:0051338 regulation of transferase activity 4 2
GO:0051347 positive regulation of transferase activity 5 2
GO:0065007 biological regulation 1 2
GO:0065009 regulation of molecular function 2 2
GO:0071704 organic substance metabolic process 2 11
GO:0090407 organophosphate biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 103 107 PF00656 0.354
CLV_C14_Caspase3-7 327 331 PF00656 0.540
CLV_C14_Caspase3-7 350 354 PF00656 0.529
CLV_C14_Caspase3-7 369 373 PF00656 0.288
CLV_NRD_NRD_1 10 12 PF00675 0.536
CLV_NRD_NRD_1 459 461 PF00675 0.440
CLV_NRD_NRD_1 466 468 PF00675 0.401
CLV_NRD_NRD_1 526 528 PF00675 0.456
CLV_NRD_NRD_1 636 638 PF00675 0.311
CLV_NRD_NRD_1 69 71 PF00675 0.326
CLV_PCSK_FUR_1 149 153 PF00082 0.423
CLV_PCSK_KEX2_1 151 153 PF00082 0.384
CLV_PCSK_KEX2_1 459 461 PF00082 0.440
CLV_PCSK_KEX2_1 466 468 PF00082 0.401
CLV_PCSK_KEX2_1 526 528 PF00082 0.437
CLV_PCSK_KEX2_1 636 638 PF00082 0.311
CLV_PCSK_KEX2_1 69 71 PF00082 0.311
CLV_PCSK_PC1ET2_1 151 153 PF00082 0.384
CLV_PCSK_PC7_1 522 528 PF00082 0.456
CLV_PCSK_SKI1_1 11 15 PF00082 0.476
CLV_PCSK_SKI1_1 151 155 PF00082 0.334
CLV_PCSK_SKI1_1 216 220 PF00082 0.509
CLV_PCSK_SKI1_1 235 239 PF00082 0.368
CLV_PCSK_SKI1_1 365 369 PF00082 0.473
CLV_PCSK_SKI1_1 503 507 PF00082 0.339
CLV_PCSK_SKI1_1 522 526 PF00082 0.157
CLV_PCSK_SKI1_1 527 531 PF00082 0.344
CLV_Separin_Metazoa 121 125 PF03568 0.456
DEG_APCC_DBOX_1 364 372 PF00400 0.485
DEG_APCC_DBOX_1 69 77 PF00400 0.331
DEG_MDM2_SWIB_1 293 301 PF02201 0.447
DEG_SCF_FBW7_2 40 46 PF00400 0.317
DOC_CKS1_1 40 45 PF01111 0.322
DOC_CYCLIN_RxL_1 232 241 PF00134 0.377
DOC_CYCLIN_yClb5_NLxxxL_5 310 319 PF00134 0.244
DOC_MAPK_gen_1 636 643 PF00069 0.423
DOC_MAPK_gen_1 69 76 PF00069 0.354
DOC_MAPK_MEF2A_6 408 415 PF00069 0.429
DOC_MAPK_MEF2A_6 481 488 PF00069 0.458
DOC_MAPK_MEF2A_6 499 508 PF00069 0.181
DOC_MAPK_MEF2A_6 636 645 PF00069 0.508
DOC_MAPK_NFAT4_5 408 416 PF00069 0.428
DOC_PP2B_LxvP_1 219 222 PF13499 0.406
DOC_PP2B_LxvP_1 622 625 PF13499 0.311
DOC_USP7_MATH_1 205 209 PF00917 0.508
DOC_USP7_MATH_1 240 244 PF00917 0.522
DOC_USP7_MATH_1 28 32 PF00917 0.508
DOC_USP7_MATH_1 325 329 PF00917 0.297
DOC_USP7_MATH_1 347 351 PF00917 0.479
DOC_USP7_MATH_1 395 399 PF00917 0.552
DOC_USP7_MATH_1 87 91 PF00917 0.455
DOC_WW_Pin1_4 39 44 PF00397 0.340
DOC_WW_Pin1_4 625 630 PF00397 0.311
LIG_14-3-3_CanoR_1 134 142 PF00244 0.401
LIG_14-3-3_CanoR_1 170 178 PF00244 0.479
LIG_14-3-3_CanoR_1 256 260 PF00244 0.469
LIG_14-3-3_CanoR_1 32 40 PF00244 0.490
LIG_14-3-3_CanoR_1 408 412 PF00244 0.452
LIG_14-3-3_CanoR_1 466 472 PF00244 0.472
LIG_14-3-3_CanoR_1 490 498 PF00244 0.456
LIG_14-3-3_CanoR_1 601 605 PF00244 0.354
LIG_14-3-3_CanoR_1 62 68 PF00244 0.446
LIG_Actin_WH2_1 408 425 PF00022 0.316
LIG_Actin_WH2_2 200 218 PF00022 0.482
LIG_Actin_WH2_2 352 367 PF00022 0.435
LIG_Actin_WH2_2 458 474 PF00022 0.378
LIG_Actin_WH2_2 46 64 PF00022 0.466
LIG_Actin_WH2_2 485 501 PF00022 0.423
LIG_Actin_WH2_2 585 603 PF00022 0.423
LIG_AP2alpha_1 135 139 PF02296 0.423
LIG_APCC_ABBA_1 304 309 PF00400 0.470
LIG_BIR_III_2 106 110 PF00653 0.423
LIG_BRCT_BRCA1_1 593 597 PF00533 0.354
LIG_Clathr_ClatBox_1 644 648 PF01394 0.478
LIG_eIF4E_1 547 553 PF01652 0.423
LIG_eIF4E_1 618 624 PF01652 0.466
LIG_eIF4E_1 68 74 PF01652 0.423
LIG_FHA_1 31 37 PF00498 0.483
LIG_FHA_1 408 414 PF00498 0.398
LIG_FHA_1 563 569 PF00498 0.456
LIG_FHA_1 614 620 PF00498 0.423
LIG_FHA_1 62 68 PF00498 0.479
LIG_FHA_1 640 646 PF00498 0.512
LIG_FHA_2 161 167 PF00498 0.357
LIG_FHA_2 265 271 PF00498 0.475
LIG_FHA_2 338 344 PF00498 0.485
LIG_FHA_2 512 518 PF00498 0.311
LIG_GBD_Chelix_1 504 512 PF00786 0.456
LIG_GBD_Chelix_1 613 621 PF00786 0.423
LIG_LIR_Gen_1 117 128 PF02991 0.432
LIG_LIR_Gen_1 136 146 PF02991 0.152
LIG_LIR_Gen_1 180 189 PF02991 0.369
LIG_LIR_Gen_1 246 254 PF02991 0.523
LIG_LIR_Gen_1 385 394 PF02991 0.360
LIG_LIR_Gen_1 435 445 PF02991 0.317
LIG_LIR_Gen_1 581 589 PF02991 0.410
LIG_LIR_Gen_1 594 605 PF02991 0.261
LIG_LIR_Gen_1 616 625 PF02991 0.427
LIG_LIR_Gen_1 628 638 PF02991 0.276
LIG_LIR_Nem_3 117 123 PF02991 0.393
LIG_LIR_Nem_3 136 142 PF02991 0.153
LIG_LIR_Nem_3 180 184 PF02991 0.354
LIG_LIR_Nem_3 246 252 PF02991 0.514
LIG_LIR_Nem_3 34 40 PF02991 0.467
LIG_LIR_Nem_3 385 389 PF02991 0.350
LIG_LIR_Nem_3 435 440 PF02991 0.322
LIG_LIR_Nem_3 514 518 PF02991 0.335
LIG_LIR_Nem_3 581 585 PF02991 0.396
LIG_LIR_Nem_3 594 600 PF02991 0.239
LIG_LIR_Nem_3 616 621 PF02991 0.410
LIG_LIR_Nem_3 628 634 PF02991 0.241
LIG_LIR_Nem_3 667 671 PF02991 0.423
LIG_NRBOX 233 239 PF00104 0.434
LIG_NRBOX 383 389 PF00104 0.452
LIG_NRBOX 444 450 PF00104 0.477
LIG_NRBOX 616 622 PF00104 0.423
LIG_NRBOX 92 98 PF00104 0.456
LIG_Pex14_2 131 135 PF04695 0.317
LIG_Pex14_2 293 297 PF04695 0.446
LIG_SH2_CRK 547 551 PF00017 0.311
LIG_SH2_CRK 631 635 PF00017 0.339
LIG_SH2_NCK_1 547 551 PF00017 0.311
LIG_SH2_PTP2 582 585 PF00017 0.416
LIG_SH2_PTP2 618 621 PF00017 0.472
LIG_SH2_STAP1 681 685 PF00017 0.588
LIG_SH2_STAT5 192 195 PF00017 0.543
LIG_SH2_STAT5 582 585 PF00017 0.421
LIG_SH2_STAT5 618 621 PF00017 0.463
LIG_SH2_STAT5 671 674 PF00017 0.515
LIG_SH3_3 37 43 PF00018 0.473
LIG_SH3_3 81 87 PF00018 0.423
LIG_SUMO_SIM_anti_2 366 373 PF11976 0.513
LIG_SUMO_SIM_anti_2 385 391 PF11976 0.217
LIG_SUMO_SIM_anti_2 46 52 PF11976 0.535
LIG_SUMO_SIM_par_1 194 202 PF11976 0.586
LIG_SUMO_SIM_par_1 347 353 PF11976 0.495
LIG_SUMO_SIM_par_1 366 373 PF11976 0.270
LIG_SUMO_SIM_par_1 46 52 PF11976 0.504
LIG_TRAF2_1 340 343 PF00917 0.493
LIG_TRAF2_1 375 378 PF00917 0.498
LIG_TRAF2_1 673 676 PF00917 0.529
LIG_WRC_WIRS_1 178 183 PF05994 0.431
MOD_CK1_1 171 177 PF00069 0.518
MOD_CK1_1 183 189 PF00069 0.385
MOD_CK1_1 229 235 PF00069 0.432
MOD_CK1_1 243 249 PF00069 0.368
MOD_CK1_1 264 270 PF00069 0.494
MOD_CK1_1 287 293 PF00069 0.407
MOD_CK1_1 31 37 PF00069 0.547
MOD_CK1_1 435 441 PF00069 0.356
MOD_CK1_1 493 499 PF00069 0.416
MOD_CK1_1 578 584 PF00069 0.331
MOD_CK1_1 595 601 PF00069 0.331
MOD_CK2_1 160 166 PF00069 0.384
MOD_CK2_1 337 343 PF00069 0.320
MOD_CK2_1 363 369 PF00069 0.443
MOD_CK2_1 470 476 PF00069 0.435
MOD_CK2_1 511 517 PF00069 0.311
MOD_CK2_1 670 676 PF00069 0.456
MOD_GlcNHglycan 170 173 PF01048 0.508
MOD_GlcNHglycan 195 198 PF01048 0.596
MOD_GlcNHglycan 263 266 PF01048 0.582
MOD_GlcNHglycan 286 289 PF01048 0.502
MOD_GlcNHglycan 355 358 PF01048 0.540
MOD_GlcNHglycan 372 375 PF01048 0.391
MOD_GlcNHglycan 472 475 PF01048 0.460
MOD_GlcNHglycan 662 666 PF01048 0.543
MOD_GlcNHglycan 672 675 PF01048 0.475
MOD_GSK3_1 133 140 PF00069 0.423
MOD_GSK3_1 160 167 PF00069 0.406
MOD_GSK3_1 225 232 PF00069 0.469
MOD_GSK3_1 257 264 PF00069 0.516
MOD_GSK3_1 27 34 PF00069 0.431
MOD_GSK3_1 283 290 PF00069 0.422
MOD_GSK3_1 325 332 PF00069 0.507
MOD_GSK3_1 591 598 PF00069 0.423
MOD_N-GLC_1 243 248 PF02516 0.502
MOD_N-GLC_1 313 318 PF02516 0.248
MOD_N-GLC_1 432 437 PF02516 0.294
MOD_NEK2_1 164 169 PF00069 0.505
MOD_NEK2_1 226 231 PF00069 0.529
MOD_NEK2_1 238 243 PF00069 0.357
MOD_NEK2_1 313 318 PF00069 0.458
MOD_NEK2_1 319 324 PF00069 0.471
MOD_NEK2_1 363 368 PF00069 0.448
MOD_NEK2_1 370 375 PF00069 0.500
MOD_NEK2_1 511 516 PF00069 0.324
MOD_NEK2_1 529 534 PF00069 0.311
MOD_NEK2_1 537 542 PF00069 0.391
MOD_NEK2_1 562 567 PF00069 0.437
MOD_NEK2_1 592 597 PF00069 0.427
MOD_NEK2_1 60 65 PF00069 0.407
MOD_NEK2_1 600 605 PF00069 0.331
MOD_NEK2_1 613 618 PF00069 0.235
MOD_NEK2_1 7 12 PF00069 0.489
MOD_PIKK_1 205 211 PF00454 0.502
MOD_PIKK_1 257 263 PF00454 0.542
MOD_PIKK_1 31 37 PF00454 0.476
MOD_PKA_2 133 139 PF00069 0.423
MOD_PKA_2 255 261 PF00069 0.410
MOD_PKA_2 31 37 PF00069 0.480
MOD_PKA_2 407 413 PF00069 0.444
MOD_PKA_2 422 428 PF00069 0.316
MOD_PKA_2 600 606 PF00069 0.354
MOD_PKA_2 61 67 PF00069 0.430
MOD_Plk_1 313 319 PF00069 0.314
MOD_Plk_1 376 382 PF00069 0.366
MOD_Plk_1 432 438 PF00069 0.524
MOD_Plk_1 575 581 PF00069 0.423
MOD_Plk_1 592 598 PF00069 0.423
MOD_Plk_4 180 186 PF00069 0.385
MOD_Plk_4 229 235 PF00069 0.534
MOD_Plk_4 376 382 PF00069 0.501
MOD_Plk_4 537 543 PF00069 0.347
MOD_Plk_4 578 584 PF00069 0.334
MOD_Plk_4 600 606 PF00069 0.329
MOD_Plk_4 613 619 PF00069 0.293
MOD_Plk_4 639 645 PF00069 0.486
MOD_ProDKin_1 39 45 PF00069 0.330
MOD_ProDKin_1 625 631 PF00069 0.311
TRG_DiLeu_BaEn_1 439 444 PF01217 0.442
TRG_DiLeu_BaEn_4 46 52 PF01217 0.424
TRG_DiLeu_BaLyEn_6 444 449 PF01217 0.469
TRG_ENDOCYTIC_2 120 123 PF00928 0.398
TRG_ENDOCYTIC_2 37 40 PF00928 0.511
TRG_ENDOCYTIC_2 547 550 PF00928 0.316
TRG_ENDOCYTIC_2 582 585 PF00928 0.396
TRG_ENDOCYTIC_2 618 621 PF00928 0.444
TRG_ENDOCYTIC_2 631 634 PF00928 0.231
TRG_ER_diArg_1 289 292 PF00400 0.463
TRG_ER_diArg_1 458 460 PF00400 0.440
TRG_ER_diArg_1 465 467 PF00400 0.401
TRG_ER_diArg_1 525 527 PF00400 0.456
TRG_ER_diArg_1 636 638 PF00400 0.315
TRG_ER_diArg_1 68 70 PF00400 0.331
TRG_ER_FFAT_2 667 676 PF00635 0.299
TRG_NES_CRM1_1 296 309 PF08389 0.478
TRG_NES_CRM1_1 497 509 PF08389 0.423
TRG_Pf-PMV_PEXEL_1 12 16 PF00026 0.526
TRG_Pf-PMV_PEXEL_1 365 369 PF00026 0.237
TRG_Pf-PMV_PEXEL_1 566 570 PF00026 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC70 Leptomonas seymouri 61% 99%
A0A1X0NNZ5 Trypanosomatidae 30% 99%
A0A3Q8IA32 Leishmania donovani 94% 100%
A0A422N3V6 Trypanosoma rangeli 30% 99%
A4H7W5 Leishmania braziliensis 84% 100%
A4HW92 Leishmania infantum 94% 100%
C9ZSR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 99%
E9APZ3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
P87145 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 24% 84%
Q9ZU97 Arabidopsis thaliana 26% 92%
V5AVZ7 Trypanosoma cruzi 30% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS