Mitochondrial pyruvate carrier

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial pyruvate carrier 2

Species:

Leishmania major

UniProt:

Q4QFI7_LEIMA

TriTrypDb:

LmjF.14.1460 , LMJLV39_140022500 , LMJSD75_140022200

Length:

140

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005743	mitochondrial inner membrane	5	11
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	11
GO:0031090	organelle membrane	3	11
GO:0031966	mitochondrial membrane	4	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QFI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFI7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006811	monoatomic ion transport	4	11
GO:0006820	monoatomic anion transport	5	11
GO:0006848	pyruvate transport	6	11
GO:0006850	mitochondrial pyruvate transmembrane transport	4	11
GO:0009987	cellular process	1	11
GO:0015711	organic anion transport	5	11
GO:0015718	monocarboxylic acid transport	7	11
GO:0015849	organic acid transport	5	11
GO:0034220	monoatomic ion transmembrane transport	3	11
GO:0046942	carboxylic acid transport	6	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0055085	transmembrane transport	2	11
GO:0071702	organic substance transport	4	11
GO:0098656	monoatomic anion transmembrane transport	4	11
GO:1901475	pyruvate transmembrane transport	5	11
GO:1903825	organic acid transmembrane transport	3	11
GO:1905039	carboxylic acid transmembrane transport	4	11
GO:1990542	mitochondrial transmembrane transport	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.274
CLV_PCSK_KEX2_1	129	131	PF00082	0.218
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.225
DOC_MAPK_MEF2A_6	105	114	PF00069	0.442
DOC_PP1_RVXF_1	72	78	PF00149	0.224
DOC_PP4_FxxP_1	30	33	PF00568	0.421
DOC_USP7_MATH_1	17	21	PF00917	0.469
DOC_USP7_MATH_1	99	103	PF00917	0.424
DOC_USP7_UBL2_3	12	16	PF12436	0.354
LIG_BIR_II_1	1	5	PF00653	0.389
LIG_eIF4E_1	47	53	PF01652	0.266
LIG_FHA_1	22	28	PF00498	0.432
LIG_FHA_1	47	53	PF00498	0.301
LIG_FHA_1	84	90	PF00498	0.253
LIG_LIR_Nem_3	67	72	PF02991	0.253
LIG_LYPXL_yS_3	69	72	PF13949	0.245
LIG_MYND_1	11	15	PF01753	0.396
LIG_PCNA_PIPBox_1	36	45	PF02747	0.381
LIG_Pex14_2	14	18	PF04695	0.438
LIG_PTB_Apo_2	41	48	PF02174	0.352
LIG_PTB_Phospho_1	41	47	PF10480	0.348
LIG_SH2_CRK	63	67	PF00017	0.301
LIG_SH2_CRK	93	97	PF00017	0.272
LIG_SH2_GRB2like	42	45	PF00017	0.347
LIG_SH2_NCK_1	47	51	PF00017	0.235
LIG_SH2_SRC	42	45	PF00017	0.360
LIG_SH2_STAP1	93	97	PF00017	0.272
LIG_SH2_STAT5	42	45	PF00017	0.362
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.466
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.242
MOD_CK1_1	3	9	PF00069	0.391
MOD_GlcNHglycan	101	104	PF01048	0.224
MOD_GlcNHglycan	124	127	PF01048	0.294
MOD_GlcNHglycan	66	69	PF01048	0.472
MOD_GlcNHglycan	79	82	PF01048	0.228
MOD_GSK3_1	17	24	PF00069	0.440
MOD_GSK3_1	42	49	PF00069	0.277
MOD_GSK3_1	99	106	PF00069	0.425
MOD_N-GLC_1	77	82	PF02516	0.253
MOD_N-GLC_2	111	113	PF02516	0.224
MOD_NEK2_1	1	6	PF00069	0.450
MOD_NEK2_1	53	58	PF00069	0.242
MOD_NEK2_1	77	82	PF00069	0.258
MOD_NEK2_1	83	88	PF00069	0.246
MOD_NEK2_2	42	47	PF00069	0.378
MOD_Plk_4	17	23	PF00069	0.405
MOD_Plk_4	42	48	PF00069	0.235
MOD_Plk_4	55	61	PF00069	0.242
TRG_ENDOCYTIC_2	63	66	PF00928	0.224
TRG_ENDOCYTIC_2	69	72	PF00928	0.224
TRG_ENDOCYTIC_2	93	96	PF00928	0.253

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T5	Leptomonas seymouri	85%	100%
A0A0S4IYK9	Bodo saltans	60%	100%
A0A1X0NNE8	Trypanosomatidae	72%	100%
A0A3S7WT79	Leishmania donovani	96%	100%
A0A422N3T5	Trypanosoma rangeli	57%	100%
A4H7W6	Leishmania braziliensis	83%	100%
A4HW93	Leishmania infantum	96%	100%
C9ZSR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9APZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q55GU3	Dictyostelium discoideum	46%	100%